Pirates vs. Angels
Prediction, Odds & Props
Apr 22 | MLB AI Picks

Updated: 2025-04-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Pittsburgh Pirates (8–14) face the Los Angeles Angels (10–10) on April 22, 2025, at Angel Stadium in Anaheim. The Angels are favored to win, with starting pitcher José Soriano (2–2, 3.16 ERA) set to take the mound against the Pirates’ Bailey Falter (1–2, 4.91 ERA).

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 22, 2025

Start Time: 9:38 PM EST​

Venue: Angel Stadium of Anaheim​

Angels Record: (11-10)

Pirates Record: (8-15)

OPENING ODDS

PIT Moneyline: +156

LAA Moneyline: -188

PIT Spread: +1.5

LAA Spread: -1.5

Over/Under: 8.5

PIT
Betting Trends

  • The Pirates have struggled against the spread (ATS), going 1–4 in their last five games.

LAA
Betting Trends

  • The Angels have been inconsistent ATS, with a 1–4 record in their last five games, but have performed better at home, going 4–2 ATS in their last six home games.

MATCHUP TRENDS

  • In their last five head-to-head matchups, the total has gone over in four games, indicating a trend toward high-scoring affairs when these teams meet.

PIT vs. LAA
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: Z. Neto over 0.5 Total Bases.

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Pittsburgh vs Los Angeles Angels Prediction & Odds:
Free MLB Betting Insights for 4/22/25

The Pittsburgh Pirates and Los Angeles Angels square off on April 22, 2025, at Angel Stadium in Anaheim in an interleague matchup between two teams seeking to find their footing as April winds down. The Pirates enter with an 8–14 record, struggling to maintain consistency across their pitching staff and offensive production. Meanwhile, the Angels are sitting at 10–10, showing flashes of promise but also revealing familiar concerns with depth and defensive lapses. Both teams have high-upside individual talent but have yet to synchronize performance across the board. This matchup will see Pittsburgh’s left-hander Bailey Falter (1–2, 4.91 ERA) take the mound against Los Angeles right-hander José Soriano (2–2, 3.16 ERA), who has been one of the more pleasant surprises for the Angels’ pitching staff. With both teams showing volatility on both ends of the field and trending toward overs in recent games, this matchup carries the potential for high scoring and late-inning drama. The Pirates’ struggles this season stem from inconsistency in the batter’s box and on the mound. Despite having promising young players like Oneil Cruz and Ke’Bryan Hayes, Pittsburgh has not found the offensive rhythm needed to support its pitching staff. The team has scored just over 3.5 runs per game through the first few weeks, and their situational hitting continues to be a glaring weakness. Cruz brings raw power and athleticism to the shortstop position, but his approach at the plate remains undisciplined at times. Hayes, long touted for his elite defensive capabilities, is still searching for consistency at the plate.

Behind them, the Pirates have rotated players in and out of the lineup, searching for the right mix to generate offensive energy. On the mound, Bailey Falter has been serviceable but far from dominant. His 4.91 ERA tells the story of a pitcher capable of giving his team a chance but too often unable to shut down innings when needed. If he can’t find ways to miss bats and reduce traffic on the basepaths, the Angels’ aggressive lineup could make him pay early. On the other side, the Angels have been buoyed by the emergence of José Soriano, who has shown maturity and confidence on the mound, carrying a 3.16 ERA into this start. Soriano’s ability to work through trouble and induce weak contact has given manager Ron Washington some level of stability in an otherwise shaky rotation. The Angels’ offense, while not elite, has enough firepower to turn games around quickly. Mike Trout, though no longer in his MVP prime, still commands respect in the heart of the lineup, and young contributors like Nolan Schanuel and Logan O’Hoppe have delivered clutch moments. However, the Angels’ defense and bullpen remain liabilities, with missed plays and blown saves costing the team in close contests. Still, their offensive output at home has been a bright spot, and if Soriano can navigate the early innings with a lead, the Angels could be poised to build confidence and pull away late. In a matchup of inconsistency, the slight edge may go to the Angels due to home field and more reliable run production—but neither team can afford to make mistakes if they hope to walk away with a needed win.

Pittsburgh Pirates MLB Preview

The Pittsburgh Pirates arrive in Anaheim carrying an 8–14 record, trying to break out of a frustrating early-season slump that has seen promising moments overshadowed by recurring inconsistency on both sides of the ball. Despite flashes of offensive potential and emerging talent on the roster, Pittsburgh has yet to string together any meaningful momentum, and their road struggles have been particularly glaring. They enter this contest with just three road wins on the season and have gone 1–4 against the spread in their last five overall. Offensively, the Pirates have struggled to produce consistently, averaging just under four runs per game. Players like Oneil Cruz and Ke’Bryan Hayes provide sparks with athleticism and occasional power, but the team has failed to capitalize with runners in scoring position, often stalling rallies before they can deliver significant damage. If they want to steal a win on the West Coast, Pittsburgh will need a much sharper, more opportunistic offensive showing than they’ve delivered so far. Bailey Falter, a left-handed starter with a 1–2 record and a 4.91 ERA, will take the mound for the Pirates. Falter has shown he can pitch effectively in stretches—limiting walks and inducing soft contact—but his inability to consistently get through opposing lineups more than once or twice has been a concern. Too often, Falter has labored through middle innings, giving up back-breaking doubles or multi-run innings that erase early leads or compound defensive miscues. Against a disciplined Angels lineup that doesn’t chase often and has shown patience, Falter’s margin for error will be thin.

The Pirates’ bullpen hasn’t helped matters, as relievers have struggled to hold slim leads or keep games close, particularly during late-inning stretches. Closer David Bednar, who was one of the team’s few All-Stars in 2023, has had limited save opportunities due to the team’s inconsistency, and setup men have not consistently delivered clean innings, making every late lead feel precarious. Defensively, Pittsburgh has been average but far from airtight. Hayes at third base remains a standout, frequently making highlight-reel plays and saving runs with his range and arm. Cruz, while athletic at shortstop, has battled issues with throws and footwork, contributing to the Pirates’ middling defensive metrics. The outfield has been serviceable, with Jack Suwinski and Bryan Reynolds anchoring the corners, but defensive lapses and occasional poor reads have cost the team extra bases and runs. For the Pirates to compete with the Angels in this game, they will need a crisp defensive effort and a more focused offensive approach. They must avoid giving away outs and work deep into counts against José Soriano, who has been impressive for Los Angeles this season. Ultimately, this game presents a valuable opportunity for the Pirates to reset on the road and begin crafting a more competitive identity. If Falter can deliver five steady innings and the offense can provide timely hits—especially from the middle of the lineup—Pittsburgh could position itself to pull off an upset and gain some much-needed traction heading into the final stretch of April.

The Pittsburgh Pirates (8–14) face the Los Angeles Angels (10–10) on April 22, 2025, at Angel Stadium in Anaheim. The Angels are favored to win, with starting pitcher José Soriano (2–2, 3.16 ERA) set to take the mound against the Pirates’ Bailey Falter (1–2, 4.91 ERA). Pittsburgh vs Los Angeles Angels AI Prediction: Free MLB Betting Insights for Apr 22. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Los Angeles Angels Angels MLB Preview

The Los Angeles Angels enter their April 22 matchup against the Pittsburgh Pirates with a 10–10 record and a firm desire to establish a winning rhythm as the first month of the 2025 season nears its close. Despite a .500 record, there is optimism in Anaheim thanks to a mix of veteran stability and young talent that has kept the club competitive even in tightly contested games. A primary factor behind that stability has been starting pitcher José Soriano, who takes the mound in this one with a 2–2 record and a strong 3.16 ERA. Soriano, a right-hander with electric stuff and improving command, has emerged as one of the early bright spots in the Angels’ rotation, filling innings effectively and giving the team a chance to win every fifth day. With an ability to induce weak contact and minimize big innings, Soriano’s outing will be crucial, especially against a Pirates lineup that, while inconsistent, features dangerous bats capable of doing damage if he falls behind in counts. Offensively, the Angels have leaned on the longtime leadership of Mike Trout, whose plate discipline and experience remain invaluable even as his power numbers level off with age. Trout remains a centerpiece in the lineup, capable of carrying the offense when needed. Around him, the Angels have infused their batting order with emerging contributors like Logan O’Hoppe and Nolan Schanuel, who have provided needed run support and energy in the heart of the order. Taylor Ward and Zach Neto have also added balance to the lineup, bringing on-base skills and occasional power, helping to stretch the batting order and create pressure for opposing pitchers.

Los Angeles is averaging a respectable 4.2 runs per game, and while they don’t necessarily overwhelm opponents with home run barrages, they are capable of stringing together productive innings and putting up crooked numbers with timely hits. At home, their offense has been even sharper, using the familiar dimensions of Angel Stadium to their advantage and feeding off crowd energy in tight situations. However, the team’s defense and bullpen remain works in progress. The Angels have committed several untimely errors that have directly impacted game outcomes, and their relievers have struggled to consistently shut down opposing rallies late in games. Closer Carlos Estévez has had moments of brilliance but lacks the dominant profile of elite ninth-inning arms, while the bridge between the starters and closer has often been turbulent. Infield defense, particularly up the middle, has been uneven at times, with miscommunication and positioning issues costing outs. The Angels will need to play a cleaner game defensively if they hope to support Soriano and limit run-scoring chances for the Pirates. Still, with a solid lineup and their most consistent starter on the mound, the Angels are well-positioned to seize control of this matchup. If they can get five or six strong innings from Soriano, avoid defensive breakdowns, and execute offensively with runners in scoring position, Los Angeles could secure a pivotal home win and continue building the type of team identity they’ve lacked in recent seasons—one that can grind out wins consistently and challenge for a postseason spot in a crowded American League.

Pittsburgh vs. Los Angeles Angels Prop Picks (AI)

AI algorithm Remi is pouring through loads of stats on each player. In fact, anytime the Pirates and Angels play there’s always several intriguing observations to key in on. Not to mention games played at Angel Stadium of Anaheim in Apr rarely follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: Z. Neto over 0.5 Total Bases.

Pittsburgh vs. Los Angeles Angels Prediction (AI)

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Remi, our AI sports genius, has been pouring over tons of data from every past game between the Pirates and Angels and using recursive machine learning and kick-ass AI to crunch the data to a single cover probability.

Remi has been most fixated on the unproportionally assigned emphasis emotional bettors regularly put on Pittsburgh’s strength factors between a Pirates team going up against a possibly improved Angels team. Trends look to say the true game analytics might reflect a moderate lean against one Vegas line in particular.

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Below is our current AI Pittsburgh vs Los Angeles Angels picks, computer picks Pirates vs Angels, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Pirates Betting Trends

The Pirates have struggled against the spread (ATS), going 1–4 in their last five games.

Angels Betting Trends

The Angels have been inconsistent ATS, with a 1–4 record in their last five games, but have performed better at home, going 4–2 ATS in their last six home games.

Pirates vs. Angels Matchup Trends

In their last five head-to-head matchups, the total has gone over in four games, indicating a trend toward high-scoring affairs when these teams meet.

Pittsburgh vs. Los Angeles Angels Game Info

Pittsburgh vs Los Angeles Angels starts on April 22, 2025 at 9:38 PM EST.

Spread: Los Angeles Angels -1.5
Moneyline: Pittsburgh +156, Los Angeles Angels -188
Over/Under: 8.5

Pittsburgh: (8-15)  |  Los Angeles Angels: (11-10)

Remi's searched hard and found the best prop for this matchup: Z. Neto over 0.5 Total Bases.. Prices move—always shop for the best number.

In their last five head-to-head matchups, the total has gone over in four games, indicating a trend toward high-scoring affairs when these teams meet.

PIT trend: The Pirates have struggled against the spread (ATS), going 1–4 in their last five games.

LAA trend: The Angels have been inconsistent ATS, with a 1–4 record in their last five games, but have performed better at home, going 4–2 ATS in their last six home games.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Pittsburgh vs. Los Angeles Angels Odds

Remi is pouring through tons of data on each player. In fact, anytime the Pittsburgh vs Los Angeles Angels trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance almost always follow normal, predictable betting trends.

Pittsburgh vs Los Angeles Angels Opening Odds

PIT Moneyline: +156
LAA Moneyline: -188
PIT Spread: +1.5
LAA Spread: -1.5
Over/Under: 8.5

Pittsburgh vs Los Angeles Angels Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+192
-235
+1.5 (-110)
-1.5 (-110)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-178
 
-1.5 (+115)
O 9.5 (+100)
U 9.5 (-120)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+135
-160
+1.5 (-160)
-1.5 (+135)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
+1.5 (-205)
-1.5 (+170)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+192
-235
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+130)
+1.5 (-155)
O 8 (-120)
U 8 (+100)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+110
-130
+1.5 (-190)
-1.5 (+158)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+175
-210
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+115
-135
+1.5 (-190)
-1.5 (+158)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+150
-178
+1.5 (-145)
-1.5 (+122)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+122
-145
+1.5 (-190)
-1.5 (+158)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+118
-140
+1.5 (-190)
-1.5 (+158)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-145
+122
-1.5 (+115)
+1.5 (-135)
O 9 (-110)
U 9 (-110)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+110
-130
+1.5 (-205)
-1.5 (+170)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
+1.5 (-195)
-1.5 (+162)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Pittsburgh Pirates vs. Los Angeles Angels Angels on April 22, 2025 at Angel Stadium of Anaheim.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN