Guardians vs. Padres
Prediction, Odds & Props
Apr 02 | MLB AI Picks

Updated: 2025-03-31T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Cleveland Guardians will face the San Diego Padres on April 2, 2025, at Petco Park in San Diego, California, concluding their three-game interleague series. The Padres aim to extend their strong start to the season, while the Guardians look to gain momentum on the road.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Apr 02, 2025

Start Time: 4:10 PM EST​

Venue: Petco Park​

Padres Record: (6-0)

Guardians Record: (2-3)

OPENING ODDS

CLE Moneyline: +151

SD Moneyline: -181

CLE Spread: +1.5

SD Spread: -1.5

Over/Under: 7.5

CLE
Betting Trends

  • The Guardians have covered the spread in 64.9% of games when favored on the moneyline last season.

SD
Betting Trends

  • The Padres covered the spread in 60.2% of games when favored on the moneyline last season.

MATCHUP TRENDS

  • The Padres have a six-game home winning streak, indicating a strong performance at Petco Park.

CLE vs. SD
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: N. Jones over 0.5 Total Bases.

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Cleveland vs San Diego Prediction & Odds:
Free MLB Betting Insights for 4/2/25

As the Cleveland Guardians and San Diego Padres face off on April 2, 2025, at Petco Park, both teams arrive at a pivotal early-season moment—but from very different starting points. The Padres have looked every bit like a team with October aspirations, storming out of the gate with an undefeated record and a roster firing on all cylinders. The Guardians, meanwhile, are still trying to find their rhythm, navigating lineup shuffles and inconsistencies while facing one of the toughest interleague opponents in the first week of the season. For San Diego, the first few games have been a display of cohesion and confidence. Their offense, which blends veteran power and young athleticism, has been among the league’s most efficient to start the year. Key players such as Fernando Tatis Jr. and Xander Bogaerts have delivered in clutch moments, while the supporting cast—including Ha-Seong Kim and Jake Cronenworth—has filled in the gaps with timely hits and aggressive baserunning. The lineup depth makes it difficult for opposing pitchers to navigate safely, and it’s one of the main reasons the Padres have been able to rack up wins even in close contests. On the mound, San Diego’s rotation is anchored by Yu Darvish and Joe Musgrove, both of whom are off to solid starts. Their ability to eat innings and limit damage has allowed the Padres’ bullpen—featuring dependable arms like Robert Suarez and Josh Hader—to avoid early burnout. The combination of high-velocity strikeout stuff and command from the starters, followed by shutdown relief, has turned late-game leads into near-automatic wins. The Padres currently ride a six-game home winning streak, and there’s no indication of a letup at Petco Park, where the team seems especially dialed in. The Guardians, on the other hand, come into this matchup with more questions than answers. Despite flashes of solid play, Cleveland has lacked consistency both at the plate and on the mound.

Their offense, built more on contact and speed than power, has struggled to string hits together against tougher pitching staffs. José Ramírez remains the heartbeat of the lineup, capable of changing a game with one swing or smart baserunning, but he hasn’t had much help so far. Young players like Bo Naylor and Gabriel Arias are still developing, and until more bats heat up, Cleveland is relying heavily on timely hitting and manufacturing runs. On the pitching side, the Guardians have talent, but their rotation has yet to hit its stride. Tanner Bibee and Triston McKenzie possess high upside but have been inconsistent with command early in the year. The bullpen—long a strength for Cleveland—has shown signs of wear, already absorbing multiple multi-inning appearances that suggest the starters haven’t been going deep enough. This game represents an important test for both sides. For San Diego, it’s an opportunity to continue asserting dominance and extend their perfect start. For Cleveland, it’s a chance to reset and prove they can compete with one of the league’s best. The Guardians will need a strong start from their pitcher and mistake-free baseball to have a shot, while the Padres will look to pounce early and keep the pressure on. Given the stakes and current trajectories, all signs point to a competitive but uphill battle for Cleveland in sunny San Diego.

Cleveland Guardians MLB Preview

The Cleveland Guardians head into their April 2, 2025, matchup against the red-hot San Diego Padres at Petco Park looking to steady the ship and recalibrate in the early going of the regular season. A team built on contact hitting, pitching depth, and strong defense, the Guardians have not yet found their full rhythm this year and now face one of their most difficult challenges to date: slowing down an undefeated Padres squad on their home turf. While Cleveland’s roster is full of talent and upside, the inconsistencies through their opening stretch have highlighted the need for sharper execution in all phases of the game. At the heart of Cleveland’s offense remains perennial MVP candidate José Ramírez, who continues to do his part with his typical mix of power, speed, and switch-hitting versatility. However, the offense around him has lacked production, particularly with runners in scoring position. Young contributors like Josh Naylor and Bo Naylor have shown flashes of promise but have yet to provide sustained run support. Andrés Giménez, a key figure in the middle infield, is also still searching for his early-season form. Without significant home run power, the Guardians rely on manufacturing runs through aggressive baserunning and situational hitting—neither of which has consistently materialized so far. The recent injury bug has only added to Cleveland’s challenges. With several bullpen arms being used early and often due to shorter outings from the rotation, manager Stephen Vogt has had to get creative with pitching matchups.

The starting staff, typically a strength, has been shaky out of the gate. Triston McKenzie and Tanner Bibee, both considered integral to the club’s long-term plans, have struggled with command, allowing too many free passes and failing to get through the fifth inning in recent outings. Shane Bieber’s absence—due to either injury or trade—is looming large, as the Guardians lack a clear ace presence at the moment. Pitching in Petco Park, however, could be an advantage for Cleveland if their staff can find the strike zone. The spacious dimensions and marine air tend to suppress power, and that could help neutralize some of the Padres’ heavy hitters. The Guardians’ defense remains one of their most reliable assets, with Giménez and Ramírez anchoring a solid infield and Steven Kwan patrolling left field with above-average range and instincts. The bullpen has been leaned on heavily, and while closer Emmanuel Clase remains one of the most dominant ninth-inning options in baseball, the bridge to get to him is showing cracks. James Karinchak and Trevor Stephan have been hit-and-miss in their appearances, and overuse early in the season is a potential concern if the rotation doesn’t begin going deeper into games. For Cleveland, this game is less about dominating and more about stabilizing. It’s about showing they can hang with a top-tier team and execute clean baseball—getting quality starts, avoiding defensive lapses, and scratching out runs however possible. If Ramírez gets hot and the pitching limits mistakes, the Guardians have the potential to pull off an upset. But against a Padres team firing on all cylinders, Cleveland will need to play their sharpest, most complete game of the young season just to stay competitive.

The Cleveland Guardians will face the San Diego Padres on April 2, 2025, at Petco Park in San Diego, California, concluding their three-game interleague series. The Padres aim to extend their strong start to the season, while the Guardians look to gain momentum on the road. Cleveland vs San Diego AI Prediction: Free MLB Betting Insights for Apr 02. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

San Diego Padres MLB Preview

The San Diego Padres enter their April 2, 2025, matchup against the Cleveland Guardians at Petco Park riding a wave of early-season momentum and looking every bit the contender they were projected to be. Off to an undefeated start, the Padres have been dominant in virtually every phase of the game, and they’ve turned their home field into a fortress—winning six straight games at Petco Park dating back to the end of last season. Their fan base is energized, the roster is clicking, and expectations are high in San Diego for a return to postseason relevance after a turbulent few years of falling short. At the plate, San Diego’s lineup is dangerous from top to bottom. Fernando Tatis Jr. has returned to superstar form, showing the speed, power, and defensive range that made him one of baseball’s most exciting players. Hitting ahead of Xander Bogaerts and Manny Machado, Tatis has been a catalyst, drawing walks and applying pressure on the basepaths. Bogaerts, meanwhile, is settling in as a table-setter and two-strike hitter, while Machado remains the team’s steady veteran presence—capable of delivering in big moments with runners in scoring position. Adding further depth is Ha-Seong Kim, whose improved bat control and contact hitting has turned him into one of the better utility weapons in the league. Jake Cronenworth is off to a hot start as well, contributing both in the field and with clutch RBIs. This version of the Padres doesn’t rely on just one or two big names—it’s a lineup that grinds down opposing starters and forces bullpens to work from behind. The starting rotation has been equally impressive, with Joe Musgrove and Yu Darvish anchoring a staff that’s lived up to its billing early on. Darvish’s latest outing saw him go six innings with nine strikeouts, showcasing his full arsenal of pitches. The staff’s ability to limit walks and keep the ball in the yard has made life much easier on the defense and bullpen.

The Padres are allowing few scoring opportunities and are efficient at shutting the door when they get the lead. In the bullpen, Josh Hader has been lights out in the closer role, already recording multiple saves without allowing a run. Setup man Robert Suarez continues to shine in high-leverage spots, and the rest of the relief corps has held firm, including lefty specialist Tim Hill and multi-inning reliever Nabil Crismatt. The bullpen’s consistency has been a massive part of the team’s early dominance. Defensively, San Diego has committed to tightening up what was a problem area last season. Tatis has adapted well to right field, while Kim’s range at second base and Bogaerts’ reliability at shortstop make it difficult for teams to capitalize on infield hits. The Padres have also emphasized run prevention through analytics-driven positioning, and the results have been evident. Heading into this matchup with the Guardians, the Padres are looking to extend their unbeaten start and continue setting the tone for what they hope is a playoff-bound season. If the bats stay hot and the pitching holds, San Diego is in prime position to deliver another win at home and complete a statement-making series sweep.

Cleveland vs. San Diego Prop Picks (AI)

Remi is pouring through loads of datapoints on each player. In fact, anytime the Guardians and Padres play there’s always several intriguing trends to key in on. Not to mention games played at Petco Park in Apr seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: N. Jones over 0.5 Total Bases.

Cleveland vs. San Diego Prediction (AI)

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Remi, our AI sports genius, has been pouring over millions of data from every simulation between the Guardians and Padres and using recursive machine learning and cutting-edge AI to examine the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most focused on the unproportionally assigned weight human bettors often put on player performance factors between a Guardians team going up against a possibly rested Padres team. Trends look to say the true game analytics appear to reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Cleveland vs San Diego picks, computer picks Guardians vs Padres, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Guardians Betting Trends

The Guardians have covered the spread in 64.9% of games when favored on the moneyline last season.

Padres Betting Trends

The Padres covered the spread in 60.2% of games when favored on the moneyline last season.

Guardians vs. Padres Matchup Trends

The Padres have a six-game home winning streak, indicating a strong performance at Petco Park.

Cleveland vs. San Diego Game Info

Cleveland vs San Diego starts on April 02, 2025 at 4:10 PM EST.

Spread: San Diego -1.5
Moneyline: Cleveland +151, San Diego -181
Over/Under: 7.5

Cleveland: (2-3)  |  San Diego: (6-0)

Remi's searched hard and found the best prop for this matchup: N. Jones over 0.5 Total Bases.. Prices move—always shop for the best number.

The Padres have a six-game home winning streak, indicating a strong performance at Petco Park.

CLE trend: The Guardians have covered the spread in 64.9% of games when favored on the moneyline last season.

SD trend: The Padres covered the spread in 60.2% of games when favored on the moneyline last season.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Cleveland vs. San Diego Odds

AI algorithm Remi is pouring through tons of stats on each player. In fact, anytime the Cleveland vs San Diego trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments can often follow normal, predictable patterns.

Cleveland vs San Diego Opening Odds

CLE Moneyline: +151
SD Moneyline: -181
CLE Spread: +1.5
SD Spread: -1.5
Over/Under: 7.5

Cleveland vs San Diego Live Odds

Games PTS ML SPR O/U
In Progress
St Louis Cardinals
Chicago Cubs
In Progress
Cardinals
Cubs
1
3
 
-425
 
-1.5 (-150)
O 7.5 (-130)
U 7.5 (+100)
In Progress
Tampa Bay Rays
Toronto Blue Jays
In Progress
Rays
Blue Jays
0
3
+460
-750
+3.5 (-130)
-3.5 (+100)
O 8.5 (-130)
U 8.5 (+100)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+190
-235
+1.5 (-105)
-1.5 (-115)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-140
+115
-1.5 (+120)
+1.5 (-145)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 5:05PM EDT
Chicago White Sox
Washington Nationals
9/27/25 5:05PM
White Sox
Nationals
-105
-115
-1.5 (+150)
+1.5 (-180)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+110
-130
+1.5 (-190)
-1.5 (+155)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+145
-175
+1.5 (-150)
-1.5 (+125)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+120
-145
+1.5 (-190)
-1.5 (+155)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+130
-155
+1.5 (-170)
-1.5 (+140)
O 7.5 (-105)
U 7.5 (-115)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-145
+120
-1.5 (+110)
+1.5 (-130)
O 9 (-110)
U 9 (-110)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
-1.5 (+175)
+1.5 (-215)
O 7 (-115)
U 7 (-105)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+155)
+1.5 (-190)
O 10 (-115)
U 10 (-105)
Sep 28, 2025 3:06PM EDT
Baltimore Orioles
New York Yankees
9/28/25 3:06PM
Orioles
Yankees
+144
-172
+1.5 (-146)
-1.5 (+122)
O 9 (-122)
U 9 (+100)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Cleveland Guardians vs. San Diego Padres on April 02, 2025 at Petco Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS