White Sox vs Tigers Prediction — AI Finds CAN'T MISS MLB Lines & Props (Apr 06)
Updated: 2025-04-04T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
On April 6, 2025, the Chicago White Sox will face the Detroit Tigers at Comerica Park in Detroit. Both teams enter the game with early-season struggles, aiming to gain momentum in this matchup.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Apr 06, 2025
Start Time: 1:40 PM EST
Venue: Comerica Park
Tigers Record: (4-4)
White Sox Record: (2-6)
OPENING ODDS
CHW Moneyline: +179
DET Moneyline: -217
CHW Spread: +1.5
DET Spread: -1.5
Over/Under: 7.5
CHW
Betting Trends
- The White Sox have been underdogs in 152 games this season, securing victories in 36 (23.7%) of them, and over their past 10 games, they have covered the spread 4 times and failed to cover 6 times.
DET
Betting Trends
- The Tigers have been favored in 66 games this season, winning 40 (60.6%) of those contests, and in their last 10 games, they have covered the spread 6 times and failed to cover 4 times.
MATCHUP TRENDS
- The Tigers have covered the spread in 6 of their last 10 games against the White Sox, while the White Sox have covered in 4 of those matchups, indicating a relatively balanced performance between the two teams.
CHW vs. DET
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: J. Amaya under 1.5 Total Bases.
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Chicago White Sox vs Detroit Prediction & Odds:
Free MLB Betting Insights for 4/6/25
Despite their offensive strength, the Tigers have struggled on the mound, particularly with Jackson Jobe, who has posted a 6.75 ERA in his first start of the season. Jobe will look to improve in this matchup, and a strong outing from him could go a long way in helping the Tigers gain a series win. The Tigers have also faced their own injury woes, with key players such as Gleyber Torres and Matt Vierling on the injured list, which has tested their depth. However, despite these setbacks, the Tigers have managed to stay competitive in a tough AL Central division. The key for the Tigers will be to get more consistent pitching while maintaining the offensive momentum generated by Greene and Carpenter. Manager A.J. Hinch will focus on using the home-field advantage at Comerica Park to push his team toward a winning record, and a series victory here would be a great confidence booster. The White Sox, meanwhile, are still searching for consistency. Manager Pedro Grifol will need to ensure that his pitching staff can provide more quality starts while finding ways to spark the offense. With Pérez and other starters like Dylan Cease needing to step up, the White Sox will hope that their top-tier pitching can help them win a crucial game on the road. This game represents an important opportunity for both teams to start finding their footing early in the season. For the Tigers, a victory could set them up for continued success, while the White Sox will need to find a way to address their offensive struggles and injuries in order to compete in this tough matchup.
Benny makes the catch! pic.twitter.com/KmDeFkNTAs
— Chicago White Sox (@whitesox) April 5, 2025
Chicago White Sox White Sox MLB Preview
The Chicago White Sox (2-6) are off to a rough start in the 2025 season, and they will look to turn things around as they face the Detroit Tigers on April 6, 2025, at Comerica Park. The White Sox have been struggling with offensive consistency, averaging just 3.6 runs per game, which has put significant pressure on their pitching staff. Despite their offensive struggles, Andrew Benintendi has emerged as one of the team’s bright spots, batting .310 with two home runs and providing much-needed consistency at the top of the lineup. Benintendi’s contributions have helped, but the White Sox are still lacking a consistent power presence to support him. With Mike Tauchman and Bryan Ramos currently on the 10-day IL, the White Sox’s depth has been further tested, and they will need other players like Luis Robert and Tim Anderson to step up and generate more offense. On the mound, the White Sox have received strong performances from Martín Pérez, who earned a win in his lone start and didn’t allow an earned run. Pérez has been a steady presence on the mound, and the White Sox will need him to continue that form if they are to have a chance in this game. The White Sox pitching staff, while capable, needs to improve their consistency, and they will rely on Pérez, along with other starters like Dylan Cease, to give them quality innings and keep the Tigers’ offense in check.
The bullpen, too, will need to be solid in late-game situations. Manager Pedro Grifol will be hoping to find the right balance between offense and pitching to help the team get back on track. Defensively, the White Sox have been solid, but they need to limit mistakes to avoid giving extra opportunities to opponents. If the White Sox are going to turn their season around, they’ll need to perform better in every facet of the game. Their offense must become more productive, and the pitching staff, led by Pérez and Cease, needs to deliver quality starts. The White Sox have the talent to be a competitive team in the AL Central, but they must start putting it all together. This series against the Tigers presents an opportunity for the White Sox to build some momentum, and a win here could be the spark they need to climb out of their early-season hole. With the Tigers also facing their own challenges, the White Sox have a chance to capitalize on Detroit’s inconsistency and secure a much-needed win. It will be crucial for the White Sox to find their offensive rhythm, get solid pitching, and avoid making mistakes on defense. If they can do that, they’ll have a good chance to secure a victory and start the road to recovery after a tough start to the season.

Credit: USA TODAY/IMAGN
Detroit Tigers MLB Preview
The Detroit Tigers (4-4) come into their April 6, 2025, matchup against the Chicago White Sox with a relatively balanced start to the season, although they’ve shown room for improvement. The Tigers have experienced some offensive success, led by Riley Greene, who is hitting .361 with three home runs and providing the team with the power and consistency they need at the top of the order. Greene has become a central figure in the lineup, offering the Tigers a reliable presence at the plate. Alongside Greene, Kerry Carpenter has stepped up, driving in eight RBIs early in the season, which highlights his potential as a consistent contributor in the middle of the order. Despite the offensive strength of Greene and Carpenter, the Tigers’ batting has been inconsistent overall, as other key players have struggled to find a rhythm. The loss of Gleyber Torres and Matt Vierling to injury has further complicated matters, leaving the team with less depth in the lineup. If the Tigers are to be competitive in this game against the White Sox, their offense will need to produce more across the board. On the pitching side, the Tigers have faced some early-season struggles, particularly with Jackson Jobe, who has a 6.75 ERA in his first start of the year. Jobe, a young and promising pitcher, will need to step up and rebound from this rough start if the Tigers are going to have a chance to win games against a potent lineup like the White Sox.
Jobe’s ability to stay composed and pitch effectively in this game will be crucial for the Tigers. Despite his struggles, the Tigers’ pitching staff has other capable arms that can help shoulder the load. However, for the Tigers to remain competitive, they’ll need more consistent performances from their starting rotation and bullpen. The team will also look to its defense to avoid errors and capitalize on any opportunities that arise. The Tigers’ bullpen has been solid in stretches, but they will need to remain consistent in high-leverage situations. Manager A.J. Hinch will focus on finding ways to get the most out of his pitchers, and his offense will need to provide run support to secure victories. At home, the Tigers have a chance to take advantage of Comerica Park’s atmosphere to give their performance a boost, particularly against a White Sox team that has been struggling offensively. A series win would be crucial to build confidence, especially with the talent the Tigers have on paper. With their offensive firepower led by Greene and Carpenter, the Tigers are capable of breaking out and taking control of the game, but their success will depend on how well they perform on the mound. Manager Hinch knows that this game is important to give the team the momentum they need for the rest of the season, and the Tigers will look to find consistency in all aspects of their game. If they can generate consistent offensive production while getting strong pitching performances, they’ll have a good chance to come out on top against the White Sox.
We’ve got sunshine, on a cloudy day 😁 pic.twitter.com/TQCdVXXjo0
— Detroit Tigers (@tigers) April 5, 2025
Chicago White Sox vs. Detroit Prop Picks (AI)
Chicago White Sox vs. Detroit Prediction (AI)

Remi, our AI sports genius, has been pouring over millions of data from every facet between the White Sox and Tigers and using recursive machine learning and cutting-edge AI to analyze the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most keyed in on the unproportionally assigned factor human bettors often put on player performance factors between a White Sox team going up against a possibly tired Tigers team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Chicago White Sox vs Detroit picks, computer picks White Sox vs Tigers, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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MLB | 10/19 | SEA@TOR | UNLOCK THIS PICK | 1 |
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MLB | 10/19 | SEA@TOR | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
White Sox Betting Trends
The White Sox have been underdogs in 152 games this season, securing victories in 36 (23.7%) of them, and over their past 10 games, they have covered the spread 4 times and failed to cover 6 times.
Tigers Betting Trends
The Tigers have been favored in 66 games this season, winning 40 (60.6%) of those contests, and in their last 10 games, they have covered the spread 6 times and failed to cover 4 times.
White Sox vs. Tigers Matchup Trends
The Tigers have covered the spread in 6 of their last 10 games against the White Sox, while the White Sox have covered in 4 of those matchups, indicating a relatively balanced performance between the two teams.
Chicago White Sox vs. Detroit Game Info
What time does Chicago White Sox vs Detroit start on April 06, 2025?
Chicago White Sox vs Detroit starts on April 06, 2025 at 1:40 PM EST.
Where is Chicago White Sox vs Detroit being played?
Venue: Comerica Park.
What are the opening odds for Chicago White Sox vs Detroit?
Spread: Detroit -1.5
Moneyline: Chicago White Sox +179, Detroit -217
Over/Under: 7.5
What are the records for Chicago White Sox vs Detroit?
Chicago White Sox: (2-6) | Detroit: (4-4)
What is the AI best bet for Chicago White Sox vs Detroit?
Remi's searched hard and found the best prop for this matchup: J. Amaya under 1.5 Total Bases.. Prices move—always shop for the best number.
What are Chicago White Sox vs Detroit trending bets?
The Tigers have covered the spread in 6 of their last 10 games against the White Sox, while the White Sox have covered in 4 of those matchups, indicating a relatively balanced performance between the two teams.
What are Chicago White Sox trending bets?
CHW trend: The White Sox have been underdogs in 152 games this season, securing victories in 36 (23.7%) of them, and over their past 10 games, they have covered the spread 4 times and failed to cover 6 times.
What are Detroit trending bets?
DET trend: The Tigers have been favored in 66 games this season, winning 40 (60.6%) of those contests, and in their last 10 games, they have covered the spread 6 times and failed to cover 4 times.
Where can I find AI Picks for Chicago White Sox vs Detroit?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Chicago White Sox vs. Detroit Odds
AI algorithm Remi is pouring through tons of data on each team. In fact, anytime the Chicago White Sox vs Detroit trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme altitude seemingly never follow normal, predictable patterns.
Chicago White Sox vs Detroit Opening Odds
CHW Moneyline:
+179 DET Moneyline: -217
CHW Spread: +1.5
DET Spread: -1.5
Over/Under: 7.5
Chicago White Sox vs Detroit Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 19, 2025 8:04PM EDT
Seattle Mariners
Toronto Blue Jays
10/19/25 8:04PM
Mariners
Blue Jays
|
–
–
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+109
-132
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+1.5 (-194)
-1.5 (+158)
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O 8 (-103)
U 8 (-117)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Chicago White Sox White Sox vs. Detroit Tigers on April 06, 2025 at Comerica Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |