Mariners vs. Giants
Prediction, Odds & Props
Apr 04 | MLB AI Picks

Updated: 2025-04-02T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The San Francisco Giants will host the Seattle Mariners at Oracle Park on April 4, 2025, marking the Giants’ home opener for the season. Both teams aim to establish early momentum in this interleague matchup.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 04, 2025

Start Time: 4:35 PM EST​

Venue: Oracle Park​

Giants Record: (5-1)

Mariners Record: (3-4)

OPENING ODDS

SEA Moneyline: +123

SF Moneyline: -148

SEA Spread: +1.5

SF Spread: -1.5

Over/Under: 8

SEA
Betting Trends

  • The Mariners have covered the spread in 64 out of 110 games where they were listed as the moneyline favorite in the previous season, reflecting a 58.2% success rate.

SF
Betting Trends

  • The Giants have demonstrated a strong performance against the spread, covering in 78 out of 162 games last season, indicating a 48.1% success rate.

MATCHUP TRENDS

  • The Giants are favored with a moneyline of -148, while the Mariners are at +123, suggesting a competitive matchup. The over/under for the game is set at 8 runs, indicating expectations of moderate scoring.

SEA vs. SF
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: C. Raleigh over 05. total Bases.

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Seattle vs San Francisco Prediction & Odds:
Free MLB Betting Insights for 4/4/25

As the San Francisco Giants return to Oracle Park for their highly anticipated home opener, they’ll be facing off against a Seattle Mariners team still navigating early-season inconsistency but brimming with youthful talent. This interleague clash on April 4 sets up a compelling contrast in roster construction, culture, and organizational goals. The Giants are leaning on experience—none more symbolic than 41-year-old Justin Verlander getting the Opening Day nod—while the Mariners continue to lean into development and upside, with young right-hander Bryce Miller set to take the ball for the visitors. Both teams are coming off seasons that saw them fall just shy of the postseason, and both enter 2025 with plenty to prove. With fan energy pulsing through Oracle Park and two teams with postseason aspirations squaring off, this matchup feels like more than just another early April game—it’s a tone-setter for two squads searching for identity and momentum. For San Francisco, the offseason brought change at the top with franchise icon Buster Posey returning as team president. The front office responded by signing shortstop Willy Adames to a seven-year, $182 million deal, a clear signal that the Giants aren’t content to merely tread water. Adames brings much-needed defense to the middle infield, as well as power potential in a lineup that struggled to generate consistent offense last season. The Giants hit just .239 as a team in 2024 and often relied too heavily on the long ball to manufacture runs. This season, they hope for a more balanced offensive approach.

That starts with table-setters like Thairo Estrada and continues with veteran bats like Michael Conforto and Mike Yastrzemski. With Adames slotted in as a central contributor and Verlander on the mound, the Giants are hoping their mix of old-school grit and new blood is enough to hang in a deep NL West. Seattle, meanwhile, is pushing forward with its youth movement. After a strong 85–77 campaign that ended in disappointment, the Mariners have returned with a lineup that’s fast, flexible, and eager to prove it’s ready for prime time. Bryce Miller, the 25-year-old right-hander starting Friday’s game, is a key piece in the Mariners’ pitching puzzle. He showed flashes of brilliance in his rookie year and will be expected to build upon that, especially with ace George Kirby starting the year on the IL. The Mariners’ offense is a mix of speed and pop, with Julio Rodríguez expected to lead the charge. They’re looking to improve on last year’s middling contact metrics (7.4 hits per game) by emphasizing situational hitting and working deeper into counts. If they can support Miller with some early run production and avoid giving away outs, Seattle has every chance to steal the opener on the road. Ultimately, this game represents two teams at very different points on their competitive timeline. The Giants are trying to make one last playoff push with veterans and high-floor contributors, while the Mariners are hoping their upside-driven roster can start cashing in on potential. Friday’s game may not decide much in the grand scheme of the 162-game grind—but it will give us a glimpse into how each of these teams plans to chase relevance in 2025.

Seattle Mariners MLB Preview

The Seattle Mariners open a crucial early-season road trip by visiting Oracle Park on April 4, where they’ll face the San Francisco Giants in the Giants’ home opener. For Seattle, the mission is clear: build on last year’s 85–77 record and finally break through to a deep playoff run. The Mariners have been hovering on the edge of contention for the past two seasons, armed with an exciting young core but often undone by streaky offense and injuries at inopportune times. Now, with their roster largely intact and many of their prospects turning into productive big leaguers, the organization is hoping 2025 is the season when it all clicks. A win in front of a hyped-up Oracle Park crowd would be an early statement—one that says the Mariners aren’t just here for the vibes, they’re here to win. Starting Friday’s game is 25-year-old right-hander Bryce Miller, one of several young arms in the Mariners’ rotation tasked with carrying more of the load this season. With ace George Kirby currently sidelined due to shoulder inflammation, Miller gets an early-season opportunity to solidify his standing. He flashed plenty of promise in his rookie year, showing a live fastball and the ability to work deep into games when his command was on. His biggest challenge will be maintaining consistency and executing under pressure, especially in environments like San Francisco’s home opener. The Giants’ lineup doesn’t feature many intimidating names, but it’s filled with savvy veterans who feast on mistakes.

If Miller can stay ahead in counts and mix his secondary stuff effectively, he could turn in a strong outing and keep the game close enough for the offense to do its job. Speaking of offense, the Mariners know it’s time to stop relying on potential and start producing runs. Their lineup features breakout star Julio Rodríguez, whose mix of power, speed, and charisma has turned him into the face of the franchise. But the burden can’t fall on him alone. Players like Cal Raleigh, J.P. Crawford, and Ty France need to contribute more consistently if this team hopes to avoid the midseason scoring droughts that haunted them last year. Seattle averaged just 7.4 hits per game in 2024—a number that simply won’t cut it in a division featuring the Astros and Rangers. Manager Scott Servais has emphasized improved situational hitting and plate discipline this spring, and this road series will offer a good early test. Oracle Park is not an easy place to hit, but it rewards teams that can work counts, go gap-to-gap, and capitalize on mistakes. Seattle will need to play fundamentally sound, aggressive baseball to scratch out runs against a savvy veteran like Justin Verlander. Defensively, the Mariners remain one of the more athletic teams in baseball, especially in the outfield where Rodríguez and company cover serious ground. The infield is steady, with J.P. Crawford providing leadership and range at shortstop, and their catching tandem doing a solid job managing the staff. With a strong bullpen and the kind of pitching depth that allows them to stay in games even when the offense is cold, the Mariners aren’t flashy—but they’re dangerous. If they can leave San Francisco with a win, it’ll reinforce what they already believe: this is the year they stop knocking on the door and start kicking it in.

The San Francisco Giants will host the Seattle Mariners at Oracle Park on April 4, 2025, marking the Giants’ home opener for the season. Both teams aim to establish early momentum in this interleague matchup. Seattle vs San Francisco AI Prediction: Free MLB Betting Insights for Apr 04. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

San Francisco Giants MLB Preview

The San Francisco Giants enter their 2025 home opener against the Seattle Mariners with cautious optimism and a renewed sense of direction. After finishing the 2024 season at 80–82 and missing the playoffs for a third straight year, the front office pulled the trigger on significant changes—none bigger than bringing franchise icon Buster Posey back into the fold as team president. Posey’s return signaled a clear cultural and competitive reset, and the team followed that with its biggest financial commitment in years, signing shortstop Willy Adames to a seven-year, $182 million contract. The Giants aren’t just patching holes—they’re trying to lay the foundation for a competitive window in the fiercely competitive National League West. Friday’s home opener at Oracle Park, against an up-and-coming Mariners squad, offers the first real chance for fans to see whether this new direction holds promise—or just more of the same. Taking the mound for San Francisco is none other than Justin Verlander, who is, somehow, entering his 20th major league season and still refusing to age like the rest of us. At 41, Verlander may not have the overpowering fastball that once won him Cy Young Awards, but he’s adapted with surgical precision and an expanded pitch mix. This spring, he worked on refining a sweeping curveball designed to increase horizontal movement, adding another layer of deception to an already polished arsenal. While the Mariners’ lineup features athleticism and pop, Verlander’s edge in experience and game-planning could neutralize their aggression.

The Giants are hoping that his presence in the rotation does more than just eat innings—it brings accountability and mentorship to a staff that needs both. Offensively, the Giants are banking on a more well-rounded lineup in 2025. Last season, they hit .239 as a team and struggled mightily with runners in scoring position. The addition of Adames is meant to address both issues—he brings solid gap-to-gap power, improved contact, and a disciplined approach that should stabilize the top half of the order. Surrounding him are familiar names like Michael Conforto, Mike Yastrzemski, and Wilmer Flores, who are capable of production but have lacked consistency in recent years. Thairo Estrada, who’s grown into a dependable middle infielder, will likely continue to serve as a catalyst on the basepaths. But the real x-factor for this team is whether the bench depth and younger call-ups can contribute meaningfully in the grind of the season. San Francisco isn’t loaded with stars, but if they can stay healthy and manufacture runs consistently, they’ll be far more dangerous than their middling 2024 numbers suggest. Defensively, the Giants are banking on Adames to shore up a leaky infield. Last year’s defense gave away too many outs, putting added pressure on the pitching staff. The hope is that a more stable middle infield—combined with seasoned corner defenders—can prevent the types of collapses that plagued them in tight games. In front of a sold-out home crowd and with fresh leadership behind the scenes, this is more than just Opening Day—it’s a first step toward reestablishing the Giants as legitimate contenders. For San Francisco, the window isn’t wide open, but for the first time in a while, it doesn’t feel shut either.

Seattle vs. San Francisco Prop Picks (AI)

AI algorithm Remi is pouring through tons of datapoints on each team. In fact, anytime the Mariners and Giants play there’s always several intriguing angles to key in on. Not to mention games played at Oracle Park in Apr can often follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: C. Raleigh over 05. total Bases.

Seattle vs. San Francisco Prediction (AI)

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Remi, our AI sports genius, has been pouring over exorbitant amounts of data from every past game between the Mariners and Giants and using recursive machine learning and kick-ass AI to crunch the data to a single cover probability.

Remi has been most watching on the unproportionally assigned factor knucklehead sportsbettors regularly put on San Francisco’s strength factors between a Mariners team going up against a possibly strong Giants team. Trends look to say the true game analytics appear to reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Seattle vs San Francisco picks, computer picks Mariners vs Giants, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Mariners Betting Trends

The Mariners have covered the spread in 64 out of 110 games where they were listed as the moneyline favorite in the previous season, reflecting a 58.2% success rate.

Giants Betting Trends

The Giants have demonstrated a strong performance against the spread, covering in 78 out of 162 games last season, indicating a 48.1% success rate.

Mariners vs. Giants Matchup Trends

The Giants are favored with a moneyline of -148, while the Mariners are at +123, suggesting a competitive matchup. The over/under for the game is set at 8 runs, indicating expectations of moderate scoring.

Seattle vs. San Francisco Game Info

Seattle vs San Francisco starts on April 04, 2025 at 4:35 PM EST.

Spread: San Francisco -1.5
Moneyline: Seattle +123, San Francisco -148
Over/Under: 8

Seattle: (3-4)  |  San Francisco: (5-1)

Remi's searched hard and found the best prop for this matchup: C. Raleigh over 05. total Bases.. Prices move—always shop for the best number.

The Giants are favored with a moneyline of -148, while the Mariners are at +123, suggesting a competitive matchup. The over/under for the game is set at 8 runs, indicating expectations of moderate scoring.

SEA trend: The Mariners have covered the spread in 64 out of 110 games where they were listed as the moneyline favorite in the previous season, reflecting a 58.2% success rate.

SF trend: The Giants have demonstrated a strong performance against the spread, covering in 78 out of 162 games last season, indicating a 48.1% success rate.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Seattle vs. San Francisco Odds

Remi is pouring through mountains of data on each line. In fact, anytime the Seattle vs San Francisco trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable betting trends.

Seattle vs San Francisco Opening Odds

SEA Moneyline: +123
SF Moneyline: -148
SEA Spread: +1.5
SF Spread: -1.5
Over/Under: 8

Seattle vs San Francisco Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+196
-240
+1.5 (-105)
-1.5 (-115)
O 9 (-105)
U 9 (-115)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-178
 
-1.5 (+115)
O 9.5 (+100)
U 9.5 (-120)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+135
-160
+1.5 (-155)
-1.5 (+130)
O 8.5 (-105)
U 8.5 (-115)
Sep 27, 2025 4:05PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:05PM
White Sox
Nationals
+100
-120
+1.5 (-205)
-1.5 (+170)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+196
-240
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+130)
+1.5 (-155)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+110
-130
+1.5 (-190)
-1.5 (+158)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+175
-210
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+115
-135
+1.5 (-190)
-1.5 (+158)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+150
-178
+1.5 (-145)
-1.5 (+122)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+122
-145
+1.5 (-190)
-1.5 (+158)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+118
-140
+1.5 (-190)
-1.5 (+158)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-140
+118
-1.5 (+115)
+1.5 (-135)
O 9 (-110)
U 9 (-110)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
+1.5 (-220)
-1.5 (+180)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
+1.5 (-195)
-1.5 (+162)
O 10 (-115)
U 10 (-105)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Seattle Mariners vs. San Francisco Giants on April 04, 2025 at Oracle Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS