Mariners vs. Giants
Prediction, Odds & Props
Apr 06 | MLB AI Picks

Updated: 2025-04-04T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On April 6, 2025, the Seattle Mariners (3-5) will conclude their series against the San Francisco Giants (6-1) at Oracle Park in San Francisco. Both teams have shown early-season promise, with the Mariners aiming to rebound from a recent loss and the Giants seeking to maintain their strong start.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 06, 2025

Start Time: 4:05 PM EST​

Venue: Oracle Park​

Giants Record: (7-1)

Mariners Record: (3-6)

OPENING ODDS

SEA Moneyline: +102

SF Moneyline: -122

SEA Spread: +1.5

SF Spread: -1.5

Over/Under: 7.5

SEA
Betting Trends

  • The Mariners have covered the spread in 2 of their last 7 games, resulting in a 28.6% success rate.

SF
Betting Trends

  • The Giants have covered the spread in 5 of their last 6 games, achieving an 83.3% success rate.

MATCHUP TRENDS

  • The Giants have secured victories in 8 of their last 12 games when favored on the moneyline, yielding a 43% return on investment.

SEA vs. SF
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: C. Raleigh over 6 Fantasy Score.

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Seattle vs San Francisco Prediction & Odds:
Free MLB Betting Insights for 4/6/25

The Seattle Mariners (3-5) will face the San Francisco Giants (6-1) on April 6, 2025, in what promises to be an exciting matchup at Oracle Park. Both teams are looking to find momentum early in the season, with the Mariners hoping to bounce back from a disappointing start and the Giants looking to maintain their strong performance. The Mariners, while possessing a powerful offense, have struggled to find consistency, averaging only 3.5 runs per game. Their lineup, led by star players like Julio Rodríguez, Randy Arozarena, and Ty France, has the potential to break out at any moment, but they have yet to consistently string together productive at-bats. Rodríguez, in particular, has the potential to ignite the offense with his power and speed, and Arozarena’s clutch hitting could be the key to a more balanced attack. However, the Mariners’ lineup needs to click as a unit, something that has been elusive in their first few games. On the mound, the Mariners will rely on Logan Gilbert, who has shown flashes of brilliance but also some inconsistency. With a 4.00 ERA through his first few starts, Gilbert has the ability to dominate when he’s on, but he’ll need to improve his control and pitch deeper into games to give the bullpen a break. The Mariners’ bullpen has been solid but has been stretched thin early in the season, which means Gilbert’s ability to go deeper into the game will be a crucial factor. The Giants, on the other hand, have had a very strong start to the season, with a 6-1 record. Their offense has been explosive, averaging 5.2 runs per game. Much of their success has come from contributions across the lineup, with players like Wilmer Flores, Mitch Haniger, and J.D. Davis all playing pivotal roles.

Haniger has been particularly important with his bat, contributing both power and average. Meanwhile, the defense has been rock solid, especially in the infield, with Flores providing stability at second base and former Gold Glove winner Evan Longoria continuing to make plays at third. The Giants’ pitching staff has been a key reason for their strong start, with Carlos Rodón leading the rotation. Rodón, who will get the start for the Giants in this game, has been excellent so far, posting a 2.10 ERA and showing the ability to overpower hitters with his fastball and slider. If Rodón can continue his dominant form, he will give the Giants a big advantage over a Mariners lineup that has struggled with consistency. The Giants’ bullpen has also been solid, with Tyler Rogers and Camilo Doval closing out games effectively. Defensively, the Giants have been sharp, and they’ll need to continue that trend against the Mariners’ potent offense. Manager Gabe Kapler will rely on his team’s depth and ability to execute in all areas of the game. This game is crucial for both teams, with the Mariners looking to recover from a slow start and the Giants aiming to keep their early-season success going. The Mariners need to find their rhythm offensively, and Gilbert’s performance on the mound will be key to keeping the game close. The Giants will look to keep their momentum rolling with Rodón on the mound and an offense that’s firing on all cylinders. The winner of this game will leave with more confidence as they move forward in the season.

Seattle Mariners MLB Preview

The Seattle Mariners (3-5) enter their April 6, 2025, matchup against the San Francisco Giants at Oracle Park hoping to find consistency after a challenging start to the season. Despite boasting a powerful offense with the likes of Julio Rodríguez, Ty France, and Randy Arozarena, the Mariners have struggled to generate consistent scoring, averaging just 3.5 runs per game. Rodríguez, known for his dynamic power and speed, has been a key player in the lineup, but even his production hasn’t been enough to carry the team’s offense. Arozarena, who brings clutch hitting to the table, has also shown promise, but like the rest of the Mariners’ bats, has been inconsistent. France has been one of the few Mariners to produce steady numbers, but they’ll need more support from their offense if they are going to compete with the Giants’ balanced lineup. The Mariners’ inability to string together quality at-bats and capitalize on scoring opportunities has put extra pressure on their pitchers, but despite the offensive struggles, their pitching staff has kept them in many games. Logan Gilbert, slated to start for the Mariners, will need to take a step forward after posting a 4.00 ERA early in the season. While he’s shown the ability to dominate when on his game, consistency remains a concern.

Against a potent Giants lineup, Gilbert will need to be sharp with his command and avoid giving up hard contact. The Mariners’ bullpen has been solid in stretches, but they’ve been forced into action frequently early in the season, making it even more important that Gilbert goes deeper into the game to provide relief. While the bullpen has arms like Andrés Muñoz and Diego Castillo, it will be up to Gilbert to prevent the game from escalating early. On defense, the Mariners have been average, but they need to ensure they avoid mistakes—something that can be crucial when facing an offense like the Giants. If they are to win, the Mariners will need to limit errors, especially in tight moments where even small mistakes could lead to runs. The speed of their offense could also come into play at Coors Field, as the Mariners are a team that relies on aggressive baserunning. With players like Rodríguez capable of stealing bases and creating scoring chances from the bottom of the order, they’ll need to continue capitalizing on those opportunities. This game is an important one for the Mariners to prove they can be competitive on the road, something they’ve struggled with in recent years. The key to success will be finding offensive consistency, getting a quality start from Gilbert, and closing the game effectively with the bullpen. If the Mariners can execute all aspects of the game well, they’ll have a chance to bounce back from their rough start and prove that they can be a contender in the AL West. A win against the Giants would not only be a morale booster but also put them on track for a more successful stretch of games.

On April 6, 2025, the Seattle Mariners (3-5) will conclude their series against the San Francisco Giants (6-1) at Oracle Park in San Francisco. Both teams have shown early-season promise, with the Mariners aiming to rebound from a recent loss and the Giants seeking to maintain their strong start. Seattle vs San Francisco AI Prediction: Free MLB Betting Insights for Apr 06. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

San Francisco Giants MLB Preview

The San Francisco Giants (6-1) have been one of the most impressive teams early in the 2025 season, and they’ll look to keep their momentum going as they face the Seattle Mariners on April 6, 2025, at Oracle Park. The Giants’ offense has been firing on all cylinders, averaging 5.2 runs per game and showcasing a well-balanced attack. Ryan McMahon has been a standout player, providing power and consistency in the middle of the lineup. McMahon’s bat has been critical in driving in runs and providing protection for other hitters like Mitch Haniger and Wilmer Flores, both of whom have also contributed significantly. Haniger has brought balance to the lineup with his ability to hit for both power and average, while Flores has provided depth with his steady contact hitting. The Giants have a deep lineup, and their ability to get contributions from up and down the order has been one of their strengths. On the mound, the Giants are led by ace Carlos Rodón, who has been a dominant force early this season with a 2.10 ERA. Rodón’s combination of power pitching and exceptional control has made him one of the top starters in the league. His fastball and slider have been especially effective against right-handed hitters, and his ability to keep hitters off balance will be key as the Giants take on a Mariners lineup that has struggled to find consistency.

Rodón’s experience and leadership on the mound have given the Giants an edge in their recent games, and they’ll be counting on him to continue his strong performances. The bullpen, which includes reliable arms like Tyler Rogers and Camilo Doval, has been solid as well, with the duo helping the team close out games effectively. The Giants’ defense has been another bright spot, with their infield playing tight, mistake-free baseball. Veterans like Evan Longoria, who continues to shine at third base, have provided stability on the field, and the team’s ability to turn double plays and make key defensive stops has allowed them to limit opposing offenses. The Giants’ defensive discipline, combined with their offensive depth and pitching prowess, has made them one of the most well-rounded teams in the league early in the season. Manager Gabe Kapler will look to continue this balanced approach, keeping the focus on both hitting and pitching to ensure that the team remains competitive in the highly competitive NL West. This game presents a great opportunity for the Giants to solidify their position as one of the top teams in the league, as they look to extend their strong early-season record. With Rodón on the mound, a lineup full of contributors, and a solid defense, the Giants are in a strong position to keep their winning streak alive. A win in this game would not only help the Giants maintain their momentum but also give them confidence as they face increasingly difficult challenges throughout the season.

Seattle vs. San Francisco Prop Picks (AI)

Remi is pouring through mountains of datapoints on each team. In fact, anytime the Mariners and Giants play there’s always several intriguing trends to key in on. Not to mention games played at Oracle Park in Apr rarely follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: C. Raleigh over 6 Fantasy Score.

Seattle vs. San Francisco Prediction (AI)

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Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every past game between the Mariners and Giants and using recursive machine learning and kick-ass AI to analyze the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most fixated on the unproportionally assigned weight emotional bettors often put on player performance factors between a Mariners team going up against a possibly healthy Giants team. We’ve found the true game analytics appear to reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Seattle vs San Francisco picks, computer picks Mariners vs Giants, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Mariners Betting Trends

The Mariners have covered the spread in 2 of their last 7 games, resulting in a 28.6% success rate.

Giants Betting Trends

The Giants have covered the spread in 5 of their last 6 games, achieving an 83.3% success rate.

Mariners vs. Giants Matchup Trends

The Giants have secured victories in 8 of their last 12 games when favored on the moneyline, yielding a 43% return on investment.

Seattle vs. San Francisco Game Info

Seattle vs San Francisco starts on April 06, 2025 at 4:05 PM EST.

Spread: San Francisco -1.5
Moneyline: Seattle +102, San Francisco -122
Over/Under: 7.5

Seattle: (3-6)  |  San Francisco: (7-1)

Remi's searched hard and found the best prop for this matchup: C. Raleigh over 6 Fantasy Score.. Prices move—always shop for the best number.

The Giants have secured victories in 8 of their last 12 games when favored on the moneyline, yielding a 43% return on investment.

SEA trend: The Mariners have covered the spread in 2 of their last 7 games, resulting in a 28.6% success rate.

SF trend: The Giants have covered the spread in 5 of their last 6 games, achieving an 83.3% success rate.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Seattle vs. San Francisco Odds

Remi is pouring through tons of stats on each line. In fact, anytime the Seattle vs San Francisco trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable betting trends.

Seattle vs San Francisco Opening Odds

SEA Moneyline: +102
SF Moneyline: -122
SEA Spread: +1.5
SF Spread: -1.5
Over/Under: 7.5

Seattle vs San Francisco Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+196
-240
+1.5 (-105)
-1.5 (-115)
O 9 (-105)
U 9 (-115)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-178
 
-1.5 (+115)
O 9.5 (+100)
U 9.5 (-120)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+135
-160
+1.5 (-155)
-1.5 (+130)
O 8.5 (-105)
U 8.5 (-115)
Sep 27, 2025 4:05PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:05PM
White Sox
Nationals
+100
-120
+1.5 (-205)
-1.5 (+170)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+196
-240
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+130)
+1.5 (-155)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+110
-130
+1.5 (-190)
-1.5 (+158)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+175
-210
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+115
-135
+1.5 (-190)
-1.5 (+158)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+150
-178
+1.5 (-145)
-1.5 (+122)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+122
-145
+1.5 (-190)
-1.5 (+158)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+118
-140
+1.5 (-190)
-1.5 (+158)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-140
+118
-1.5 (+115)
+1.5 (-135)
O 9 (-110)
U 9 (-110)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
+1.5 (-220)
-1.5 (+180)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
+1.5 (-195)
-1.5 (+162)
O 10 (-115)
U 10 (-105)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Seattle Mariners vs. San Francisco Giants on April 06, 2025 at Oracle Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS