Cubs vs. Padres
Prediction, Odds & Props
Apr 16 | MLB AI Picks

Updated: 2025-04-14T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Chicago Cubs and San Diego Padres conclude their six-game season series today at Petco Park, with both teams seeking to gain momentum early in the 2025 campaign. The Cubs have demonstrated resilience against formidable opponents, while the Padres aim to capitalize on their home-field advantage.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 16, 2025

Start Time: 4:10 PM EST​

Venue: Petco Park​

Padres Record: (14-4)

Cubs Record: (12-8)

OPENING ODDS

CHC Moneyline: +105

SD Moneyline: -124

CHC Spread: +1.5

SD Spread: -1.5

Over/Under: 7.5

CHC
Betting Trends

  • The Cubs have covered the spread in 11 of their 18 games this season, showcasing a strong performance against the spread (ATS) in the early part of the season.

SD
Betting Trends

  • The Padres have an ATS record of 11–5, indicating consistent success in covering the spread during their games.

MATCHUP TRENDS

  • The Cubs have historically performed well at Petco Park, while the Padres have won six of seven games this season when listed as favorites and tend to push games OVER the total in higher-scoring matchups. Together, these trends suggest a competitive, offense-leaning game with a slight edge to the favored home team.

CHC vs. SD
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: P. Crow-Armstrong over 0.5 Hits+Runs+RBI.

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Chicago Cubs vs San Diego Prediction & Odds:
Free MLB Betting Insights for 4/16/25

The Chicago Cubs enter the final game of their West Coast road trip with an 11–7 record, proving early in the 2025 season that they can compete with top-tier opponents. Their recent form includes a 4–2 stretch against powerhouse teams like the Texas Rangers and Los Angeles Dodgers, which has boosted confidence in the clubhouse and underscored the team’s ability to grind out close victories. Manager Craig Counsell has emphasized consistency and smart situational baseball, and the results have reflected that philosophy, particularly on the road. The Cubs’ lineup, while not loaded with superstar firepower, has developed a reputation for timely hitting and versatile base running. Kyle Tucker, in particular, has delivered key at-bats and sparked several offensive rallies, acting as a catalyst in the middle of the order and helping to keep the team competitive in low-scoring contests. On the mound, left-hander Matthew Boyd has been one of the biggest bright spots in Chicago’s early season. Boyd brings a 1.59 ERA and 1.176 WHIP into today’s matchup, thanks to effective use of his off-speed pitches and an ability to neutralize right-handed power hitters, something that will be crucial against a San Diego lineup that features heavy hitters like Manny Machado and Fernando Tatis Jr. Boyd has consistently worked into the middle innings, giving the Cubs bullpen a chance to preserve leads rather than play from behind. With Adbert Alzolay and Mark Leiter Jr. anchoring the late-inning relief corps, the Cubs have a reliable backend if Boyd can keep the Padres quiet through five or six frames.

The pitching staff’s success has been a key reason the Cubs have covered the spread in 11 of their 18 games so far this year. From a betting perspective, the Cubs have been solid on the road and have traditionally played well at Petco Park, boasting a winning record in San Diego over the past several seasons. Their ability to stay competitive in games where they are underdogs has rewarded ATS backers, and their 2025 form suggests they will continue to be a value team in that regard. Offensively, if the Cubs can generate early offense and apply pressure to Nick Pivetta, they could tilt momentum in their favor. Patience at the plate and capitalizing on any mistakes will be essential, as the Padres have dominated games when they get out to early leads. If Boyd can match Pivetta inning for inning, the Cubs have the tools and the grit to steal a road win and head back to Wrigleyville with a series win against one of the National League’s hottest teams.

Chicago Cubs Cubs MLB Preview

The Chicago Cubs arrive at Petco Park for the finale of their series against the red-hot San Diego Padres with an 11–7 record and the confidence that comes from competing well against elite competition. Over the past week, they’ve gone 4–2 against the Rangers and Dodgers, a demanding stretch that tested their pitching depth and lineup versatility. Despite operating without a traditional superstar core, the Cubs have forged an identity based on gritty at-bats, clean defense, and clutch bullpen performances. Kyle Tucker has emerged as a stabilizing force in the middle of the lineup, offering power and timely run production, while Nico Hoerner and Ian Happ have contributed with solid OBP and heads-up base running. Chicago’s offense isn’t explosive, but it’s opportunistic, and that has helped them stay within reach in tight, low-scoring games—exactly the type they expect today against a Padres team anchored by top-tier pitching. The Cubs will hand the ball to left-hander Matthew Boyd, who brings a 1.59 ERA and 1.176 WHIP into this crucial matchup. Boyd has exceeded expectations so far in 2025, keeping hitters off balance with a mix of changeups and sliders while staying out of high-leverage jams. His ability to limit walks and induce ground balls has allowed Chicago’s defense to stay active and engaged, while reducing the strain on the bullpen.

Against the Padres’ power-laden lineup, Boyd’s pitch sequencing and ability to work both sides of the plate will be tested, especially by right-handed bats like Machado and Tatis Jr. If he can keep them from squaring balls up early, he’ll buy time for Chicago’s offense to grind down Nick Pivetta and manufacture run support. The Cubs bullpen, with Adbert Alzolay and Julian Merryweather in form, has closed the door effectively when given leads to protect. On the betting front, Chicago continues to be an ATS-friendly team, covering in 11 of 18 games this season and showing profitability as road underdogs. Their track record at Petco Park is also notable, as they hold a better winning percentage there than at most National League stadiums, which could give bettors a reason to lean toward them despite San Diego’s dominance. The key for the Cubs today lies in their ability to control the early innings, keep the Padres from establishing rhythm, and avoid falling behind against a team that thrives when leading. With Boyd in good form, the Cubs have the opportunity to neutralize San Diego’s offensive edge and turn this finale into a tense, tactical battle that plays into their strengths. A win would not only secure a statement road series, but also further validate their position as a quietly dangerous contender in the National League picture.

The Chicago Cubs and San Diego Padres conclude their six-game season series today at Petco Park, with both teams seeking to gain momentum early in the 2025 campaign. The Cubs have demonstrated resilience against formidable opponents, while the Padres aim to capitalize on their home-field advantage. Chicago Cubs vs San Diego AI Prediction: Free MLB Betting Insights for Apr 16. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

San Diego Padres MLB Preview

The San Diego Padres enter the series finale against the Chicago Cubs riding a wave of early-season momentum and holding a dominant 13–3 record, one of the best in Major League Baseball as of mid-April. With a deep and potent roster finally clicking on both sides of the ball, the Padres have asserted themselves as a formidable force in the National League. Their recent success has come in part thanks to a favorable schedule, as they’ve capitalized on matchups against sub-.500 opponents, but their consistent execution has been impressive regardless of competition. Playing at Petco Park, where they’ve already established a strong home-field edge this season, the Padres will look to complete another series victory behind the steady arm of Nick Pivetta. San Diego has won six of seven games this season when favored by bookmakers, and with Pivetta holding a 1.59 ERA and a WHIP of just 0.824, they are once again poised to deliver a complete team effort. Pivetta’s presence on the mound gives the Padres an anchor for today’s matchup. The right-hander has looked locked in through his early outings, commanding all quadrants of the strike zone and showing excellent control over his secondary pitches. He’s limited opposing lineups to minimal baserunners and has proven especially effective in jamming left-handed hitters—something he’ll need to replicate against Chicago’s lefty-laden order. Pivetta’s ability to pitch deep into games has allowed the Padres to manage their bullpen efficiently, with setup man Robert Suarez and closer Josh Hader rested and ready to go.

The pitching staff as a whole has helped keep the Padres ahead in tight games, contributing significantly to their strong ATS record of 11–5 this season. Their ability to cover spreads and control tempo has made them one of the most trustworthy early-season teams in MLB from both a baseball and betting standpoint. Offensively, San Diego continues to benefit from a dangerous and well-rounded lineup led by Manny Machado and Fernando Tatis Jr., both of whom have come up big in clutch situations. Tatis has provided explosive speed and power at the top of the order, while Machado remains the heartbeat of the lineup with his veteran leadership and ability to drive in runs from any count. Behind them, the supporting cast—Xander Bogaerts, Jake Cronenworth, and Luis Campusano—has added depth and consistency. The Padres also thrive on aggressive base running and situational awareness, often taking extra bases and forcing errors that don’t show up on traditional stat sheets. If they continue their disciplined approach at the plate and get ahead early, the Cubs could struggle to mount a comeback against a bullpen that rarely falters. For the Padres, the formula for success remains simple: rely on elite starting pitching, a relentless lineup, and sound defense. A win today would further cement their status as early National League contenders and affirm their dominance at home, where they’ve looked nearly untouchable.

Chicago Cubs vs. San Diego Prop Picks (AI)

AI algorithm Remi is pouring through mountains of datapoints on each line. In fact, anytime the Cubs and Padres play there’s always several intriguing trends to key in on. Not to mention games played at Petco Park in Apr seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: P. Crow-Armstrong over 0.5 Hits+Runs+RBI.

Chicago Cubs vs. San Diego Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over tons of data from every angle between the Cubs and Padres and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.

Interestingly enough, the data has been most focused on the unproportionally assigned weight human bettors often put on player performance factors between a Cubs team going up against a possibly deflated Padres team. It appears the true game analytics might reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Chicago Cubs vs San Diego picks, computer picks Cubs vs Padres, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Cubs Betting Trends

The Cubs have covered the spread in 11 of their 18 games this season, showcasing a strong performance against the spread (ATS) in the early part of the season.

Padres Betting Trends

The Padres have an ATS record of 11–5, indicating consistent success in covering the spread during their games.

Cubs vs. Padres Matchup Trends

The Cubs have historically performed well at Petco Park, while the Padres have won six of seven games this season when listed as favorites and tend to push games OVER the total in higher-scoring matchups. Together, these trends suggest a competitive, offense-leaning game with a slight edge to the favored home team.

Chicago Cubs vs. San Diego Game Info

Chicago Cubs vs San Diego starts on April 16, 2025 at 4:10 PM EST.

Spread: San Diego -1.5
Moneyline: Chicago Cubs +105, San Diego -124
Over/Under: 7.5

Chicago Cubs: (12-8)  |  San Diego: (14-4)

Remi's searched hard and found the best prop for this matchup: P. Crow-Armstrong over 0.5 Hits+Runs+RBI.. Prices move—always shop for the best number.

The Cubs have historically performed well at Petco Park, while the Padres have won six of seven games this season when listed as favorites and tend to push games OVER the total in higher-scoring matchups. Together, these trends suggest a competitive, offense-leaning game with a slight edge to the favored home team.

CHC trend: The Cubs have covered the spread in 11 of their 18 games this season, showcasing a strong performance against the spread (ATS) in the early part of the season.

SD trend: The Padres have an ATS record of 11–5, indicating consistent success in covering the spread during their games.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Chicago Cubs vs. San Diego Odds

AI algorithm Remi is pouring through mountains of stats on each team. In fact, anytime the Chicago Cubs vs San Diego trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable betting trends.

Chicago Cubs vs San Diego Opening Odds

CHC Moneyline: +105
SD Moneyline: -124
CHC Spread: +1.5
SD Spread: -1.5
Over/Under: 7.5

Chicago Cubs vs San Diego Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-180
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+125
-150
+1.5 (-180)
-1.5 (+150)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+145
-175
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-195)
-1.5 (+160)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+105
-125
+1.5 (-205)
-1.5 (+170)
O 7.5 (+105)
U 7.5 (-125)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

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We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Chicago Cubs Cubs vs. San Diego Padres on April 16, 2025 at Petco Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN