Cardinals vs. Pirates
Prediction, Odds & Props
Apr 08 | MLB AI Picks

Updated: 2025-04-06T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The St. Louis Cardinals are set to face the Pittsburgh Pirates on April 8, 2025, at PNC Park in Pittsburgh, Pennsylvania, with the first pitch scheduled for 6:40 p.m. ET. This National League Central matchup features two teams aiming to improve their standings early in the season.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 08, 2025

Start Time: 6:40 PM EST​

Venue: PNC Park​

Pirates Record: (4-7)

Cardinals Record: (4-6)

OPENING ODDS

STL Moneyline: +114

PIT Moneyline: -134

STL Spread: +1.5

PIT Spread: -1.5

Over/Under: 6.5

STL
Betting Trends

  • The Cardinals have had a mixed performance against the spread (ATS) recently. Notably, they faced a challenging series against the Boston Red Sox, including an 18-7 loss on April 6, 2025.

PIT
Betting Trends

  • The Pirates have shown resilience in their recent ATS performance. They secured a 5-4 victory over the New York Yankees on April 6, 2025, demonstrating their capability to compete against strong opponents.

MATCHUP TRENDS

  • Historically, matchups between the Cardinals and Pirates have been competitive. For instance, the Cardinals won eight of thirteen meetings against the Pirates in the previous season, indicating a closely contested rivalry.

STL vs. PIT
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: A. Burleson over 0.5 Hits+Runs+RBI.

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St. Louis vs Pittsburgh Prediction & Odds:
Free MLB Betting Insights for 4/8/25

The April 8, 2025 matchup between the St. Louis Cardinals and the Pittsburgh Pirates at PNC Park serves as a critical early-season test for both National League Central rivals as they attempt to establish rhythm and momentum in the opening month. The Cardinals enter the contest looking to bounce back from a humbling 18-7 defeat to the Boston Red Sox just two days earlier, a game in which their pitching staff was completely overwhelmed and exposed vulnerabilities in both the rotation and bullpen. While the offense was able to generate some production, it became clear that St. Louis will need far more consistency from its arms to stay competitive in a division that doesn’t afford much margin for error. On the other side, the Pirates are riding a wave of confidence after a gritty 5-4 victory over the New York Yankees, a win that showcased their ability to battle elite teams and execute in high-pressure situations. Pittsburgh has benefitted from balanced production throughout the lineup, timely hitting from emerging contributors, and a bullpen that has shown early signs of composure. This game will be a tale of two narratives—one team aiming to right the ship after a blowout loss, and the other looking to validate a strong showing against one of baseball’s most feared opponents. The Cardinals still possess the offensive depth to turn things around quickly, with veterans like Paul Goldschmidt and Nolan Arenado anchoring the lineup and providing the kind of leadership necessary to rebound after adversity.

However, their pitching, particularly the middle relief corps, will need to find its form against a Pirates team that thrives on extending at-bats and manufacturing runs. Defensively, both clubs have had uneven starts, with mental lapses and fielding errors creeping into otherwise manageable innings, making clean defensive execution a key to whichever side emerges victorious. The Pirates, meanwhile, appear to be embracing their underdog role, combining youthful energy with opportunistic play. Their ability to respond to adversity and string together competitive at-bats gives them an edge in tightly contested games, especially when playing at home. The matchup also marks the continuation of a rivalry that was lopsided last season, with the Cardinals taking 8 of 13 meetings—a stat that Pittsburgh is eager to flip as it eyes a stronger start in 2025. The pitching matchup will play a decisive role, with both teams needing length from their starters to spare taxed bullpens and maintain tempo. In a division where the standings can shift quickly, especially in April, this game serves not only as a litmus test for current form but also as a potential tone-setter for the rest of the month. Whichever team can better blend aggressive offense, consistent pitching, and mistake-free defense will likely walk away with a valuable victory that could have implications deeper into the season.

St. Louis Cardinals MLB Preview

The St. Louis Cardinals enter their April 8, 2025 road contest against the Pittsburgh Pirates in urgent need of a reset after a rough outing against the Boston Red Sox, where they were dismantled in an 18-7 loss. That defeat not only exposed glaring weaknesses in their pitching depth but also raised questions about their defensive discipline and ability to respond when the game spirals. The Cardinals, traditionally known for strong fundamentals and tight, efficient play, have found themselves playing catch-up too often this season—something they cannot afford against a Pirates team beginning to show signs of early-season confidence. Offensively, St. Louis still possesses one of the more respected lineups in the division, with cornerstone veterans Paul Goldschmidt and Nolan Arenado leading the charge. Their ability to generate runs through extra-base power and timely contact hitting remains intact, but a lack of consistency through the middle and bottom of the order has hindered their ability to capitalize on scoring opportunities. The supporting cast, including young contributors like Brendan Donovan and Jordan Walker, will need to step up and offer better on-base production to keep pressure on opposing pitchers throughout the lineup. Pitching, however, remains the Cardinals’ most immediate concern. Their rotation has struggled to work deep into games, leaving a heavily burdened bullpen to patch together too many innings in short succession.

The recent series against Boston amplified these shortcomings, with multiple relievers surrendering runs in key situations, indicating both fatigue and execution issues. If the Cardinals are to turn things around, they’ll need a quality start in Pittsburgh—something that not only gives their bullpen a breather but restores confidence in their staff’s ability to control the game. The Pirates aren’t an offensive juggernaut, but they’ve proven resourceful at the plate, which could challenge a Cardinals staff that’s struggling to avoid extended innings. In addition, limiting walks and keeping the ball in the yard must be priorities, especially in a park like PNC where quick runs can flip a game’s momentum. Defensively, St. Louis is capable of tightening up—it’s been a foundational strength of the organization for years—but lapses have crept in at the worst possible moments this season, extending innings and contributing to big scoring swings by opponents. Clean fielding, sharper communication, and sharper execution on double plays and cutoffs will be key, especially when facing a Pirates team that will test the defense with aggressive baserunning and situational awareness. The Cardinals need to reestablish their identity—gritty, balanced, and mistake-averse baseball—and this game represents an opportunity to hit the reset button against a division rival. A win on the road at PNC Park would not only cool the lingering sting of their recent blowout loss but also inject confidence into a clubhouse looking for early stability and momentum. With a veteran core, talented youth, and a sense of urgency, the Cardinals have the pieces to turn things around—but execution must begin now.

The St. Louis Cardinals are set to face the Pittsburgh Pirates on April 8, 2025, at PNC Park in Pittsburgh, Pennsylvania, with the first pitch scheduled for 6:40 p.m. ET. This National League Central matchup features two teams aiming to improve their standings early in the season. St. Louis vs Pittsburgh AI Prediction: Free MLB Betting Insights for Apr 08. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Pittsburgh Pirates MLB Preview

The Pittsburgh Pirates return to PNC Park on April 8, 2025, with a renewed sense of confidence following a thrilling 5-4 victory over the New York Yankees—an early-season win that has begun to reshape expectations around this young and ambitious squad. Entering their matchup against the division-rival St. Louis Cardinals, the Pirates are hoping to capitalize on their home-field advantage and the positive momentum created by their recent clutch performances. That win over the Yankees not only showcased the Pirates’ ability to go toe-to-toe with top-tier opponents but also highlighted the emergence of timely hitting, bullpen resilience, and situational awareness that had been inconsistent in past seasons. The lineup, while not stacked with high-profile names, is beginning to coalesce around a group of reliable contact hitters and scrappy baserunners. Players like Ke’Bryan Hayes and Oneil Cruz have provided steady production, with Hayes delivering in key moments and Cruz adding speed and power to the middle of the order. Their ability to manufacture runs through base hits and aggressive running puts pressure on opposing defenses—something the Pirates will look to exploit against a Cardinals team that just surrendered 18 runs to Boston and has struggled defensively in recent games.

From a pitching standpoint, the Pirates have seen both bright spots and learning moments through the season’s opening week. The rotation may lack a true ace, but the staff has found success by pitching to contact, relying on defense, and avoiding extended innings through early-count efficiency. The bullpen, one of the team’s strengths so far, has stepped up in high-leverage moments, including critical late-inning holds against the Yankees. Manager Derek Shelton has managed the relief corps well, strategically matching arms to game situations and avoiding overuse where possible. Against St. Louis, the Pirates will likely lean on this bullpen again—especially if the starter can deliver five or more solid innings and keep sluggers like Paul Goldschmidt and Nolan Arenado from taking over the game. Pittsburgh’s defensive alignment has also contributed to their recent success. With improved communication and crisp execution, the Pirates have minimized errors and capitalized on opponent miscues, helping them stay competitive even in tight contests. Looking ahead to this divisional showdown, the Pirates know that the Cardinals, despite their recent blowout loss, still pose a significant threat with their veteran core and deep offensive talent. But what Pittsburgh lacks in star power, they’re beginning to make up for in cohesion, hustle, and execution—traits that are critical in early-season games where small advantages often decide the outcome. A win against St. Louis would not only serve as a statement within the division but also further validate the belief that this Pirates team, long viewed as a rebuild in progress, is capable of winning now. With a home crowd behind them, the right combination of strong pitching, disciplined hitting, and mistake-free defense could very well lead Pittsburgh to another confidence-building victory, continuing their push for relevance in the NL Central race.

St. Louis vs. Pittsburgh Prop Picks (AI)

Remi is pouring through mountains of data on each line. In fact, anytime the Cardinals and Pirates play there’s always several intriguing angles to key in on. Not to mention games played at PNC Park in Apr seemingly never follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: A. Burleson over 0.5 Hits+Runs+RBI.

St. Louis vs. Pittsburgh Prediction (AI)

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Remi, our AI sports genius, has been pouring over tons of data from every simulation between the Cardinals and Pirates and using recursive machine learning and impressive AI to examine the data to a single cover probability.

Remi has been most keyed in on the trending factor knucklehead sportsbettors often put on coaching factors between a Cardinals team going up against a possibly strong Pirates team. In reality, the true game analytics appear to reflect a strong lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI St. Louis vs Pittsburgh picks, computer picks Cardinals vs Pirates, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Cardinals Betting Trends

The Cardinals have had a mixed performance against the spread (ATS) recently. Notably, they faced a challenging series against the Boston Red Sox, including an 18-7 loss on April 6, 2025.

Pirates Betting Trends

The Pirates have shown resilience in their recent ATS performance. They secured a 5-4 victory over the New York Yankees on April 6, 2025, demonstrating their capability to compete against strong opponents.

Cardinals vs. Pirates Matchup Trends

Historically, matchups between the Cardinals and Pirates have been competitive. For instance, the Cardinals won eight of thirteen meetings against the Pirates in the previous season, indicating a closely contested rivalry.

St. Louis vs. Pittsburgh Game Info

St. Louis vs Pittsburgh starts on April 08, 2025 at 6:40 PM EST.

Spread: Pittsburgh -1.5
Moneyline: St. Louis +114, Pittsburgh -134
Over/Under: 6.5

St. Louis: (4-6)  |  Pittsburgh: (4-7)

Remi's searched hard and found the best prop for this matchup: A. Burleson over 0.5 Hits+Runs+RBI.. Prices move—always shop for the best number.

Historically, matchups between the Cardinals and Pirates have been competitive. For instance, the Cardinals won eight of thirteen meetings against the Pirates in the previous season, indicating a closely contested rivalry.

STL trend: The Cardinals have had a mixed performance against the spread (ATS) recently. Notably, they faced a challenging series against the Boston Red Sox, including an 18-7 loss on April 6, 2025.

PIT trend: The Pirates have shown resilience in their recent ATS performance. They secured a 5-4 victory over the New York Yankees on April 6, 2025, demonstrating their capability to compete against strong opponents.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

St. Louis vs. Pittsburgh Odds

Remi is pouring through tons of data on each line. In fact, anytime the St. Louis vs Pittsburgh trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps can often follow normal, predictable betting trends.

St. Louis vs Pittsburgh Opening Odds

STL Moneyline: +114
PIT Moneyline: -134
STL Spread: +1.5
PIT Spread: -1.5
Over/Under: 6.5

St. Louis vs Pittsburgh Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+192
-235
+1.5 (-110)
-1.5 (-110)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-178
 
-1.5 (+115)
O 9.5 (+100)
U 9.5 (-120)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+135
-160
+1.5 (-160)
-1.5 (+135)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
+1.5 (-205)
-1.5 (+170)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+192
-235
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+130)
+1.5 (-155)
O 8 (-120)
U 8 (+100)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+110
-130
+1.5 (-190)
-1.5 (+158)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+175
-210
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+115
-135
+1.5 (-190)
-1.5 (+158)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+150
-178
+1.5 (-145)
-1.5 (+122)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+122
-145
+1.5 (-190)
-1.5 (+158)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+118
-140
+1.5 (-190)
-1.5 (+158)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-145
+122
-1.5 (+115)
+1.5 (-135)
O 9 (-110)
U 9 (-110)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+110
-130
+1.5 (-205)
-1.5 (+170)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
+1.5 (-195)
-1.5 (+162)
O 10 (-110)
U 10 (-110)

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We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers St. Louis Cardinals vs. Pittsburgh Pirates on April 08, 2025 at PNC Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN