Guardians vs. Orioles
Prediction, Odds & Props
Apr 17 | MLB AI Picks

Updated: 2025-04-15T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Cleveland Guardians (9–8) and Baltimore Orioles (7–10) conclude their three-game series at Oriole Park at Camden Yards, with each team seeking to gain momentum in the early season. First pitch is scheduled for 6:35 PM ET, featuring a pitching matchup between Tanner Bibee (1–1, 4.40 ERA) for the Guardians and Tomoyuki Sugano (1–1, 3.86 ERA) for the Orioles.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 17, 2025

Start Time: 6:35 PM EST​

Venue: Oriole Park at Camden Yards​

Orioles Record: (7-10)

Guardians Record: (9-8)

OPENING ODDS

CLE Moneyline: -118

BAL Moneyline: -101

CLE Spread: -1.5

BAL Spread: +1.5

Over/Under: 8.5

CLE
Betting Trends

  • The Guardians have covered the run line in 3 of their last 5 games, indicating a moderate performance against the spread.

BAL
Betting Trends

  • The Orioles have failed to cover the run line in 3 of their last 5 games, reflecting recent struggles to meet betting expectations.

MATCHUP TRENDS

  • In their last 5 head-to-head matchups, the Guardians have covered the run line in 3 games, suggesting a slight edge in recent encounters.

CLE vs. BAL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: C. Mullins over 0.5 Total Bases.

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Cleveland vs Baltimore Prediction & Odds:
Free MLB Betting Insights for 4/17/25

Tonight’s final game of the series between the Cleveland Guardians and Baltimore Orioles at Oriole Park at Camden Yards offers both teams a valuable early-season opportunity to generate momentum, shake off inconsistency, and leave a mark in what has been a tightly contested series thus far. Cleveland enters the game at 9–8, and while they haven’t dazzled statistically, their brand of baseball has remained sharp, disciplined, and well-managed. Offensively, the Guardians continue to rely on a steady contact-oriented approach anchored by the ever-reliable Steven Kwan, who enters the day hitting .322 with a .403 on-base percentage. His ability to get on base and create havoc in the top spot has consistently set the table for slugger José Ramírez, who has already racked up 4 home runs and 15 RBIs and remains the heartbeat of Cleveland’s offense. Complementary pieces like Josh Naylor and Andrés Giménez have also chipped in, helping to give the Guardians a balanced attack that doesn’t depend on the long ball but can manufacture runs with small-ball efficiency. Cleveland’s lineup emphasizes plate discipline, situational hitting, and base-running aggressiveness, all of which have served them well against teams that allow free passes or struggle in tight, late-game situations. The Guardians will hand the ball to right-hander Tanner Bibee, who enters tonight’s game with a 1–1 record and a 4.40 ERA through three starts. Bibee, one of the more promising young arms in the AL Central, has flashed solid strikeout potential and good poise on the mound, but he’s yet to fully find his rhythm. His success tonight will depend on limiting early walks and staying ahead in the count, especially against a Baltimore offense that’s capable of putting up runs in bunches. Cleveland’s bullpen, meanwhile, has been one of the more consistent units early in the season, giving manager Stephen Vogt the confidence to go to his late-inning arms with a lead.

Defensively, the Guardians have been sharp—particularly in the infield—helping limit second-chance opportunities for opposing teams and maintaining pressure through clean play. All of this makes Cleveland a tough out in any matchup, especially when their starting pitching can carry the load for five or six quality innings. A win tonight would mark their third series victory of the season and position them firmly above .500 as they prepare for a more grueling stretch in the AL Central schedule. The Orioles, at 7–10, remain a work-in-progress, oscillating between flashes of potential and frustrating lapses on both sides of the ball. Their most recent 9–1 win was fueled by a grand slam from rookie sensation Jackson Holliday—an electrifying moment that reminded fans why the franchise is so high on its top prospect. Holliday has brought energy and upside to the lineup, and as the season progresses, he could become a central figure in Baltimore’s offensive resurgence. Tonight, veteran right-hander Tomoyuki Sugano takes the hill with a 1–1 record and a solid 3.86 ERA, looking to replicate the consistency he showed in his most recent start. Sugano mixes pitches well and has been effective at keeping hitters off balance, but he’ll face a Cleveland lineup that thrives against finesse and demands precise execution. Baltimore’s offensive core, including Adley Rutschman, Gunnar Henderson, and Anthony Santander, remains potent but has been sporadic in production, and the key tonight will be stringing together quality at-bats against Bibee and finding ways to drive in early runs. With both teams featuring starters capable of keeping the game close, the contest may come down to bullpen management and defensive execution in the late innings. For Cleveland, the goal is consolidation and series control. For Baltimore, it’s about finding footing and using a home win to launch a more consistent stretch. With high-end talent scattered across both rosters and a pair of competitive arms on the mound, fans should expect a tense, strategic battle with playoff-style intensity even in mid-April.
Cleveland Guardians

Cleveland Guardians MLB Preview

The Cleveland Guardians enter tonight’s series finale against the Baltimore Orioles with a 9–8 record and an opportunity to walk away with a key early-season series win, powered by a formula that has long been their identity: contact hitting, sound defense, and resilient pitching. Under new manager Stephen Vogt, the Guardians have maintained the steady, methodical approach that has kept them competitive in recent seasons. At the top of the lineup, Steven Kwan continues to thrive as one of the most disciplined hitters in the league, posting a .322 average and getting on base at a .403 clip. His ability to consistently put the ball in play and extend at-bats makes him a nuisance for opposing pitchers and a perfect table-setter for Cleveland’s most dangerous offensive weapon, José Ramírez. Ramírez, with 4 home runs and 15 RBIs already, remains the team’s emotional and statistical anchor, producing power from both sides of the plate and excelling in clutch moments. Surrounding him is a supporting cast led by Josh Naylor and Andrés Giménez, both of whom bring versatility and a left-handed presence that helps balance the offense. While the Guardians don’t rank among the league leaders in home runs or slugging percentage, they consistently put pressure on defenses with timely hits, smart base running, and fundamentally sound situational play. On the mound tonight is right-hander Tanner Bibee, a young and developing arm who holds a 1–1 record and a 4.40 ERA across three starts this season. Bibee has shown moments of dominance with his fastball-slider combo, and when he’s in rhythm, he’s more than capable of navigating deep into games while keeping damage to a minimum.

However, he’ll need to improve on his early-inning command and avoid falling behind in counts, particularly against a Baltimore lineup that has the potential to erupt if given free baserunners. The Guardians’ bullpen has been a steady complement to their starters, anchored by reliable arms like Emmanuel Clase and Tim Herrin, both of whom have been effective in shutting down late-inning threats. Cleveland’s defense, long one of its strongest assets, continues to perform well, especially up the middle with Giménez and Brayan Rocchio forming a solid double-play duo and Myles Straw providing range in center field. This defense has played a critical role in limiting big innings and helping pitchers escape jams without excessive pitch counts. The Guardians have covered the run line in three of their last five games and continue to thrive in tight contests—games where one extra-base hit or one defensive miscue can swing the outcome. If Bibee can keep Baltimore’s dangerous top half in check and the offense can do just enough against veteran Tomoyuki Sugano, Cleveland is well-positioned to steal another road win and return home with positive momentum. While the AL Central race remains wide open, opportunities like tonight—on the road against an underperforming Orioles team—are ones that contenders need to capitalize on. With Kwan setting the tone, Ramírez driving in runs, and a dependable bullpen behind them, the Guardians are primed to execute their style of baseball and grind out another tough, meaningful victory.

The Cleveland Guardians (9–8) and Baltimore Orioles (7–10) conclude their three-game series at Oriole Park at Camden Yards, with each team seeking to gain momentum in the early season. First pitch is scheduled for 6:35 PM ET, featuring a pitching matchup between Tanner Bibee (1–1, 4.40 ERA) for the Guardians and Tomoyuki Sugano (1–1, 3.86 ERA) for the Orioles. Cleveland vs Baltimore AI Prediction: Free MLB Betting Insights for Apr 17. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Baltimore Orioles MLB Preview

The Baltimore Orioles return to Camden Yards tonight looking to even their series against the Cleveland Guardians and climb back on track in what has been a frustrating 7–10 start to the 2025 campaign. Despite the early struggles, the Orioles still carry significant upside, and their 9–1 rout in Game 2 of the series served as a reminder of what this young, talented roster is capable of when it fires on all cylinders. Rookie phenom Jackson Holliday provided the exclamation point in that victory with a grand slam, his first in the majors, signaling the arrival of a player poised to become the face of the franchise for years to come. Holliday’s promotion and rapid impact have energized the team and fan base, and his ability to get on base and deliver power from the left side has lengthened a lineup that includes Adley Rutschman, Gunnar Henderson, Ryan Mountcastle, and Anthony Santander. Rutschman, in particular, remains a cornerstone, both for his ability to manage the pitching staff and for his knack for producing in high-leverage spots. Still, the offense has been inconsistent, especially in series openers, and the key for Baltimore moving forward will be stringing together quality at-bats and building early leads to ease the burden on their arms. That responsibility tonight falls on the shoulders of veteran right-hander Tomoyuki Sugano, who enters with a 1–1 record and a 3.86 ERA through his first few starts in a major league uniform. After a decorated career in Japan, Sugano has quickly adapted to big-league hitters, showing excellent command and poise.

He mixes his pitches well, limits hard contact, and keeps hitters guessing with late-breaking movement, though he’ll face a tough challenge in a Cleveland lineup that’s built to grind out at-bats and force starters into long innings. Sugano’s success tonight will depend on his ability to stay ahead in counts and avoid free passes to contact-heavy hitters like Steven Kwan and José Ramírez, both of whom have been Cleveland’s offensive anchors. Should Sugano keep the game close through five or six innings, Baltimore’s bullpen—while uneven to start the season—has the arms to hold leads, especially with arms like Félix Bautista and Yennier Cano in the later innings if they’re called upon. However, the bullpen has struggled when overused, so length from Sugano will be essential in keeping Baltimore in the contest. Defensively, the Orioles have remained solid, with Holliday and Henderson bringing range and soft hands to the infield, while Austin Hays and Cedric Mullins continue to track down balls in the outfield. The defensive structure has helped suppress big innings, even when the pitching hasn’t been perfect. What Baltimore needs now is a complete effort—six to seven strong innings from their starter, timely hits with runners in scoring position, and clean defense across the board. A win tonight wouldn’t just secure a series split against a playoff-caliber opponent, it would offer a reset after an up-and-down start and serve as a turning point for a team expected to contend in the highly competitive AL East. The talent is there, and if Holliday, Rutschman, and company can stay hot at the plate while Sugano holds the line, the Orioles have a clear path to a much-needed home victory and a restored sense of rhythm heading into the weekend.

Baltimore Orioles

Cleveland vs. Baltimore Prop Picks (AI)

Remi is pouring through mountains of datapoints on each player. In fact, anytime the Guardians and Orioles play there’s always several intriguing observations to key in on. Not to mention games played at Oriole Park at Camden Yards in Apr seemingly never follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: C. Mullins over 0.5 Total Bases.

Cleveland vs. Baltimore Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over mountains of data from every past game between the Guardians and Orioles and using recursive machine learning and kick-ass AI to crunch the data to a single cover probability.

The Algorithm has been most keyed in on the growing factor emotional bettors regularly put on player performance factors between a Guardians team going up against a possibly deflated Orioles team. In reality, the true game analytics appear to reflect a strong lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Cleveland vs Baltimore picks, computer picks Guardians vs Orioles, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Guardians Betting Trends

The Guardians have covered the run line in 3 of their last 5 games, indicating a moderate performance against the spread.

Orioles Betting Trends

The Orioles have failed to cover the run line in 3 of their last 5 games, reflecting recent struggles to meet betting expectations.

Guardians vs. Orioles Matchup Trends

In their last 5 head-to-head matchups, the Guardians have covered the run line in 3 games, suggesting a slight edge in recent encounters.

Cleveland vs. Baltimore Game Info

Cleveland vs Baltimore starts on April 17, 2025 at 6:35 PM EST.

Venue: Oriole Park at Camden Yards.

Spread: Baltimore +1.5
Moneyline: Cleveland -118, Baltimore -101
Over/Under: 8.5

Cleveland: (9-8)  |  Baltimore: (7-10)

Remi's searched hard and found the best prop for this matchup: C. Mullins over 0.5 Total Bases.. Prices move—always shop for the best number.

In their last 5 head-to-head matchups, the Guardians have covered the run line in 3 games, suggesting a slight edge in recent encounters.

CLE trend: The Guardians have covered the run line in 3 of their last 5 games, indicating a moderate performance against the spread.

BAL trend: The Orioles have failed to cover the run line in 3 of their last 5 games, reflecting recent struggles to meet betting expectations.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Cleveland vs. Baltimore Odds

AI algorithm Remi is pouring through mountains of data on each player. In fact, anytime the Cleveland vs Baltimore trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps can often follow normal, predictable patterns.

Cleveland vs Baltimore Opening Odds

CLE Moneyline: -118
BAL Moneyline: -101
CLE Spread: -1.5
BAL Spread: +1.5
Over/Under: 8.5

Cleveland vs Baltimore Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+192
-235
+1.5 (-110)
-1.5 (-110)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-178
 
-1.5 (+115)
O 9.5 (+100)
U 9.5 (-120)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+135
-160
+1.5 (-160)
-1.5 (+135)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
+1.5 (-205)
-1.5 (+170)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+192
-235
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+130)
+1.5 (-155)
O 8 (-120)
U 8 (+100)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+110
-130
+1.5 (-190)
-1.5 (+158)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+175
-210
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+115
-135
+1.5 (-190)
-1.5 (+158)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+150
-178
+1.5 (-145)
-1.5 (+122)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+122
-145
+1.5 (-190)
-1.5 (+158)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+118
-140
+1.5 (-190)
-1.5 (+158)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-145
+122
-1.5 (+115)
+1.5 (-135)
O 9 (-110)
U 9 (-110)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+110
-130
+1.5 (-205)
-1.5 (+170)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
+1.5 (-195)
-1.5 (+162)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Cleveland Guardians vs. Baltimore Orioles on April 17, 2025 at Oriole Park at Camden Yards.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN