Brewers vs. Giants
Prediction, Odds & Props
Apr 22 | MLB AI Picks
Updated: 2025-04-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Milwaukee Brewers (12–10) travel to Oracle Park to face the San Francisco Giants (11–11) on April 22, 2025, in a matchup between two National League teams aiming to gain momentum early in the season. Both teams have shown flashes of potential, making this game a pivotal point to establish consistency.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Apr 22, 2025
Start Time: 9:45 PM EST
Venue: Oracle Park
Giants Record: (15-8)
Brewers Record: (12-11)
OPENING ODDS
MIL Moneyline: +115
SF Moneyline: -137
MIL Spread: +1.5
SF Spread: -1.5
Over/Under: 7.5
MIL
Betting Trends
- The Brewers have covered the spread in 3 of their last 5 games, indicating a positive trend in their recent performances.
SF
Betting Trends
- The Giants have struggled against the spread recently, covering in only 2 of their last 5 games, highlighting some inconsistencies in their play.
MATCHUP TRENDS
- In their last 6 head-to-head matchups, the total has gone under in 4 games, suggesting a trend toward lower-scoring contests between these teams.
MIL vs. SF
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: C. Durbin over 0.5 Hits+Runs+RBI.
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Milwaukee vs San Francisco Prediction & Odds:
Free MLB Betting Insights for 4/22/25
The emergence of Brice Turang and the steady contributions from William Contreras have given the Brewers a diversified offensive attack that doesn’t rely solely on the long ball. Milwaukee’s success in close games—paired with solid defense in the infield and efficient baserunning—makes them a tough matchup for teams that struggle in the late innings. Against a Giants bullpen that has been vulnerable, Milwaukee will look to pounce if the game stays close into the sixth or seventh frame. For the Giants, the 2025 season has been a mix of encouraging developments and frustrating stumbles. Offensively, they’ve shown the capability to score in bunches, with veterans like Michael Conforto and Thairo Estrada providing pop and productivity. LaMonte Wade Jr. and Mike Yastrzemski have also stepped up in key situations, but the lineup has lacked consistency from game to game, often relying on home runs to mask broader offensive deficiencies. The starting rotation has been solid, keeping the team competitive into the middle innings and often turning games over with manageable deficits or narrow leads. However, the bullpen has been San Francisco’s Achilles’ heel—failing to preserve leads in late innings and inflating run totals in otherwise well-pitched games. If the Giants hope to keep pace with a disciplined and opportunistic Brewers club, they’ll need both offensive execution and a clean night from their relievers. The game figures to hinge on pitching depth, situational hitting, and which team can avoid defensive miscues under pressure. With Oracle Park favoring pitchers and both squads fielding fundamentally sound defenses, expect a tightly contested matchup where each pitch carries heightened stakes.
Caleb is EVERYWHERE pic.twitter.com/fZsf5MtyRH
— Milwaukee Brewers (@Brewers) April 22, 2025
Milwaukee Brewers MLB Preview
The Milwaukee Brewers head into Oracle Park with a 12–10 record, looking to build on a promising start to the 2025 season that has been grounded in reliable pitching, timely hitting, and fundamentally sound baseball. This version of the Brewers isn’t overwhelming in any one area, but their balanced, opportunistic style has made them a tough out for any opponent. Manager Pat Murphy’s squad has embraced the “next man up” mentality, with steady contributions across the roster rather than dependence on a single superstar. While the offense has been streaky at times, it has done enough to complement a pitching staff that has quietly been one of the better-performing units in the National League. Milwaukee has covered the spread in three of its last five games and has shown an ability to pull out close wins, an encouraging trend as they enter a series against a Giants team that has struggled to close out games. At the plate, the Brewers have relied on a mix of veteran leadership and youthful energy. Christian Yelich has rediscovered some of the plate discipline and bat speed that made him an MVP, showing better contact rates and finding ways to reach base even when the hits aren’t falling. Willy Adames continues to serve as the offensive heartbeat, providing power in the middle of the order and thriving in clutch situations. The steady presence of William Contreras behind the plate not only adds offensive value but also gives the pitching staff a trusted game-caller. Meanwhile, youngsters like Brice Turang and Joey Ortiz have added depth and speed, helping Milwaukee apply pressure on opposing defenses with aggressive baserunning.
This lineup may not lead the league in home runs, but it grinds out at-bats, manufactures runs with smart baseball, and capitalizes on opponents’ mistakes. Against a San Francisco bullpen that has faltered late in games, Milwaukee’s ability to maintain offensive pressure throughout nine innings could prove decisive. Pitching, however, is where the Brewers shine brightest. While they don’t feature a household ace, their rotation has been dependable. Starters are consistently getting into the sixth inning, handing games off to one of the more quietly effective bullpens in the league. The trio of Abner Uribe, Joel Payamps, and Hoby Milner has locked down the back end, keeping leads intact and minimizing late-game drama. Milwaukee’s pitching philosophy emphasizes attacking the strike zone, limiting walks, and forcing hitters to put the ball in play—allowing a sound defense to do the rest. Their infield defense, anchored by Adames and Turang, has been particularly sharp, consistently turning double plays and making the routine look automatic. In a pitcher-friendly park like Oracle, this formula bodes well. If the Brewers can get a solid outing from their starter and play clean defense behind him, they’ll be in an excellent position to take advantage of any cracks in the Giants’ bullpen armor. With momentum building and confidence growing, Milwaukee appears poised to continue its steady ascent in the standings by outlasting opponents with grit, discipline, and execution.

Credit: USA TODAY/IMAGN
San Francisco Giants MLB Preview
The San Francisco Giants enter their April 22 showdown with the Milwaukee Brewers sitting at an even 11–11, a record that mirrors the inconsistency they’ve shown through the early part of the 2025 season. At times, the Giants have looked like a team capable of making a serious push in the National League West, with explosive offensive innings and quality starting pitching performances. At other moments, bullpen breakdowns, situational hitting woes, and defensive lapses have undercut their efforts. This matchup against the Brewers—who arrive with momentum and a balanced roster—offers San Francisco a chance to establish a rhythm and regain footing in a crowded divisional race. Manager Bob Melvin has emphasized resilience and adaptation, especially as the roster continues to juggle a mix of veteran leadership and younger, less-proven contributors. Against a fundamentally sound Milwaukee squad, the Giants will need to play with precision and urgency to avoid falling into a stretch of missed opportunities. Offensively, the Giants have found production from both familiar faces and emerging contributors. Michael Conforto has provided a steady bat with flashes of power, while Thairo Estrada and LaMonte Wade Jr. have added consistency at the top and middle of the order. Estrada in particular has been key to manufacturing runs, with timely hits and aggressive base running that forces mistakes from opponents. Rookie outfielder Luis Matos has brought energy and defensive athleticism to the outfield, while Mike Yastrzemski remains a trusted presence in clutch moments. Despite the individual performances, the Giants’ offense has often lacked cohesion.
They have struggled to capitalize with runners in scoring position, leaving too many opportunities on the basepaths and putting pressure on the pitching staff to keep games close. If they’re to break through against Milwaukee, the lineup will need to show better patience at the plate, drive up pitch counts, and string together consistent contact instead of relying on isolated home runs. Pitching remains the relative strength of this Giants team, but even here, concerns have begun to surface—primarily in the bullpen. The starting rotation, led by Logan Webb and Alex Cobb, has generally done its part by keeping games within reach, but the bridge to the ninth inning has been shaky. The bullpen has squandered multiple late-inning leads, with inconsistency in setup roles and a closer committee that has yet to solidify. Camilo Doval, when sharp, has the stuff to shut the door, but control issues and overuse have made him unpredictable. Defensively, the Giants have held their own in the infield, with Crawford and Estrada maintaining a reliable double-play tandem, while the outfield defense has shown range and stability. Oracle Park plays to the Giants’ strengths with its spacious dimensions, encouraging pitchers to attack the zone and trust their defense. However, the margin for error against a disciplined team like Milwaukee is thin. To secure a win, San Francisco must limit walks, avoid defensive miscues, and capitalize on every scoring opportunity. If they can pair a quality start with clean bullpen innings, the Giants can reclaim momentum and send a message that they intend to compete seriously as the NL season unfolds.
Same time tomorrow? pic.twitter.com/ONz1hglJ9e
— SFGiants (@SFGiants) April 22, 2025
Milwaukee vs. San Francisco Prop Picks (AI)
Milwaukee vs. San Francisco Prediction (AI)

Remi, our AI sports wizard, has been pouring over mountains of data from every facet between the Brewers and Giants and using recursive machine learning and kick-ass AI to analyze the data to a single cover probability.
Remi has been most focused on the trending factor human bettors tend to put on player performance factors between a Brewers team going up against a possibly rested Giants team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Milwaukee vs San Francisco picks, computer picks Brewers vs Giants, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 9/26 | DET@BOS | UNLOCK THIS PICK | 5 |
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MLB | 9/26 | BAL@NYY | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | ARI@SD | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | NYM@MIA | UNLOCK THIS PICK | 1 |
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MLB | 9/26 | NYM@MIA | GET FREE PICK NOW | 1 | – | |
MLB | 9/26 | COL@SF | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Brewers Betting Trends
The Brewers have covered the spread in 3 of their last 5 games, indicating a positive trend in their recent performances.
Giants Betting Trends
The Giants have struggled against the spread recently, covering in only 2 of their last 5 games, highlighting some inconsistencies in their play.
Brewers vs. Giants Matchup Trends
In their last 6 head-to-head matchups, the total has gone under in 4 games, suggesting a trend toward lower-scoring contests between these teams.
Milwaukee vs. San Francisco Game Info
What time does Milwaukee vs San Francisco start on April 22, 2025?
Milwaukee vs San Francisco starts on April 22, 2025 at 9:45 PM EST.
Where is Milwaukee vs San Francisco being played?
Venue: Oracle Park.
What are the opening odds for Milwaukee vs San Francisco?
Spread: San Francisco -1.5
Moneyline: Milwaukee +115, San Francisco -137
Over/Under: 7.5
What are the records for Milwaukee vs San Francisco?
Milwaukee: (12-11) | San Francisco: (15-8)
What is the AI best bet for Milwaukee vs San Francisco?
Remi's searched hard and found the best prop for this matchup: C. Durbin over 0.5 Hits+Runs+RBI.. Prices move—always shop for the best number.
What are Milwaukee vs San Francisco trending bets?
In their last 6 head-to-head matchups, the total has gone under in 4 games, suggesting a trend toward lower-scoring contests between these teams.
What are Milwaukee trending bets?
MIL trend: The Brewers have covered the spread in 3 of their last 5 games, indicating a positive trend in their recent performances.
What are San Francisco trending bets?
SF trend: The Giants have struggled against the spread recently, covering in only 2 of their last 5 games, highlighting some inconsistencies in their play.
Where can I find AI Picks for Milwaukee vs San Francisco?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Milwaukee vs. San Francisco Odds
Remi is pouring through mountains of data on each player. In fact, anytime the Milwaukee vs San Francisco trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable betting trends.
Milwaukee vs San Francisco Opening Odds
MIL Moneyline:
+115 SF Moneyline: -137
MIL Spread: +1.5
SF Spread: -1.5
Over/Under: 7.5
Milwaukee vs San Francisco Live Odds
Games | PTS | ML | SPR | O/U | |
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Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
|
–
–
|
+192
-235
|
+1.5 (-110)
-1.5 (-110)
|
O 9 (+100)
U 9 (-120)
|
|
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
|
–
–
|
-178
|
-1.5 (+115)
|
O 9.5 (+100)
U 9.5 (-120)
|
|
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
|
–
–
|
+135
-160
|
+1.5 (-160)
-1.5 (+135)
|
O 8.5 (-110)
U 8.5 (-110)
|
|
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
|
–
–
|
+100
-120
|
+1.5 (-205)
-1.5 (+170)
|
O 8.5 (-110)
U 8.5 (-110)
|
|
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
|
–
–
|
+192
-235
|
+1.5 (-110)
-1.5 (-110)
|
O 8 (-105)
U 8 (-115)
|
|
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
|
–
–
|
-130
+110
|
-1.5 (+130)
+1.5 (-155)
|
O 8 (-120)
U 8 (+100)
|
|
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
|
–
–
|
+110
-130
|
+1.5 (-190)
-1.5 (+158)
|
O 9 (+100)
U 9 (-120)
|
|
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
|
–
–
|
+175
-210
|
+1.5 (-120)
-1.5 (+100)
|
O 8.5 (-115)
U 8.5 (-105)
|
|
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
|
–
–
|
+115
-135
|
+1.5 (-190)
-1.5 (+158)
|
O 7.5 (-120)
U 7.5 (+100)
|
|
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
|
–
–
|
+150
-178
|
+1.5 (-145)
-1.5 (+122)
|
O 8 (-110)
U 8 (-110)
|
|
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
|
–
–
|
+122
-145
|
+1.5 (-190)
-1.5 (+158)
|
O 7 (-120)
U 7 (+100)
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Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
|
–
–
|
+118
-140
|
+1.5 (-190)
-1.5 (+158)
|
O 7.5 (-115)
U 7.5 (-105)
|
|
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
|
–
–
|
-145
+122
|
-1.5 (+115)
+1.5 (-135)
|
O 9 (-110)
U 9 (-110)
|
|
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
|
–
–
|
+110
-130
|
+1.5 (-205)
-1.5 (+170)
|
O 7 (-120)
U 7 (+100)
|
|
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
|
–
–
|
+100
-120
|
+1.5 (-195)
-1.5 (+162)
|
O 10 (-110)
U 10 (-110)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Milwaukee Brewers vs. San Francisco Giants on April 22, 2025 at Oracle Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |
CIN@ARI | KEBRYAN HAYES STRIKEOUTS UNDER 0.5 | 56.2% | 6 | WIN |
LAD@SD | SD +110 | 50.9% | 6 | WIN |