Mariners vs. Red Sox
Prediction, Odds & Props
Apr 22 | MLB AI Picks
Updated: 2025-04-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Seattle Mariners (12–10) and Boston Red Sox (12–11) open a three-game series at Fenway Park on April 22, 2025, with first pitch scheduled for 6:45 PM ET. Seattle’s Bryce Miller (2–1, 3.86 ERA) will face Boston’s Brayan Bello (1–2, 4.50 ERA) in a matchup of promising young right-handers.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Apr 22, 2025
Start Time: 6:45 PM EST
Venue: Fenway Park
Red Sox Record: (13-11)
Mariners Record: (12-10)
OPENING ODDS
SEA Moneyline: +114
BOS Moneyline: -135
SEA Spread: +1.5
BOS Spread: -1.5
Over/Under: 9
SEA
Betting Trends
- The Mariners have a 12–10 record against the spread (ATS) this season, covering 54.6% of the time, indicating a consistent performance for bettors.
BOS
Betting Trends
- The Red Sox have struggled ATS, with a 7–11 record, covering only 38.9% of the time, reflecting challenges in meeting betting expectations.
MATCHUP TRENDS
- Seattle has covered the run line in four of their last five games, showcasing a strong recent trend. Conversely, Boston has failed to cover in five of their last seven home games, highlighting potential vulnerabilities at Fenway Park.
SEA vs. BOS
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: R. Tellez over 0.5 Total Bases.
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Seattle vs Boston Prediction & Odds:
Free MLB Betting Insights for 4/22/25
The Red Sox counter with Brayan Bello, a promising but still-developing right-hander who owns a 1–2 record and a 4.50 ERA entering this matchup. Bello has shown flashes of brilliance, particularly with his changeup, but control issues and early-inning command lapses have led to elevated pitch counts and short outings. This puts additional strain on Boston’s bullpen, which has been good in spots—especially with Aroldis Chapman closing games—but cannot continue to shoulder extended workloads. Offensively, the Red Sox will look to Trevor Story and Wilyer Abreu to carry the load. Story is hitting .308 with three homers and has been steady in the middle of the lineup, while Abreu has been electric, posting a .340 average and leading the team with a 1.068 OPS. However, the supporting cast around them has struggled with runners in scoring position, leading to squandered opportunities in close games. From a betting standpoint, Seattle enters this series with more reliability against the spread and superior early-game execution. Their ability to seize momentum in the first five innings has translated into tangible betting value, while Boston’s struggles to meet the number at home cast doubt on their ability to protect Fenway. The Red Sox have the offensive tools to make it competitive, but they’ll need more from their pitching staff and tighter defensive execution to hold off a Mariners team that seems to be heating up. With both teams eager to find consistency, this series opener promises a compelling chess match between two clubs with playoff aspirations and urgency to prove their staying power.
DMO was on fire last week! #TridentsUp pic.twitter.com/hjDZIvb19V
— Seattle Mariners (@Mariners) April 21, 2025
Seattle Mariners MLB Preview
The Seattle Mariners enter Tuesday’s series opener at Fenway Park with a 12–10 record, carrying momentum and confidence following a string of solid performances that have them trending upward in the American League West. What stands out about this Mariners club is its blend of emerging talent and tested contributors who are beginning to find a rhythm as April closes. From a betting standpoint, they’ve been one of the more consistent teams against the spread, covering the run line in four of their last five games and boasting a 12–10 ATS record on the season. That reliability is rooted in their early-inning execution, strong bullpen depth, and timely power, which gives them an edge over less consistent opponents. Manager Scott Servais has been deliberate in his deployment of arms and bats, making in-game adjustments that have paid off, especially on the road where the Mariners have shown no fear of hostile environments. Seattle will send Bryce Miller to the mound, a young right-hander who has quickly established himself as a stabilizing force in the rotation. Miller enters the contest with a 2–1 record and a 3.86 ERA, demonstrating command and poise beyond his years. His ability to attack the strike zone with a sharp fastball and a developing off-speed mix has made him particularly effective against lineups that chase early in counts. While he’s not a strikeout-heavy pitcher in the traditional sense, Miller relies on inducing weak contact and generating ground balls to escape innings efficiently. Against a Boston lineup that can be dangerous when it gets extended looks, his ability to get ahead early and stay away from full counts will be key.
The Mariners will look to Miller to set the tone, keep the game within reach, and allow their bullpen—which has been a strength—to control the late innings. Offensively, the Mariners are beginning to unlock their potential. Cal Raleigh leads the charge with nine home runs and 15 RBIs, providing power from behind the plate and setting the emotional tone with his intensity and timely hitting. Jorge Polanco has been red-hot, hitting .346 and delivering clutch hits in the heart of the lineup. Meanwhile, all eyes remain on Julio Rodríguez, whose start has been somewhat subdued by his standards but who still poses a major threat with his combination of speed, power, and defensive range. If Rodríguez finds his swing during this series, it could tilt the balance heavily in Seattle’s favor. Supporting players like Ty France and Mitch Haniger have contributed in spurts, and if the lineup as a whole can improve its collective average of .233, the Mariners could become a far more dangerous opponent going forward. Defensively, Seattle is steady and athletic, with above-average range across the infield and reliable arms in the outfield. Their defensive efficiency has helped limit damage during innings where opposing teams threaten, and their ability to convert routine plays into outs has been key in close games. With a dependable bullpen led by Andrés Muñoz and Ryne Stanek, the Mariners have shown the ability to protect narrow leads and close out contests with composure. This trip to Boston offers an opportunity to build on their momentum, capitalize on a Red Sox team still trying to find itself at home, and reinforce their identity as a disciplined, well-rounded squad capable of competing with any team in the league.

Credit: USA TODAY/IMAGN
Boston Red Sox MLB Preview
The Boston Red Sox enter Tuesday’s clash with the Seattle Mariners sitting at 12–11, a record that reflects the up-and-down nature of their early 2025 campaign. While the club remains competitive in a loaded American League East, it has struggled with consistency in all three phases of the game. Offensively, Boston has shown glimpses of power and aggression, but those bursts have too often been followed by cold spells that stall rallies and prevent them from closing the door on winnable games. At home, the Red Sox have been particularly erratic, failing to cover the run line in five of their last seven games at Fenway Park—a troubling trend that suggests a combination of pitching volatility and underwhelming situational execution. Manager Alex Cora continues to seek the right lineup combinations and bullpen strategies to restore the rhythm that defined the club’s best stretches last season, but injuries and inconsistency have made that pursuit challenging in the opening month. On the mound for Boston is right-hander Brayan Bello, a promising arm with a high ceiling but one that has yet to fully settle into a groove this season. Bello enters the matchup with a 1–2 record and a 4.50 ERA, numbers that speak to his uneven outings through April. While he’s shown flashes of brilliance—particularly when his changeup and fastball location are sharp—he’s also had trouble working deep into games due to early command issues and an occasional vulnerability to the long ball. His outing will be critical not only for setting the tone against a disciplined Mariners lineup but also in providing a breather for a bullpen that has been leaned on heavily.
Aroldis Chapman has brought stability at the back end with electric stuff and a fiery edge, but the bridge from starter to closer has been bumpy at times, and Bello’s ability to minimize damage early will determine whether Boston can hand the game over to its trusted late-inning arms with a lead. Offensively, the Red Sox are anchored by the consistent presence of Trevor Story, who’s off to a solid start batting .308 with three home runs and eight RBIs. His leadership and steady bat have provided Boston with a backbone in the heart of the order. Wilyer Abreu has emerged as one of the most exciting young players in the lineup, hitting .340 with a 1.068 OPS and offering a mix of speed and power that has sparked the offense on multiple occasions. However, outside of these two bright spots, production has been uneven. The supporting cast has struggled with runners in scoring position, and the lineup has yet to develop the kind of top-to-bottom threat that can consistently pressure opposing pitchers. If Boston hopes to contend in a crowded division and flip its home-field narrative, it must improve in clutch situations and tighten up defensive lapses that have led to unearned runs and extra outs. As they welcome a surging Seattle team to Fenway, the Red Sox face an early litmus test of their resilience and capacity for in-game adjustments. The Mariners’ strength lies in their pitching discipline and timely offense, two areas where Boston must respond with precision. Tuesday’s game offers not only a chance to secure a valuable win but also a critical opportunity to set a new tone at home—something the team desperately needs as the season begins to take shape. For Boston, a return to fundamentals, efficient starting pitching, and smart at-bats will be key to keeping pace with a Seattle team that has proven it can capitalize on mistakes.
Series win on Patriots' Day!
— Red Sox (@RedSox) April 21, 2025
🗒️ https://t.co/FWGp0PadoT pic.twitter.com/WNKZXFPADY
Seattle vs. Boston Prop Picks (AI)
Seattle vs. Boston Prediction (AI)

Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every simulation between the Mariners and Red Sox and using recursive machine learning and impressive AI to crunch the data to a single cover probability.
Remi has been most watching on the growing emphasis knucklehead sportsbettors often put on Boston’s strength factors between a Mariners team going up against a possibly healthy Red Sox team. Trends look to say the true game analytics might reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Seattle vs Boston picks, computer picks Mariners vs Red Sox, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 9/26 | DET@BOS | UNLOCK THIS PICK | 5 |
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MLB | 9/26 | BAL@NYY | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | ARI@SD | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | NYM@MIA | UNLOCK THIS PICK | 1 |
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MLB | 9/26 | NYM@MIA | GET FREE PICK NOW | 1 | – | |
MLB | 9/26 | COL@SF | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Mariners Betting Trends
The Mariners have a 12–10 record against the spread (ATS) this season, covering 54.6% of the time, indicating a consistent performance for bettors.
Red Sox Betting Trends
The Red Sox have struggled ATS, with a 7–11 record, covering only 38.9% of the time, reflecting challenges in meeting betting expectations.
Mariners vs. Red Sox Matchup Trends
Seattle has covered the run line in four of their last five games, showcasing a strong recent trend. Conversely, Boston has failed to cover in five of their last seven home games, highlighting potential vulnerabilities at Fenway Park.
Seattle vs. Boston Game Info
What time does Seattle vs Boston start on April 22, 2025?
Seattle vs Boston starts on April 22, 2025 at 6:45 PM EST.
Where is Seattle vs Boston being played?
Venue: Fenway Park.
What are the opening odds for Seattle vs Boston?
Spread: Boston -1.5
Moneyline: Seattle +114, Boston -135
Over/Under: 9
What are the records for Seattle vs Boston?
Seattle: (12-10) | Boston: (13-11)
What is the AI best bet for Seattle vs Boston?
Remi's searched hard and found the best prop for this matchup: R. Tellez over 0.5 Total Bases.. Prices move—always shop for the best number.
What are Seattle vs Boston trending bets?
Seattle has covered the run line in four of their last five games, showcasing a strong recent trend. Conversely, Boston has failed to cover in five of their last seven home games, highlighting potential vulnerabilities at Fenway Park.
What are Seattle trending bets?
SEA trend: The Mariners have a 12–10 record against the spread (ATS) this season, covering 54.6% of the time, indicating a consistent performance for bettors.
What are Boston trending bets?
BOS trend: The Red Sox have struggled ATS, with a 7–11 record, covering only 38.9% of the time, reflecting challenges in meeting betting expectations.
Where can I find AI Picks for Seattle vs Boston?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Seattle vs. Boston Odds
Remi is pouring through tons of data points on each line. In fact, anytime the Seattle vs Boston trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable betting trends.
Seattle vs Boston Opening Odds
SEA Moneyline:
+114 BOS Moneyline: -135
SEA Spread: +1.5
BOS Spread: -1.5
Over/Under: 9
Seattle vs Boston Live Odds
Games | PTS | ML | SPR | O/U | |
---|---|---|---|---|---|
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
|
–
–
|
+190
-235
|
+1.5 (-110)
-1.5 (-110)
|
O 8.5 (-120)
U 8.5 (+100)
|
|
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
|
–
–
|
-175
|
-1.5 (+115)
|
O 9.5 (-105)
U 9.5 (-115)
|
|
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
|
–
–
|
+130
-155
|
+1.5 (-155)
-1.5 (+130)
|
O 8.5 (-110)
U 8.5 (-110)
|
|
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
|
–
–
|
+100
-120
|
-1.5 (+165)
+1.5 (-200)
|
O 8.5 (-110)
U 8.5 (-110)
|
|
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
|
–
–
|
+185
-225
|
+1.5 (-110)
-1.5 (-110)
|
O 8 (-105)
U 8 (-115)
|
|
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
|
–
–
|
-130
+110
|
-1.5 (+125)
+1.5 (-150)
|
O 8.5 (-105)
U 8.5 (-115)
|
|
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
|
–
–
|
+170
-205
|
+1.5 (-120)
-1.5 (+100)
|
O 8.5 (-115)
U 8.5 (-105)
|
|
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
|
–
–
|
+125
-150
|
+1.5 (-180)
-1.5 (+150)
|
O 8 (-105)
U 8 (-115)
|
|
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
|
–
–
|
+140
-170
|
+1.5 (-155)
-1.5 (+130)
|
O 8 (-110)
U 8 (-110)
|
|
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
|
–
–
|
+135
-165
|
+1.5 (-180)
-1.5 (+150)
|
O 7 (-120)
U 7 (+100)
|
|
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
|
–
–
|
+115
-140
|
+1.5 (-190)
-1.5 (+155)
|
O 7.5 (-120)
U 7.5 (+100)
|
|
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
|
–
–
|
-165
+135
|
-1.5 (+105)
+1.5 (-125)
|
O 9 (+100)
U 9 (-120)
|
|
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
|
–
–
|
+100
-120
|
-1.5 (+170)
+1.5 (-205)
|
O 7.5 (-110)
U 7.5 (-110)
|
|
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
|
–
–
|
+100
-120
|
-1.5 (+150)
+1.5 (-180)
|
O 10 (-110)
U 10 (-110)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Seattle Mariners vs. Boston Red Sox on April 22, 2025 at Fenway Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |
CIN@ARI | KEBRYAN HAYES STRIKEOUTS UNDER 0.5 | 56.2% | 6 | WIN |
LAD@SD | SD +110 | 50.9% | 6 | WIN |