Pirates vs. Angels
Prediction, Odds & Props
Apr 22 | MLB AI Picks
Updated: 2025-04-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Pittsburgh Pirates (8–14) face the Los Angeles Angels (10–10) on April 22, 2025, at Angel Stadium in Anaheim. The Angels are favored to win, with starting pitcher José Soriano (2–2, 3.16 ERA) set to take the mound against the Pirates’ Bailey Falter (1–2, 4.91 ERA).
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Apr 22, 2025
Start Time: 9:38 PM EST
Venue: Angel Stadium of Anaheim
Angels Record: (11-10)
Pirates Record: (8-15)
OPENING ODDS
PIT Moneyline: +156
LAA Moneyline: -188
PIT Spread: +1.5
LAA Spread: -1.5
Over/Under: 8.5
PIT
Betting Trends
- The Pirates have struggled against the spread (ATS), going 1–4 in their last five games.
LAA
Betting Trends
- The Angels have been inconsistent ATS, with a 1–4 record in their last five games, but have performed better at home, going 4–2 ATS in their last six home games.
MATCHUP TRENDS
- In their last five head-to-head matchups, the total has gone over in four games, indicating a trend toward high-scoring affairs when these teams meet.
PIT vs. LAA
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: Z. Neto over 0.5 Total Bases.
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Pittsburgh vs Los Angeles Angels Prediction & Odds:
Free MLB Betting Insights for 4/22/25
Behind them, the Pirates have rotated players in and out of the lineup, searching for the right mix to generate offensive energy. On the mound, Bailey Falter has been serviceable but far from dominant. His 4.91 ERA tells the story of a pitcher capable of giving his team a chance but too often unable to shut down innings when needed. If he can’t find ways to miss bats and reduce traffic on the basepaths, the Angels’ aggressive lineup could make him pay early. On the other side, the Angels have been buoyed by the emergence of José Soriano, who has shown maturity and confidence on the mound, carrying a 3.16 ERA into this start. Soriano’s ability to work through trouble and induce weak contact has given manager Ron Washington some level of stability in an otherwise shaky rotation. The Angels’ offense, while not elite, has enough firepower to turn games around quickly. Mike Trout, though no longer in his MVP prime, still commands respect in the heart of the lineup, and young contributors like Nolan Schanuel and Logan O’Hoppe have delivered clutch moments. However, the Angels’ defense and bullpen remain liabilities, with missed plays and blown saves costing the team in close contests. Still, their offensive output at home has been a bright spot, and if Soriano can navigate the early innings with a lead, the Angels could be poised to build confidence and pull away late. In a matchup of inconsistency, the slight edge may go to the Angels due to home field and more reliable run production—but neither team can afford to make mistakes if they hope to walk away with a needed win.
Headed out west.
— Pittsburgh Pirates (@Pirates) April 21, 2025
Pittsburgh ➡️ Los Angeles pic.twitter.com/tFhYszyc5G
Pittsburgh Pirates MLB Preview
The Pittsburgh Pirates arrive in Anaheim carrying an 8–14 record, trying to break out of a frustrating early-season slump that has seen promising moments overshadowed by recurring inconsistency on both sides of the ball. Despite flashes of offensive potential and emerging talent on the roster, Pittsburgh has yet to string together any meaningful momentum, and their road struggles have been particularly glaring. They enter this contest with just three road wins on the season and have gone 1–4 against the spread in their last five overall. Offensively, the Pirates have struggled to produce consistently, averaging just under four runs per game. Players like Oneil Cruz and Ke’Bryan Hayes provide sparks with athleticism and occasional power, but the team has failed to capitalize with runners in scoring position, often stalling rallies before they can deliver significant damage. If they want to steal a win on the West Coast, Pittsburgh will need a much sharper, more opportunistic offensive showing than they’ve delivered so far. Bailey Falter, a left-handed starter with a 1–2 record and a 4.91 ERA, will take the mound for the Pirates. Falter has shown he can pitch effectively in stretches—limiting walks and inducing soft contact—but his inability to consistently get through opposing lineups more than once or twice has been a concern. Too often, Falter has labored through middle innings, giving up back-breaking doubles or multi-run innings that erase early leads or compound defensive miscues. Against a disciplined Angels lineup that doesn’t chase often and has shown patience, Falter’s margin for error will be thin.
The Pirates’ bullpen hasn’t helped matters, as relievers have struggled to hold slim leads or keep games close, particularly during late-inning stretches. Closer David Bednar, who was one of the team’s few All-Stars in 2023, has had limited save opportunities due to the team’s inconsistency, and setup men have not consistently delivered clean innings, making every late lead feel precarious. Defensively, Pittsburgh has been average but far from airtight. Hayes at third base remains a standout, frequently making highlight-reel plays and saving runs with his range and arm. Cruz, while athletic at shortstop, has battled issues with throws and footwork, contributing to the Pirates’ middling defensive metrics. The outfield has been serviceable, with Jack Suwinski and Bryan Reynolds anchoring the corners, but defensive lapses and occasional poor reads have cost the team extra bases and runs. For the Pirates to compete with the Angels in this game, they will need a crisp defensive effort and a more focused offensive approach. They must avoid giving away outs and work deep into counts against José Soriano, who has been impressive for Los Angeles this season. Ultimately, this game presents a valuable opportunity for the Pirates to reset on the road and begin crafting a more competitive identity. If Falter can deliver five steady innings and the offense can provide timely hits—especially from the middle of the lineup—Pittsburgh could position itself to pull off an upset and gain some much-needed traction heading into the final stretch of April.

Credit: USA TODAY/IMAGN
Los Angeles Angels Angels MLB Preview
The Los Angeles Angels enter their April 22 matchup against the Pittsburgh Pirates with a 10–10 record and a firm desire to establish a winning rhythm as the first month of the 2025 season nears its close. Despite a .500 record, there is optimism in Anaheim thanks to a mix of veteran stability and young talent that has kept the club competitive even in tightly contested games. A primary factor behind that stability has been starting pitcher José Soriano, who takes the mound in this one with a 2–2 record and a strong 3.16 ERA. Soriano, a right-hander with electric stuff and improving command, has emerged as one of the early bright spots in the Angels’ rotation, filling innings effectively and giving the team a chance to win every fifth day. With an ability to induce weak contact and minimize big innings, Soriano’s outing will be crucial, especially against a Pirates lineup that, while inconsistent, features dangerous bats capable of doing damage if he falls behind in counts. Offensively, the Angels have leaned on the longtime leadership of Mike Trout, whose plate discipline and experience remain invaluable even as his power numbers level off with age. Trout remains a centerpiece in the lineup, capable of carrying the offense when needed. Around him, the Angels have infused their batting order with emerging contributors like Logan O’Hoppe and Nolan Schanuel, who have provided needed run support and energy in the heart of the order. Taylor Ward and Zach Neto have also added balance to the lineup, bringing on-base skills and occasional power, helping to stretch the batting order and create pressure for opposing pitchers.
Los Angeles is averaging a respectable 4.2 runs per game, and while they don’t necessarily overwhelm opponents with home run barrages, they are capable of stringing together productive innings and putting up crooked numbers with timely hits. At home, their offense has been even sharper, using the familiar dimensions of Angel Stadium to their advantage and feeding off crowd energy in tight situations. However, the team’s defense and bullpen remain works in progress. The Angels have committed several untimely errors that have directly impacted game outcomes, and their relievers have struggled to consistently shut down opposing rallies late in games. Closer Carlos Estévez has had moments of brilliance but lacks the dominant profile of elite ninth-inning arms, while the bridge between the starters and closer has often been turbulent. Infield defense, particularly up the middle, has been uneven at times, with miscommunication and positioning issues costing outs. The Angels will need to play a cleaner game defensively if they hope to support Soriano and limit run-scoring chances for the Pirates. Still, with a solid lineup and their most consistent starter on the mound, the Angels are well-positioned to seize control of this matchup. If they can get five or six strong innings from Soriano, avoid defensive breakdowns, and execute offensively with runners in scoring position, Los Angeles could secure a pivotal home win and continue building the type of team identity they’ve lacked in recent seasons—one that can grind out wins consistently and challenge for a postseason spot in a crowded American League.
nice and easy 😇 pic.twitter.com/DowgH9HHxd
— Los Angeles Angels (@Angels) April 21, 2025
Pittsburgh vs. Los Angeles Angels Prop Picks (AI)
Pittsburgh vs. Los Angeles Angels Prediction (AI)

Remi, our AI sports genius, has been pouring over tons of data from every past game between the Pirates and Angels and using recursive machine learning and kick-ass AI to crunch the data to a single cover probability.
Remi has been most fixated on the unproportionally assigned emphasis emotional bettors regularly put on Pittsburgh’s strength factors between a Pirates team going up against a possibly improved Angels team. Trends look to say the true game analytics might reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Pittsburgh vs Los Angeles Angels picks, computer picks Pirates vs Angels, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 9/26 | DET@BOS | UNLOCK THIS PICK | 5 |
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MLB | 9/26 | BAL@NYY | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | ARI@SD | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | NYM@MIA | UNLOCK THIS PICK | 1 |
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MLB | 9/26 | NYM@MIA | GET FREE PICK NOW | 1 | – | |
MLB | 9/26 | COL@SF | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Pirates Betting Trends
The Pirates have struggled against the spread (ATS), going 1–4 in their last five games.
Angels Betting Trends
The Angels have been inconsistent ATS, with a 1–4 record in their last five games, but have performed better at home, going 4–2 ATS in their last six home games.
Pirates vs. Angels Matchup Trends
In their last five head-to-head matchups, the total has gone over in four games, indicating a trend toward high-scoring affairs when these teams meet.
Pittsburgh vs. Los Angeles Angels Game Info
What time does Pittsburgh vs Los Angeles Angels start on April 22, 2025?
Pittsburgh vs Los Angeles Angels starts on April 22, 2025 at 9:38 PM EST.
Where is Pittsburgh vs Los Angeles Angels being played?
Venue: Angel Stadium of Anaheim.
What are the opening odds for Pittsburgh vs Los Angeles Angels?
Spread: Los Angeles Angels -1.5
Moneyline: Pittsburgh +156, Los Angeles Angels -188
Over/Under: 8.5
What are the records for Pittsburgh vs Los Angeles Angels?
Pittsburgh: (8-15) | Los Angeles Angels: (11-10)
What is the AI best bet for Pittsburgh vs Los Angeles Angels?
Remi's searched hard and found the best prop for this matchup: Z. Neto over 0.5 Total Bases.. Prices move—always shop for the best number.
What are Pittsburgh vs Los Angeles Angels trending bets?
In their last five head-to-head matchups, the total has gone over in four games, indicating a trend toward high-scoring affairs when these teams meet.
What are Pittsburgh trending bets?
PIT trend: The Pirates have struggled against the spread (ATS), going 1–4 in their last five games.
What are Los Angeles Angels trending bets?
LAA trend: The Angels have been inconsistent ATS, with a 1–4 record in their last five games, but have performed better at home, going 4–2 ATS in their last six home games.
Where can I find AI Picks for Pittsburgh vs Los Angeles Angels?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Pittsburgh vs. Los Angeles Angels Odds
Remi is pouring through tons of data on each player. In fact, anytime the Pittsburgh vs Los Angeles Angels trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance almost always follow normal, predictable betting trends.
Pittsburgh vs Los Angeles Angels Opening Odds
PIT Moneyline:
+156 LAA Moneyline: -188
PIT Spread: +1.5
LAA Spread: -1.5
Over/Under: 8.5
Pittsburgh vs Los Angeles Angels Live Odds
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U 9 (-120)
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U 8.5 (-110)
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O 8.5 (-110)
U 8.5 (-110)
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Sep 27, 2025 4:06PM EDT
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O 8 (-105)
U 8 (-115)
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Sep 27, 2025 4:11PM EDT
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-130
+110
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-1.5 (+130)
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O 8 (-120)
U 8 (+100)
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Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
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–
–
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+110
-130
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+1.5 (-190)
-1.5 (+158)
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O 9 (+100)
U 9 (-120)
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Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
|
–
–
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+175
-210
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+1.5 (-120)
-1.5 (+100)
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O 8.5 (-115)
U 8.5 (-105)
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Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
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–
–
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+115
-135
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+1.5 (-190)
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O 7.5 (-120)
U 7.5 (+100)
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Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
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+150
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+1.5 (-145)
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O 8 (-110)
U 8 (-110)
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Sep 27, 2025 7:16PM EDT
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+122
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+1.5 (-190)
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O 7 (-120)
U 7 (+100)
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Sep 27, 2025 8:40PM EDT
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+118
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+1.5 (-190)
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O 7.5 (-115)
U 7.5 (-105)
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Sep 27, 2025 9:39PM EDT
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-145
+122
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-1.5 (+115)
+1.5 (-135)
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O 9 (-110)
U 9 (-110)
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Sep 27, 2025 9:41PM EDT
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Dodgers
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+110
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+1.5 (-205)
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O 7 (-120)
U 7 (+100)
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Sep 27, 2025 10:05PM EDT
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–
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+100
-120
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+1.5 (-195)
-1.5 (+162)
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O 10 (-110)
U 10 (-110)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Pittsburgh Pirates vs. Los Angeles Angels Angels on April 22, 2025 at Angel Stadium of Anaheim.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |
CIN@ARI | KEBRYAN HAYES STRIKEOUTS UNDER 0.5 | 56.2% | 6 | WIN |
LAD@SD | SD +110 | 50.9% | 6 | WIN |