Reds vs Brewers Prediction — AI Finds CAN'T MISS MLB Lines & Props (Apr 06)

Updated: 2025-04-04T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On April 6, 2025, the Cincinnati Reds will conclude their series against the Milwaukee Brewers at American Family Field in Milwaukee. Both teams aim to improve their early-season records, with the Reds seeking consistency and the Brewers looking to build on their recent successes.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 06, 2025

Start Time: 2:10 PM EST​

Venue: American Family Field​

Brewers Record: (4-5)

Reds Record: (3-6)

OPENING ODDS

CIN Moneyline: +122

MIL Moneyline: -144

CIN Spread: +1.5

MIL Spread: -1.5

Over/Under: 8.5

CIN
Betting Trends

  • The Reds have covered the spread in 2 of their last 5 games on the road, resulting in a -1.5 unit loss (-30% ROI).

MIL
Betting Trends

  • The Brewers have covered the spread in 3 of their last 5 home games, yielding a +0.8 unit gain (16% ROI).

MATCHUP TRENDS

  • In their previous matchup on April 5, the Reds covered the spread as +1.5 underdogs, winning 11-7 against the Brewers. The game’s total exceeded the over/under line, highlighting the offensive strengths of both teams.

CIN vs. MIL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: C. Spiers over 2.5 Earned runs.

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Cincinnati vs Milwaukee Prediction & Odds:
Free MLB Betting Insights for 4/6/25

The Cincinnati Reds (2-6) and Milwaukee Brewers (4-4) will meet on April 6, 2025, at American Family Field, with both teams looking to rebound from early-season struggles. The Reds, after a rough start, managed to snap a four-game losing streak with an explosive 11-7 win over the Brewers on April 5. In that game, they showcased their power, with four home runs, including two-run shots from TJ Friedl and Jose Trevino. Friedl’s hitting has been a highlight for the Reds, while Rutschman continues to be an offensive anchor. The Reds will look to ride the momentum of that offensive outburst into this game. Starting pitcher Carson Spiers (0-1, 1.50 ERA) will be key for the Reds as he tries to improve on his previous outing. Spiers has shown promise in limited appearances, and the Reds need him to provide a solid start to give them a chance to win on the road. The Reds’ bullpen, while effective at times, has shown vulnerability in late-game situations, and they’ll need to remain sharp to keep the Brewers from rallying. The Brewers, coming off a tough loss, will look to bounce back with a strong performance in front of their home crowd at American Family Field. The Brewers’ offense has been potent at times, with standout performances from Sal Frelick, who is batting .394, and Brice Turang, who has added two home runs and six RBIs. However, the Brewers are adjusting to the absence of star shortstop Willy Adames, who was traded to the Giants earlier in the season.

Despite that, the Brewers’ offense remains deep, with players like Pete Alonso and Christian Yelich providing significant firepower. On the mound, Chad Patrick (0-0, 3.18 ERA) will take the start for the Brewers. Patrick has been steady in his outings so far and will need to deliver a quality start to keep the Reds’ powerful offense at bay. The Brewers’ bullpen has been a strength in the past but will need to prove its reliability this season, especially after a few rough outings early on. Manager Craig Counsell will emphasize pitching consistency and capitalizing on offensive opportunities to stay competitive in the tight NL Central division. One of the keys to this game will be the performance of the starting pitchers. For the Reds, Spiers will need to continue his promising development and keep the Brewers’ lineup from getting hot. On the other side, the Brewers will need a solid outing from Patrick to keep the Reds’ lineup from building on their recent success. Another important factor will be defense, as both teams will need to avoid costly mistakes, especially when facing strong offenses that can capitalize on any errors. The Reds have struggled on the road, with an 0-5 record away from home, so this game represents an opportunity for them to prove they can compete outside of Cincinnati. The Brewers, on the other hand, will be looking to use their home-field advantage to secure a series split after a tough loss. The outcome of this game may hinge on which team can deliver in key moments—whether it’s the Reds finding more consistency on the mound or the Brewers showing their depth in both pitching and offense. This matchup will also showcase some exciting individual performances, especially from Frelick, Rutschman, and the Brewers’ pitching staff. Fans can expect an exciting contest with both teams hungry for a win.

Cincinnati Reds MLB Preview

The Cincinnati Reds (2-6) will head into their April 6, 2025, matchup against the Milwaukee Brewers at American Family Field hoping to build on their first win of the season, a thrilling 11-7 victory on April 5. The Reds have had a tough start to the season, struggling with consistency across both sides of the ball. However, their offense showed a glimpse of what it’s capable of in the win, with TJ Friedl, Jose Trevino, and the rest of the lineup contributing to a power surge, including multiple home runs. Friedl’s bat has been one of the more reliable sources of offense for the Reds, and his performance at the top of the order will be crucial for setting the tone. Alongside him, Adley Rutschman, who has been a key figure in the Reds’ lineup, continues to provide consistency and leadership, making him an integral part of their offensive game plan. With a 0-5 record on the road, the Reds will need to improve their performance away from home to turn their season around. On the mound, Carson Spiers, who will make the start for the Reds in this game, has looked promising in his limited appearances. With a solid 1.50 ERA, Spiers has shown that he has the potential to be a key contributor, but he will need to take another step forward in his development. His control will be critical, as he’ll be facing a potent Brewers lineup that has been successful against pitchers who leave the ball in the zone.

The Reds will need Spiers to provide length in this game, keeping the Brewers off balance and limiting their scoring opportunities. While the Reds’ bullpen has been effective at times, it has also shown vulnerability in tight games, and they will need to be sharp in this contest to keep the Brewers from mounting a comeback. The Reds have struggled defensively at times, committing costly errors that have hurt their chances in several games. For this game, they’ll need to tighten up their fielding, especially when facing a Brewers offense that can capitalize on any mistake. The Reds’ lineup, led by Friedl, Rutschman, and others, will need to provide more consistent run support. The team has shown flashes of its potential but has struggled to put together complete games. Manager Terry Francona will be focused on improving both offensive consistency and defensive execution, as well as getting strong performances from his pitchers. If Spiers can keep the Brewers’ lineup from heating up, and if the Reds’ offense can stay hot from their recent outburst, they have a good chance to secure their first road win of the season. With the Brewers also looking to rebound, this game will be crucial for both teams to gain momentum early in the season. The Reds will need to capitalize on any mistakes made by the Brewers while continuing to develop consistency across all facets of their game.

On April 6, 2025, the Cincinnati Reds will conclude their series against the Milwaukee Brewers at American Family Field in Milwaukee. Both teams aim to improve their early-season records, with the Reds seeking consistency and the Brewers looking to build on their recent successes. Cincinnati vs Milwaukee AI Prediction: Free MLB Betting Insights for Apr 06. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Milwaukee Brewers MLB Preview

The Milwaukee Brewers (4-4) will look to bounce back from a tough loss in their previous game against the Cincinnati Reds as they prepare to face them again on April 6, 2025, at American Family Field. The Brewers’ offense has been inconsistent but remains potent, especially with the presence of key players like Brice Turang, who has been one of their top hitters, and Sal Frelick, who leads the team with a .394 batting average. Frelick’s contributions at the top of the order have provided a spark, and his ability to get on base has helped the Brewers generate offense in spurts. The team also features power hitters like Christian Yelich and the ever-dangerous Pete Alonso, who can change the course of a game with one swing of the bat. However, the Brewers’ offense has struggled to find consistency, and they will need a more balanced approach to secure a win in this game. Despite the offensive inconsistencies, the Brewers’ pitching staff remains a strong point. Chad Patrick, slated to start, has shown promise with a 3.18 ERA and has been effective in his outings so far. Patrick will be crucial for the Brewers to get a quality start and keep the Reds’ powerful offense at bay. His ability to control the strike zone and avoid walks will be key to his success against a Reds team that has shown they can be dangerous when they get on base.

The Brewers’ bullpen, which has been a reliable asset in recent seasons, will also need to be sharp in this game, as the team cannot afford to give up late-game rallies like they did in their previous matchup with the Reds. Manager Craig Counsell will need to ensure that his bullpen remains strong, especially in high-leverage situations. Defensively, the Brewers have been solid, but they will need to continue minimizing errors and making the right plays, as any mistakes could open the door for the Reds’ offense to build momentum. At home, the Brewers have a slight edge, and they will be looking to capitalize on that advantage in front of their home crowd. With a 3-1 record at home this season, they have shown they can perform well in familiar surroundings. The Brewers will also be looking to bounce back from the loss to the Reds by tightening up their game across the board. If they can get strong pitching from Patrick, produce more consistency from their lineup, and maintain their defensive discipline, the Brewers will have a good chance to get back on track. A win against the Reds would not only help them gain momentum but also solidify their position in a competitive NL Central. The Brewers know that they need to find balance in both their offense and defense, and this game presents an opportunity to put together a complete performance and keep pace in the division.

Cincinnati vs. Milwaukee Prop Picks (AI)

Remi is pouring through mountains of datapoints on each line. In fact, anytime the Reds and Brewers play there’s always several intriguing observations to key in on. Not to mention games played at American Family Field in Apr can often follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: C. Spiers over 2.5 Earned runs.

Cincinnati vs. Milwaukee Prediction (AI)

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Remi, our AI sports wizard, has been pouring over mountains of data from every simulation between the Reds and Brewers and using recursive machine learning and industry leading AI to analyze the data to a single cover probability.

The Algorithm has been most keyed in on the linear correlation of emphasis emotional bettors tend to put on player performance factors between a Reds team going up against a possibly tired Brewers team. Trends look to say the true game analytics appear to reflect a strong lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Cincinnati vs Milwaukee picks, computer picks Reds vs Brewers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Reds Betting Trends

The Reds have covered the spread in 2 of their last 5 games on the road, resulting in a -1.5 unit loss (-30% ROI).

Brewers Betting Trends

The Brewers have covered the spread in 3 of their last 5 home games, yielding a +0.8 unit gain (16% ROI).

Reds vs. Brewers Matchup Trends

In their previous matchup on April 5, the Reds covered the spread as +1.5 underdogs, winning 11-7 against the Brewers. The game’s total exceeded the over/under line, highlighting the offensive strengths of both teams.

Cincinnati vs. Milwaukee Game Info

Cincinnati vs Milwaukee starts on April 06, 2025 at 2:10 PM EST.

Venue: American Family Field.

Spread: Milwaukee -1.5
Moneyline: Cincinnati +122, Milwaukee -144
Over/Under: 8.5

Cincinnati: (3-6)  |  Milwaukee: (4-5)

Remi's searched hard and found the best prop for this matchup: C. Spiers over 2.5 Earned runs.. Prices move—always shop for the best number.

In their previous matchup on April 5, the Reds covered the spread as +1.5 underdogs, winning 11-7 against the Brewers. The game’s total exceeded the over/under line, highlighting the offensive strengths of both teams.

CIN trend: The Reds have covered the spread in 2 of their last 5 games on the road, resulting in a -1.5 unit loss (-30% ROI).

MIL trend: The Brewers have covered the spread in 3 of their last 5 home games, yielding a +0.8 unit gain (16% ROI).

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Cincinnati vs. Milwaukee Odds

Remi is pouring through tons of data points on each line. In fact, anytime the Cincinnati vs Milwaukee trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme travel distance seemingly never follow normal, predictable patterns.

Cincinnati vs Milwaukee Opening Odds

CIN Moneyline: +122
MIL Moneyline: -144
CIN Spread: +1.5
MIL Spread: -1.5
Over/Under: 8.5

Cincinnati vs Milwaukee Live Odds

Games PTS ML SPR O/U
Oct 19, 2025 8:04PM EDT
Seattle Mariners
Toronto Blue Jays
10/19/25 8:04PM
Mariners
Blue Jays
+108
-130
+1.5 (-215)
-1.5 (+165)
O 7.5 (-121)
U 7.5 (-106)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Cincinnati Reds vs. Milwaukee Brewers on April 06, 2025 at American Family Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TOR@SEA OVER 7 54.9% 3 WIN
LAD@MIL UNDER 7.5 56.6% 6 WIN
TOR@NYY OVER 8 54.9% 4 WIN
TOR@NYY CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED 53.3% 3 WIN
NYY@TOR OVER 7.5 54.8% 2 WIN
LAD@PHI OVER 7 53.8% 3 WIN
SD@CHC CHC -109 53.8% 3 WIN
SD@CHC OVER 7.5 54.5% 4 LOSS
SD@CHC CHC -111 54.8% 4 LOSS
CIN@LAD SHOHEI OHTANI OVER 1.5 BASES 53.5% 3 WIN
BOS@NYY OVER 7 53.8% 3 LOSS
CIN@LAD ELLY DE LA CRUZ OVER 0.5 BASES 54.4% 4 LOSS
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN