The Boston Red Sox and Chicago White Sox will meet for the final game of their four-game series on April 21, 2025, at Fenway Park, in a Patriots’ Day matinee that carries historical significance and added emotion for the home side. Boston currently leads the series 2–1 after taking the first two games with strong pitching and timely hitting, though the White Sox responded with a breakout 8–4 win in Game 3, fueled by a much-needed offensive surge. Monday’s game features a starting pitching matchup between Walker Buehler for Boston (2–1, 5.23 ERA) and Jonathan Cannon for Chicago (0–2, 4.42 ERA), two right-handers with very different trajectories. Buehler is continuing his comeback campaign with flashes of his dominant pre-injury form, while Cannon is still searching for his first win as he tries to provide stability in the White Sox’s struggling rotation. The Red Sox enter with a 10–10 record and a .500 ATS mark, while the White Sox, at 4–14 overall and winless on the road (0–7), continue to search for traction in what has been a difficult start to their 2025 season. Boston’s superior lineup depth, stronger bullpen, and undeniable home-field advantage on a day as spirited as Patriots’ Day will make them favorites to close the series strong. Boston’s offense has been one of the more balanced and opportunistic in the American League to start the season, with contributions up and down the lineup. Trevor Story has been red-hot, batting .318 with five home runs, consistently igniting rallies and providing power from the middle of the order. He’s been complemented by Alex Bregman, whose 16 RBIs lead the team and whose defensive presence at third base has shored up the left side of the infield. The Red Sox lineup has consistently produced with runners in scoring position, showing discipline and clutch hitting, and their team speed has allowed them to put pressure on opposing defenses.

On the mound, Buehler has shown glimpses of regaining his ace-level form, especially with improved fastball velocity and command in recent starts. He’ll be backed by a bullpen that has been solid, with closer Kenley Jansen continuing to provide late-game stability. Boston’s defense has also limited extra outs, playing clean and confident baseball. With the energy of the Patriots’ Day crowd behind them and a chance to secure a third win in four games, the Red Sox are poised to play aggressively and continue establishing themselves as early contenders in the AL East. For Chicago, the story remains one of frustration and sporadic execution, though their Game 3 victory offers a flicker of hope. The White Sox offense, which has mostly been quiet to start the year, came to life with eight runs behind contributions from Andrew Benintendi and Andrew Vaughn, both of whom have been among the team’s most productive hitters. Benintendi’s power has begun to emerge with three home runs, and Vaughn continues to lead the club in RBIs with 10. However, beyond those two, the offense has lacked consistency, and too often the lineup struggles to extend innings or capitalize on scoring chances. Jonathan Cannon will take the ball still searching for his first win, and while his 4.42 ERA suggests he’s been serviceable, he’ll face a tough test against a Boston lineup that’s been excellent at home. Chicago’s bullpen has been overworked due to short outings from the rotation, and the defense has not helped matters, frequently giving opponents extra opportunities. For the White Sox to earn a series split, they’ll need a strong, efficient outing from Cannon, timely hitting early in the game, and a much-improved defensive effort. Otherwise, the Red Sox could quickly seize control and cruise to another series win in front of one of baseball’s most passionate holiday crowds.