Cardinals vs. Braves
Prediction, Odds & Props
Apr 21 | MLB AI Picks
Updated: 2025-04-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The St. Louis Cardinals (9–12) travel to Truist Park to face the Atlanta Braves (7–13) on April 21, 2025, in a matchup between two National League teams aiming to improve their standings. Both teams are looking to gain momentum early in the season.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Apr 21, 2025
Start Time: 7:15 PM EST
Venue: Truist Park
Braves Record: (8-13)
Cardinals Record: (9-13)
OPENING ODDS
STL Moneyline: +156
ATL Moneyline: -187
STL Spread: +1.5
ATL Spread: -1.5
Over/Under: 8.5
STL
Betting Trends
- The Cardinals have covered the spread in 3 of their last 5 games, showing signs of improvement.
ATL
Betting Trends
- The Braves have covered the spread in 2 of their last 6 home games, indicating challenges in meeting expectations at home.
MATCHUP TRENDS
- The Cardinals have a -15 run differential, while the Braves have a -30 run differential, reflecting struggles on both sides but more pronounced for the Braves.
STL vs. ATL
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: J. Walker over 0.5 Total Bases.
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St. Louis vs Atlanta Prediction & Odds:
Free MLB Betting Insights for 4/21/25
The Braves’ offense ranks in the bottom third in the National League in team OPS, and their -30 run differential is among the worst in baseball, a stark departure from their usual dominance. Injuries to the starting rotation and bullpen fatigue have further complicated matters, as Atlanta pitchers have been unable to string together quality outings, forcing manager Brian Snitker to shuffle roles and lean more heavily on untested arms. Defensively, Atlanta has not played to its usual standard either, with several costly miscues contributing to extended innings and unearned runs. Still, this is a team with the pedigree and personnel to bounce back quickly, and a return home offers the potential for that turnaround to begin. This matchup, while lacking the shine of two top-tier records, features all the elements of a pressure-filled, high-stakes divisional-style clash between two proud franchises. For the Cardinals, the opportunity is clear: take advantage of a reeling Braves squad and continue their climb toward .500 with consistent contact hitting and solid pitching. For the Braves, the urgency to protect their home turf and stop the bleeding is paramount—they must get back to fundamentals, limit defensive lapses, and capitalize on scoring chances early to give their pitching a cushion. Both teams are desperate to shift the tone of their seasons, and Monday’s contest may serve as the catalyst for one to do just that. Expect a scrappy, competitive game where execution, bullpen stability, and timely power hitting could make the difference as both clubs seek a spark to jumpstart their April.
Thomas Saggese ties the game in the 7th! pic.twitter.com/2mtkI5HZzS
— St. Louis Cardinals (@Cardinals) April 20, 2025
St. Louis Cardinals MLB Preview
The St. Louis Cardinals arrive at Truist Park on April 21, 2025, with a 9–12 record and the renewed optimism of a club starting to find its footing after a rocky opening stretch. Following several disappointing series to begin the season, the Cardinals have managed to cover the spread in three of their last five games, a sign that their performances are trending in the right direction. A key component in that improvement has been the gradual reawakening of their offense. Paul Goldschmidt and Nolan Arenado, the cornerstones of the Cardinals’ lineup, have begun to heat up after a slow start, combining for 23 RBIs and showing improved pitch selection and timing over the past week. The emergence of young talents like Jordan Walker and Masyn Winn has added energy and versatility to the lower third of the order, while Lars Nootbaar and Brendan Donovan have provided flexibility in matchups with their ability to get on base and extend innings. Although the Cardinals still sit at a -15 run differential, many of those deficits were accumulated during blowout losses early in the season—since then, the team has tightened up in key moments and looked far more competitive. On the mound, St. Louis turns to right-hander Erick Fedde, who has become a stabilizing presence in the rotation with a 3.43 ERA through four starts. Fedde’s ability to induce weak contact and pitch deep into games has been invaluable for a team still seeking consistency from its pitching staff. His control and poise have allowed the bullpen to enter games with manageable leverage, and the Cardinals’ relief corps—featuring Giovanny Gallegos and Ryan Helsley—has responded with a string of solid performances.
The bullpen’s effectiveness in holding late-inning leads has played a significant role in helping St. Louis stay in tight games, particularly against divisional opponents. Defensively, the Cardinals remain one of the sharper teams in the National League, with Goldschmidt, Arenado, and Tommy Edman anchoring a reliable infield that limits mistakes and supports the pitching staff by consistently converting routine outs. Behind the plate, Willson Contreras continues to manage the staff effectively and has improved his framing and pitch-calling since last season. Facing an Atlanta team that has struggled both offensively and defensively in 2025, the Cardinals have a prime opportunity to steal a key road win and continue their climb back toward .500. With Fedde on the mound and their lineup trending upward, St. Louis will look to set the tone early, take advantage of any defensive lapses by the Braves, and build a lead that their bullpen can protect. To do so, they’ll need to maintain their recent improvements in situational hitting, especially with runners in scoring position—a metric that has historically been a swing factor for the club. This game represents more than just a single win in April; it’s a chance for the Cardinals to solidify their progress, assert their veteran presence on the road, and signal that their early-season struggles are behind them as they chase momentum heading into the summer months.

Credit: USA TODAY/IMAGN
Atlanta Braves MLB Preview
The Atlanta Braves return home to Truist Park on April 21, 2025, carrying a 7–13 record and a sense of urgency to reverse a discouraging start to the season that has included uncharacteristic struggles in nearly every facet of their game. The Braves, a perennial playoff contender over the past several seasons, currently sit at the bottom of the NL East and face mounting pressure as both their offense and pitching staff have failed to meet expectations. With a -30 run differential, Atlanta has been on the wrong side of multiple lopsided results, and what’s most surprising is that these struggles are occurring despite a lineup filled with star-caliber talent. Ronald Acuña Jr. has yet to find his stride, batting just .247 with limited extra-base production, while Matt Olson has shown some power but is struggling with consistency and strikeouts. Austin Riley and Ozzie Albies have had sporadic success, but the team overall has lacked the timely hitting and patient at-bats that fueled their offensive dominance in prior years. Defensive miscues have further compounded their problems, extending innings and adding unnecessary stress on a pitching staff that’s already operating under strain due to early injuries and ineffectiveness from key starters. The Braves’ starting rotation has been in flux, as both the front-end arms and younger options have struggled to find consistency. Without a dominant ace to set the tone, the rest of the staff has labored through starts, often exiting games early and leaving the bullpen to absorb too many innings. Atlanta’s relievers, while talented, have been overused, leading to fatigue and declining effectiveness in high-leverage situations. Manager Brian Snitker has juggled roles and matchups in an effort to find a winning formula, but until the starters provide length and the defense stabilizes, the bullpen’s workload remains unsustainable.
At home, the Braves are just 3–6 this season and have covered the spread in only two of their last six games at Truist Park—a dramatic shift from their usual dominance in Atlanta, where they’ve built their success on feeding off the crowd and creating early offensive momentum. If the Braves are going to right the ship, it will need to begin with improved execution from the mound and more disciplined approaches at the plate to avoid chasing early deficits. Despite the current state of affairs, the Braves remain one of the most talented rosters in baseball, and a single breakout performance could serve as the catalyst for a much-needed turnaround. With a home crowd eager to see signs of life and a struggling opponent in the Cardinals coming to town, Atlanta has an opportunity to start that process with a strong showing Monday night. For the Braves, the formula is straightforward—get solid innings from the starter, play clean defense, and let the middle of the lineup do damage when given the opportunity. If they can string together quality at-bats early, take advantage of St. Louis’s shaky run prevention, and give the bullpen a lead to work with, they can start to reclaim their footing and begin climbing out of their early-season hole. With pride, talent, and postseason expectations all on the line, the Braves know that the turnaround has to start somewhere—and their best chance to spark it might just come at home.
Solid Sunday at the yard 🔥#BravesCountry pic.twitter.com/JXrQiH16qN
— Atlanta Braves (@Braves) April 20, 2025
St. Louis vs. Atlanta Prop Picks (AI)
St. Louis vs. Atlanta Prediction (AI)

Remi, our AI sports genius, has been pouring over tons of data from every facet between the Cardinals and Braves and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.
Remi has been most fixated on the growing weight emotional bettors tend to put on Atlanta’s strength factors between a Cardinals team going up against a possibly deflated Braves team. We’ve found the true game analytics appear to reflect a strong lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI St. Louis vs Atlanta picks, computer picks Cardinals vs Braves, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 9/26 | DET@BOS | UNLOCK THIS PICK | 5 |
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MLB | 9/26 | BAL@NYY | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | ARI@SD | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | NYM@MIA | UNLOCK THIS PICK | 1 |
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MLB | 9/26 | NYM@MIA | GET FREE PICK NOW | 1 | – | |
MLB | 9/26 | COL@SF | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Cardinals Betting Trends
The Cardinals have covered the spread in 3 of their last 5 games, showing signs of improvement.
Braves Betting Trends
The Braves have covered the spread in 2 of their last 6 home games, indicating challenges in meeting expectations at home.
Cardinals vs. Braves Matchup Trends
The Cardinals have a -15 run differential, while the Braves have a -30 run differential, reflecting struggles on both sides but more pronounced for the Braves.
St. Louis vs. Atlanta Game Info
What time does St. Louis vs Atlanta start on April 21, 2025?
St. Louis vs Atlanta starts on April 21, 2025 at 7:15 PM EST.
Where is St. Louis vs Atlanta being played?
Venue: Truist Park.
What are the opening odds for St. Louis vs Atlanta?
Spread: Atlanta -1.5
Moneyline: St. Louis +156, Atlanta -187
Over/Under: 8.5
What are the records for St. Louis vs Atlanta?
St. Louis: (9-13) | Atlanta: (8-13)
What is the AI best bet for St. Louis vs Atlanta?
Remi's searched hard and found the best prop for this matchup: J. Walker over 0.5 Total Bases.. Prices move—always shop for the best number.
What are St. Louis vs Atlanta trending bets?
The Cardinals have a -15 run differential, while the Braves have a -30 run differential, reflecting struggles on both sides but more pronounced for the Braves.
What are St. Louis trending bets?
STL trend: The Cardinals have covered the spread in 3 of their last 5 games, showing signs of improvement.
What are Atlanta trending bets?
ATL trend: The Braves have covered the spread in 2 of their last 6 home games, indicating challenges in meeting expectations at home.
Where can I find AI Picks for St. Louis vs Atlanta?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
St. Louis vs. Atlanta Odds
Remi is pouring through loads of stats on each team. In fact, anytime the St. Louis vs Atlanta trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable patterns.
St. Louis vs Atlanta Opening Odds
STL Moneyline:
+156 ATL Moneyline: -187
STL Spread: +1.5
ATL Spread: -1.5
Over/Under: 8.5
St. Louis vs Atlanta Live Odds
Games | PTS | ML | SPR | O/U | |
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Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
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–
–
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+190
-235
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+1.5 (-110)
-1.5 (-110)
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O 8.5 (-120)
U 8.5 (+100)
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Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
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Cardinals
Cubs
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–
–
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-180
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-1.5 (+115)
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O 9.5 (-105)
U 9.5 (-115)
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Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
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–
–
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+130
-155
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+1.5 (-155)
-1.5 (+130)
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O 8.5 (-110)
U 8.5 (-110)
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Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
|
–
–
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+100
-120
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-1.5 (+165)
+1.5 (-200)
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O 8.5 (-110)
U 8.5 (-110)
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Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
|
–
–
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+185
-225
|
+1.5 (-110)
-1.5 (-110)
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O 8 (-105)
U 8 (-115)
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Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
|
–
–
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-130
+110
|
-1.5 (+125)
+1.5 (-150)
|
O 8 (-115)
U 8 (-105)
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Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
|
–
–
|
+125
-150
|
+1.5 (-180)
-1.5 (+150)
|
O 9 (+100)
U 9 (-120)
|
|
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
|
–
–
|
+170
-205
|
+1.5 (-120)
-1.5 (+100)
|
O 8.5 (-115)
U 8.5 (-105)
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Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
|
–
–
|
+125
-150
|
+1.5 (-180)
-1.5 (+150)
|
O 8 (-105)
U 8 (-115)
|
|
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
|
–
–
|
+145
-175
|
+1.5 (-155)
-1.5 (+130)
|
O 8 (-110)
U 8 (-110)
|
|
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
|
–
–
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+135
-165
|
+1.5 (-180)
-1.5 (+150)
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O 7 (-120)
U 7 (+100)
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Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
|
–
–
|
+115
-140
|
+1.5 (-195)
-1.5 (+160)
|
O 7.5 (-120)
U 7.5 (+100)
|
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Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
|
–
–
|
-165
+135
|
-1.5 (+105)
+1.5 (-125)
|
O 9 (+100)
U 9 (-120)
|
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Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
|
–
–
|
+105
-125
|
+1.5 (-205)
-1.5 (+170)
|
O 7.5 (+105)
U 7.5 (-125)
|
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Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
|
–
–
|
+100
-120
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-1.5 (+150)
+1.5 (-180)
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O 10 (-110)
U 10 (-110)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers St. Louis Cardinals vs. Atlanta Braves on April 21, 2025 at Truist Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |
CIN@ARI | KEBRYAN HAYES STRIKEOUTS UNDER 0.5 | 56.2% | 6 | WIN |
LAD@SD | SD +110 | 50.9% | 6 | WIN |