Mariners vs Reds Prediction — AI Finds CAN'T MISS MLB Lines & Props (Apr 16)

Updated: 2025-04-14T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Seattle Mariners (9–8) and Cincinnati Reds (7–10) continue their interleague series at Great American Ball Park, with both teams aiming to build momentum in the early stages of the season. Seattle enters the matchup on a four-game winning streak, while Cincinnati looks to rebound after recent struggles.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 16, 2025

Start Time: 6:40 PM EST​

Venue: Great American Ball Park​

Reds Record: (9-8)

Mariners Record: (8-9)

OPENING ODDS

SEA Moneyline: -122

CIN Moneyline: +103

SEA Spread: -1.5

CIN Spread: +1.5

Over/Under: 8.5

SEA
Betting Trends

  • The Mariners have covered the spread in four of their last six games, showcasing a strong performance against the spread (ATS) during this period.

CIN
Betting Trends

  • The Reds have struggled ATS recently, going 2–4 in their last six games, indicating challenges in meeting betting expectations.

MATCHUP TRENDS

  • Seattle has historically performed well against Cincinnati, winning 16 of their last 20 matchups. Additionally, the total has gone OVER in four of Seattle’s last six games against National League opponents, suggesting a tendency toward higher-scoring games.

SEA vs. CIN
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: R. Arozarena over 5.5 Fantasy Score.

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Seattle vs Cincinnati Prediction & Odds:
Free MLB Betting Insights for 4/16/25

The Seattle Mariners and Cincinnati Reds meet for the second contest of their interleague set on April 16, 2025, at Great American Ball Park in a matchup between a team finding its stride and one searching for consistency. The Mariners, sitting at 9–8 and riding a four-game winning streak, are beginning to show signs of the contender many expected them to be entering the season. Their recent 5–1 homestand featured a critical turnaround in offensive execution, with nearly 40% of their runs during that stretch coming in the seventh inning or later—a testament to the team’s resilience, depth, and ability to make adjustments. The bullpen has also steadied after early hiccups, and the starting rotation has given manager Scott Servais a dependable foundation to work from. Meanwhile, the Reds are trying to find balance amid a slow start and roster inconsistency, sitting at 7–10. Though early injuries to key players like Matt McLain, Austin Hays, and Tyler Stephenson have dented their offensive depth, Cincinnati has stayed afloat largely because of its rotation. Hunter Greene, Nick Lodolo, and newly acquired Brady Singer have formed a trio that gives the Reds hope in almost every series, and Singer in particular has emerged as a stabilizer with a 3.18 ERA and elite strikeout rate through his first three outings. Cincinnati has struggled to score consistently, however, with their run total ranking near the bottom of the National League despite solid pitching and a decent run differential. Their offense hinges heavily on Elly De La Cruz, whose electrifying speed and improved plate approach have made him both a fan favorite and a nightmare for opposing pitchers and catchers. But without consistent production around him, De La Cruz’s individual brilliance has often gone unsupported.

Seattle, on the other hand, has found production up and down the lineup, and players like Julio Rodríguez, Ty France, and Cal Raleigh have contributed timely hits while the team has emphasized situational baseball. Their approach—grinding down pitchers, extending at-bats, and cashing in late—is proving sustainable. The Mariners have also fared well against National League opponents, particularly teams in rebuilding or transitional phases, and their 16–4 record against the Reds in their last 20 meetings is difficult to ignore. From a betting standpoint, Seattle has been solid ATS recently and continues to cover spreads thanks to their ability to close games strong, while the Reds have failed to cover in four of their last six, often falling short as favorites. The key to this matchup may lie in which bullpen cracks first, especially if both starting pitchers hold their ground early. If Seattle can once again execute their late-game magic and force the Reds to rely heavily on their middle relief, it could be another frustrating night for the home team. Conversely, if Cincinnati can scratch out an early lead and take advantage of Seattle’s occasional first-inning lapses, they might finally string together a much-needed win. This interleague clash offers contrasting identities—Seattle’s discipline and depth versus Cincinnati’s youth and raw potential—and it sets the stage for an intriguing chess match under the Cincinnati lights.

Seattle Mariners MLB Preview

The Seattle Mariners enter today’s matchup against the Cincinnati Reds riding the momentum of a four-game winning streak and an improving 9–8 record, which signals a team beginning to shake off early-season inconsistencies and take control of its identity. After a 5–1 homestand that featured several comeback victories and late-inning offensive surges, the Mariners now look to translate that success onto the road, where their grit and ability to produce in high-leverage moments has begun to stand out. A hallmark of Seattle’s success during this recent stretch has been their uncanny knack for scoring late—nearly 40% of their runs have come in the seventh inning or later over their last six games, an indicator of both offensive depth and mental toughness. Players like Julio Rodríguez have started to find their rhythm, while Ty France and Cal Raleigh have delivered timely hits to turn close games into wins. J.P. Crawford’s consistency at the top of the order has also set the tone, and the team’s overall plate discipline has improved since a rough opening week, allowing Seattle to wear down starters and exploit bullpens late. With the long ball beginning to supplement their otherwise contact-oriented offense, the Mariners now resemble the balanced threat that carried them to postseason contention in recent years. Seattle’s pitching has also been critical in keeping the team afloat early, particularly the rotation, which has begun to stabilize after some uneven early outings. Logan Gilbert, George Kirby, and Luis Castillo have offered quality starts, while Bryan Woo and Emerson Hancock have filled in admirably amid minor injuries and rotation shuffles. The bullpen, a major strength last year, has returned to form after a shaky opening week, with Andrés Muñoz regaining closer duties and Justin Topa providing key bridge innings.

The relievers have also contributed to Seattle’s late-game success by keeping games close and preventing inherited runners from scoring, a vital part of their identity as a grind-it-out, win-the-late-innings team. The Mariners will look to extend their dominance over Cincinnati—against whom they’ve won 16 of the last 20 matchups—by sticking to the formula that’s worked: patient at-bats early, shutdown relief late, and just enough power sprinkled in to keep pitchers honest. Against a Reds staff that has limited scoring well but received minimal run support, Seattle’s offense will aim to apply pressure from the sixth inning on and force Cincinnati’s middle relievers into uncomfortable situations. From a betting standpoint, Seattle has rewarded backers by covering the spread in four of their last six games, often doing so in comeback fashion. That resiliency makes them a dangerous road team, especially against clubs with inconsistent offensive output. While they may still be ironing out a few kinks defensively and in terms of situational hitting with runners in scoring position, the Mariners are trending upward and appear to have found their late-game identity. A win today would push them back to double-digit wins and potentially vault them into early playoff-positioning conversations, especially in a tight American League West. If they continue executing with the same poise and energy they’ve shown in the last week, the Mariners could easily emerge from Cincinnati with another series victory and a growing reputation as one of the AL’s most dangerous “closers” when the game is on the line.

The Seattle Mariners (9–8) and Cincinnati Reds (7–10) continue their interleague series at Great American Ball Park, with both teams aiming to build momentum in the early stages of the season. Seattle enters the matchup on a four-game winning streak, while Cincinnati looks to rebound after recent struggles. Seattle vs Cincinnati AI Prediction: Free MLB Betting Insights for Apr 16. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Cincinnati Reds MLB Preview

The Cincinnati Reds return to Great American Ball Park for today’s game with a 7–10 record and a pressing need to regain footing after an up-and-down start to the 2025 season that’s been marked by both promise and frustration. While expectations this year were more tempered compared to seasons past, the Reds still find themselves underperforming even relative to internal projections, thanks in part to an offense that has struggled to keep pace with a surprisingly resilient pitching staff. Key injuries have not helped the cause—Matt McLain, Tyler Stephenson, and Austin Hays have all missed significant time—and those absences have thinned out a batting order already lacking depth. Amid this void, Elly De La Cruz has emerged as the team’s most electric and productive player, combining game-breaking speed, improved plate discipline, and raw athleticism to spark the Reds whenever he’s on base. His evolution as a top-of-the-order threat has given Cincinnati a foundation to build around, but the lineup behind him has yet to show consistent run-producing ability. Players like Spencer Steer and Jake Fraley have flashed at times, but not frequently enough to alleviate the pressure on De La Cruz to do everything. As a result, the Reds have ranked near the bottom of the league in both total runs scored and team batting average despite playing in one of baseball’s more hitter-friendly parks. Where Cincinnati has defied expectations, however, is on the mound. Their pitching staff has been one of the quiet surprises of the National League, allowing the third-fewest runs in the league despite the team’s losing record. The rotation has shown balance and growth, particularly from Brady Singer, acquired from Kansas City, who has provided much-needed stability with a 3.18 ERA, 2.71 FIP, and an impressive early-season strikeout rate.

Nick Lodolo and Nick Martinez have also given manager David Bell competitive outings, with Lodolo’s mix of velocity and movement especially effective against left-handed-heavy lineups. Today’s pitching matchup will likely lean heavily on the bullpen, where Cincinnati has been respectable but overtaxed due to the offense’s inability to generate comfortable leads. Closer Alexis Díaz remains a dominant option late, but the path to getting him the ball with a lead has been murky. In close games, the Reds have often found themselves needing perfection on the mound just to keep pace—a trend they’ll need to reverse quickly if they hope to dig out of the NL Central’s lower tier. From a betting perspective, the Reds have been difficult to trust, going 2–4 ATS in their last six games and 3–7 in their last ten overall. This underwhelming stretch has reflected not only losses but a troubling inability to play to market expectations, particularly at home. If Cincinnati is to shift that narrative, it must begin by converting quality pitching into actual wins—especially against beatable opponents like the Mariners, who have relied heavily on late-game production. That puts even more pressure on the Reds’ offense to strike early and give their starters room to breathe. Should De La Cruz continue to get on base and generate havoc, and if one or two bats behind him can deliver with runners in scoring position, Cincinnati may finally be able to pair solid pitching with a complete team effort. A win today could help reset the tone for the homestand and remind the Reds—and their fans—that this young, evolving roster still has the pieces to play competitive baseball in 2025.

Seattle vs. Cincinnati Prop Picks (AI)

Remi is pouring through mountains of stats on each team. In fact, anytime the Mariners and Reds play there’s always several intriguing angles to key in on. Not to mention games played at Great American Ball Park in Apr almost always follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: R. Arozarena over 5.5 Fantasy Score.

Seattle vs. Cincinnati Prediction (AI)

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Remi, our AI sports genius, has been pouring over mountains of data from every angle between the Mariners and Reds and using recursive machine learning and industry leading AI to examine the data to a single cover probability.

The Algorithm has been most keyed in on the growing factor emotional bettors tend to put on Seattle’s strength factors between a Mariners team going up against a possibly healthy Reds team. In reality, the true game analytics appear to reflect a strong lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Seattle vs Cincinnati picks, computer picks Mariners vs Reds, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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Mariners Betting Trends

The Mariners have covered the spread in four of their last six games, showcasing a strong performance against the spread (ATS) during this period.

Reds Betting Trends

The Reds have struggled ATS recently, going 2–4 in their last six games, indicating challenges in meeting betting expectations.

Mariners vs. Reds Matchup Trends

Seattle has historically performed well against Cincinnati, winning 16 of their last 20 matchups. Additionally, the total has gone OVER in four of Seattle’s last six games against National League opponents, suggesting a tendency toward higher-scoring games.

Seattle vs. Cincinnati Game Info

Seattle vs Cincinnati starts on April 16, 2025 at 6:40 PM EST.

Venue: Great American Ball Park.

Spread: Cincinnati +1.5
Moneyline: Seattle -122, Cincinnati +103
Over/Under: 8.5

Seattle: (8-9)  |  Cincinnati: (9-8)

Remi's searched hard and found the best prop for this matchup: R. Arozarena over 5.5 Fantasy Score.. Prices move—always shop for the best number.

Seattle has historically performed well against Cincinnati, winning 16 of their last 20 matchups. Additionally, the total has gone OVER in four of Seattle’s last six games against National League opponents, suggesting a tendency toward higher-scoring games.

SEA trend: The Mariners have covered the spread in four of their last six games, showcasing a strong performance against the spread (ATS) during this period.

CIN trend: The Reds have struggled ATS recently, going 2–4 in their last six games, indicating challenges in meeting betting expectations.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Seattle vs. Cincinnati Odds

Remi is pouring through mountains of data points on each line. In fact, anytime the Seattle vs Cincinnati trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance seemingly never follow normal, predictable patterns.

Seattle vs Cincinnati Opening Odds

SEA Moneyline: -122
CIN Moneyline: +103
SEA Spread: -1.5
CIN Spread: +1.5
Over/Under: 8.5

Seattle vs Cincinnati Live Odds

Games PTS ML SPR O/U

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Seattle Mariners vs. Cincinnati Reds on April 16, 2025 at Great American Ball Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
LAD@TOR TOR +1.5 56.7% 2 WIN
TOR@LAD TOR +1.5 55.3% 4 WIN
TOR@SEA OVER 7 54.9% 3 WIN
LAD@MIL UNDER 7.5 56.6% 6 WIN
TOR@NYY OVER 8 54.9% 4 WIN
TOR@NYY CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED 53.3% 3 WIN
NYY@TOR OVER 7.5 54.8% 2 WIN
LAD@PHI OVER 7 53.8% 3 WIN
SD@CHC CHC -109 53.8% 3 WIN
SD@CHC OVER 7.5 54.5% 4 LOSS
SD@CHC CHC -111 54.8% 4 LOSS
CIN@LAD SHOHEI OHTANI OVER 1.5 BASES 53.5% 3 WIN
BOS@NYY OVER 7 53.8% 3 LOSS
CIN@LAD ELLY DE LA CRUZ OVER 0.5 BASES 54.4% 4 LOSS
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN