Cardinals vs. Braves
Prediction, Odds & Props
Apr 21 | MLB AI Picks

Updated: 2025-04-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The St. Louis Cardinals (9–12) travel to Truist Park to face the Atlanta Braves (7–13) on April 21, 2025, in a matchup between two National League teams aiming to improve their standings. Both teams are looking to gain momentum early in the season.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 21, 2025

Start Time: 7:15 PM EST​

Venue: Truist Park​

Braves Record: (8-13)

Cardinals Record: (9-13)

OPENING ODDS

STL Moneyline: +156

ATL Moneyline: -187

STL Spread: +1.5

ATL Spread: -1.5

Over/Under: 8.5

STL
Betting Trends

  • The Cardinals have covered the spread in 3 of their last 5 games, showing signs of improvement.

ATL
Betting Trends

  • The Braves have covered the spread in 2 of their last 6 home games, indicating challenges in meeting expectations at home.

MATCHUP TRENDS

  • The Cardinals have a -15 run differential, while the Braves have a -30 run differential, reflecting struggles on both sides but more pronounced for the Braves.

STL vs. ATL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Walker over 0.5 Total Bases.

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St. Louis vs Atlanta Prediction & Odds:
Free MLB Betting Insights for 4/21/25

The April 21, 2025 matchup between the St. Louis Cardinals and the Atlanta Braves at Truist Park highlights a pair of National League clubs working to stabilize inconsistent starts and claw their way back into contention. The Cardinals, sitting at 9–12, have shown signs of life after a sluggish beginning, with improved play over the last week marked by more cohesive offense and better bullpen execution. Key contributors such as Paul Goldschmidt and Nolan Arenado have begun to find their rhythm at the plate, combining for five home runs and 23 RBIs through the first three weeks of the season, while younger players like Jordan Walker and Masyn Winn have injected energy into the bottom half of the lineup. The pitching staff, led into this contest by right-hander Erick Fedde, has begun to steady itself as well. Fedde carries a 3.43 ERA and has been effective at limiting hard contact, keeping games within reach even when the offense stalls. The Cardinals’ run differential sits at -15, reflecting some of their early season blowout losses, but recent results suggest a team that’s starting to string competitive innings together. Having covered the spread in three of their last five games, St. Louis is trending in a more disciplined, focused direction. On the other side, the Braves are off to a surprising 7–13 start and enter this contest in need of a reset. Atlanta’s roster, which remains filled with high-end talent like Ronald Acuña Jr., Matt Olson, and Austin Riley, has underperformed expectations on both sides of the ball. Acuña, who entered the season as an MVP candidate, is batting just .247 and has struggled to get on base consistently, while Olson has shown flashes of power but has been largely neutralized by opposing pitching.

The Braves’ offense ranks in the bottom third in the National League in team OPS, and their -30 run differential is among the worst in baseball, a stark departure from their usual dominance. Injuries to the starting rotation and bullpen fatigue have further complicated matters, as Atlanta pitchers have been unable to string together quality outings, forcing manager Brian Snitker to shuffle roles and lean more heavily on untested arms. Defensively, Atlanta has not played to its usual standard either, with several costly miscues contributing to extended innings and unearned runs. Still, this is a team with the pedigree and personnel to bounce back quickly, and a return home offers the potential for that turnaround to begin. This matchup, while lacking the shine of two top-tier records, features all the elements of a pressure-filled, high-stakes divisional-style clash between two proud franchises. For the Cardinals, the opportunity is clear: take advantage of a reeling Braves squad and continue their climb toward .500 with consistent contact hitting and solid pitching. For the Braves, the urgency to protect their home turf and stop the bleeding is paramount—they must get back to fundamentals, limit defensive lapses, and capitalize on scoring chances early to give their pitching a cushion. Both teams are desperate to shift the tone of their seasons, and Monday’s contest may serve as the catalyst for one to do just that. Expect a scrappy, competitive game where execution, bullpen stability, and timely power hitting could make the difference as both clubs seek a spark to jumpstart their April.

St. Louis Cardinals MLB Preview

The St. Louis Cardinals arrive at Truist Park on April 21, 2025, with a 9–12 record and the renewed optimism of a club starting to find its footing after a rocky opening stretch. Following several disappointing series to begin the season, the Cardinals have managed to cover the spread in three of their last five games, a sign that their performances are trending in the right direction. A key component in that improvement has been the gradual reawakening of their offense. Paul Goldschmidt and Nolan Arenado, the cornerstones of the Cardinals’ lineup, have begun to heat up after a slow start, combining for 23 RBIs and showing improved pitch selection and timing over the past week. The emergence of young talents like Jordan Walker and Masyn Winn has added energy and versatility to the lower third of the order, while Lars Nootbaar and Brendan Donovan have provided flexibility in matchups with their ability to get on base and extend innings. Although the Cardinals still sit at a -15 run differential, many of those deficits were accumulated during blowout losses early in the season—since then, the team has tightened up in key moments and looked far more competitive. On the mound, St. Louis turns to right-hander Erick Fedde, who has become a stabilizing presence in the rotation with a 3.43 ERA through four starts. Fedde’s ability to induce weak contact and pitch deep into games has been invaluable for a team still seeking consistency from its pitching staff. His control and poise have allowed the bullpen to enter games with manageable leverage, and the Cardinals’ relief corps—featuring Giovanny Gallegos and Ryan Helsley—has responded with a string of solid performances.

The bullpen’s effectiveness in holding late-inning leads has played a significant role in helping St. Louis stay in tight games, particularly against divisional opponents. Defensively, the Cardinals remain one of the sharper teams in the National League, with Goldschmidt, Arenado, and Tommy Edman anchoring a reliable infield that limits mistakes and supports the pitching staff by consistently converting routine outs. Behind the plate, Willson Contreras continues to manage the staff effectively and has improved his framing and pitch-calling since last season. Facing an Atlanta team that has struggled both offensively and defensively in 2025, the Cardinals have a prime opportunity to steal a key road win and continue their climb back toward .500. With Fedde on the mound and their lineup trending upward, St. Louis will look to set the tone early, take advantage of any defensive lapses by the Braves, and build a lead that their bullpen can protect. To do so, they’ll need to maintain their recent improvements in situational hitting, especially with runners in scoring position—a metric that has historically been a swing factor for the club. This game represents more than just a single win in April; it’s a chance for the Cardinals to solidify their progress, assert their veteran presence on the road, and signal that their early-season struggles are behind them as they chase momentum heading into the summer months.

The St. Louis Cardinals (9–12) travel to Truist Park to face the Atlanta Braves (7–13) on April 21, 2025, in a matchup between two National League teams aiming to improve their standings. Both teams are looking to gain momentum early in the season. St. Louis vs Atlanta AI Prediction: Free MLB Betting Insights for Apr 21. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Atlanta Braves MLB Preview

The Atlanta Braves return home to Truist Park on April 21, 2025, carrying a 7–13 record and a sense of urgency to reverse a discouraging start to the season that has included uncharacteristic struggles in nearly every facet of their game. The Braves, a perennial playoff contender over the past several seasons, currently sit at the bottom of the NL East and face mounting pressure as both their offense and pitching staff have failed to meet expectations. With a -30 run differential, Atlanta has been on the wrong side of multiple lopsided results, and what’s most surprising is that these struggles are occurring despite a lineup filled with star-caliber talent. Ronald Acuña Jr. has yet to find his stride, batting just .247 with limited extra-base production, while Matt Olson has shown some power but is struggling with consistency and strikeouts. Austin Riley and Ozzie Albies have had sporadic success, but the team overall has lacked the timely hitting and patient at-bats that fueled their offensive dominance in prior years. Defensive miscues have further compounded their problems, extending innings and adding unnecessary stress on a pitching staff that’s already operating under strain due to early injuries and ineffectiveness from key starters. The Braves’ starting rotation has been in flux, as both the front-end arms and younger options have struggled to find consistency. Without a dominant ace to set the tone, the rest of the staff has labored through starts, often exiting games early and leaving the bullpen to absorb too many innings. Atlanta’s relievers, while talented, have been overused, leading to fatigue and declining effectiveness in high-leverage situations. Manager Brian Snitker has juggled roles and matchups in an effort to find a winning formula, but until the starters provide length and the defense stabilizes, the bullpen’s workload remains unsustainable.

At home, the Braves are just 3–6 this season and have covered the spread in only two of their last six games at Truist Park—a dramatic shift from their usual dominance in Atlanta, where they’ve built their success on feeding off the crowd and creating early offensive momentum. If the Braves are going to right the ship, it will need to begin with improved execution from the mound and more disciplined approaches at the plate to avoid chasing early deficits. Despite the current state of affairs, the Braves remain one of the most talented rosters in baseball, and a single breakout performance could serve as the catalyst for a much-needed turnaround. With a home crowd eager to see signs of life and a struggling opponent in the Cardinals coming to town, Atlanta has an opportunity to start that process with a strong showing Monday night. For the Braves, the formula is straightforward—get solid innings from the starter, play clean defense, and let the middle of the lineup do damage when given the opportunity. If they can string together quality at-bats early, take advantage of St. Louis’s shaky run prevention, and give the bullpen a lead to work with, they can start to reclaim their footing and begin climbing out of their early-season hole. With pride, talent, and postseason expectations all on the line, the Braves know that the turnaround has to start somewhere—and their best chance to spark it might just come at home.

St. Louis vs. Atlanta Prop Picks (AI)

Remi is pouring through loads of stats on each team. In fact, anytime the Cardinals and Braves play there’s always several intriguing trends to key in on. Not to mention games played at Truist Park in Apr seemingly never follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: J. Walker over 0.5 Total Bases.

St. Louis vs. Atlanta Prediction (AI)

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Remi, our AI sports genius, has been pouring over tons of data from every facet between the Cardinals and Braves and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.

Remi has been most fixated on the growing weight emotional bettors tend to put on Atlanta’s strength factors between a Cardinals team going up against a possibly deflated Braves team. We’ve found the true game analytics appear to reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI St. Louis vs Atlanta picks, computer picks Cardinals vs Braves, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Cardinals Betting Trends

The Cardinals have covered the spread in 3 of their last 5 games, showing signs of improvement.

Braves Betting Trends

The Braves have covered the spread in 2 of their last 6 home games, indicating challenges in meeting expectations at home.

Cardinals vs. Braves Matchup Trends

The Cardinals have a -15 run differential, while the Braves have a -30 run differential, reflecting struggles on both sides but more pronounced for the Braves.

St. Louis vs. Atlanta Game Info

St. Louis vs Atlanta starts on April 21, 2025 at 7:15 PM EST.

Spread: Atlanta -1.5
Moneyline: St. Louis +156, Atlanta -187
Over/Under: 8.5

St. Louis: (9-13)  |  Atlanta: (8-13)

Remi's searched hard and found the best prop for this matchup: J. Walker over 0.5 Total Bases.. Prices move—always shop for the best number.

The Cardinals have a -15 run differential, while the Braves have a -30 run differential, reflecting struggles on both sides but more pronounced for the Braves.

STL trend: The Cardinals have covered the spread in 3 of their last 5 games, showing signs of improvement.

ATL trend: The Braves have covered the spread in 2 of their last 6 home games, indicating challenges in meeting expectations at home.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

St. Louis vs. Atlanta Odds

Remi is pouring through loads of stats on each team. In fact, anytime the St. Louis vs Atlanta trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable patterns.

St. Louis vs Atlanta Opening Odds

STL Moneyline: +156
ATL Moneyline: -187
STL Spread: +1.5
ATL Spread: -1.5
Over/Under: 8.5

St. Louis vs Atlanta Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-180
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+125
-150
+1.5 (-180)
-1.5 (+150)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+145
-175
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-195)
-1.5 (+160)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+105
-125
+1.5 (-205)
-1.5 (+170)
O 7.5 (+105)
U 7.5 (-125)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers St. Louis Cardinals vs. Atlanta Braves on April 21, 2025 at Truist Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN