Padres vs Cubs Prediction — AI Finds CAN'T MISS MLB Lines & Props (Apr 04)
Updated: 2025-04-02T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The San Diego Padres will face the Chicago Cubs at Wrigley Field on April 4, 2025, with the first pitch scheduled for 2:20 PM ET. Both teams aim to build momentum early in the season, setting the stage for an engaging matchup.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Apr 04, 2025
Start Time: 2:20 PM EST
Venue: Wrigley Field
Cubs Record: (5-4)
Padres Record: (7-0)
OPENING ODDS
SD Moneyline: +141
CHC Moneyline: -166
SD Spread: +1.5
CHC Spread: -1.5
Over/Under: 6.5
SD
Betting Trends
- The Padres have covered the spread in 60% of their last five games, demonstrating strong performance against the spread.
CHC
Betting Trends
- The Cubs have covered the spread in 40% of their recent five games, indicating some inconsistency in meeting betting expectations.
MATCHUP TRENDS
- Historically, matchups between these two teams have seen the total go UNDER in 8 of their last 11 meetings, suggesting a trend toward lower-scoring games.
SD vs. CHC
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: S. Suzuki over 0.5 Total Bases.
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San Diego vs Chicago Cubs Prediction & Odds:
Free MLB Betting Insights for 4/4/25
Even more impressively, this offensive explosion has taken place while their starting pitching has been merely serviceable, suggesting there’s still another gear they can hit once the rotation settles in. San Diego’s lone question mark heading into this game is their starting pitcher, Randy Vásquez, who sports a 5.87 ERA and a loss on his record. But with the offense rolling and the bullpen doing its job, the Padres have managed to weather shaky starts and still come out on top. For the Cubs, the game plan starts with left-hander Shota Imanaga, who’s looked dominant so far in his transition to MLB. With a 1–0 record and a microscopic 0.82 ERA, Imanaga has shown poise, control, and swing-and-miss stuff, all of which will be needed to slow down San Diego’s powerful lineup. Chicago’s offense has been up and down, but Kyle Tucker has been a bright spot, hitting .324 with four home runs and 11 RBIs in just the first week. If Imanaga can keep the Padres in check early, the Cubs will need timely hitting from their supporting cast—names like Christopher Morel, Nico Hoerner, and Cody Bellinger—to manufacture runs and avoid falling into an early hole. That’s been the story of their season so far: solid individual moments, but not enough cohesion from inning to inning. Historically, games between these two teams tend to go under the run total, with 8 of their last 11 meetings falling short of the betting line. That could hold if Imanaga keeps dealing and the Cubs’ staff limits big innings. But San Diego’s offense is a different beast this year—balanced, aggressive, and dangerous from the first pitch. The Cubs will need a near-perfect execution day to derail a Padres team currently playing like it knows exactly who it is. A win at Wrigley would not only cool off the hottest team in baseball—it might just spark the consistency Chicago’s been waiting for.
Nothing but love for No. 3 💛 pic.twitter.com/iDt8ppJHoe
— San Diego Padres (@Padres) April 3, 2025
San Diego Padres MLB Preview
The San Diego Padres arrive in Chicago on April 4, 2025, sitting atop the league with a pristine 5–0 record and the swagger of a team that already feels like October in April. After years of inconsistent starts and bloated expectations, this Padres group looks polished, focused, and—most terrifying for their opponents—completely in sync. Whether it’s their lineup pounding out runs like a drumline, or the bullpen shutting doors with ruthless efficiency, San Diego has opened the season with a statement: we’re not easing into this. Now, they walk into Wrigley Field to face the Chicago Cubs, a team still figuring things out. But the Padres aren’t interested in anyone else’s growth arc—they’re here to extend their own winning streak and punish any mistake along the way. Leading the charge for the Padres is Fernando Tatis Jr., who has come out of the gate with a vengeance. Batting .423 through the first five games, Tatis has been a nightmare for pitchers, getting on base, driving in runs, and applying pressure from the moment he steps into the box. He’s backed up by a surprisingly deep supporting cast, including breakout rookie Jackson Merrill, who has already tallied two home runs and eight RBIs. This isn’t the one-man show that plagued the Padres in years past.
This is a balanced, versatile, and dangerous offense that doesn’t let up. Whether it’s Manny Machado ripping doubles, Xander Bogaerts grinding out at-bats, or Jake Cronenworth flipping the order with sneaky power, this team can score from every angle. And they’ve been doing it early and often, averaging 7.4 runs per game and knocking opposing starters out before the fifth inning more than once. Starting pitcher Randy Vásquez takes the mound for San Diego, and while he’s the biggest question mark of the roster at the moment, he doesn’t need to be perfect—just competent. He enters the game with an 0–1 record and a 5.87 ERA, the result of some shaky command and one big inning that got away from him. But the pressure is eased when your lineup is averaging nearly eight runs per game. Vásquez’s job is to keep the Cubs from getting early momentum. If he can do that and make it into the middle innings, the Padres’ bullpen can take over. Anchored by proven arms like Robert Suarez and setup man Wandy Peralta, San Diego’s relief corps has been airtight, with late-game leads feeling more like final chapters than tense drama. Defensively, the Padres have also shown a level of sharpness often missing in early April. Their infield play has been clean, the outfield has tracked down tough fly balls, and their catchers are controlling the running game well. It’s a team that doesn’t beat itself—no extra outs, no sloppy basepaths, no mental lapses. That’s what makes them especially dangerous on the road. They travel well, hit in any park, and know how to control pace. Against a promising but unsettled Cubs team, the Padres have a golden chance to stay perfect. They don’t need the wind blowing out. They don’t need lucky bounces. Right now, they just need nine innings—and they’ll usually take care of the rest themselves.

Credit: USA TODAY/IMAGN
Chicago Cubs Cubs MLB Preview
The Chicago Cubs return to Wrigley Field on April 4, 2025, to face a scorching San Diego Padres team, and while the visitors arrive undefeated, the Cubs remain quietly confident. At 3–4, Chicago’s record doesn’t scream “contender,” but it also doesn’t reflect the flashes of brilliance that have defined their first week. They’ve been a team of contrasts—outstanding in spots, underwhelming in others—but now, back on their home turf and with one of their best arms on the mound, they have a chance to pull off a statement win. And if there’s one thing Wrigley Field loves more than ivy and skyline views, it’s the opportunity to humble a hot team under blue skies and hometown roars. Shota Imanaga will take the mound for the Cubs, and right now, he’s the ace in every sense of the word. With a 1–0 record and a pristine 0.82 ERA through his first two starts, the Japanese left-hander has been as advertised—and possibly more. He’s shown excellent command, a deceptive fastball, and a split-finger pitch that’s generating awkward swings and weak contact. Most importantly, he brings a calmness to the mound that has been contagious for a rotation still searching for consistency. Against a Padres lineup that’s averaging over seven runs per game, Imanaga will be tasked with more than just pitching—he’ll need to control the tempo, keep runners off base, and give his offense a chance to keep it close. If he can carry over the dominance he’s already displayed, the Cubs will be in business.
Offensively, the Cubs haven’t fully clicked, but there are clear signs of life. Kyle Tucker, one of the marquee offseason acquisitions, has wasted no time earning his paycheck. He enters Friday with a .324 batting average, four home runs, and 11 RBIs—leading the team in nearly every major category. What the Cubs need now is for the rest of the lineup to follow his lead. Cody Bellinger has shown flashes, and youngsters like Christopher Morel and Seiya Suzuki have the tools to change games—but so far, timely hitting has been elusive. The Cubs have struggled with runners in scoring position and haven’t capitalized on early opportunities. With Imanaga likely keeping it close, even small bursts of offense—sacrifice flies, aggressive baserunning, productive outs—could be enough to tilt the game in Chicago’s favor. Defensively, the Cubs are solid if not flashy. They’ve committed few errors and have been reliable with the basics, which is crucial in a park like Wrigley where the wind and walls can turn routine into chaos. Manager Craig Counsell will likely emphasize clean innings, smart situational play, and finding a way to get the bullpen involved with a lead. That unit, while still taking shape, has been quietly competent, especially in holding games close. This isn’t a must-win for the Cubs by any stretch—but it’s an opportunity. A strong showing against the league’s hottest team could shift the narrative in Chicago’s dugout from “feeling things out” to “finding our groove.” And in a city where hope springs eternal, there’s no better place to start building that belief than at Wrigley.
drop a “🧹” pic.twitter.com/GapojdO8s3
— Chicago Cubs (@Cubs) April 2, 2025
San Diego vs. Chicago Cubs Prop Picks (AI)
San Diego vs. Chicago Cubs Prediction (AI)

Remi, our AI sports algorithm, has been pouring over mountains of data from every facet between the Padres and Cubs and using recursive machine learning and cutting-edge AI to analyze the data to a single cover probability.
Interestingly enough, the data has been most focused on the trending weight knucklehead sportsbettors tend to put on player performance factors between a Padres team going up against a possibly unhealthy Cubs team. We’ve found the true game analytics appear to reflect a strong lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI San Diego vs Chicago Cubs picks, computer picks Padres vs Cubs, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Padres Betting Trends
The Padres have covered the spread in 60% of their last five games, demonstrating strong performance against the spread.
Cubs Betting Trends
The Cubs have covered the spread in 40% of their recent five games, indicating some inconsistency in meeting betting expectations.
Padres vs. Cubs Matchup Trends
Historically, matchups between these two teams have seen the total go UNDER in 8 of their last 11 meetings, suggesting a trend toward lower-scoring games.
San Diego vs. Chicago Cubs Game Info
What time does San Diego vs Chicago Cubs start on April 04, 2025?
San Diego vs Chicago Cubs starts on April 04, 2025 at 2:20 PM EST.
Where is San Diego vs Chicago Cubs being played?
Venue: Wrigley Field.
What are the opening odds for San Diego vs Chicago Cubs?
Spread: Chicago Cubs -1.5
Moneyline: San Diego +141, Chicago Cubs -166
Over/Under: 6.5
What are the records for San Diego vs Chicago Cubs?
San Diego: (7-0) | Chicago Cubs: (5-4)
What is the AI best bet for San Diego vs Chicago Cubs?
Remi's searched hard and found the best prop for this matchup: S. Suzuki over 0.5 Total Bases.. Prices move—always shop for the best number.
What are San Diego vs Chicago Cubs trending bets?
Historically, matchups between these two teams have seen the total go UNDER in 8 of their last 11 meetings, suggesting a trend toward lower-scoring games.
What are San Diego trending bets?
SD trend: The Padres have covered the spread in 60% of their last five games, demonstrating strong performance against the spread.
What are Chicago Cubs trending bets?
CHC trend: The Cubs have covered the spread in 40% of their recent five games, indicating some inconsistency in meeting betting expectations.
Where can I find AI Picks for San Diego vs Chicago Cubs?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
San Diego vs. Chicago Cubs Odds
Remi is pouring through tons of data on each team. In fact, anytime the San Diego vs Chicago Cubs trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable patterns.
San Diego vs Chicago Cubs Opening Odds
SD Moneyline:
+141 CHC Moneyline: -166
SD Spread: +1.5
CHC Spread: -1.5
Over/Under: 6.5
San Diego vs Chicago Cubs Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 19, 2025 8:04PM EDT
Seattle Mariners
Toronto Blue Jays
10/19/25 8:04PM
Mariners
Blue Jays
|
–
–
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+104
-127
|
+1.5 (-206)
-1.5 (+166)
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O 7.5 (-116)
U 7.5 (-104)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers San Diego Padres vs. Chicago Cubs Cubs on April 04, 2025 at Wrigley Field.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |