Reds vs. Brewers
Prediction, Odds & Props
Apr 06 | MLB AI Picks
Updated: 2025-04-04T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
On April 6, 2025, the Cincinnati Reds will conclude their series against the Milwaukee Brewers at American Family Field in Milwaukee. Both teams aim to improve their early-season records, with the Reds seeking consistency and the Brewers looking to build on their recent successes.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Apr 06, 2025
Start Time: 2:10 PM EST
Venue: American Family Field
Brewers Record: (4-5)
Reds Record: (3-6)
OPENING ODDS
CIN Moneyline: +122
MIL Moneyline: -144
CIN Spread: +1.5
MIL Spread: -1.5
Over/Under: 8.5
CIN
Betting Trends
- The Reds have covered the spread in 2 of their last 5 games on the road, resulting in a -1.5 unit loss (-30% ROI).
MIL
Betting Trends
- The Brewers have covered the spread in 3 of their last 5 home games, yielding a +0.8 unit gain (16% ROI).
MATCHUP TRENDS
- In their previous matchup on April 5, the Reds covered the spread as +1.5 underdogs, winning 11-7 against the Brewers. The game’s total exceeded the over/under line, highlighting the offensive strengths of both teams.
CIN vs. MIL
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: C. Spiers over 2.5 Earned runs.
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Cincinnati vs Milwaukee Prediction & Odds:
Free MLB Betting Insights for 4/6/25
Despite that, the Brewers’ offense remains deep, with players like Pete Alonso and Christian Yelich providing significant firepower. On the mound, Chad Patrick (0-0, 3.18 ERA) will take the start for the Brewers. Patrick has been steady in his outings so far and will need to deliver a quality start to keep the Reds’ powerful offense at bay. The Brewers’ bullpen has been a strength in the past but will need to prove its reliability this season, especially after a few rough outings early on. Manager Craig Counsell will emphasize pitching consistency and capitalizing on offensive opportunities to stay competitive in the tight NL Central division. One of the keys to this game will be the performance of the starting pitchers. For the Reds, Spiers will need to continue his promising development and keep the Brewers’ lineup from getting hot. On the other side, the Brewers will need a solid outing from Patrick to keep the Reds’ lineup from building on their recent success. Another important factor will be defense, as both teams will need to avoid costly mistakes, especially when facing strong offenses that can capitalize on any errors. The Reds have struggled on the road, with an 0-5 record away from home, so this game represents an opportunity for them to prove they can compete outside of Cincinnati. The Brewers, on the other hand, will be looking to use their home-field advantage to secure a series split after a tough loss. The outcome of this game may hinge on which team can deliver in key moments—whether it’s the Reds finding more consistency on the mound or the Brewers showing their depth in both pitching and offense. This matchup will also showcase some exciting individual performances, especially from Frelick, Rutschman, and the Brewers’ pitching staff. Fans can expect an exciting contest with both teams hungry for a win.
Runs and dub. #ATOBTTR pic.twitter.com/QIJjRdyTUH
— Cincinnati Reds (@Reds) April 6, 2025
Cincinnati Reds MLB Preview
The Cincinnati Reds (2-6) will head into their April 6, 2025, matchup against the Milwaukee Brewers at American Family Field hoping to build on their first win of the season, a thrilling 11-7 victory on April 5. The Reds have had a tough start to the season, struggling with consistency across both sides of the ball. However, their offense showed a glimpse of what it’s capable of in the win, with TJ Friedl, Jose Trevino, and the rest of the lineup contributing to a power surge, including multiple home runs. Friedl’s bat has been one of the more reliable sources of offense for the Reds, and his performance at the top of the order will be crucial for setting the tone. Alongside him, Adley Rutschman, who has been a key figure in the Reds’ lineup, continues to provide consistency and leadership, making him an integral part of their offensive game plan. With a 0-5 record on the road, the Reds will need to improve their performance away from home to turn their season around. On the mound, Carson Spiers, who will make the start for the Reds in this game, has looked promising in his limited appearances. With a solid 1.50 ERA, Spiers has shown that he has the potential to be a key contributor, but he will need to take another step forward in his development. His control will be critical, as he’ll be facing a potent Brewers lineup that has been successful against pitchers who leave the ball in the zone.
The Reds will need Spiers to provide length in this game, keeping the Brewers off balance and limiting their scoring opportunities. While the Reds’ bullpen has been effective at times, it has also shown vulnerability in tight games, and they will need to be sharp in this contest to keep the Brewers from mounting a comeback. The Reds have struggled defensively at times, committing costly errors that have hurt their chances in several games. For this game, they’ll need to tighten up their fielding, especially when facing a Brewers offense that can capitalize on any mistake. The Reds’ lineup, led by Friedl, Rutschman, and others, will need to provide more consistent run support. The team has shown flashes of its potential but has struggled to put together complete games. Manager Terry Francona will be focused on improving both offensive consistency and defensive execution, as well as getting strong performances from his pitchers. If Spiers can keep the Brewers’ lineup from heating up, and if the Reds’ offense can stay hot from their recent outburst, they have a good chance to secure their first road win of the season. With the Brewers also looking to rebound, this game will be crucial for both teams to gain momentum early in the season. The Reds will need to capitalize on any mistakes made by the Brewers while continuing to develop consistency across all facets of their game.
Credit: USA TODAY/IMAGN
Milwaukee Brewers MLB Preview
The Milwaukee Brewers (4-4) will look to bounce back from a tough loss in their previous game against the Cincinnati Reds as they prepare to face them again on April 6, 2025, at American Family Field. The Brewers’ offense has been inconsistent but remains potent, especially with the presence of key players like Brice Turang, who has been one of their top hitters, and Sal Frelick, who leads the team with a .394 batting average. Frelick’s contributions at the top of the order have provided a spark, and his ability to get on base has helped the Brewers generate offense in spurts. The team also features power hitters like Christian Yelich and the ever-dangerous Pete Alonso, who can change the course of a game with one swing of the bat. However, the Brewers’ offense has struggled to find consistency, and they will need a more balanced approach to secure a win in this game. Despite the offensive inconsistencies, the Brewers’ pitching staff remains a strong point. Chad Patrick, slated to start, has shown promise with a 3.18 ERA and has been effective in his outings so far. Patrick will be crucial for the Brewers to get a quality start and keep the Reds’ powerful offense at bay. His ability to control the strike zone and avoid walks will be key to his success against a Reds team that has shown they can be dangerous when they get on base.
The Brewers’ bullpen, which has been a reliable asset in recent seasons, will also need to be sharp in this game, as the team cannot afford to give up late-game rallies like they did in their previous matchup with the Reds. Manager Craig Counsell will need to ensure that his bullpen remains strong, especially in high-leverage situations. Defensively, the Brewers have been solid, but they will need to continue minimizing errors and making the right plays, as any mistakes could open the door for the Reds’ offense to build momentum. At home, the Brewers have a slight edge, and they will be looking to capitalize on that advantage in front of their home crowd. With a 3-1 record at home this season, they have shown they can perform well in familiar surroundings. The Brewers will also be looking to bounce back from the loss to the Reds by tightening up their game across the board. If they can get strong pitching from Patrick, produce more consistency from their lineup, and maintain their defensive discipline, the Brewers will have a good chance to get back on track. A win against the Reds would not only help them gain momentum but also solidify their position in a competitive NL Central. The Brewers know that they need to find balance in both their offense and defense, and this game presents an opportunity to put together a complete performance and keep pace in the division.
A little fifth inning recap for ya
— Milwaukee Brewers (@Brewers) April 6, 2025
🔵 @Bryanchourio11 single
🔵 @ChristianYelich RBI
🔵 @Wcontreras42 single
🔵 @SalFrelick RBI & 2 more on an error pic.twitter.com/U0x6d4AaxN
Cincinnati vs. Milwaukee Prop Picks (AI)
Cincinnati vs. Milwaukee Prediction (AI)
Remi, our AI sports algorithm, has been pouring over tons of data from every past game between the Reds and Brewers and using recursive machine learning and industry leading AI to examine the data to a single cover probability.
Remi has been most watching on the growing weight knucklehead sportsbettors often put on coaching factors between a Reds team going up against a possibly deflated Brewers team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Cincinnati vs Milwaukee picks, computer picks Reds vs Brewers, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
|---|---|---|---|---|---|---|
| ACTIVE PICKS LOCKED - SEE NOW | ||||||
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Reds Betting Trends
The Reds have covered the spread in 2 of their last 5 games on the road, resulting in a -1.5 unit loss (-30% ROI).
Brewers Betting Trends
The Brewers have covered the spread in 3 of their last 5 home games, yielding a +0.8 unit gain (16% ROI).
Reds vs. Brewers Matchup Trends
In their previous matchup on April 5, the Reds covered the spread as +1.5 underdogs, winning 11-7 against the Brewers. The game’s total exceeded the over/under line, highlighting the offensive strengths of both teams.
Cincinnati vs. Milwaukee Game Info
What time does Cincinnati vs Milwaukee start on April 06, 2025?
Cincinnati vs Milwaukee starts on April 06, 2025 at 2:10 PM EST.
Where is Cincinnati vs Milwaukee being played?
Venue: American Family Field.
What are the opening odds for Cincinnati vs Milwaukee?
Spread: Milwaukee -1.5
Moneyline: Cincinnati +122, Milwaukee -144
Over/Under: 8.5
What are the records for Cincinnati vs Milwaukee?
Cincinnati: (3-6) | Milwaukee: (4-5)
What is the AI best bet for Cincinnati vs Milwaukee?
Remi's searched hard and found the best prop for this matchup: C. Spiers over 2.5 Earned runs.. Prices move—always shop for the best number.
What are Cincinnati vs Milwaukee trending bets?
In their previous matchup on April 5, the Reds covered the spread as +1.5 underdogs, winning 11-7 against the Brewers. The game’s total exceeded the over/under line, highlighting the offensive strengths of both teams.
What are Cincinnati trending bets?
CIN trend: The Reds have covered the spread in 2 of their last 5 games on the road, resulting in a -1.5 unit loss (-30% ROI).
What are Milwaukee trending bets?
MIL trend: The Brewers have covered the spread in 3 of their last 5 home games, yielding a +0.8 unit gain (16% ROI).
Where can I find AI Picks for Cincinnati vs Milwaukee?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Cincinnati vs. Milwaukee Odds
AI algorithm Remi is pouring through tons of data points on each player. In fact, anytime the Cincinnati vs Milwaukee trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable betting trends.
Cincinnati vs Milwaukee Opening Odds
CIN Moneyline:
+122 MIL Moneyline: -144
CIN Spread: +1.5
MIL Spread: -1.5
Over/Under: 8.5
Cincinnati vs Milwaukee Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
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Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
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–
–
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+196
-240
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+1.5 (-105)
-1.5 (-115)
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O 9 (-105)
U 9 (-115)
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Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
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–
–
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-178
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-1.5 (+115)
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O 9.5 (+100)
U 9.5 (-120)
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Sep 27, 2025 3:09PM EDT
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Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
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–
–
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+135
-160
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+1.5 (-155)
-1.5 (+130)
|
O 8.5 (-105)
U 8.5 (-115)
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Sep 27, 2025 4:05PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:05PM
White Sox
Nationals
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–
–
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+100
-120
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+1.5 (-205)
-1.5 (+170)
|
O 8.5 (-115)
U 8.5 (-105)
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Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
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–
–
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+196
-240
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+1.5 (-110)
-1.5 (-110)
|
O 8 (-105)
U 8 (-115)
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Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
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–
–
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-130
+110
|
-1.5 (+130)
+1.5 (-155)
|
O 8 (-115)
U 8 (-105)
|
|
|
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
|
–
–
|
+110
-130
|
+1.5 (-190)
-1.5 (+158)
|
O 9 (+100)
U 9 (-120)
|
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Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
|
–
–
|
+175
-210
|
+1.5 (-120)
-1.5 (+100)
|
O 8.5 (-115)
U 8.5 (-105)
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|
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Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
|
–
–
|
+115
-135
|
+1.5 (-190)
-1.5 (+158)
|
O 7.5 (-120)
U 7.5 (+100)
|
|
|
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
|
–
–
|
+150
-178
|
+1.5 (-145)
-1.5 (+122)
|
O 8 (-110)
U 8 (-110)
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|
|
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
|
–
–
|
+122
-145
|
+1.5 (-190)
-1.5 (+158)
|
O 7 (-120)
U 7 (+100)
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|
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
|
–
–
|
+118
-140
|
+1.5 (-190)
-1.5 (+158)
|
O 7.5 (-115)
U 7.5 (-105)
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Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
|
–
–
|
-140
+118
|
-1.5 (+115)
+1.5 (-135)
|
O 9 (-110)
U 9 (-110)
|
|
|
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
|
–
–
|
+100
-120
|
+1.5 (-220)
-1.5 (+180)
|
O 7 (-120)
U 7 (+100)
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|
|
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
|
–
–
|
+100
-120
|
+1.5 (-195)
-1.5 (+162)
|
O 10 (-115)
U 10 (-105)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Cincinnati Reds vs. Milwaukee Brewers on April 06, 2025 at American Family Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
| MLB |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| ARI@SD | SD -131 | 57.3% | 4 | WIN |
| DET@BOS | BOS -115 | 56.4% | 5 | WIN |
| NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
| HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
| NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
| STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
| KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
| MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
| MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
| WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
| LAA@COL | COL +108 | 50.5% | 3 | WIN |
| TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
| SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
| NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
| MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
| MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
| SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
| PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
| NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
| KC@PHI | PHI -130 | 58.3% | 4 | WIN |
| LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
| NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
| KC@CLE | KC -104 | 52.0% | 3 | WIN |
| CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
| WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
| LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
| TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
| SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
| SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
| MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
| NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
| TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
| TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
| ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
| PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
| ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
| SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
| CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
| NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |
| PHI@NYM | OVER 8.5 | 55.6% | 4 | LOSS |
| LAA@TEX | LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS | 54.1% | 4 | LOSS |
| KC@CHW | KC -109 | 54.2% | 4 | WIN |
| SD@SEA | DYLAN CEASE OVER 16.5 OUTS | 53.9% | 3 | LOSS |
| SD@SEA | UNDER 8.5 | 54.4% | 4 | LOSS |
| MIN@TOR | JOE RYAN UNDER 2.5 EARNED RUNS | 54.1% | 4 | LOSS |
| SF@MIL | MIL +100 | 54.0% | 6 | LOSS |
| TOR@MIA | MIA +1.5 | 62.0% | 6 | WIN |
| CHC@LAA | OVER 9.5 | 54.9% | 4 | LOSS |
| BOS@NYY | CARLOS RODON UNDER 4.5 HITS ALLOWED | 54.2% | 4 | WIN |
| KC@DET | DET -115 | 56.1% | 5 | WIN |
| CHC@LAA | LAA +1.5 | 57.6% | 5 | LOSS |