White Sox vs Tigers Prediction — AI Finds CAN'T MISS MLB Lines & Props (Apr 05)

Updated: 2025-04-03T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Chicago White Sox are set to face the Detroit Tigers on April 5, 2025, at Comerica Park in Detroit, Michigan. This American League Central matchup features two teams aiming to improve their standings early in the season.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 05, 2025

Start Time: 1:10 PM EST​

Venue: Comerica Park​

Tigers Record: (3-4)

White Sox Record: (2-5)

OPENING ODDS

CHW Moneyline: +183

DET Moneyline: -222

CHW Spread: +1.5

DET Spread: -1.5

Over/Under: 7.5

CHW
Betting Trends

  • As of April 5, 2025, the Chicago White Sox have an Against The Spread (ATS) record of 2-0-0, indicating they have covered the spread in both of their games this season.

DET
Betting Trends

  • The Detroit Tigers currently hold an ATS record of 0-1, suggesting they failed to cover the spread in their only game this season.

MATCHUP TRENDS

  • In their recent head-to-head matchups during the 2024 season, the Tigers and White Sox had varying results. For instance, on September 27, 2024, the Tigers were favored with a moneyline of -200, and they won the game 4-1, covering the spread. Conversely, on September 28, 2024, the Tigers were again favored with a moneyline of -225 but lost 4-0 to the White Sox, failing to cover.

CHW vs. DET
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: L. Robert over 0.5 Total Bases.

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Chicago White Sox vs Detroit Prediction & Odds:
Free MLB Betting Insights for 4/5/25

Saturday’s American League Central showdown between the Chicago White Sox and the Detroit Tigers at Comerica Park serves as an early-season litmus test for two teams trending in vastly different directions. The White Sox have stumbled out of the gate in 2025, continuing the struggles that plagued them at the end of last season, including a frustrating inability to produce runs or string together quality at-bats. Meanwhile, the Tigers have emerged from their own rebuild with renewed energy and are enjoying one of their more encouraging starts in recent memory. Detroit has taken 15 of the last 24 meetings between these two clubs, and with home-field advantage and pitching momentum on their side, they enter this game as slight favorites. With Jack Flaherty set to take the mound for the Tigers against Jonathan Cannon for the White Sox, the matchup features a contrast between a seasoned veteran trying to anchor his team’s resurgence and a younger arm searching for confidence amidst inconsistency. For the White Sox, this matchup arrives at a critical time. Their 3–17 record over their last 20 games against American League opponents illustrates the depth of their current struggles, particularly when it comes to generating offense. Jonathan Cannon showed promise in his last start, tossing five scoreless innings and striking out five while limiting opposing hitters to just four hits and three walks. However, the lack of run support once again loomed large, a recurring theme in a lineup that has failed to consistently drive in runners in scoring position. Key hitters like Eloy Jiménez, Andrew Vaughn, and Yoán Moncada have not delivered the impact expected, leaving the team too reliant on sporadic solo homers and occasional late-inning rallies. Cannon’s approach—throwing first-pitch strikes and working efficiently through the order—gives Chicago a chance to stay competitive, but the margin for error is thin. The bullpen has also been unreliable, with blown saves and inherited runners scoring at an alarming rate. To stay in this game, the White Sox need timely hitting, tighter defensive execution, and aggressive base running—areas where they’ve lagged thus far. Against a confident Tigers squad, anything short of a near-flawless effort could send them further into their early-season hole. Detroit, on the other hand, appears to be playing with renewed purpose.

At 4–3 on the year, the Tigers have already picked up a series win over the Seattle Mariners and will look to build off that momentum against a division rival they’ve handled well in recent years. Jack Flaherty, making his second start of the season, delivered a solid first outing with 5.2 innings pitched, five strikeouts, and just two earned runs allowed on three hits. The Tigers are optimistic that Flaherty, now fully healthy, can reclaim the form that made him a breakout ace in St. Louis a few years ago. At the plate, Detroit is benefiting from standout performances by Riley Greene, who went 5-for-13 with two home runs and two doubles in his last series, and Spencer Torkelson, who’s showing signs of becoming the middle-of-the-order threat the club envisioned. Injuries to Gleyber Torres and Matt Vierling have thinned the lower half of the lineup, but the Tigers’ improved plate discipline and situational hitting have helped offset that. Defensively, they’ve been sharp, with strong fundamentals and few mental lapses. Manager A.J. Hinch has shown confidence in his bullpen, rotating relievers effectively in close games and managing pitch counts wisely. Against a sputtering White Sox team, Detroit has an opportunity not only to secure a series win but to continue building a competitive rhythm that could make them a dark horse in the AL Central. Overall, this matchup features two teams in contrasting phases of their development. The White Sox are searching for answers amid lineup underperformance and mounting pressure, while the Tigers appear to be coalescing around their young core and new acquisitions. The outcome of this game could hinge on whether the White Sox can finally string together offensive production to back another promising start from Cannon—or if the Tigers, behind a steady Flaherty and timely hitting, can continue to assert themselves as a rising threat in the division. With early-season momentum and morale on the line, Saturday’s clash offers far more than just a notch in the standings—it could serve as a turning point for both clubs.

Chicago White Sox White Sox MLB Preview

The Chicago White Sox travel to Comerica Park to face the Detroit Tigers on April 5, 2025, with cautious optimism and a desire to continue shaking off the shadows of a disappointing 2024 season. After an offseason focused on refining fundamentals, developing young talent, and building around a leaner, more versatile roster, the White Sox have started the new campaign on the right foot with a 2-0 record both straight up and against the spread (ATS). While it’s still early, the signs point toward a group more disciplined at the plate, more focused on defense, and more consistent on the mound. With an American League Central that remains wide open in the early stages, Chicago knows every divisional matchup matters—especially against a Tigers team that has been trying to climb back into contention in similar fashion. For the White Sox, this road game is an opportunity not only to maintain their momentum but to make an early statement that they are not the same team that underperformed last year. Jonathan Cannon will take the hill for the White Sox, making his second appearance of the season after a very promising debut in which he tossed five scoreless innings. The right-hander displayed poise beyond his years in that outing, using a mix of fastballs, sliders, and changeups to induce weak contact while limiting free passes. Though Cannon is still developing into a full-time starter, early flashes suggest he has the mental makeup and control to hold down a mid-rotation role. He’ll be tasked with neutralizing a Tigers lineup that includes heavy hitters like Spencer Torkelson and Riley Greene, both of whom can punish mistakes over the plate. Cannon’s key to success will be working ahead in counts, keeping the ball down in the zone, and not letting Detroit’s more dangerous hitters beat him early in at-bats.

If he can get through the lineup twice with minimal damage, the bullpen—featuring Gregory Santos, Aaron Bummer, and José Ruiz—should be able to close the door. Offensively, the White Sox are relying on the emergence of a few key bats to sustain early-season energy. Andrew Vaughn has stepped into a leadership role in the lineup, bringing a balanced approach and the ability to hit to all fields. Luis Robert Jr., the club’s most explosive player, remains a constant threat with his ability to turn any pitch into an extra-base hit. The team’s approach at the plate has looked more deliberate, with fewer strikeouts and better situational hitting—two areas that were glaring weaknesses in 2024. The bottom of the order, featuring players like Oscar Colás and Braden Shewmake, will need to contribute consistently if the White Sox are to extend rallies and wear down opposing starters like Jack Flaherty. Defensively, the White Sox have placed a renewed emphasis on fundamentals. With cleaner infield coordination and more aggressive outfield play, the early signs suggest a unit that’s committed to reducing unearned runs and converting outs more efficiently. Manager Pedro Grifol’s influence is becoming more visible, particularly in how the team manages tight games and executes small-ball strategies. While the season is still young, road games like this will define whether Chicago’s improvements are sustainable or simply a short-term surge. A win in Detroit would not only validate their approach but help solidify the identity of a team looking to re-establish itself as a playoff contender.

The Chicago White Sox are set to face the Detroit Tigers on April 5, 2025, at Comerica Park in Detroit, Michigan. This American League Central matchup features two teams aiming to improve their standings early in the season. Chicago White Sox vs Detroit AI Prediction: Free MLB Betting Insights for Apr 05. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Detroit Tigers MLB Preview

The Detroit Tigers enter their April 5, 2025 matchup against the Chicago White Sox at Comerica Park looking to recover from an early stumble and assert themselves as a contender in the American League Central. With a 1-1 start to the season and a 0-1 ATS record, the Tigers have shown flashes of promise but also areas of concern that need immediate attention. Playing at home provides a key opportunity to build momentum and set the tone for a long season ahead. After narrowly missing postseason contention in 2024, Detroit made offseason moves to bolster both their rotation and lineup. With young core pieces maturing and veteran leadership in place, the Tigers believe they’re positioned to take the next step. However, games against divisional opponents like the White Sox carry added weight, as early wins could be crucial when standings tighten later in the year. Starting pitcher Jack Flaherty will be tasked with setting the tone on the mound for the Tigers. Signed in the offseason to add veteran stability to the rotation, Flaherty made his Detroit debut earlier this week with a solid outing—tossing 5 2/3 innings, allowing two runs, and striking out five. His ability to mix speeds and change eye levels makes him a challenging opponent, particularly for aggressive lineups like Chicago’s. The key for Flaherty will be command; when he’s locating his fastball and staying ahead in counts, he limits damage and induces soft contact. However, inconsistency has crept into his game in recent seasons, and the Tigers need him to emerge as a dependable presence in the rotation. Against a White Sox team that can generate offense quickly through their top order, Flaherty’s early innings will be especially critical.

Offensively, Detroit will look to capitalize on Spencer Torkelson’s hot start. Torkelson, coming off a breakout 2024 season, continues to showcase power and improved plate discipline, already batting .340 with five home runs to his name. Alongside him, Riley Greene provides a dynamic spark with his left-handed bat and speed on the basepaths. The middle of the Tigers’ order has shown the ability to create scoring opportunities, but the bottom half has been inconsistent—a trend that dates back to last season. For Detroit to break games open and put pressure on opposing pitchers, they’ll need greater production from the likes of Matt Vierling and Andy Ibáñez. Manager A.J. Hinch has emphasized a more aggressive offensive philosophy this season, and executing that vision will require patience at the plate, timely base running, and capitalizing on mistakes. Defensively, the Tigers have looked sharper in the early going, particularly in the infield where improved chemistry between Javier Báez and Colt Keith has been noticeable. The outfield, anchored by Greene and Parker Meadows, boasts good range and arm strength, which could prove vital against a White Sox team that thrives on extra-base hits. Detroit’s bullpen, an area of concern in past seasons, has performed admirably so far, with relievers like Shelby Miller and Tyler Holton providing crucial outs in the later innings. If the Tigers can receive a strong start from Flaherty, limit defensive miscues, and get production throughout the lineup, they’ll have a solid chance to earn a statement win at home. This early-season contest presents an important litmus test for a team that believes it’s ready to compete—not just against the White Sox, but in the broader playoff picture.

Chicago White Sox vs. Detroit Prop Picks (AI)

AI algorithm Remi is pouring through loads of datapoints on each line. In fact, anytime the White Sox and Tigers play there’s always several intriguing trends to key in on. Not to mention games played at Comerica Park in Apr almost always follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: L. Robert over 0.5 Total Bases.

Chicago White Sox vs. Detroit Prediction (AI)

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Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every past game between the White Sox and Tigers and using recursive machine learning and industry leading AI to examine the data to a single cover probability.

Interestingly enough, the data has been most focused on the trending weight human bettors regularly put on Chicago White Sox’s strength factors between a White Sox team going up against a possibly improved Tigers team. Trends look to say the true game analytics might reflect a moderate lean against one Vegas line in particular.

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Below is our current AI Chicago White Sox vs Detroit picks, computer picks White Sox vs Tigers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

White Sox Betting Trends

As of April 5, 2025, the Chicago White Sox have an Against The Spread (ATS) record of 2-0-0, indicating they have covered the spread in both of their games this season.

Tigers Betting Trends

The Detroit Tigers currently hold an ATS record of 0-1, suggesting they failed to cover the spread in their only game this season.

White Sox vs. Tigers Matchup Trends

In their recent head-to-head matchups during the 2024 season, the Tigers and White Sox had varying results. For instance, on September 27, 2024, the Tigers were favored with a moneyline of -200, and they won the game 4-1, covering the spread. Conversely, on September 28, 2024, the Tigers were again favored with a moneyline of -225 but lost 4-0 to the White Sox, failing to cover.

Chicago White Sox vs. Detroit Game Info

Chicago White Sox vs Detroit starts on April 05, 2025 at 1:10 PM EST.

Spread: Detroit -1.5
Moneyline: Chicago White Sox +183, Detroit -222
Over/Under: 7.5

Chicago White Sox: (2-5)  |  Detroit: (3-4)

Remi's searched hard and found the best prop for this matchup: L. Robert over 0.5 Total Bases.. Prices move—always shop for the best number.

In their recent head-to-head matchups during the 2024 season, the Tigers and White Sox had varying results. For instance, on September 27, 2024, the Tigers were favored with a moneyline of -200, and they won the game 4-1, covering the spread. Conversely, on September 28, 2024, the Tigers were again favored with a moneyline of -225 but lost 4-0 to the White Sox, failing to cover.

CHW trend: As of April 5, 2025, the Chicago White Sox have an Against The Spread (ATS) record of 2-0-0, indicating they have covered the spread in both of their games this season.

DET trend: The Detroit Tigers currently hold an ATS record of 0-1, suggesting they failed to cover the spread in their only game this season.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Chicago White Sox vs. Detroit Odds

AI algorithm Remi is pouring through mountains of stats on each team. In fact, anytime the Chicago White Sox vs Detroit trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude almost always follow normal, predictable patterns.

Chicago White Sox vs Detroit Opening Odds

CHW Moneyline: +183
DET Moneyline: -222
CHW Spread: +1.5
DET Spread: -1.5
Over/Under: 7.5

Chicago White Sox vs Detroit Live Odds

Games PTS ML SPR O/U
Oct 19, 2025 8:04PM EDT
Seattle Mariners
Toronto Blue Jays
10/19/25 8:04PM
Mariners
Blue Jays
+112
-123
+1.5 (-195)
-1.5 (+171)
O 7.5 (-114)
U 7.5 (-101)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Chicago White Sox White Sox vs. Detroit Tigers on April 05, 2025 at Comerica Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TOR@SEA OVER 7 54.9% 3 WIN
LAD@MIL UNDER 7.5 56.6% 6 WIN
TOR@NYY OVER 8 54.9% 4 WIN
TOR@NYY CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED 53.3% 3 WIN
NYY@TOR OVER 7.5 54.8% 2 WIN
LAD@PHI OVER 7 53.8% 3 WIN
SD@CHC CHC -109 53.8% 3 WIN
SD@CHC OVER 7.5 54.5% 4 LOSS
SD@CHC CHC -111 54.8% 4 LOSS
CIN@LAD SHOHEI OHTANI OVER 1.5 BASES 53.5% 3 WIN
BOS@NYY OVER 7 53.8% 3 LOSS
CIN@LAD ELLY DE LA CRUZ OVER 0.5 BASES 54.4% 4 LOSS
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN