Mariners vs Giants Prediction — AI Finds CAN'T MISS MLB Lines & Props (Apr 05)

Updated: 2025-04-03T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

On April 5, 2025, the Seattle Mariners will face the San Francisco Giants at Oracle Park in San Francisco, California, with the first pitch scheduled for 9:05 PM ET. This interleague matchup features two teams with contrasting starts to their seasons: the Mariners aiming to reach a .500 record and the Giants looking to extend their impressive early-season form.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 05, 2025

Start Time: 9:05 PM EST​

Venue: Oracle Park​

Giants Record: (6-1)

Mariners Record: (3-5)

OPENING ODDS

SEA Moneyline: +110

SF Moneyline: -129

SEA Spread: +1.5

SF Spread: -1.5

Over/Under: 7.5

SEA
Betting Trends

  • The Mariners have had a mixed start to the season, with a 3-4 record. Specific against the spread (ATS) statistics for the Mariners are not readily available.

SF
Betting Trends

  • The Giants have started the season strongly with a 5-1 record. Detailed ATS statistics for the Giants are also not readily accessible.

MATCHUP TRENDS

  • Given the Giants’ strong start and home-field advantage, they may be favored in this matchup. Bettors should consider the overall performance and recent momentum of both teams when evaluating this game.

SEA vs. SF
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: C. Raleigh over 0.5 Total Bases.

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Seattle vs San Francisco Prediction & Odds:
Free MLB Betting Insights for 4/5/25

Saturday’s interleague matchup between the Seattle Mariners and the San Francisco Giants at Oracle Park sets up as an exciting West Coast showdown between two teams on very different trajectories to start the 2025 season. The Giants have opened with a blistering 5–1 record, feeding off a potent combination of timely hitting, improved pitching, and steady defense under new leadership. In contrast, the Mariners sit at 3–4, trying to stabilize after a rocky start that’s seen them struggle to find consistent offense and close out close games. This matchup features two intriguing starters in Bryan Woo for Seattle, a Bay Area native and lifelong Giants fan, and Robbie Ray for San Francisco, a veteran who has introduced a new changeup to his arsenal this season in an effort to reinvent his effectiveness on the mound. With both clubs boasting dynamic players and strong pitching potential, this game could easily come down to the bullpens, timely hitting, and a few defensive plays that tip the balance. The San Francisco Giants are enjoying a strong start to 2025 and appear poised to be early contenders in the National League West. Their success so far has been built on a mix of veteran leadership and younger contributors stepping up at key moments. One of the key offseason acquisitions, shortstop Willy Adames, has already delivered high-impact performances—none bigger than his walk-off hit against the Dodgers earlier in the week. Matt Chapman has also provided steady contributions, both at the plate and with his glove at third base, helping to lock down the left side of the infield. Behind the plate, catcher Patrick Bailey has been exceptional in handling the pitching staff and controlling the running game. On the mound, Robbie Ray brings experience and firepower, and his addition of a changeup could be a major asset against Seattle’s predominantly right-handed lineup.

The bullpen has been a steadying force as well, with relievers consistently bridging the gap between starters and closer. Defensively, the Giants are solid, and Oracle Park’s outfield size demands athleticism and precise positioning—qualities this team has handled well so far. With strong momentum and the comfort of playing at home, the Giants will look to extend their win streak and reinforce their place atop the standings. For the Mariners, the season has begun with mixed results. They’ve shown flashes of the talent that propelled them into contention in recent years, but offensive inconsistency and bullpen issues have kept them from capitalizing on early opportunities. Bryan Woo, their young starter, adds an emotional layer to this game. A Bay Area native who grew up a Giants fan, Woo now has a chance to shine in his hometown and show off the command and poise that earned him a spot in the rotation. Seattle’s offense is anchored by Julio Rodríguez, who remains one of the most exciting young players in baseball thanks to his combination of power, speed, and defensive range. He’s joined by Randy Arozarena, whose presence as a new offensive weapon has already paid dividends in clutch situations. However, the Mariners have struggled to string together runs, often relying too heavily on solo homers or extra-base hits without consistently advancing runners. The bullpen has also been a concern, with blown leads and late-inning walks costing the team dearly in a couple of early losses. Manager Scott Servais will be looking for better execution in situational hitting and a tighter effort from the relievers if Seattle hopes to steal a road win against one of the hottest teams in baseball. This game represents not only a potential turning point for the Mariners’ confidence but also a measuring stick against a Giants team that’s clicking on all cylinders.

Seattle Mariners MLB Preview

The Seattle Mariners enter Saturday’s interleague tilt against the San Francisco Giants with a 3–4 record and a growing sense of urgency to find their rhythm early in the 2025 campaign. Despite featuring a talented and athletic roster, the team has struggled with offensive consistency and late-inning execution—issues that have cost them winnable games through the season’s opening stretch. This matchup against a surging Giants club presents both a challenge and an opportunity: a chance to reset their momentum against a quality opponent while also giving promising young right-hander Bryan Woo a spotlight start in his hometown. Woo, who grew up a fan of the Giants in the Bay Area, will be taking the mound in familiar territory and is expected to channel that emotional backdrop into a poised and competitive performance. His ability to attack the strike zone and avoid early damage will be key in keeping the Mariners in the game long enough for their offense to potentially break through. Offensively, Seattle remains anchored by center fielder Julio Rodríguez, whose tools and tenacity make him the heartbeat of the team. While he hasn’t erupted statistically yet in 2025, Rodríguez’s combination of speed, power, and defense continues to impact games in ways that don’t always show up in the box score. Batting alongside him, Randy Arozarena brings postseason swagger and run-producing ability, having already delivered in key moments this season. The rest of the lineup, however, has been hit or miss—capable of big innings when locked in, but prone to long stretches of low-contact at-bats and stranded baserunners.

The Mariners’ coaching staff has emphasized situational hitting and plate discipline in recent practices, knowing full well that stringing together professional at-bats is the key to breaking their early-season funk. Seattle has power, no doubt—but without consistent contact and execution with runners in scoring position, that power has been too often wasted. On the defensive side, the Mariners remain one of the more underrated fielding units in baseball. Rodríguez patrols center with Gold Glove-caliber range and instincts, while the infield—particularly shortstop J.P. Crawford and third baseman Eugenio Suárez—has turned in several highlight-reel plays through the season’s first week. However, their bullpen has been a source of growing concern. Multiple leads have slipped away late in games, and the bridge from the starters to the back-end arms hasn’t been as solid as expected. Closer Andrés Muñoz has shown flashes of dominance, but setup relievers have been inconsistent in command and pitch selection. Against a Giants team that thrives on manufacturing runs and taking advantage of mistakes, Seattle’s relievers must limit walks and stay ahead in counts to avoid falling into the same late-inning trap. For the Mariners, this game is more than a road test—it’s a pivotal chance to establish consistency and show they can win close games against top-tier opposition. If Woo can keep them in it early and the bats deliver situationally, Seattle has the tools to pull off a much-needed win.

On April 5, 2025, the Seattle Mariners will face the San Francisco Giants at Oracle Park in San Francisco, California, with the first pitch scheduled for 9:05 PM ET. This interleague matchup features two teams with contrasting starts to their seasons: the Mariners aiming to reach a .500 record and the Giants looking to extend their impressive early-season form. Seattle vs San Francisco AI Prediction: Free MLB Betting Insights for Apr 05. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

San Francisco Giants MLB Preview

The San Francisco Giants enter Saturday’s game against the Seattle Mariners riding a wave of early-season momentum. With a 5–1 record, they’ve surged to a commanding start in the National League West and are beginning to show signs that their offseason retooling and renewed front-office direction are paying off. Buster Posey’s expanded leadership role has coincided with a noticeable shift in energy and player focus throughout the clubhouse, while new acquisitions like Willy Adames have already made significant contributions. Adames, who signed a multi-year deal to bolster the Giants’ infield and provide offensive punch, has proven his value early with key at-bats and late-game heroics—his walk-off hit against the Dodgers being a defining moment in the first week of the season. With Oracle Park buzzing and the roster clicking, the Giants are proving to be more than just an improved team—they’re a dangerous one. One of the most anticipated developments heading into this game is Robbie Ray’s start. After recovering from injury and adapting his approach on the mound, Ray has introduced a new changeup into his pitch mix. Designed to keep right-handed hitters honest, the changeup adds a wrinkle to his already formidable fastball-slider combination. His ability to command all three pitches and maintain composure deep into starts could be a key difference-maker against Seattle’s top-heavy lineup. Behind him, the Giants have leaned on a consistent bullpen that includes both power arms and versatile relievers capable of handling high-leverage situations.

This group has kept opponents at bay late in games and preserved slim leads—something that has elevated the team in close contests so far this season. Their ability to complement Ray’s start and close out innings could be crucial against a Mariners team that tends to rely on explosive bursts of offense. Offensively, San Francisco has found balance and depth. Alongside Adames, third baseman Matt Chapman has added both defensive flair and timely offense, helping stabilize the infield and keep innings alive with clutch hits. Patrick Bailey, behind the plate, continues to shine defensively with elite framing, quick release times, and chemistry with the pitching staff. In the outfield, young players like Heliot Ramos are beginning to carve out meaningful roles, and veteran bats have provided enough production to keep pressure on opposing pitchers throughout the lineup. The Giants’ ability to manufacture runs—through situational hitting, aggressive base running, and defensive pressure—has been one of their most defining characteristics in this strong start. With home-field advantage, a steady starting arm, and a team playing unified baseball, the Giants enter this game with confidence and the clear expectation to extend their winning streak. They’ll look to strike early, maintain sharp defensive discipline, and let their improved pitching core carry them late into the game as they continue asserting themselves as legitimate contenders.

Seattle vs. San Francisco Prop Picks (AI)

AI algorithm Remi is pouring through tons of data on each team. In fact, anytime the Mariners and Giants play there’s always several intriguing observations to key in on. Not to mention games played at Oracle Park in Apr seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: C. Raleigh over 0.5 Total Bases.

Seattle vs. San Francisco Prediction (AI)

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Remi, our AI sports wizard, has been pouring over mountains of data from every simulation between the Mariners and Giants and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most fixated on the growing weight human bettors often put on Seattle’s strength factors between a Mariners team going up against a possibly improved Giants team. We’ve found the true game analytics appear to reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Seattle vs San Francisco picks, computer picks Mariners vs Giants, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Mariners Betting Trends

The Mariners have had a mixed start to the season, with a 3-4 record. Specific against the spread (ATS) statistics for the Mariners are not readily available.

Giants Betting Trends

The Giants have started the season strongly with a 5-1 record. Detailed ATS statistics for the Giants are also not readily accessible.

Mariners vs. Giants Matchup Trends

Given the Giants’ strong start and home-field advantage, they may be favored in this matchup. Bettors should consider the overall performance and recent momentum of both teams when evaluating this game.

Seattle vs. San Francisco Game Info

Seattle vs San Francisco starts on April 05, 2025 at 9:05 PM EST.

Spread: San Francisco -1.5
Moneyline: Seattle +110, San Francisco -129
Over/Under: 7.5

Seattle: (3-5)  |  San Francisco: (6-1)

Remi's searched hard and found the best prop for this matchup: C. Raleigh over 0.5 Total Bases.. Prices move—always shop for the best number.

Given the Giants’ strong start and home-field advantage, they may be favored in this matchup. Bettors should consider the overall performance and recent momentum of both teams when evaluating this game.

SEA trend: The Mariners have had a mixed start to the season, with a 3-4 record. Specific against the spread (ATS) statistics for the Mariners are not readily available.

SF trend: The Giants have started the season strongly with a 5-1 record. Detailed ATS statistics for the Giants are also not readily accessible.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Seattle vs. San Francisco Odds

AI algorithm Remi is pouring through mountains of data points on each team. In fact, anytime the Seattle vs San Francisco trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable patterns.

Seattle vs San Francisco Opening Odds

SEA Moneyline: +110
SF Moneyline: -129
SEA Spread: +1.5
SF Spread: -1.5
Over/Under: 7.5

Seattle vs San Francisco Live Odds

Games PTS ML SPR O/U
Oct 19, 2025 8:04PM EDT
Seattle Mariners
Toronto Blue Jays
10/19/25 8:04PM
Mariners
Blue Jays
+105
-125
+1.5 (-205)
-1.5 (+170)
O 7.5 (-115)
U 7.5 (-105)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Seattle Mariners vs. San Francisco Giants on April 05, 2025 at Oracle Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TOR@SEA OVER 7 54.9% 3 WIN
LAD@MIL UNDER 7.5 56.6% 6 WIN
TOR@NYY OVER 8 54.9% 4 WIN
TOR@NYY CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED 53.3% 3 WIN
NYY@TOR OVER 7.5 54.8% 2 WIN
LAD@PHI OVER 7 53.8% 3 WIN
SD@CHC CHC -109 53.8% 3 WIN
SD@CHC OVER 7.5 54.5% 4 LOSS
SD@CHC CHC -111 54.8% 4 LOSS
CIN@LAD SHOHEI OHTANI OVER 1.5 BASES 53.5% 3 WIN
BOS@NYY OVER 7 53.8% 3 LOSS
CIN@LAD ELLY DE LA CRUZ OVER 0.5 BASES 54.4% 4 LOSS
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN