Mariners vs. Red Sox
Prediction, Odds & Props
Apr 22 | MLB AI Picks

Updated: 2025-04-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Seattle Mariners (12–10) and Boston Red Sox (12–11) open a three-game series at Fenway Park on April 22, 2025, with first pitch scheduled for 6:45 PM ET. Seattle’s Bryce Miller (2–1, 3.86 ERA) will face Boston’s Brayan Bello (1–2, 4.50 ERA) in a matchup of promising young right-handers.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 22, 2025

Start Time: 6:45 PM EST​

Venue: Fenway Park​

Red Sox Record: (13-11)

Mariners Record: (12-10)

OPENING ODDS

SEA Moneyline: +114

BOS Moneyline: -135

SEA Spread: +1.5

BOS Spread: -1.5

Over/Under: 9

SEA
Betting Trends

  • The Mariners have a 12–10 record against the spread (ATS) this season, covering 54.6% of the time, indicating a consistent performance for bettors.

BOS
Betting Trends

  • The Red Sox have struggled ATS, with a 7–11 record, covering only 38.9% of the time, reflecting challenges in meeting betting expectations.

MATCHUP TRENDS

  • Seattle has covered the run line in four of their last five games, showcasing a strong recent trend. Conversely, Boston has failed to cover in five of their last seven home games, highlighting potential vulnerabilities at Fenway Park.

SEA vs. BOS
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: R. Tellez over 0.5 Total Bases.

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Seattle vs Boston Prediction & Odds:
Free MLB Betting Insights for 4/22/25

The upcoming three-game series between the Seattle Mariners and the Boston Red Sox at Fenway Park is shaping up to be a tightly contested matchup between two American League teams hovering near .500 but with very different trajectories and internal narratives. The Mariners enter the contest with a 12–10 record and a wave of recent momentum, having covered the run line in four of their last five games, showcasing both early-game effectiveness and late-game poise. On the other hand, the Red Sox stand at 12–11, battling inconsistency and searching for rhythm, particularly at home where they have failed to cover the run line in five of their last seven appearances. This sets the stage for a series rich with implications for both clubs—Seattle is trying to assert itself in the competitive AL West, while Boston is attempting to stabilize its roster and performance before a brutal May schedule begins. Seattle will send right-hander Bryce Miller to the mound in the opener. Miller has been a beacon of consistency so far, sporting a 2–1 record with a 3.86 ERA and giving the Mariners valuable innings while limiting hard contact. His ability to mix speeds and change eye levels has made him especially tough on right-handed hitters, something Boston’s predominantly righty-heavy lineup must contend with. Backing Miller is an offense that has steadily improved after a slow start to the season. Cal Raleigh has emerged as the team’s top slugger, already clubbing nine home runs, while Jorge Polanco continues to rake, batting .346 and serving as a table-setter and run producer. Though Julio Rodríguez has not yet reached his full potential this season, his multi-dimensional talent remains a constant threat at the top of the order. Seattle’s bullpen, anchored by Andrés Muñoz and Ryne Stanek, has performed admirably, converting tight leads and holding down opponents in the later innings—an area where they may hold an edge over Boston.

The Red Sox counter with Brayan Bello, a promising but still-developing right-hander who owns a 1–2 record and a 4.50 ERA entering this matchup. Bello has shown flashes of brilliance, particularly with his changeup, but control issues and early-inning command lapses have led to elevated pitch counts and short outings. This puts additional strain on Boston’s bullpen, which has been good in spots—especially with Aroldis Chapman closing games—but cannot continue to shoulder extended workloads. Offensively, the Red Sox will look to Trevor Story and Wilyer Abreu to carry the load. Story is hitting .308 with three homers and has been steady in the middle of the lineup, while Abreu has been electric, posting a .340 average and leading the team with a 1.068 OPS. However, the supporting cast around them has struggled with runners in scoring position, leading to squandered opportunities in close games. From a betting standpoint, Seattle enters this series with more reliability against the spread and superior early-game execution. Their ability to seize momentum in the first five innings has translated into tangible betting value, while Boston’s struggles to meet the number at home cast doubt on their ability to protect Fenway. The Red Sox have the offensive tools to make it competitive, but they’ll need more from their pitching staff and tighter defensive execution to hold off a Mariners team that seems to be heating up. With both teams eager to find consistency, this series opener promises a compelling chess match between two clubs with playoff aspirations and urgency to prove their staying power.

Seattle Mariners MLB Preview

The Seattle Mariners enter Tuesday’s series opener at Fenway Park with a 12–10 record, carrying momentum and confidence following a string of solid performances that have them trending upward in the American League West. What stands out about this Mariners club is its blend of emerging talent and tested contributors who are beginning to find a rhythm as April closes. From a betting standpoint, they’ve been one of the more consistent teams against the spread, covering the run line in four of their last five games and boasting a 12–10 ATS record on the season. That reliability is rooted in their early-inning execution, strong bullpen depth, and timely power, which gives them an edge over less consistent opponents. Manager Scott Servais has been deliberate in his deployment of arms and bats, making in-game adjustments that have paid off, especially on the road where the Mariners have shown no fear of hostile environments. Seattle will send Bryce Miller to the mound, a young right-hander who has quickly established himself as a stabilizing force in the rotation. Miller enters the contest with a 2–1 record and a 3.86 ERA, demonstrating command and poise beyond his years. His ability to attack the strike zone with a sharp fastball and a developing off-speed mix has made him particularly effective against lineups that chase early in counts. While he’s not a strikeout-heavy pitcher in the traditional sense, Miller relies on inducing weak contact and generating ground balls to escape innings efficiently. Against a Boston lineup that can be dangerous when it gets extended looks, his ability to get ahead early and stay away from full counts will be key.

The Mariners will look to Miller to set the tone, keep the game within reach, and allow their bullpen—which has been a strength—to control the late innings. Offensively, the Mariners are beginning to unlock their potential. Cal Raleigh leads the charge with nine home runs and 15 RBIs, providing power from behind the plate and setting the emotional tone with his intensity and timely hitting. Jorge Polanco has been red-hot, hitting .346 and delivering clutch hits in the heart of the lineup. Meanwhile, all eyes remain on Julio Rodríguez, whose start has been somewhat subdued by his standards but who still poses a major threat with his combination of speed, power, and defensive range. If Rodríguez finds his swing during this series, it could tilt the balance heavily in Seattle’s favor. Supporting players like Ty France and Mitch Haniger have contributed in spurts, and if the lineup as a whole can improve its collective average of .233, the Mariners could become a far more dangerous opponent going forward. Defensively, Seattle is steady and athletic, with above-average range across the infield and reliable arms in the outfield. Their defensive efficiency has helped limit damage during innings where opposing teams threaten, and their ability to convert routine plays into outs has been key in close games. With a dependable bullpen led by Andrés Muñoz and Ryne Stanek, the Mariners have shown the ability to protect narrow leads and close out contests with composure. This trip to Boston offers an opportunity to build on their momentum, capitalize on a Red Sox team still trying to find itself at home, and reinforce their identity as a disciplined, well-rounded squad capable of competing with any team in the league.

The Seattle Mariners (12–10) and Boston Red Sox (12–11) open a three-game series at Fenway Park on April 22, 2025, with first pitch scheduled for 6:45 PM ET. Seattle’s Bryce Miller (2–1, 3.86 ERA) will face Boston’s Brayan Bello (1–2, 4.50 ERA) in a matchup of promising young right-handers. Seattle vs Boston AI Prediction: Free MLB Betting Insights for Apr 22. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Boston Red Sox MLB Preview

The Boston Red Sox enter Tuesday’s clash with the Seattle Mariners sitting at 12–11, a record that reflects the up-and-down nature of their early 2025 campaign. While the club remains competitive in a loaded American League East, it has struggled with consistency in all three phases of the game. Offensively, Boston has shown glimpses of power and aggression, but those bursts have too often been followed by cold spells that stall rallies and prevent them from closing the door on winnable games. At home, the Red Sox have been particularly erratic, failing to cover the run line in five of their last seven games at Fenway Park—a troubling trend that suggests a combination of pitching volatility and underwhelming situational execution. Manager Alex Cora continues to seek the right lineup combinations and bullpen strategies to restore the rhythm that defined the club’s best stretches last season, but injuries and inconsistency have made that pursuit challenging in the opening month. On the mound for Boston is right-hander Brayan Bello, a promising arm with a high ceiling but one that has yet to fully settle into a groove this season. Bello enters the matchup with a 1–2 record and a 4.50 ERA, numbers that speak to his uneven outings through April. While he’s shown flashes of brilliance—particularly when his changeup and fastball location are sharp—he’s also had trouble working deep into games due to early command issues and an occasional vulnerability to the long ball. His outing will be critical not only for setting the tone against a disciplined Mariners lineup but also in providing a breather for a bullpen that has been leaned on heavily.

Aroldis Chapman has brought stability at the back end with electric stuff and a fiery edge, but the bridge from starter to closer has been bumpy at times, and Bello’s ability to minimize damage early will determine whether Boston can hand the game over to its trusted late-inning arms with a lead. Offensively, the Red Sox are anchored by the consistent presence of Trevor Story, who’s off to a solid start batting .308 with three home runs and eight RBIs. His leadership and steady bat have provided Boston with a backbone in the heart of the order. Wilyer Abreu has emerged as one of the most exciting young players in the lineup, hitting .340 with a 1.068 OPS and offering a mix of speed and power that has sparked the offense on multiple occasions. However, outside of these two bright spots, production has been uneven. The supporting cast has struggled with runners in scoring position, and the lineup has yet to develop the kind of top-to-bottom threat that can consistently pressure opposing pitchers. If Boston hopes to contend in a crowded division and flip its home-field narrative, it must improve in clutch situations and tighten up defensive lapses that have led to unearned runs and extra outs. As they welcome a surging Seattle team to Fenway, the Red Sox face an early litmus test of their resilience and capacity for in-game adjustments. The Mariners’ strength lies in their pitching discipline and timely offense, two areas where Boston must respond with precision. Tuesday’s game offers not only a chance to secure a valuable win but also a critical opportunity to set a new tone at home—something the team desperately needs as the season begins to take shape. For Boston, a return to fundamentals, efficient starting pitching, and smart at-bats will be key to keeping pace with a Seattle team that has proven it can capitalize on mistakes.

Seattle vs. Boston Prop Picks (AI)

AI algorithm Remi is pouring through loads of data on each line. In fact, anytime the Mariners and Red Sox play there’s always several intriguing trends to key in on. Not to mention games played at Fenway Park in Apr seemingly never follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: R. Tellez over 0.5 Total Bases.

Seattle vs. Boston Prediction (AI)

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Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every simulation between the Mariners and Red Sox and using recursive machine learning and impressive AI to crunch the data to a single cover probability.

Remi has been most watching on the growing emphasis knucklehead sportsbettors often put on Boston’s strength factors between a Mariners team going up against a possibly healthy Red Sox team. Trends look to say the true game analytics might reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Seattle vs Boston picks, computer picks Mariners vs Red Sox, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Mariners Betting Trends

The Mariners have a 12–10 record against the spread (ATS) this season, covering 54.6% of the time, indicating a consistent performance for bettors.

Red Sox Betting Trends

The Red Sox have struggled ATS, with a 7–11 record, covering only 38.9% of the time, reflecting challenges in meeting betting expectations.

Mariners vs. Red Sox Matchup Trends

Seattle has covered the run line in four of their last five games, showcasing a strong recent trend. Conversely, Boston has failed to cover in five of their last seven home games, highlighting potential vulnerabilities at Fenway Park.

Seattle vs. Boston Game Info

Seattle vs Boston starts on April 22, 2025 at 6:45 PM EST.

Spread: Boston -1.5
Moneyline: Seattle +114, Boston -135
Over/Under: 9

Seattle: (12-10)  |  Boston: (13-11)

Remi's searched hard and found the best prop for this matchup: R. Tellez over 0.5 Total Bases.. Prices move—always shop for the best number.

Seattle has covered the run line in four of their last five games, showcasing a strong recent trend. Conversely, Boston has failed to cover in five of their last seven home games, highlighting potential vulnerabilities at Fenway Park.

SEA trend: The Mariners have a 12–10 record against the spread (ATS) this season, covering 54.6% of the time, indicating a consistent performance for bettors.

BOS trend: The Red Sox have struggled ATS, with a 7–11 record, covering only 38.9% of the time, reflecting challenges in meeting betting expectations.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Seattle vs. Boston Odds

Remi is pouring through tons of data points on each line. In fact, anytime the Seattle vs Boston trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable betting trends.

Seattle vs Boston Opening Odds

SEA Moneyline: +114
BOS Moneyline: -135
SEA Spread: +1.5
BOS Spread: -1.5
Over/Under: 9

Seattle vs Boston Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-175
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8.5 (-105)
U 8.5 (-115)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+140
-170
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-190)
-1.5 (+155)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
-1.5 (+170)
+1.5 (-205)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Seattle Mariners vs. Boston Red Sox on April 22, 2025 at Fenway Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN