Angels vs. Cardinals
Prediction, Odds & Props
Apr 02 | MLB AI Picks

Updated: 2025-03-31T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Los Angeles Angels will face the St. Louis Cardinals on April 2, 2025, at Busch Stadium in St. Louis, Missouri. Both teams aim to secure a win in this early-season matchup to build momentum.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 02, 2025

Start Time: 1:15 PM EST​

Venue: Busch Stadium​

Cardinals Record: (3-2)

Angels Record: (4-1)

OPENING ODDS

LAA Moneyline: +119

STL Moneyline: -141

LAA Spread: +1.5

STL Spread: -1.5

Over/Under: 7.5

LAA
Betting Trends

  • The Angels have a 4-1 record against the spread (ATS) in their recent games, indicating strong performance on the road

STL
Betting Trends

  • The Cardinals hold a 3-2 ATS record in their recent games, reflecting a solid start to their season at home.

MATCHUP TRENDS

  • The Angels are currently on a four-game road winning streak, which could influence betting considerations for this matchup.

LAA vs. STL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: M. Winn over 0.5 Total Bases.

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Los Angeles Angels vs St. Louis Prediction & Odds:
Free MLB Betting Insights for 4/2/25

The upcoming game between the Los Angeles Angels and the St. Louis Cardinals on April 2, 2025, at Busch Stadium presents an intriguing early-season contest. The Angels, boasting a 4-1 record, have demonstrated strong form, particularly on the road, where they are on a four-game winning streak. Conversely, the Cardinals, with a 3-2 record, have shown resilience at home and aim to leverage their familiarity with Busch Stadium to counter the Angels’ momentum. Starting pitchers for the game are Yusei Kikuchi for the Angels and Sonny Gray for the Cardinals. Kikuchi, who signed a three-year, $63 million contract with the Angels in the offseason, brings experience and a left-handed presence to the mound. In his previous outing, Kikuchi recorded a 4.50 ERA, indicating room for improvement as he settles into his new team. On the other side, Gray has started the season with a 1-0 record and a 3.60 ERA, showcasing his capability to anchor the Cardinals’ rotation. Offensively, the Angels have been propelled by key contributions from their lineup, leading to their strong start. The addition of catcher Travis d’Arnaud, who joined on a two-year, $12 million deal, has provided stability both behind the plate and in the batting order. The Cardinals counter with a balanced offensive approach, relying on a mix of seasoned veterans and emerging talents to generate runs.

Defensively, both teams have exhibited competence, with the Angels integrating new acquisitions into their fielding strategies and the Cardinals maintaining consistency in their defensive alignments. This aspect of the game could play a pivotal role in determining the outcome, especially in high-leverage situations. Betting trends highlight the Angels’ impressive 4-1 ATS record, particularly their success on the road, which may influence wagering decisions. The Cardinals’ 3-2 ATS record reflects their solid performance at home, suggesting a potentially close contest. In summary, this matchup features two teams with aspirations to establish dominance early in the season. The performance of the starting pitchers, the effectiveness of offensive strategies, and defensive execution will be critical factors. Given the Angels’ current road form and the Cardinals’ home-field advantage, fans can anticipate a competitive and engaging game at Busch Stadium.

Los Angeles Angels Angels MLB Preview

The Los Angeles Angels enter their April 2, 2025, matchup against the St. Louis Cardinals on a high note, boasting a 4–1 record and riding a four-game winning streak on the road. For a team that came into the season surrounded by skepticism after losing Shohei Ohtani in free agency, the Angels have responded with a sharp and cohesive start, showcasing both offensive versatility and surprising stability in their pitching. As they continue this road trip, their focus turns to sustaining the momentum and proving their early-season success is more than just a hot start. Yusei Kikuchi will get the start on the mound for the Angels, coming off a debut that was serviceable but left room for improvement. He enters the game with a 4.50 ERA after signing a three-year, $63 million deal during the offseason. The Angels brought him in to bring veteran experience and to help stabilize a rotation that lacked consistency in 2024. Kikuchi’s effectiveness often hinges on his fastball command and whether he can keep hitters off-balance with his slider and changeup. If he can manage the Cardinals’ disciplined lineup and avoid falling behind in counts, he has the tools to give the Angels a quality start. Offensively, the Angels have leaned into a team-first approach, with production coming from multiple areas of the lineup rather than relying on a single superstar. Mike Trout, now the sole face of the franchise, remains the focal point. Though health remains a yearly question mark, Trout has looked sharp to begin 2025, delivering clutch hits and providing leadership to a lineup that blends veteran presence with emerging talent. Alongside him, Anthony Rendon is healthy and contributing both in the field and at the plate, giving the Angels much-needed production at third base.

One of the most impactful additions has been catcher Travis d’Arnaud, who signed a two-year, $12 million deal in the offseason. His presence has been immediately felt—not just with timely hits, but in managing the pitching staff and adding defensive stability behind the plate. Taylor Ward and Logan O’Hoppe have also impressed early, with Ward showing off improved plate discipline and O’Hoppe delivering timely power. Altogether, the Angels’ offensive strategy has revolved around getting on base, applying pressure through situational hitting, and avoiding the prolonged dry spells that haunted them in past seasons. The bullpen has quietly been a strength in the early going, anchored by closer Carlos Estévez, who has already notched two saves. The setup roles have been handled well by José Soriano and Matt Moore, both of whom have helped bridge the gap between the starters and the ninth inning. This is a notable upgrade from last season, when blown leads in the middle innings were a persistent problem. Defensively, the Angels have looked sharper than in previous seasons, with improved communication and fewer unforced errors. Infield positioning and outfield coverage have been efficient, aided by better advanced scouting and shifts. In summary, the Angels are entering this game with momentum, a balanced offensive identity, and a pitching staff that’s exceeding early expectations. If Kikuchi can settle in and the bats stay hot, they’ll have a strong chance of continuing their road dominance—and perhaps sending another early-season message that this team is ready to compete in the post-Ohtani era.

The Los Angeles Angels will face the St. Louis Cardinals on April 2, 2025, at Busch Stadium in St. Louis, Missouri. Both teams aim to secure a win in this early-season matchup to build momentum. Los Angeles Angels vs St. Louis AI Prediction: Free MLB Betting Insights for Apr 02. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

St. Louis Cardinals MLB Preview

The St. Louis Cardinals enter their April 2, 2025, matchup against the Los Angeles Angels with a 3-2 record, aiming to capitalize on their home-field advantage at Busch Stadium. The Cardinals have demonstrated resilience in the early stages of the season, balancing a mix of experienced players and emerging talents to navigate the competitive landscape of Major League Baseball. Starting pitcher Sonny Gray is slated to take the mound for the Cardinals. Gray has begun the season with a 1-0 record and a 3.60 ERA, indicating effective command and control in his outings. His ability to neutralize opposing hitters and provide depth in his starts is crucial for the Cardinals’ pitching strategy. Gray’s experience and tactical approach make him a reliable asset in the rotation. Offensively, the Cardinals rely on a cohesive lineup that blends power and precision. Key contributors have stepped up in pivotal moments, delivering clutch performances that have translated into victories. The team’s approach at the plate emphasizes discipline and situational awareness, aiming to capitalize on scoring opportunities and apply pressure on opposing defenses.

Defensively, the Cardinals have maintained a standard of excellence, with coordinated efforts across the infield and outfield. The team’s defensive strategies are designed to support their pitchers by minimizing errors and executing plays with precision. This defensive solidity is instrumental in maintaining competitiveness throughout the season. In terms of betting trends, the Cardinals’ 3-2 record against the spread (ATS) reflects their ability to meet expectations, particularly when playing at home. This statistic suggests a level of consistency that bettors may consider when evaluating the team’s performance in upcoming games. As the Cardinals prepare to face the Angels, the focus will be on leveraging their home-field advantage, executing their game plan effectively, and building upon the positive aspects of their early-season performances. The synergy between pitching, offense, and defense will be pivotal in determining the outcome of this matchup.

Los Angeles Angels vs. St. Louis Prop Picks (AI)

Remi is pouring through mountains of stats on each line. In fact, anytime the Angels and Cardinals play there’s always several intriguing angles to key in on. Not to mention games played at Busch Stadium in Apr almost always follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: M. Winn over 0.5 Total Bases.

Los Angeles Angels vs. St. Louis Prediction (AI)

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Remi, our AI sports genius, has been pouring over tons of data from every angle between the Angels and Cardinals and using recursive machine learning and impressive AI to examine the data to a single cover probability.

Remi has been most fixated on the unproportionally assigned emphasis human bettors tend to put on Los Angeles Angels’s strength factors between a Angels team going up against a possibly strong Cardinals team. Trends look to say the true game analytics appear to reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Los Angeles Angels vs St. Louis picks, computer picks Angels vs Cardinals, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Angels Betting Trends

The Angels have a 4-1 record against the spread (ATS) in their recent games, indicating strong performance on the road

Cardinals Betting Trends

The Cardinals hold a 3-2 ATS record in their recent games, reflecting a solid start to their season at home.

Angels vs. Cardinals Matchup Trends

The Angels are currently on a four-game road winning streak, which could influence betting considerations for this matchup.

Los Angeles Angels vs. St. Louis Game Info

Los Angeles Angels vs St. Louis starts on April 02, 2025 at 1:15 PM EST.

Spread: St. Louis -1.5
Moneyline: Los Angeles Angels +119, St. Louis -141
Over/Under: 7.5

Los Angeles Angels: (4-1)  |  St. Louis: (3-2)

Remi's searched hard and found the best prop for this matchup: M. Winn over 0.5 Total Bases.. Prices move—always shop for the best number.

The Angels are currently on a four-game road winning streak, which could influence betting considerations for this matchup.

LAA trend: The Angels have a 4-1 record against the spread (ATS) in their recent games, indicating strong performance on the road

STL trend: The Cardinals hold a 3-2 ATS record in their recent games, reflecting a solid start to their season at home.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Los Angeles Angels vs. St. Louis Odds

AI algorithm Remi is pouring through tons of data on each line. In fact, anytime the Los Angeles Angels vs St. Louis trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme altitude rarely follow normal, predictable betting trends.

Los Angeles Angels vs St. Louis Opening Odds

LAA Moneyline: +119
STL Moneyline: -141
LAA Spread: +1.5
STL Spread: -1.5
Over/Under: 7.5

Los Angeles Angels vs St. Louis Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-180
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+125
-150
+1.5 (-180)
-1.5 (+150)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+145
-175
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-195)
-1.5 (+160)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+105
-125
+1.5 (-205)
-1.5 (+170)
O 7.5 (+105)
U 7.5 (-125)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Los Angeles Angels Angels vs. St. Louis Cardinals on April 02, 2025 at Busch Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN