Orioles vs. Nationals
Prediction, Odds & Props
Apr 22 | MLB AI Picks

Updated: 2025-04-20T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Baltimore Orioles (9–12) and Washington Nationals (9–13) commence a three-game series at Nationals Park on April 22, 2025, with first pitch scheduled for 6:45 PM ET. Baltimore’s Dean Kremer (2–2, 6.41 ERA) will face Washington’s Mitchell Parker (2–1, 1.85 ERA) in a matchup of right-handers aiming to set the tone for their respective teams.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 22, 2025

Start Time: 6:45 PM EST​

Venue: Nationals Park​

Nationals Record: (9-13)

Orioles Record: (9-12)

OPENING ODDS

BAL Moneyline: -133

WAS Moneyline: +113

BAL Spread: -1.5

WAS Spread: +1.5

Over/Under: 9

BAL
Betting Trends

  • The Orioles have struggled against the spread (ATS) recently, failing to cover in four of their last six games, reflecting inconsistencies in both pitching and offense.

WAS
Betting Trends

  • The Nationals have shown improvement ATS, covering in three of their last five games, indicating a positive trend in their recent performances.

MATCHUP TRENDS

  • Baltimore has a 4–6 ATS record on the road this season, highlighting challenges in away games. Conversely, Washington has covered the run line in four of their last six home games, suggesting a stronger performance at Nationals Park.

BAL vs. WAS
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: N. Lowe over 0.5 Total Bases.

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Baltimore vs Washington Prediction & Odds:
Free MLB Betting Insights for 4/22/25

The Baltimore Orioles and Washington Nationals begin a three-game interleague series at Nationals Park on April 22, 2025, with both clubs attempting to shake off slow starts and find early-season traction. Baltimore arrives with a 9–12 record, having shown flashes of offensive potential but struggling mightily with pitching consistency, especially on the road. Their opponent, the Nationals, sit at 9–13 and have managed to put together a more competitive stretch at home, where they’ve covered the run line in four of their last six games. This matchup presents an intriguing contrast in approaches: the Orioles rely heavily on power and timely hitting, while the Nationals are beginning to see the dividends of their investment in young pitching talent. Both teams view this series as a crucial opportunity to build momentum heading into the latter half of April, and while neither is currently in playoff form, the right adjustments in this series could jumpstart a more positive trajectory. Baltimore turns to right-hander Dean Kremer to open the series, but the 2–2 starter comes in with an unsightly 6.41 ERA and questions surrounding his command and durability. Kremer has struggled to keep hitters off balance, and his road ERA has been particularly concerning. He’ll face a Washington lineup that doesn’t always overwhelm with power but has become increasingly opportunistic in run-scoring situations. Kremer’s key to success will be limiting the long ball and avoiding big innings, which have repeatedly derailed his outings this season. Meanwhile, the Orioles will depend on Cedric Mullins to spark the offense.

Mullins, hitting .284 with six home runs and 19 RBIs, continues to be a reliable leadoff threat and one of the most productive bats in the lineup. Baltimore also looks for more consistency from Anthony Santander and Gunnar Henderson, who have both delivered in spurts but haven’t yet sustained elite-level production. Baltimore’s bullpen, although talented, has been overexposed due to short outings from starters, making Kremer’s efficiency in this game even more critical. On the other side, the Nationals are handing the ball to Mitchell Parker, who’s off to a strong start with a 2–1 record and an impressive 1.85 ERA. Parker has quietly become one of the more effective arms in the Nationals’ rotation, commanding the strike zone with poise and minimizing traffic on the bases. Against a power-heavy Orioles lineup, Parker’s ability to induce weak contact and pitch to ground balls will be essential. The Nationals’ offense is led by rookie James Wood, who already has seven home runs and has brought an energy to the team that fans haven’t seen since their 2019 title run. Keibert Ruiz has also provided consistency at the plate with a .306 batting average and sound defense behind the plate. If the Nationals can pair Parker’s strong outing with timely production from the middle of their order, they could exploit Baltimore’s pitching vulnerabilities. With Washington showing better form at home and Baltimore still searching for a complete game on the road, this series opener leans slightly in the Nationals’ favor. However, if the Orioles’ bats get hot early and Kremer manages to hold the line through five or six innings, the game could tilt quickly in the visitors’ direction. Either way, this matchup offers fans a compelling battle between two hungry clubs trying to claw back into relevance.

Baltimore Orioles MLB Preview

The Baltimore Orioles arrive at Nationals Park with a 9–12 record, searching for stability after a rocky stretch marked by inconsistency in both pitching and offense. Though the team showed promise last season and entered 2025 with expectations of building on that foundation, they have yet to find a sustained rhythm, particularly on the road where they’ve struggled to cover the spread and string together complete performances. Dean Kremer gets the start for Baltimore, bringing a 2–2 record and a concerning 6.41 ERA into this interleague clash. Kremer has shown the ability to eat innings and keep the ball in the park at times, but control issues and elevated pitch counts have limited his effectiveness, especially away from Camden Yards. For the Orioles to turn the tide in this series, they’ll need Kremer to avoid early damage and keep the game within reach for a bullpen that has been overextended by short starts. Offensively, the Orioles are led by Cedric Mullins, who continues to set the tone at the top of the order with a .284 average, six home runs, and 19 RBIs. Mullins has been a dynamic presence, not just as a leadoff hitter, but also as a sparkplug who can change the game with one swing or on the base paths. His ability to get on base and pressure pitchers opens opportunities for the likes of Gunnar Henderson, Adley Rutschman, and Anthony Santander to produce runs in the middle of the lineup. Rutschman, one of the most promising young catchers in baseball, has shown elite pitch recognition and plate discipline but hasn’t yet broken out offensively in 2025.

The same can be said for Santander, who has provided power in previous seasons but has been searching for consistency. The Orioles’ overall offensive numbers remain respectable, but the key challenge lies in executing with runners in scoring position—an area where they’ve missed several key opportunities that could have shifted outcomes in recent games. Defensively, Baltimore has been serviceable, but far from elite. Errors and miscommunications have crept into their infield play, leading to extended innings and increased pressure on their already-taxed pitching staff. These lapses, while not always costly in the box score, often contribute to momentum swings that opposing teams have capitalized on. The bullpen, once a reliable asset, has been stretched thin due to poor starting pitching depth and overuse, with key relievers like Yennier Canó and Cionel Pérez being forced into high-leverage situations night after night. If the Orioles are to reverse their current trajectory, they’ll need more than individual excellence—they’ll need consistency across all facets of the game: solid starts, timely hits, and crisp defensive execution. Against a Nationals team that has been much better at home and is beginning to find an offensive identity, Baltimore must approach the series opener with urgency and discipline. A victory in this matchup would not only provide a morale boost but also a much-needed foundation for improved play as they push deeper into the season.

The Baltimore Orioles (9–12) and Washington Nationals (9–13) commence a three-game series at Nationals Park on April 22, 2025, with first pitch scheduled for 6:45 PM ET. Baltimore’s Dean Kremer (2–2, 6.41 ERA) will face Washington’s Mitchell Parker (2–1, 1.85 ERA) in a matchup of right-handers aiming to set the tone for their respective teams. Baltimore vs Washington AI Prediction: Free MLB Betting Insights for Apr 22. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Washington Nationals MLB Preview

The Washington Nationals enter Tuesday’s series opener against the Baltimore Orioles with a 9–13 record, showing modest but meaningful progress in the early stages of the 2025 season. Though the win-loss column doesn’t reflect a dramatic turnaround, this youthful Nationals squad has quietly begun to carve out a more competitive identity, particularly at home where they’ve covered the run line in four of their last six games. The emergence of several young stars, improved pitching, and sharper play on defense have helped Washington remain feisty in matchups that many expected them to simply survive. With the Orioles coming to town and both clubs sitting near the bottom of their respective divisions, this interleague series carries weight—not just in terms of standings, but also for building confidence and rhythm as both teams attempt to forge consistency before May arrives. The Nationals will rely on Mitchell Parker to take the mound in the opener, and the rookie right-hander has been a revelation so far in 2025. Parker sports a 2–1 record with a stellar 1.85 ERA, proving adept at limiting hard contact and working efficiently through lineups despite his relative inexperience. His command of the strike zone and ability to sequence pitches have frustrated hitters and given Washington a chance to win in each of his starts. He faces an Orioles lineup with dangerous hitters, but one that has been inconsistent away from home, which could play into his strengths. Parker’s poise and willingness to pitch to contact allow him to extend outings and preserve the bullpen, which has been a critical factor in his early-season success. Washington’s relief corps, anchored by Hunter Harvey and Kyle Finnegan, has also shown growth, keeping the team in close games and capitalizing when the offense provides a late spark.

Offensively, the Nationals are beginning to establish an identity around their young core. Rookie sensation James Wood has been the centerpiece, slugging seven home runs and injecting much-needed power into a lineup that previously leaned more on contact and speed. His presence in the middle of the order has taken pressure off veterans like Joey Meneses and allowed Keibert Ruiz to operate with more freedom. Ruiz, hitting .306, has provided steady production and leadership from behind the plate, giving Washington a reliable anchor both offensively and defensively. C.J. Abrams and Luis García Jr. have also contributed key moments, helping the team manufacture runs even in low-scoring contests. The Nationals aren’t a team that will routinely mash their way to victory, but they have shown improved situational hitting and a willingness to play small ball when needed—a hallmark of manager Dave Martinez’s preferred style. Defensively, Washington has cleaned up many of the mistakes that plagued them last season. Their infield has made routine plays look routine again, and their outfield, led by Wood and Victor Robles, has covered ground efficiently. The combination of strong defensive positioning, confident young pitching, and a growing offensive punch has turned Nationals Park into a more challenging venue for visiting teams. Against a Baltimore squad that has faltered on the road and is struggling to find consistent starting pitching, Washington will look to set the tone early with Parker’s arm and back it up with smart at-bats. If they can maintain their recent form, the Nationals have a strong opportunity to take control of this series and continue redefining themselves as more than just a rebuilding roster.

Baltimore vs. Washington Prop Picks (AI)

AI algorithm Remi is pouring through tons of stats on each player. In fact, anytime the Orioles and Nationals play there’s always several intriguing observations to key in on. Not to mention games played at Nationals Park in Apr almost always follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: N. Lowe over 0.5 Total Bases.

Baltimore vs. Washington Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over exorbitant amounts of data from every angle between the Orioles and Nationals and using recursive machine learning and kick-ass AI to examine the data to a single cover probability.

Interestingly enough, the data has been most fixated on the unproportionally assigned factor emotional bettors tend to put on player performance factors between a Orioles team going up against a possibly strong Nationals team. Trends look to say the true game analytics appear to reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Baltimore vs Washington picks, computer picks Orioles vs Nationals, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Orioles Betting Trends

The Orioles have struggled against the spread (ATS) recently, failing to cover in four of their last six games, reflecting inconsistencies in both pitching and offense.

Nationals Betting Trends

The Nationals have shown improvement ATS, covering in three of their last five games, indicating a positive trend in their recent performances.

Orioles vs. Nationals Matchup Trends

Baltimore has a 4–6 ATS record on the road this season, highlighting challenges in away games. Conversely, Washington has covered the run line in four of their last six home games, suggesting a stronger performance at Nationals Park.

Baltimore vs. Washington Game Info

Baltimore vs Washington starts on April 22, 2025 at 6:45 PM EST.

Spread: Washington +1.5
Moneyline: Baltimore -133, Washington +113
Over/Under: 9

Baltimore: (9-12)  |  Washington: (9-13)

Remi's searched hard and found the best prop for this matchup: N. Lowe over 0.5 Total Bases.. Prices move—always shop for the best number.

Baltimore has a 4–6 ATS record on the road this season, highlighting challenges in away games. Conversely, Washington has covered the run line in four of their last six home games, suggesting a stronger performance at Nationals Park.

BAL trend: The Orioles have struggled against the spread (ATS) recently, failing to cover in four of their last six games, reflecting inconsistencies in both pitching and offense.

WAS trend: The Nationals have shown improvement ATS, covering in three of their last five games, indicating a positive trend in their recent performances.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Baltimore vs. Washington Odds

Remi is pouring through tons of stats on each line. In fact, anytime the Baltimore vs Washington trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme altitude almost always follow normal, predictable patterns.

Baltimore vs Washington Opening Odds

BAL Moneyline: -133
WAS Moneyline: +113
BAL Spread: -1.5
WAS Spread: +1.5
Over/Under: 9

Baltimore vs Washington Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-175
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8.5 (-105)
U 8.5 (-115)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+140
-170
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-190)
-1.5 (+155)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
-1.5 (+170)
+1.5 (-205)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Baltimore Orioles vs. Washington Nationals on April 22, 2025 at Nationals Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN