Cubs vs. Padres
Prediction, Odds & Props
Apr 16 | MLB AI Picks
Updated: 2025-04-14T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Chicago Cubs and San Diego Padres conclude their six-game season series today at Petco Park, with both teams seeking to gain momentum early in the 2025 campaign. The Cubs have demonstrated resilience against formidable opponents, while the Padres aim to capitalize on their home-field advantage.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Apr 16, 2025
Start Time: 4:10 PM EST
Venue: Petco Park
Padres Record: (14-4)
Cubs Record: (12-8)
OPENING ODDS
CHC Moneyline: +105
SD Moneyline: -124
CHC Spread: +1.5
SD Spread: -1.5
Over/Under: 7.5
CHC
Betting Trends
- The Cubs have covered the spread in 11 of their 18 games this season, showcasing a strong performance against the spread (ATS) in the early part of the season.
SD
Betting Trends
- The Padres have an ATS record of 11–5, indicating consistent success in covering the spread during their games.
MATCHUP TRENDS
- The Cubs have historically performed well at Petco Park, while the Padres have won six of seven games this season when listed as favorites and tend to push games OVER the total in higher-scoring matchups. Together, these trends suggest a competitive, offense-leaning game with a slight edge to the favored home team.
CHC vs. SD
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: P. Crow-Armstrong over 0.5 Hits+Runs+RBI.
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Chicago Cubs vs San Diego Prediction & Odds:
Free MLB Betting Insights for 4/16/25
The pitching staff’s success has been a key reason the Cubs have covered the spread in 11 of their 18 games so far this year. From a betting perspective, the Cubs have been solid on the road and have traditionally played well at Petco Park, boasting a winning record in San Diego over the past several seasons. Their ability to stay competitive in games where they are underdogs has rewarded ATS backers, and their 2025 form suggests they will continue to be a value team in that regard. Offensively, if the Cubs can generate early offense and apply pressure to Nick Pivetta, they could tilt momentum in their favor. Patience at the plate and capitalizing on any mistakes will be essential, as the Padres have dominated games when they get out to early leads. If Boyd can match Pivetta inning for inning, the Cubs have the tools and the grit to steal a road win and head back to Wrigleyville with a series win against one of the National League’s hottest teams.
Sleep well, friends. 😌 pic.twitter.com/8SpxNCEKif
— Chicago Cubs (@Cubs) April 16, 2025
Chicago Cubs Cubs MLB Preview
The Chicago Cubs arrive at Petco Park for the finale of their series against the red-hot San Diego Padres with an 11–7 record and the confidence that comes from competing well against elite competition. Over the past week, they’ve gone 4–2 against the Rangers and Dodgers, a demanding stretch that tested their pitching depth and lineup versatility. Despite operating without a traditional superstar core, the Cubs have forged an identity based on gritty at-bats, clean defense, and clutch bullpen performances. Kyle Tucker has emerged as a stabilizing force in the middle of the lineup, offering power and timely run production, while Nico Hoerner and Ian Happ have contributed with solid OBP and heads-up base running. Chicago’s offense isn’t explosive, but it’s opportunistic, and that has helped them stay within reach in tight, low-scoring games—exactly the type they expect today against a Padres team anchored by top-tier pitching. The Cubs will hand the ball to left-hander Matthew Boyd, who brings a 1.59 ERA and 1.176 WHIP into this crucial matchup. Boyd has exceeded expectations so far in 2025, keeping hitters off balance with a mix of changeups and sliders while staying out of high-leverage jams. His ability to limit walks and induce ground balls has allowed Chicago’s defense to stay active and engaged, while reducing the strain on the bullpen.
Against the Padres’ power-laden lineup, Boyd’s pitch sequencing and ability to work both sides of the plate will be tested, especially by right-handed bats like Machado and Tatis Jr. If he can keep them from squaring balls up early, he’ll buy time for Chicago’s offense to grind down Nick Pivetta and manufacture run support. The Cubs bullpen, with Adbert Alzolay and Julian Merryweather in form, has closed the door effectively when given leads to protect. On the betting front, Chicago continues to be an ATS-friendly team, covering in 11 of 18 games this season and showing profitability as road underdogs. Their track record at Petco Park is also notable, as they hold a better winning percentage there than at most National League stadiums, which could give bettors a reason to lean toward them despite San Diego’s dominance. The key for the Cubs today lies in their ability to control the early innings, keep the Padres from establishing rhythm, and avoid falling behind against a team that thrives when leading. With Boyd in good form, the Cubs have the opportunity to neutralize San Diego’s offensive edge and turn this finale into a tense, tactical battle that plays into their strengths. A win would not only secure a statement road series, but also further validate their position as a quietly dangerous contender in the National League picture.

Credit: USA TODAY/IMAGN
San Diego Padres MLB Preview
The San Diego Padres enter the series finale against the Chicago Cubs riding a wave of early-season momentum and holding a dominant 13–3 record, one of the best in Major League Baseball as of mid-April. With a deep and potent roster finally clicking on both sides of the ball, the Padres have asserted themselves as a formidable force in the National League. Their recent success has come in part thanks to a favorable schedule, as they’ve capitalized on matchups against sub-.500 opponents, but their consistent execution has been impressive regardless of competition. Playing at Petco Park, where they’ve already established a strong home-field edge this season, the Padres will look to complete another series victory behind the steady arm of Nick Pivetta. San Diego has won six of seven games this season when favored by bookmakers, and with Pivetta holding a 1.59 ERA and a WHIP of just 0.824, they are once again poised to deliver a complete team effort. Pivetta’s presence on the mound gives the Padres an anchor for today’s matchup. The right-hander has looked locked in through his early outings, commanding all quadrants of the strike zone and showing excellent control over his secondary pitches. He’s limited opposing lineups to minimal baserunners and has proven especially effective in jamming left-handed hitters—something he’ll need to replicate against Chicago’s lefty-laden order. Pivetta’s ability to pitch deep into games has allowed the Padres to manage their bullpen efficiently, with setup man Robert Suarez and closer Josh Hader rested and ready to go.
The pitching staff as a whole has helped keep the Padres ahead in tight games, contributing significantly to their strong ATS record of 11–5 this season. Their ability to cover spreads and control tempo has made them one of the most trustworthy early-season teams in MLB from both a baseball and betting standpoint. Offensively, San Diego continues to benefit from a dangerous and well-rounded lineup led by Manny Machado and Fernando Tatis Jr., both of whom have come up big in clutch situations. Tatis has provided explosive speed and power at the top of the order, while Machado remains the heartbeat of the lineup with his veteran leadership and ability to drive in runs from any count. Behind them, the supporting cast—Xander Bogaerts, Jake Cronenworth, and Luis Campusano—has added depth and consistency. The Padres also thrive on aggressive base running and situational awareness, often taking extra bases and forcing errors that don’t show up on traditional stat sheets. If they continue their disciplined approach at the plate and get ahead early, the Cubs could struggle to mount a comeback against a bullpen that rarely falters. For the Padres, the formula for success remains simple: rely on elite starting pitching, a relentless lineup, and sound defense. A win today would further cement their status as early National League contenders and affirm their dominance at home, where they’ve looked nearly untouchable.
Final. pic.twitter.com/JvwrjpG5Zt
— San Diego Padres (@Padres) April 16, 2025
Chicago Cubs vs. San Diego Prop Picks (AI)
Chicago Cubs vs. San Diego Prediction (AI)

Remi, our AI sports algorithm, has been pouring over tons of data from every angle between the Cubs and Padres and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.
Interestingly enough, the data has been most focused on the unproportionally assigned weight human bettors often put on player performance factors between a Cubs team going up against a possibly deflated Padres team. It appears the true game analytics might reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Chicago Cubs vs San Diego picks, computer picks Cubs vs Padres, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 9/26 | DET@BOS | UNLOCK THIS PICK | 5 |
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MLB | 9/26 | BAL@NYY | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | ARI@SD | UNLOCK THIS PICK | 4 |
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MLB | 9/26 | NYM@MIA | UNLOCK THIS PICK | 1 |
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MLB | 9/26 | NYM@MIA | GET FREE PICK NOW | 1 | – | |
MLB | 9/26 | COL@SF | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Cubs Betting Trends
The Cubs have covered the spread in 11 of their 18 games this season, showcasing a strong performance against the spread (ATS) in the early part of the season.
Padres Betting Trends
The Padres have an ATS record of 11–5, indicating consistent success in covering the spread during their games.
Cubs vs. Padres Matchup Trends
The Cubs have historically performed well at Petco Park, while the Padres have won six of seven games this season when listed as favorites and tend to push games OVER the total in higher-scoring matchups. Together, these trends suggest a competitive, offense-leaning game with a slight edge to the favored home team.
Chicago Cubs vs. San Diego Game Info
What time does Chicago Cubs vs San Diego start on April 16, 2025?
Chicago Cubs vs San Diego starts on April 16, 2025 at 4:10 PM EST.
Where is Chicago Cubs vs San Diego being played?
Venue: Petco Park.
What are the opening odds for Chicago Cubs vs San Diego?
Spread: San Diego -1.5
Moneyline: Chicago Cubs +105, San Diego -124
Over/Under: 7.5
What are the records for Chicago Cubs vs San Diego?
Chicago Cubs: (12-8) | San Diego: (14-4)
What is the AI best bet for Chicago Cubs vs San Diego?
Remi's searched hard and found the best prop for this matchup: P. Crow-Armstrong over 0.5 Hits+Runs+RBI.. Prices move—always shop for the best number.
What are Chicago Cubs vs San Diego trending bets?
The Cubs have historically performed well at Petco Park, while the Padres have won six of seven games this season when listed as favorites and tend to push games OVER the total in higher-scoring matchups. Together, these trends suggest a competitive, offense-leaning game with a slight edge to the favored home team.
What are Chicago Cubs trending bets?
CHC trend: The Cubs have covered the spread in 11 of their 18 games this season, showcasing a strong performance against the spread (ATS) in the early part of the season.
What are San Diego trending bets?
SD trend: The Padres have an ATS record of 11–5, indicating consistent success in covering the spread during their games.
Where can I find AI Picks for Chicago Cubs vs San Diego?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Chicago Cubs vs. San Diego Odds
AI algorithm Remi is pouring through mountains of stats on each team. In fact, anytime the Chicago Cubs vs San Diego trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable betting trends.
Chicago Cubs vs San Diego Opening Odds
CHC Moneyline:
+105 SD Moneyline: -124
CHC Spread: +1.5
SD Spread: -1.5
Over/Under: 7.5
Chicago Cubs vs San Diego Live Odds
Games | PTS | ML | SPR | O/U | |
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Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
|
–
–
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+190
-235
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+1.5 (-110)
-1.5 (-110)
|
O 8.5 (-120)
U 8.5 (+100)
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Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
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–
–
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-180
|
-1.5 (+115)
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O 9.5 (-105)
U 9.5 (-115)
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|
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
|
–
–
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+130
-155
|
+1.5 (-155)
-1.5 (+130)
|
O 8.5 (-110)
U 8.5 (-110)
|
|
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
|
–
–
|
+100
-120
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-1.5 (+165)
+1.5 (-200)
|
O 8.5 (-110)
U 8.5 (-110)
|
|
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
|
–
–
|
+185
-225
|
+1.5 (-110)
-1.5 (-110)
|
O 8 (-105)
U 8 (-115)
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|
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
|
–
–
|
-130
+110
|
-1.5 (+125)
+1.5 (-150)
|
O 8 (-115)
U 8 (-105)
|
|
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
|
–
–
|
+125
-150
|
+1.5 (-180)
-1.5 (+150)
|
O 9 (+100)
U 9 (-120)
|
|
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
|
–
–
|
+170
-205
|
+1.5 (-120)
-1.5 (+100)
|
O 8.5 (-115)
U 8.5 (-105)
|
|
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
|
–
–
|
+125
-150
|
+1.5 (-180)
-1.5 (+150)
|
O 8 (-105)
U 8 (-115)
|
|
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
|
–
–
|
+145
-175
|
+1.5 (-155)
-1.5 (+130)
|
O 8 (-110)
U 8 (-110)
|
|
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
|
–
–
|
+135
-165
|
+1.5 (-180)
-1.5 (+150)
|
O 7 (-120)
U 7 (+100)
|
|
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
|
–
–
|
+115
-140
|
+1.5 (-195)
-1.5 (+160)
|
O 7.5 (-120)
U 7.5 (+100)
|
|
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
|
–
–
|
-165
+135
|
-1.5 (+105)
+1.5 (-125)
|
O 9 (+100)
U 9 (-120)
|
|
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
|
–
–
|
+105
-125
|
+1.5 (-205)
-1.5 (+170)
|
O 7.5 (+105)
U 7.5 (-125)
|
|
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
|
–
–
|
+100
-120
|
-1.5 (+150)
+1.5 (-180)
|
O 10 (-110)
U 10 (-110)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Chicago Cubs Cubs vs. San Diego Padres on April 16, 2025 at Petco Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
KC@CHW | KC -109 | 54.2% | 4 | WIN |
SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
KC@DET | DET -115 | 56.1% | 5 | WIN |
CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |
CIN@ARI | KEBRYAN HAYES STRIKEOUTS UNDER 0.5 | 56.2% | 6 | WIN |
LAD@SD | SD +110 | 50.9% | 6 | WIN |