Yankees vs. Pirates
Prediction, Odds & Props
Apr 04 | MLB AI Picks

Updated: 2025-04-02T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Pittsburgh Pirates will host the New York Yankees at PNC Park on April 4, 2025, with the first pitch scheduled for 4:12 p.m. ET—a nod to Pittsburgh’s 412 area code. This marks the first time in franchise history that the Pirates will face the Yankees in their home opener.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 04, 2025

Start Time: 4:12 PM EST​

Venue: PNC Park​

Pirates Record: (2-5)

Yankees Record: (4-2)

OPENING ODDS

NYY Moneyline: -159

PIT Moneyline: +134

NYY Spread: -1.5

PIT Spread: +1.5

Over/Under: 8

NYY
Betting Trends

  • The Yankees have demonstrated strong performance against the spread (ATS), covering in 52 out of 88 games when playing away, indicating a 59% success rate.

PIT
Betting Trends

  • The Pirates have covered the spread in 38 out of 81 home games, reflecting a 47% success rate.

MATCHUP TRENDS

  • The Yankees are favored with a moneyline of -163, while the Pirates are at +138, suggesting expectations of a competitive game. The over/under for the game is set at 8 runs, indicating predictions of moderate scoring.

NYY vs. PIT
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Chisholm over 0.5 Total Bases.

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New York Yankees vs Pittsburgh Prediction & Odds:
Free MLB Betting Insights for 4/4/25

For the first time in franchise history, the Pittsburgh Pirates will host the New York Yankees in their home opener at PNC Park, and the buzz surrounding this April 4 showdown is electric. Pittsburgh is coming off a grueling seven-game road trip that left them at 2–5, while the Yankees arrive with a 4–2 record and the swagger of an early-season contender. The matchup itself might seem lopsided on paper—big-budget Bronx Bombers vs. small-market Pirates—but the Pirates are counting on the energy of Opening Day and the support of a packed stadium to even the playing field. With festivities timed to start at 4:12 p.m. as a nod to Pittsburgh’s area code, the city is treating this game like a celebration, but don’t mistake that for a lack of urgency. Both clubs see this game as a tone-setter for very different reasons. The Yankees have started the 2025 campaign looking exactly like a team that spent its offseason upgrading everywhere it could. Max Fried, one of the club’s big acquisitions, is expected to start the game after a solid debut where he allowed just two runs over 4.2 innings. He’ll be facing a Pirates lineup that has struggled to score runs consistently, making this a favorable matchup on paper for the Yankees’ southpaw.

Offensively, the Yankees have already flashed their trademark firepower. Aaron Judge is on a tear, leading the team with five home runs and batting .417 through six games. His presence alone alters how pitchers attack the lineup, but he’s hardly alone—Giancarlo Stanton, Anthony Volpe, and Gleyber Torres all pose serious threats. The Yankees have also generated headlines with the debut of their “torpedo bats,” a new bat design that’s sparked conversations about its impact on home run production. If it’s working, the Pirates may need more than good pitching to contain this lineup. On the Pirates’ side, Mitch Keller will get the Opening Day start at home, and he’s the right man for the job. Keller opened the season with a strong six-inning outing, giving up just one run and striking out seven. He’ll need to be even sharper against the Yankees, and Pittsburgh will rely heavily on his ability to manage pitch counts and avoid the long ball. On offense, Oneil Cruz has shown flashes of the superstar potential he’s long been projected for, hitting two homers already and batting a respectable .261. The rest of the lineup, however, has yet to find a groove, and that’s a problem when facing a team that could drop six runs in a blink. The Pirates will have to play near-flawless baseball—clean defense, efficient bullpen work, and clutch situational hitting—to have a real chance of defending their turf. With Yankee fans known for traveling well and the novelty of this interleague matchup in Pittsburgh, expect a sold-out crowd and an energized atmosphere. This may not be a postseason preview, but it feels bigger than a typical April game. For the Yankees, it’s another step in what they hope is a dominant campaign. For the Pirates, it’s a statement opportunity—one day, one game, to show they belong on a national stage.

New York Yankees Yankees MLB Preview

The New York Yankees arrive in Pittsburgh for the Pirates’ home opener with a 4–2 record and the sort of quiet confidence that only comes when you know you’ve already started clicking. After opening the 2025 season with dominant performances on both sides of the ball, the Yankees now get the rare chance to spoil an opponent’s party in front of a packed house. This will be the first time the Yankees have ever opened a season on the road at PNC Park—and they plan to make it as uncomfortable for the Pirates as possible. It’s a high-profile interleague clash that leans heavily in favor of the Bombers, both on paper and in terms of momentum. The Pirates are reeling from a difficult road stretch, while the Yankees come in with their bats hot, their ace on the mound, and their lineup looking as fearsome as advertised. Starting for New York is left-hander Max Fried, who was acquired in the offseason to help anchor a rotation that’s aiming to be elite from top to bottom. Fried posted a 3.86 ERA in his debut and has the kind of poise, pitch mix, and playoff-level experience that gives this rotation real bite. Against a Pirates offense that’s averaged under three runs per game, Fried will look to pound the strike zone early, induce soft contact, and work efficiently through the middle innings to preserve the Yankees’ bullpen.

Given how much trouble Pittsburgh has had creating sustained rallies, the key for Fried will be simply avoiding mistakes to Oneil Cruz, the Pirates’ lone offensive threat through the first week of the season. If Fried executes, there’s every reason to believe he could dominate in front of what will be a very loud, very hostile Opening Day crowd. Offensively, the Yankees are scorching. Aaron Judge has come out of the gate swinging like it’s August, already launching five home runs and batting .417. The lineup around him, which includes Giancarlo Stanton, Gleyber Torres, and a resurgent Anthony Volpe, offers little to no breathing room for opposing pitchers. The addition of “torpedo bats”—a controversial new piece of equipment reportedly boosting launch angles and exit velocity—has only added intrigue and power to a team that didn’t really need the help. If the ball continues flying off Yankee bats like it has through the first week, the Pirates may find themselves in an early hole. That said, the Yankees don’t rely solely on power. This lineup works counts, draws walks, and pounces on mistakes with veteran precision. And when the top third of the order gets on base, chaos tends to follow. Defensively and in the bullpen, the Yankees are getting healthier and sharper by the day. Closer Devin Williams has rejoined the team after a brief paternity leave, bolstering a relief unit that’s already been lights out in late innings. The defense behind Fried is sound, with elite outfield range and reliable infield fundamentals. This is a well-rounded, well-coached club that’s built to handle both tight games and blowouts. If the Yankees strike early and keep the pressure on, it’s entirely possible they walk out of PNC Park with another win—and leave the Pirates and their fans wondering what hit them. New year, new bats, same Bronx swagger.

The Pittsburgh Pirates will host the New York Yankees at PNC Park on April 4, 2025, with the first pitch scheduled for 4:12 p.m. ET—a nod to Pittsburgh’s 412 area code.  This marks the first time in franchise history that the Pirates will face the Yankees in their home opener. New York Yankees vs Pittsburgh AI Prediction: Free MLB Betting Insights for Apr 04. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Pittsburgh Pirates MLB Preview

The Pittsburgh Pirates return home to PNC Park on April 4, 2025, following a tough seven-game road stretch that left them at 2–5. The team’s early struggles have not dampened the excitement in the Steel City, however, as they prepare to host the New York Yankees for the first time ever in a home opener. A 4:12 p.m. first pitch—timed to match Pittsburgh’s iconic 412 area code—sets the stage for what is already being billed as one of the franchise’s most anticipated regular-season games in years. From street festivals and citywide celebrations to a sellout crowd expected to flood the North Shore, this isn’t just a game—it’s a moment. The Pirates will need to channel that buzz into performance, because the Bronx Bombers aren’t just here for photos and fireworks. Leading the charge for Pittsburgh is ace right-hander Mitch Keller, who’s already looked sharp to start the season. In his debut outing, Keller tossed six innings of one-run ball and struck out seven, showing excellent command and mound presence. He’ll be counted on to do more than just pitch well—he’ll need to set the tone against one of the most dangerous lineups in baseball. Facing Aaron Judge and a Yankees roster that leads the league in early-season home runs is no small task, especially at hitter-friendly PNC Park. Keller will have to rely on his curveball to keep hitters off balance and avoid falling behind in counts where the Yankees feast on fastballs. If he can make it through five or six solid innings while limiting damage, the Pirates may have a real chance to hang in the game. Offensively, the Pirates will need someone—anyone—to step up behind shortstop Oneil Cruz.

Cruz has been one of the few bright spots in the lineup, posting a .261 average with two home runs already in the young season. His blend of power and athleticism is unique, and his ability to flip a game with one swing makes him the clear centerpiece of the lineup. But he can’t do it alone. Players like Bryan Reynolds, Ke’Bryan Hayes, and Henry Davis have shown flashes, but consistency has been elusive. If Pittsburgh hopes to contend with the Yankees’ relentless run-scoring machine, they’ll need traffic on the bases, better situational hitting, and ideally a few extra-base hits to keep the crowd engaged. A quiet night at the plate could turn Opening Day energy into quiet resignation very quickly. On the defensive side, the Pirates have been competent, though not perfect. They’ll need a clean game in the field—no errors, no extra outs—to support Keller and keep innings short. The bullpen has been a question mark, and any lead the Pirates manage to hold late in the game will likely test their resilience. Still, the opportunity is there. The fans will show up, the city will buzz, and the Yankees will bring the pressure. All the Pirates need to do is rise to the occasion. If they can ride the crowd and play the type of scrappy, fundamentally sound baseball that keeps games tight, Pittsburgh could make its 2025 home debut one to remember—for reasons beyond just the spectacle.

New York Yankees vs. Pittsburgh Prop Picks (AI)

AI algorithm Remi is pouring through loads of data on each line. In fact, anytime the Yankees and Pirates play there’s always several intriguing trends to key in on. Not to mention games played at PNC Park in Apr seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: J. Chisholm over 0.5 Total Bases.

New York Yankees vs. Pittsburgh Prediction (AI)

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Remi, our AI sports genius, has been pouring over mountains of data from every past game between the Yankees and Pirates and using recursive machine learning and cutting-edge AI to boil down the data to a single cover probability.

The Algorithm has been most focused on the linear correlation of emphasis emotional bettors often put on player performance factors between a Yankees team going up against a possibly improved Pirates team. It appears the true game analytics appear to reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI New York Yankees vs Pittsburgh picks, computer picks Yankees vs Pirates, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Yankees Betting Trends

The Yankees have demonstrated strong performance against the spread (ATS), covering in 52 out of 88 games when playing away, indicating a 59% success rate.

Pirates Betting Trends

The Pirates have covered the spread in 38 out of 81 home games, reflecting a 47% success rate.

Yankees vs. Pirates Matchup Trends

The Yankees are favored with a moneyline of -163, while the Pirates are at +138, suggesting expectations of a competitive game. The over/under for the game is set at 8 runs, indicating predictions of moderate scoring.

New York Yankees vs. Pittsburgh Game Info

New York Yankees vs Pittsburgh starts on April 04, 2025 at 4:12 PM EST.

Spread: Pittsburgh +1.5
Moneyline: New York Yankees -159, Pittsburgh +134
Over/Under: 8

New York Yankees: (4-2)  |  Pittsburgh: (2-5)

Remi's searched hard and found the best prop for this matchup: J. Chisholm over 0.5 Total Bases.. Prices move—always shop for the best number.

The Yankees are favored with a moneyline of -163, while the Pirates are at +138, suggesting expectations of a competitive game. The over/under for the game is set at 8 runs, indicating predictions of moderate scoring.

NYY trend: The Yankees have demonstrated strong performance against the spread (ATS), covering in 52 out of 88 games when playing away, indicating a 59% success rate.

PIT trend: The Pirates have covered the spread in 38 out of 81 home games, reflecting a 47% success rate.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

New York Yankees vs. Pittsburgh Odds

Remi is pouring through mountains of stats on each team. In fact, anytime the New York Yankees vs Pittsburgh trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps seemingly never follow normal, predictable betting trends.

New York Yankees vs Pittsburgh Opening Odds

NYY Moneyline: -159
PIT Moneyline: +134
NYY Spread: -1.5
PIT Spread: +1.5
Over/Under: 8

New York Yankees vs Pittsburgh Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+196
-240
+1.5 (-105)
-1.5 (-115)
O 9 (-105)
U 9 (-115)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-178
 
-1.5 (+115)
O 9.5 (+100)
U 9.5 (-120)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+135
-160
+1.5 (-155)
-1.5 (+130)
O 8.5 (-105)
U 8.5 (-115)
Sep 27, 2025 4:05PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:05PM
White Sox
Nationals
+100
-120
+1.5 (-205)
-1.5 (+170)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+196
-240
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+130)
+1.5 (-155)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+110
-130
+1.5 (-190)
-1.5 (+158)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+175
-210
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+115
-135
+1.5 (-190)
-1.5 (+158)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+150
-178
+1.5 (-145)
-1.5 (+122)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+122
-145
+1.5 (-190)
-1.5 (+158)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+118
-140
+1.5 (-190)
-1.5 (+158)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-140
+118
-1.5 (+115)
+1.5 (-135)
O 9 (-110)
U 9 (-110)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
+1.5 (-220)
-1.5 (+180)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
+1.5 (-195)
-1.5 (+162)
O 10 (-115)
U 10 (-105)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers New York Yankees Yankees vs. Pittsburgh Pirates on April 04, 2025 at PNC Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS