Cardinals vs. Red Sox
Prediction, Odds & Props
Apr 05 | MLB AI Picks

Updated: 2025-04-03T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Boston Red Sox will host the St. Louis Cardinals on April 5, 2025, at Fenway Park, with the first pitch scheduled for 4:10 PM ET. This matchup marks the second game of a three-game interleague series between the two teams.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 05, 2025

Start Time: 4:10 PM EST​

Venue: Fenway Park​

Red Sox Record: (4-4)

Cardinals Record: (4-3)

OPENING ODDS

STL Moneyline: +106

BOS Moneyline: -125

STL Spread: +1.5

BOS Spread: -1.5

Over/Under: 9

STL
Betting Trends

  • The Cardinals have shown a balanced performance against the spread (ATS) early in the season, reflecting their competitive play in both home and away games.

BOS
Betting Trends

  • The Red Sox have had a mixed ATS record, with their performance varying notably between home and away games.

MATCHUP TRENDS

  • The Cardinals have demonstrated resilience in close games, often covering the spread in matchups decided by one or two runs. Conversely, the Red Sox have been more successful ATS when their offense produces higher run totals, indicating a correlation between offensive output and covering the spread.

STL vs. BOS
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: M. Winn over 0.5 Total Bases.

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St. Louis vs Boston Prediction & Odds:
Free MLB Betting Insights for 4/5/25

Saturday’s interleague matchup between the St. Louis Cardinals and the Boston Red Sox at Fenway Park promises to be a compelling contest between two historic franchises looking to gain early momentum in the 2025 season. The Cardinals, off to a solid 3–1 start, are playing efficient, balanced baseball driven by veteran leadership, a reliable rotation, and timely hitting. Meanwhile, the Red Sox come in at 3–4, trying to find consistency following a retooled offseason that brought in key acquisitions like Alex Bregman and Garrett Crochet. Both clubs view this series as a measuring stick—St. Louis, to affirm their resurgence after a disappointing 2024, and Boston, to validate the offseason investments meant to bring them back into contention. With Andre Pallante expected to start for the Cardinals and Richard Fitts getting the ball for the Red Sox in his Fenway debut, the outcome may hinge on whose supporting cast can rise to the moment. The Cardinals’ early-season success can largely be attributed to execution and experience. Offensively, Paul Goldschmidt and Nolan Arenado remain the cornerstones of the lineup, providing both run production and veteran presence. Though neither is off to a red-hot start statistically, their discipline and situational awareness continue to shape the approach of the entire batting order. Around them, the Cardinals have integrated a mix of role players and rising contributors, with hitters like Brendan Donovan and Lars Nootbaar offering on-base ability and clutch contact. St. Louis is also playing with a fundamentally sound style—advancing runners, avoiding base-running mistakes, and capitalizing on scoring opportunities. On the mound, Andre Pallante brings a steady presence. He’s not a strikeout artist, but his ability to generate ground balls and limit walks makes him a reliable starter capable of eating innings and keeping his team in games. He will face a Red Sox lineup that is improving but has not yet fully clicked, making early innings crucial for momentum.

The Red Sox, for their part, are still trying to assemble all their pieces into a cohesive unit. The team made waves in the offseason by acquiring Alex Bregman to bolster the infield and middle of the lineup, adding to a core that includes Rafael Devers and Triston Casas. Devers has shown signs of heating up after a sluggish spring, while Bregman’s experience and plate discipline add a stabilizing factor. However, Boston’s offensive rhythm has yet to settle, and inconsistency with runners in scoring position has cost them winnable games. Richard Fitts, who makes his first home start on Saturday, has shown flashes of promise but also signs of inexperience. His ability to navigate the top of the Cardinals’ order will be critical. The Red Sox bullpen, featuring Tanner Houck and Garrett Whitlock, has been solid in stretches, but has also blown late leads, which adds pressure on the starters to go deeper into games. If Boston’s offense can provide run support early, it would ease the burden on their developing pitching staff. Saturday’s game will likely come down to execution and bullpen reliability. The Cardinals have the advantage of experience and consistency, while the Red Sox are banking on upside and energy from new faces. Defense could also play a key role, with both teams aiming to minimize mistakes and control the tempo of the game. For St. Louis, this is a chance to build on a strong start and send a message that they are back in NL contention. For Boston, it’s an opportunity to turn promise into production and begin reestablishing Fenway as a home-field advantage. Expect a competitive, tightly contested game shaped by veteran savvy, youthful ambition, and pivotal moments in the middle innings.

St. Louis Cardinals MLB Preview

The St. Louis Cardinals enter their April 5, 2025 matchup against the Boston Red Sox at Fenway Park with a clear focus: establish consistency on the road and build momentum early in what they hope will be a bounce-back season. After a disappointing 2023 campaign and an uneven 2024 showing, the Cardinals retooled their roster with modest but strategic changes, aiming to reignite the winning culture that has long defined the franchise. Under the leadership of manager Oliver Marmol, the Cardinals are blending a veteran core with ascending young talent to create a more adaptable and resilient lineup. While their record so far this season has been mixed, St. Louis has shown flashes of the crisp, fundamentally sound baseball that has long been their identity. A victory at Fenway would not only even the series but also give the Cards a confidence boost as they navigate a tough early-season schedule. Andre Pallante takes the hill for the Cardinals, continuing his transition from bullpen workhorse to full-time starter. Pallante has been effective early this season, relying on a low-90s sinker, tight slider, and an emerging changeup to keep hitters off balance. What he lacks in velocity, he makes up for in movement, pitch efficiency, and the ability to induce ground balls. That profile plays especially well at hitter-friendly Fenway Park, where minimizing elevation and avoiding barrels is key to limiting damage. Pallante will need to stay ahead in counts and be particularly sharp against left-handed hitters like Rafael Devers, who thrives on mistake pitches over the plate. The Cardinals’ infield defense, anchored by Gold Glove third baseman Nolan Arenado, will be pivotal in turning those grounders into outs and keeping Pallante’s pitch count in check.

The Cardinals’ offense, while not overwhelming, is one of the more fundamentally sound lineups in the National League. Nolan Arenado remains the team’s centerpiece, offering elite defense and a consistent offensive approach that includes power, situational hitting, and leadership. Lars Nootbaar has become a key spark in the top half of the order, bringing plate discipline, energy, and surprising pop. The development of young players like Jordan Walker and Masyn Winn adds athleticism and long-term upside, though both are still finding consistency at the plate. The biggest key for the Cardinals offensively is timely execution. Too often in 2024, the team faltered with runners in scoring position, and reversing that trend is a major point of emphasis. Against Boston’s starter Richard Fitts—a young, promising righty still getting acclimated to the majors—St. Louis will aim to grind at-bats, force elevated pitch counts, and take advantage of fastballs early in the count. Defensively, the Cardinals continue to be one of the most technically proficient teams in baseball. Arenado and Tommy Edman provide elite glove work on the infield, while the outfield—featuring Nootbaar and Dylan Carlson—offers range and reliable arms. The bullpen, anchored by fireballer Ryan Helsley and middle-inning options like Giovanny Gallegos and Zack Thompson, gives the Cardinals flexibility in close games. If Pallante can hand off a lead, the bullpen is more than capable of securing the win. St. Louis will need all phases to click against a Red Sox team that can score in bunches at home. But if the Cardinals can pair Pallante’s efficiency with strong defense and timely offense, they stand a strong chance of walking away with a key road win and continuing to build a competitive identity early in the 2025 season.

The Boston Red Sox will host the St. Louis Cardinals on April 5, 2025, at Fenway Park, with the first pitch scheduled for 4:10 PM ET. This matchup marks the second game of a three-game interleague series between the two teams. St. Louis vs Boston AI Prediction: Free MLB Betting Insights for Apr 05. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Boston Red Sox MLB Preview

The Boston Red Sox return to Fenway Park on April 5, 2025, for a high-profile interleague clash with the St. Louis Cardinals, seeking to gain traction after an uneven start to their season. Following a major offseason overhaul that saw the arrivals of Walker Buehler, Garrett Crochet, and Alex Bregman, Boston has signaled its commitment to contending once again in the AL East. However, translating those bold moves into consistent wins has proven to be a challenge in the early going. The Red Sox currently sit around the .500 mark and are looking to capitalize on their home-field advantage at Fenway to ignite their season. Saturday’s game against the Cardinals represents more than just another outing—it’s a pivotal opportunity for Boston to show they can execute cohesively as a new-look team against a playoff-tested National League opponent. Richard Fitts, the young right-hander acquired from the Yankees as part of the Alex Verdugo trade, is expected to take the mound for Boston. Fitts brings with him a high ceiling and the potential to develop into a steady mid-rotation starter. While his early outings have shown promise—highlighted by solid command and a developing curveball—he has also shown the inconsistency typical of young arms adjusting to major league lineups. Facing a Cardinals team that relies on smart situational hitting and veterans like Nolan Arenado, Fitts will need to be sharp, particularly with his fastball command and ability to stay ahead in counts. Boston’s bullpen, meanwhile, has been somewhat unpredictable early in the season.

With key arms like Tanner Houck, Aroldis Chapman, and Josh Winckowski in the late-inning mix, the Red Sox have options, but their effectiveness hinges on matchups and clean defense behind them. A quality start from Fitts will go a long way in stabilizing the game plan and keeping high-leverage arms fresh. Offensively, the Red Sox have the firepower to put up big innings, but consistency has been elusive. Rafael Devers remains the anchor of the lineup, combining power and bat speed that make him a threat in every plate appearance. The acquisition of Alex Bregman has added depth and a cerebral presence to the batting order, though he is still finding his rhythm with his new team. Emerging prospects like Roman Anthony and Kristian Campbell have added youthful energy, while Jarren Duran’s speed continues to disrupt opposing pitchers. Boston’s offensive blueprint involves a balance of patience, power, and aggressiveness on the basepaths, but execution has varied from game to game. Against Cardinals starter Andre Pallante, a contact-oriented pitcher who excels at keeping the ball on the ground, the Red Sox will need to avoid chasing early in counts and look to drive the ball into Fenway’s spacious gaps. Timely hitting will be especially crucial if the game remains tight late into the contest. Defensively, Boston is still meshing as a unit, particularly on the infield where Bregman and Trevor Story are developing chemistry on the left side. Mistakes have been costly in several early losses, and sharper execution will be necessary against a Cardinals team that capitalizes on errors. In the outfield, Duran and Wilyer Abreu have shown flashes of elite range, and their ability to cut off extra-base hits will be vital. Saturday’s matchup is a chance for the Red Sox to align talent with performance, defend home turf, and send a message that they’re more than just an offseason headline—they’re a legitimate force in the AL, capable of beating tough competition and climbing the standings with purpose.

St. Louis vs. Boston Prop Picks (AI)

Remi is pouring through loads of data on each line. In fact, anytime the Cardinals and Red Sox play there’s always several intriguing trends to key in on. Not to mention games played at Fenway Park in Apr can often follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: M. Winn over 0.5 Total Bases.

St. Louis vs. Boston Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over millions of data from every facet between the Cardinals and Red Sox and using recursive machine learning and industry leading AI to examine the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most watching on the growing weight emotional bettors often put on coaching factors between a Cardinals team going up against a possibly unhealthy Red Sox team. Trends look to say the true game analytics might reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI St. Louis vs Boston picks, computer picks Cardinals vs Red Sox, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Cardinals Betting Trends

The Cardinals have shown a balanced performance against the spread (ATS) early in the season, reflecting their competitive play in both home and away games.

Red Sox Betting Trends

The Red Sox have had a mixed ATS record, with their performance varying notably between home and away games.

Cardinals vs. Red Sox Matchup Trends

The Cardinals have demonstrated resilience in close games, often covering the spread in matchups decided by one or two runs. Conversely, the Red Sox have been more successful ATS when their offense produces higher run totals, indicating a correlation between offensive output and covering the spread.

St. Louis vs. Boston Game Info

St. Louis vs Boston starts on April 05, 2025 at 4:10 PM EST.

Spread: Boston -1.5
Moneyline: St. Louis +106, Boston -125
Over/Under: 9

St. Louis: (4-3)  |  Boston: (4-4)

Remi's searched hard and found the best prop for this matchup: M. Winn over 0.5 Total Bases.. Prices move—always shop for the best number.

The Cardinals have demonstrated resilience in close games, often covering the spread in matchups decided by one or two runs. Conversely, the Red Sox have been more successful ATS when their offense produces higher run totals, indicating a correlation between offensive output and covering the spread.

STL trend: The Cardinals have shown a balanced performance against the spread (ATS) early in the season, reflecting their competitive play in both home and away games.

BOS trend: The Red Sox have had a mixed ATS record, with their performance varying notably between home and away games.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

St. Louis vs. Boston Odds

AI algorithm Remi is pouring through tons of data on each team. In fact, anytime the St. Louis vs Boston trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance almost always follow normal, predictable patterns.

St. Louis vs Boston Opening Odds

STL Moneyline: +106
BOS Moneyline: -125
STL Spread: +1.5
BOS Spread: -1.5
Over/Under: 9

St. Louis vs Boston Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-180
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+125
-150
+1.5 (-180)
-1.5 (+150)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+145
-175
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-195)
-1.5 (+160)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+105
-125
+1.5 (-205)
-1.5 (+170)
O 7.5 (+105)
U 7.5 (-125)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers St. Louis Cardinals vs. Boston Red Sox on April 05, 2025 at Fenway Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN