Red Sox vs. White Sox
Prediction, Odds & Props
Apr 11 | MLB AI Picks

Updated: 2025-04-09T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On April 11, 2025, the Boston Red Sox (7–7) will face the Chicago White Sox (2–10) at Guaranteed Rate Field in Chicago. The Red Sox aim to capitalize on the White Sox’s struggles and improve their standing in the AL East, while the White Sox seek to snap a five-game losing streak and find momentum in their 125th-anniversary season.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 11, 2025

Start Time: 7:40 PM EST​

Venue: Rate Field​

White Sox Record: (2-10)

Red Sox Record: (7-7)

OPENING ODDS

BOS Moneyline: -170

CHW Moneyline: +143

BOS Spread: -1.5

CHW Spread: +1.5

Over/Under: 8

BOS
Betting Trends

  • The Red Sox have a 3–4 record on the road this season, indicating challenges in covering the spread away from Fenway Park.

CHW
Betting Trends

  • The White Sox are 2–4 at home, reflecting difficulties in leveraging home-field advantage against the spread.

MATCHUP TRENDS

  • The White Sox have struggled offensively, ranking 28th in MLB with a team batting average of .199, which has impacted their ability to cover spreads. Conversely, the Red Sox have shown resilience, maintaining a .500 record despite a middling team ERA of 3.86, suggesting potential value in betting on them against underperforming teams like the White Sox.

BOS vs. CHW
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: K. Campbell over 0.5 Total Bases.

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Boston vs Chicago White Sox Prediction & Odds:
Free MLB Betting Insights for 4/11/25

The April 11, 2025 matchup between the Boston Red Sox and the Chicago White Sox at Guaranteed Rate Field opens a three-game series between two American League clubs trending in very different directions to start the season. The Red Sox enter the contest at 7–7, fresh off a hard-fought extra-inning win and looking to build on an encouraging stretch of performances that have kept them competitive in the AL East. Boston has displayed a balanced approach—scoring timely runs while getting just enough from a pitching staff that’s maintained a respectable 3.86 team ERA. With a road record of 3–4, the Red Sox are striving for more consistency away from Fenway Park, but their recent play suggests they’re close to finding their stride. Meanwhile, the White Sox have stumbled out of the gate with a 2–10 record, including a 2–4 home mark, and continue to search for solutions on both sides of the ball. Offensively, Chicago ranks near the bottom of the league with a .199 team batting average, and their lack of run production has been a central reason for their five-game losing streak entering this series. Boston’s lineup has shown signs of life, with several new faces stepping up in key moments. While they may not be leading the league in any particular category, the Red Sox are generating offense through quality at-bats and contact-driven approaches, especially with runners in scoring position. Their bullpen has held up well in close games, giving manager Alex Cora the confidence to manage with flexibility late in contests. With series wins already under their belt and competitive showings against division rivals, the Red Sox are trending in the right direction as they prepare to face a reeling White Sox club.

A series like this presents an opportunity to build confidence and bank wins before re-entering the gauntlet of AL East matchups. Boston’s starting rotation, though still finding its footing, has benefited from solid early outings and an improving defense behind them, which will be crucial to shutting down Chicago’s limited offensive threats. The White Sox, by contrast, are already facing a sense of urgency just two weeks into the season. Celebrating their 125th anniversary this year, the franchise had hoped to energize fans and open the campaign with purpose, but the results have been disappointing on nearly every front. They’ve struggled to manufacture runs, hitting just .199 as a team, and have failed to support a pitching staff that has been regularly forced to work under pressure. Defensive lapses and bullpen instability have only added to their issues, and morale has dipped as the losses have mounted. Despite these setbacks, Chicago will look to rally behind the home crowd and draw motivation from their anniversary celebrations to spark a turnaround. If they can limit mistakes and find a rhythm at the plate, they may yet be able to challenge the Red Sox in individual games, but the momentum clearly favors Boston. Friday’s opener is more than just another game for the White Sox—it’s a chance to stop the bleeding, restore confidence, and reset expectations before April slips away. For Boston, it’s an opportunity to stay hot, apply pressure early, and assert control over a struggling opponent.

Boston Red Sox MLB Preview

The Boston Red Sox enter their April 11 road matchup against the Chicago White Sox with a 7–7 record and cautious optimism as they look to string together wins and climb the AL East standings. Despite opening the season with inconsistency, the Red Sox have stabilized thanks to timely hitting, balanced offensive contributions, and a bullpen that has shown the ability to hold leads late in games. The team ERA of 3.86 reflects a pitching staff that, while not dominant, has managed to keep Boston competitive by avoiding big innings and giving the offense chances to respond. Although their road record stands at 3–4, the Red Sox have been competitive in nearly every contest away from Fenway, including several late-game rallies that reflect a team capable of grinding out wins. Led by manager Alex Cora, Boston has adopted a scrappy, opportunistic identity early in the year—one they’ll look to reinforce against a vulnerable White Sox squad. At the plate, the Red Sox have found contributors throughout the lineup. While they may not yet have a player dominating headlines, several hitters—including veterans and emerging prospects—have stepped up in key moments to generate offense. Boston’s run production has been driven more by situational execution than brute power, with a focus on advancing runners, working counts, and forcing opposing pitchers into mistakes. This strategic approach should serve them well against a Chicago staff that has struggled with command and has frequently fallen behind early in counts.

The Red Sox will be looking to get on base early, pressure the defense, and avoid relying solely on home runs to produce scoring. Their ability to manufacture runs has been crucial in keeping them afloat while the pitching rotation rounds into form. As they open this series in Chicago, the Red Sox have a prime opportunity to capitalize on a struggling opponent and push themselves above .500. Facing a White Sox team that ranks among the league’s worst in batting average and run prevention, Boston’s keys to success will include attacking early in the count, staying aggressive on the basepaths, and maintaining defensive sharpness to back up their pitchers. If the Red Sox can limit free passes and avoid letting the White Sox build confidence through early scoring, they’ll be in an excellent position to dictate the series tempo. A win in the opener would not only improve their road mark but would signal that Boston is maturing quickly into a team capable of taking care of business against lower-tier opponents. With tough AL East competition always looming, the Red Sox understand that games like this are critical—and they appear poised to seize the opportunity.

On April 11, 2025, the Boston Red Sox (7–7) will face the Chicago White Sox (2–10) at Guaranteed Rate Field in Chicago. The Red Sox aim to capitalize on the White Sox’s struggles and improve their standing in the AL East, while the White Sox seek to snap a five-game losing streak and find momentum in their 125th-anniversary season. Boston vs Chicago White Sox AI Prediction: Free MLB Betting Insights for Apr 11. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Chicago White Sox White Sox MLB Preview

The Chicago White Sox return to Guaranteed Rate Field on April 11 desperately seeking a spark to reverse what has become a dismal start to their 2025 campaign. With a 2–10 record and riding a five-game losing streak, the White Sox are struggling to establish any semblance of rhythm on offense or on the mound. Their 2–4 home record reflects missed opportunities to capitalize in front of their fans, and as they celebrate their 125th anniversary this season, the timing of their struggles couldn’t be more frustrating. A league-worst .199 team batting average underscores their inability to generate consistent offense, and their lack of power and situational hitting has left the pitching staff with minimal margin for error. The team has routinely fallen behind early in games, and defensive miscues have only compounded the issues—allowing opponents to exploit gaps and stretch leads beyond recovery. Offensively, the White Sox have yet to find a steady contributor in the heart of the lineup. Veterans who were expected to anchor the offense have underperformed, while younger players have struggled to adjust to major league pitching. Run production has been sparse, and extended scoreless innings have put immense pressure on both the starting rotation and bullpen.

While there have been occasional flashes of life—a home run here, a strong inning there—Chicago has failed to string together rallies or capitalize with runners in scoring position. These offensive issues are not only limiting their chances of victory, but also diminishing confidence throughout the roster. Manager Pedro Grifol has urged patience, but with each loss, the pressure mounts for someone to step up and provide a spark—whether it’s a clutch hit, a shutdown start, or a game-changing defensive play. Facing a Boston Red Sox team that is sitting at .500 and starting to gather momentum, the White Sox must approach this series with urgency and energy. The first step will be getting a strong performance from their starting pitcher to prevent early deficits, giving the offense a chance to play with less pressure. Chicago’s path to a series-opening win likely involves keeping the game low-scoring, turning double plays, and seizing any scoring opportunity they’re given—particularly with small ball and aggressive base running. The 125th-anniversary festivities could offer a morale boost, but the team needs on-field results more than anything. For the White Sox to salvage their April and restore faith among their fans, this game offers a much-needed chance to reset. A win against a respected opponent like Boston could be the first building block in changing the tone of their season—but it will take execution, resilience, and a level of consistency that has thus far been elusive.

Boston vs. Chicago White Sox Prop Picks (AI)

Remi is pouring through mountains of data on each team. In fact, anytime the Red Sox and White Sox play there’s always several intriguing trends to key in on. Not to mention games played at Rate Field in Apr rarely follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: K. Campbell over 0.5 Total Bases.

Boston vs. Chicago White Sox Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over tons of data from every simulation between the Red Sox and White Sox and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most keyed in on the trending weight human bettors tend to put on player performance factors between a Red Sox team going up against a possibly improved White Sox team. In reality, the true game analytics appear to reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Boston vs Chicago White Sox picks, computer picks Red Sox vs White Sox, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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Red Sox Betting Trends

The Red Sox have a 3–4 record on the road this season, indicating challenges in covering the spread away from Fenway Park.

White Sox Betting Trends

The White Sox are 2–4 at home, reflecting difficulties in leveraging home-field advantage against the spread.

Red Sox vs. White Sox Matchup Trends

The White Sox have struggled offensively, ranking 28th in MLB with a team batting average of .199, which has impacted their ability to cover spreads. Conversely, the Red Sox have shown resilience, maintaining a .500 record despite a middling team ERA of 3.86, suggesting potential value in betting on them against underperforming teams like the White Sox.

Boston vs. Chicago White Sox Game Info

Boston vs Chicago White Sox starts on April 11, 2025 at 7:40 PM EST.

Spread: Chicago White Sox +1.5
Moneyline: Boston -170, Chicago White Sox +143
Over/Under: 8

Boston: (7-7)  |  Chicago White Sox: (2-10)

Remi's searched hard and found the best prop for this matchup: K. Campbell over 0.5 Total Bases.. Prices move—always shop for the best number.

The White Sox have struggled offensively, ranking 28th in MLB with a team batting average of .199, which has impacted their ability to cover spreads. Conversely, the Red Sox have shown resilience, maintaining a .500 record despite a middling team ERA of 3.86, suggesting potential value in betting on them against underperforming teams like the White Sox.

BOS trend: The Red Sox have a 3–4 record on the road this season, indicating challenges in covering the spread away from Fenway Park.

CHW trend: The White Sox are 2–4 at home, reflecting difficulties in leveraging home-field advantage against the spread.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Boston vs. Chicago White Sox Odds

Remi is pouring through loads of data points on each line. In fact, anytime the Boston vs Chicago White Sox trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance can often follow normal, predictable patterns.

Boston vs Chicago White Sox Opening Odds

BOS Moneyline: -170
CHW Moneyline: +143
BOS Spread: -1.5
CHW Spread: +1.5
Over/Under: 8

Boston vs Chicago White Sox Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+196
-240
+1.5 (-105)
-1.5 (-115)
O 9 (-105)
U 9 (-115)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-178
 
-1.5 (+115)
O 9.5 (+100)
U 9.5 (-120)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+135
-160
+1.5 (-155)
-1.5 (+130)
O 8.5 (-105)
U 8.5 (-115)
Sep 27, 2025 4:05PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:05PM
White Sox
Nationals
+100
-120
+1.5 (-205)
-1.5 (+170)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+196
-240
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+130)
+1.5 (-155)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+110
-130
+1.5 (-190)
-1.5 (+158)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+175
-210
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+115
-135
+1.5 (-190)
-1.5 (+158)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+150
-178
+1.5 (-145)
-1.5 (+122)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+122
-145
+1.5 (-190)
-1.5 (+158)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+118
-140
+1.5 (-190)
-1.5 (+158)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-140
+118
-1.5 (+115)
+1.5 (-135)
O 9 (-110)
U 9 (-110)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
+1.5 (-220)
-1.5 (+180)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
+1.5 (-195)
-1.5 (+162)
O 10 (-115)
U 10 (-105)

MLB Past Picks

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We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Boston Red Sox vs. Chicago White Sox White Sox on April 11, 2025 at Rate Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS