Padres vs. Cubs
Prediction, Odds & Props
Apr 04 | MLB AI Picks

Updated: 2025-04-02T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The San Diego Padres will face the Chicago Cubs at Wrigley Field on April 4, 2025, with the first pitch scheduled for 2:20 PM ET. Both teams aim to build momentum early in the season, setting the stage for an engaging matchup.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 04, 2025

Start Time: 2:20 PM EST​

Venue: Wrigley Field​

Cubs Record: (5-4)

Padres Record: (7-0)

OPENING ODDS

SD Moneyline: +141

CHC Moneyline: -166

SD Spread: +1.5

CHC Spread: -1.5

Over/Under: 6.5

SD
Betting Trends

  • The Padres have covered the spread in 60% of their last five games, demonstrating strong performance against the spread.

CHC
Betting Trends

  • The Cubs have covered the spread in 40% of their recent five games, indicating some inconsistency in meeting betting expectations.

MATCHUP TRENDS

  • Historically, matchups between these two teams have seen the total go UNDER in 8 of their last 11 meetings, suggesting a trend toward lower-scoring games.

SD vs. CHC
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: S. Suzuki over 0.5 Total Bases.

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San Diego vs Chicago Cubs Prediction & Odds:
Free MLB Betting Insights for 4/4/25

The San Diego Padres head into Wrigley Field on April 4 with a perfect 5–0 record, bringing one of the hottest starts in baseball to the North Side of Chicago. Their opponent, the Cubs, sits at 3–4, showing flashes of promise but struggling with consistency as they work through early-season growing pains. Friday’s matchup pits two clubs with vastly different April vibes: one team has clicked into gear from the first pitch of Opening Day, and the other is still trying to figure out what buttons to push. With the backdrop of one of baseball’s most iconic stadiums and the unpredictable breeze off Lake Michigan, this interleague tilt between San Diego and Chicago has the makings of a compelling, momentum-shifting showdown. The Padres have looked sharp across the board. Offensively, they’re averaging over seven runs per game, led by the red-hot bat of Fernando Tatis Jr., who’s hitting .423 and looking every bit like the MVP candidate fans hoped for. He’s been supported by Jackson Merrill, who’s already tallied two home runs and eight RBIs through the first week of the season. The Padres aren’t just slugging—they’re creating pressure on the basepaths, working counts, and punishing mistakes.

Even more impressively, this offensive explosion has taken place while their starting pitching has been merely serviceable, suggesting there’s still another gear they can hit once the rotation settles in. San Diego’s lone question mark heading into this game is their starting pitcher, Randy Vásquez, who sports a 5.87 ERA and a loss on his record. But with the offense rolling and the bullpen doing its job, the Padres have managed to weather shaky starts and still come out on top. For the Cubs, the game plan starts with left-hander Shota Imanaga, who’s looked dominant so far in his transition to MLB. With a 1–0 record and a microscopic 0.82 ERA, Imanaga has shown poise, control, and swing-and-miss stuff, all of which will be needed to slow down San Diego’s powerful lineup. Chicago’s offense has been up and down, but Kyle Tucker has been a bright spot, hitting .324 with four home runs and 11 RBIs in just the first week. If Imanaga can keep the Padres in check early, the Cubs will need timely hitting from their supporting cast—names like Christopher Morel, Nico Hoerner, and Cody Bellinger—to manufacture runs and avoid falling into an early hole. That’s been the story of their season so far: solid individual moments, but not enough cohesion from inning to inning. Historically, games between these two teams tend to go under the run total, with 8 of their last 11 meetings falling short of the betting line. That could hold if Imanaga keeps dealing and the Cubs’ staff limits big innings. But San Diego’s offense is a different beast this year—balanced, aggressive, and dangerous from the first pitch. The Cubs will need a near-perfect execution day to derail a Padres team currently playing like it knows exactly who it is. A win at Wrigley would not only cool off the hottest team in baseball—it might just spark the consistency Chicago’s been waiting for.

San Diego Padres MLB Preview

The San Diego Padres arrive in Chicago on April 4, 2025, sitting atop the league with a pristine 5–0 record and the swagger of a team that already feels like October in April. After years of inconsistent starts and bloated expectations, this Padres group looks polished, focused, and—most terrifying for their opponents—completely in sync. Whether it’s their lineup pounding out runs like a drumline, or the bullpen shutting doors with ruthless efficiency, San Diego has opened the season with a statement: we’re not easing into this. Now, they walk into Wrigley Field to face the Chicago Cubs, a team still figuring things out. But the Padres aren’t interested in anyone else’s growth arc—they’re here to extend their own winning streak and punish any mistake along the way. Leading the charge for the Padres is Fernando Tatis Jr., who has come out of the gate with a vengeance. Batting .423 through the first five games, Tatis has been a nightmare for pitchers, getting on base, driving in runs, and applying pressure from the moment he steps into the box. He’s backed up by a surprisingly deep supporting cast, including breakout rookie Jackson Merrill, who has already tallied two home runs and eight RBIs. This isn’t the one-man show that plagued the Padres in years past.

This is a balanced, versatile, and dangerous offense that doesn’t let up. Whether it’s Manny Machado ripping doubles, Xander Bogaerts grinding out at-bats, or Jake Cronenworth flipping the order with sneaky power, this team can score from every angle. And they’ve been doing it early and often, averaging 7.4 runs per game and knocking opposing starters out before the fifth inning more than once. Starting pitcher Randy Vásquez takes the mound for San Diego, and while he’s the biggest question mark of the roster at the moment, he doesn’t need to be perfect—just competent. He enters the game with an 0–1 record and a 5.87 ERA, the result of some shaky command and one big inning that got away from him. But the pressure is eased when your lineup is averaging nearly eight runs per game. Vásquez’s job is to keep the Cubs from getting early momentum. If he can do that and make it into the middle innings, the Padres’ bullpen can take over. Anchored by proven arms like Robert Suarez and setup man Wandy Peralta, San Diego’s relief corps has been airtight, with late-game leads feeling more like final chapters than tense drama. Defensively, the Padres have also shown a level of sharpness often missing in early April. Their infield play has been clean, the outfield has tracked down tough fly balls, and their catchers are controlling the running game well. It’s a team that doesn’t beat itself—no extra outs, no sloppy basepaths, no mental lapses. That’s what makes them especially dangerous on the road. They travel well, hit in any park, and know how to control pace. Against a promising but unsettled Cubs team, the Padres have a golden chance to stay perfect. They don’t need the wind blowing out. They don’t need lucky bounces. Right now, they just need nine innings—and they’ll usually take care of the rest themselves.

The San Diego Padres will face the Chicago Cubs at Wrigley Field on April 4, 2025, with the first pitch scheduled for 2:20 PM ET. Both teams aim to build momentum early in the season, setting the stage for an engaging matchup. San Diego vs Chicago Cubs AI Prediction: Free MLB Betting Insights for Apr 04. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Chicago Cubs Cubs MLB Preview

The Chicago Cubs return to Wrigley Field on April 4, 2025, to face a scorching San Diego Padres team, and while the visitors arrive undefeated, the Cubs remain quietly confident. At 3–4, Chicago’s record doesn’t scream “contender,” but it also doesn’t reflect the flashes of brilliance that have defined their first week. They’ve been a team of contrasts—outstanding in spots, underwhelming in others—but now, back on their home turf and with one of their best arms on the mound, they have a chance to pull off a statement win. And if there’s one thing Wrigley Field loves more than ivy and skyline views, it’s the opportunity to humble a hot team under blue skies and hometown roars. Shota Imanaga will take the mound for the Cubs, and right now, he’s the ace in every sense of the word. With a 1–0 record and a pristine 0.82 ERA through his first two starts, the Japanese left-hander has been as advertised—and possibly more. He’s shown excellent command, a deceptive fastball, and a split-finger pitch that’s generating awkward swings and weak contact. Most importantly, he brings a calmness to the mound that has been contagious for a rotation still searching for consistency. Against a Padres lineup that’s averaging over seven runs per game, Imanaga will be tasked with more than just pitching—he’ll need to control the tempo, keep runners off base, and give his offense a chance to keep it close. If he can carry over the dominance he’s already displayed, the Cubs will be in business.

Offensively, the Cubs haven’t fully clicked, but there are clear signs of life. Kyle Tucker, one of the marquee offseason acquisitions, has wasted no time earning his paycheck. He enters Friday with a .324 batting average, four home runs, and 11 RBIs—leading the team in nearly every major category. What the Cubs need now is for the rest of the lineup to follow his lead. Cody Bellinger has shown flashes, and youngsters like Christopher Morel and Seiya Suzuki have the tools to change games—but so far, timely hitting has been elusive. The Cubs have struggled with runners in scoring position and haven’t capitalized on early opportunities. With Imanaga likely keeping it close, even small bursts of offense—sacrifice flies, aggressive baserunning, productive outs—could be enough to tilt the game in Chicago’s favor. Defensively, the Cubs are solid if not flashy. They’ve committed few errors and have been reliable with the basics, which is crucial in a park like Wrigley where the wind and walls can turn routine into chaos. Manager Craig Counsell will likely emphasize clean innings, smart situational play, and finding a way to get the bullpen involved with a lead. That unit, while still taking shape, has been quietly competent, especially in holding games close. This isn’t a must-win for the Cubs by any stretch—but it’s an opportunity. A strong showing against the league’s hottest team could shift the narrative in Chicago’s dugout from “feeling things out” to “finding our groove.” And in a city where hope springs eternal, there’s no better place to start building that belief than at Wrigley.

San Diego vs. Chicago Cubs Prop Picks (AI)

Remi is pouring through tons of stats on each line. In fact, anytime the Padres and Cubs play there’s always several intriguing trends to key in on. Not to mention games played at Wrigley Field in Apr rarely follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: S. Suzuki over 0.5 Total Bases.

San Diego vs. Chicago Cubs Prediction (AI)

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Remi, our AI sports wizard, has been pouring over tons of data from every simulation between the Padres and Cubs and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.

The Algorithm has been most focused on the growing factor emotional bettors tend to put on coaching factors between a Padres team going up against a possibly unhealthy Cubs team. It appears the true game analytics appear to reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI San Diego vs Chicago Cubs picks, computer picks Padres vs Cubs, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Padres Betting Trends

The Padres have covered the spread in 60% of their last five games, demonstrating strong performance against the spread.

Cubs Betting Trends

The Cubs have covered the spread in 40% of their recent five games, indicating some inconsistency in meeting betting expectations.

Padres vs. Cubs Matchup Trends

Historically, matchups between these two teams have seen the total go UNDER in 8 of their last 11 meetings, suggesting a trend toward lower-scoring games.

San Diego vs. Chicago Cubs Game Info

San Diego vs Chicago Cubs starts on April 04, 2025 at 2:20 PM EST.

Spread: Chicago Cubs -1.5
Moneyline: San Diego +141, Chicago Cubs -166
Over/Under: 6.5

San Diego: (7-0)  |  Chicago Cubs: (5-4)

Remi's searched hard and found the best prop for this matchup: S. Suzuki over 0.5 Total Bases.. Prices move—always shop for the best number.

Historically, matchups between these two teams have seen the total go UNDER in 8 of their last 11 meetings, suggesting a trend toward lower-scoring games.

SD trend: The Padres have covered the spread in 60% of their last five games, demonstrating strong performance against the spread.

CHC trend: The Cubs have covered the spread in 40% of their recent five games, indicating some inconsistency in meeting betting expectations.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

San Diego vs. Chicago Cubs Odds

AI algorithm Remi is pouring through loads of data on each team. In fact, anytime the San Diego vs Chicago Cubs trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments almost always follow normal, predictable betting trends.

San Diego vs Chicago Cubs Opening Odds

SD Moneyline: +141
CHC Moneyline: -166
SD Spread: +1.5
CHC Spread: -1.5
Over/Under: 6.5

San Diego vs Chicago Cubs Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-180
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+125
-150
+1.5 (-180)
-1.5 (+150)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+145
-175
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-195)
-1.5 (+160)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+105
-125
+1.5 (-205)
-1.5 (+170)
O 7.5 (+105)
U 7.5 (-125)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers San Diego Padres vs. Chicago Cubs Cubs on April 04, 2025 at Wrigley Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN