Angels vs. Cardinals
Prediction, Odds & Props
Mar 31 | MLB AI Picks

Updated: 2025-03-29T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The St. Louis Cardinals will host the Los Angeles Angels at Busch Stadium on March 31, 2025, marking the beginning of a three-game interleague series. Both teams aim to start their seasons positively, with the Cardinals looking to build on their opening weekend success and the Angels seeking to rebound from a challenging 2024 season.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Mar 31, 2025

Start Time: 7:45 PM EST​

Venue: Busch Stadium​

Cardinals Record: (3-0)

Angels Record: (2-1)

OPENING ODDS

LAA Moneyline: +113

STL Moneyline: -134

LAA Spread: +1.5

STL Spread: -1.5

Over/Under: 8

LAA
Betting Trends

  • In the 2024 season, the Angels struggled on the road, impacting their performance against the spread (ATS).

STL
Betting Trends

  • The Cardinals had a mixed ATS record at home during the 2024 season, reflecting their overall performance fluctuations.

MATCHUP TRENDS

  • Historically, interleague matchups between the Angels and Cardinals have seen varied outcomes, making ATS predictions challenging for this series.

LAA vs. STL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: N. Arenado over 0.5 Total Bases.

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Los Angeles Angels vs St. Louis Prediction & Odds:
Free MLB Betting Insights for 3/31/25

The Los Angeles Angels and St. Louis Cardinals are set to face off on March 31, 2025, at Busch Stadium, initiating a three-game interleague series. This encounter presents an opportunity for both teams to gauge their early-season form and address areas highlighted during the offseason. The Angels enter the 2025 season with the goal of overcoming the difficulties faced in 2024, where they concluded with a 63-99 record, placing fifth in the American League West. Their offseason was marked by strategic moves aimed at bolstering both their lineup and pitching staff. Key players such as Mike Trout and Shohei Ohtani remain central to the team’s ambitions, with expectations for them to lead both offensively and on the mound. Additionally, the Angels have focused on developing young talents like Zach Neto, who showed promise in the previous season. Conversely, the Cardinals come into this series with momentum, having swept the Minnesota Twins during the opening weekend of the 2025 season. This strong start underscores their aspirations within the National League Central. The team’s lineup features stalwarts like Nolan Arenado and Lars Nootbaar, who have been instrumental in their recent successes. On the mound, Miles Mikolas is slated to start, bringing his experience and consistency to the forefront.

Defensively, the Cardinals have demonstrated cohesion and reliability, factors that contributed to their opening series sweep. The Angels, while possessing individual defensive talents, have emphasized improving their overall fielding efficiency to support their pitching staff more effectively. This matchup also highlights the strategic decisions made by both teams during the offseason. The Angels’ management has prioritized a blend of veteran leadership and emerging talent, aiming to create a balanced and competitive roster. The Cardinals have focused on maintaining a core group of players while integrating key additions to enhance their depth and versatility. As the series unfolds, attention will be on how the Angels’ lineup performs against the Cardinals’ pitching staff, particularly in high-leverage situations. Equally, the Cardinals will look to capitalize on any inconsistencies in the Angels’ bullpen, aiming to extend their early-season winning streak. In summary, the upcoming series between the Los Angeles Angels and St. Louis Cardinals presents a compelling early-season narrative. For the Angels, it’s an opportunity to set a positive tone and demonstrate resilience following a challenging 2024 season. For the Cardinals, it’s a chance to build upon their strong start and reinforce their status as contenders within their division. Fans can anticipate a series marked by strategic play, individual performances, and the unpredictable nature inherent in baseball.

Los Angeles Angels Angels MLB Preview

The Los Angeles Angels arrive at Busch Stadium on March 31, 2025, to face the surging St. Louis Cardinals, seeking to begin their first road trip of the season on a stronger note after a disappointing 2024 campaign. The Angels are coming off a 63-99 season that placed them at the bottom of the American League West, a sobering reality for a team with star power but years of underachievement. Now under renewed leadership and direction, Los Angeles enters 2025 with tempered expectations but a clear mission to rebuild credibility, develop young talent, and finally provide a winning framework around their marquee players. This series against the Cardinals offers a stiff early test for a team still searching for consistency and cohesion. At the heart of the Angels’ lineup remains Mike Trout, one of the game’s most generational talents. Despite health concerns that have limited him in recent seasons, Trout is still capable of elite production when on the field. In 2024, he managed 27 home runs in limited action and posted an OPS near .900, reminding fans and opponents alike of his immense impact when healthy. Now entering his age-33 season, Trout is focused not only on staying productive but staying on the field—an outcome that may define the Angels’ season. Behind him in the lineup is Taylor Ward, who stepped up last year as a legitimate middle-of-the-order presence. Ward provides power and plate discipline, and his emergence has given the Angels a valuable right-handed bat to complement Trout. One of the team’s biggest offseason moves was not a splashy acquisition but a quiet commitment to letting young players play. That includes shortstop Zach Neto, who debuted last season and quickly showed advanced defensive instincts and a mature approach at the plate. His bat continues to develop, and he enters 2025 with the shortstop job fully in his control.

Joining him in the youth movement is Logan O’Hoppe behind the plate. O’Hoppe, acquired in a previous trade from the Phillies, has become a cornerstone catcher with power and solid framing ability. His rapport with the pitching staff and growing leadership qualities give the Angels a long-term asset behind the dish. The Angels’ starting rotation remains a concern, particularly after the departure of Shohei Ohtani. In this game, Griffin Canning is projected to take the mound. Canning, a right-hander with above-average stuff, made strides in 2024 with increased strikeout rates and improved command. He posted a 4.18 ERA across 25 starts, showing flashes of top-tier potential. However, consistency remains elusive, and against a disciplined lineup like St. Louis, he will need to limit walks and work efficiently to give his team a fighting chance. The bullpen has been restructured but still lacks depth. Carlos Estévez returns as the closer, though his performance waned in the second half of last season. Setup duties are likely to fall to José Soriano and Matt Moore, both of whom bring power arms but have struggled with command. Defensively, the Angels have improved in the infield with Neto and Brandon Drury, but questions linger in the outfield beyond Trout. Hunter Renfroe’s departure has left a hole in right field, and the team is still sorting through defensive options with limited depth. These inconsistencies often expose the pitching staff to extra pitches and extended innings—issues that plagued Los Angeles throughout last season. Manager Ron Washington, hired in the offseason, brings energy, accountability, and a strong reputation for developing infield defense and young players. His impact may take time to materialize, but early signs indicate improved effort and structure within the clubhouse. Washington’s focus will be on instilling discipline and avoiding the mental lapses that undermined the team in 2024. As they face the Cardinals, the Angels know they’re facing an opponent firing on all cylinders. But for Los Angeles, this series is less about domination and more about establishing an identity—competing hard, staying healthy, and giving their young core the opportunity to grow under fire. Wins may not come easily, but meaningful progress can start here, even in a hostile road environment.

The St. Louis Cardinals will host the Los Angeles Angels at Busch Stadium on March 31, 2025, marking the beginning of a three-game interleague series. Both teams aim to start their seasons positively, with the Cardinals looking to build on their opening weekend success and the Angels seeking to rebound from a challenging 2024 season. Los Angeles Angels vs St. Louis AI Prediction: Free MLB Betting Insights for Mar 31. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

St. Louis Cardinals MLB Preview

The St. Louis Cardinals enter their home matchup against the Los Angeles Angels on March 31, 2025, riding the momentum of a three-game sweep over the Minnesota Twins to open the season. It’s an ideal start for a franchise that underperformed in 2024 and came into this year with renewed focus, roster reinforcements, and a familiar foundation of experienced leadership. With clear objectives set for redemption and playoff contention in the National League Central, the Cardinals have already begun to signal their intent early in the season. Returning to Busch Stadium for this interleague series, they’ll look to maintain their hot start and capitalize on a home-field advantage that has historically served them well. The Cardinals’ offense remains centered around perennial All-Star third baseman Nolan Arenado, who continues to anchor the lineup with his elite defense and reliable power production. Coming off a season in which he delivered 28 home runs and over 90 RBIs, Arenado remains one of the most dangerous right-handed bats in the game and a driving force behind St. Louis’ offensive approach. Providing support in the lineup is Lars Nootbaar, who is coming off a breakout year where he delivered above-average production and played with high energy in the outfield. Nootbaar’s blend of gap power, defensive versatility, and ability to get on base gives manager Oliver Marmol the flexibility to plug him in across the lineup and defensive alignment. Another key piece for St. Louis is utility man Brendan Donovan, who provides high contact rates, a left-handed bat, and multi-positional defensive coverage. Donovan has quickly become an integral part of the Cardinals’ everyday roster thanks to his baseball IQ and ability to execute in situational hitting scenarios. The Cardinals also expect continued growth from young players like Jordan Walker, whose elite raw power and strong arm from right field offer a glimpse of a long-term cornerstone player. With Paul Goldschmidt continuing to contribute solid production at first base and the ever-dependable Tommy Edman adding speed and defense, the Cardinals lineup is deep, balanced, and equipped to produce runs consistently against any level of pitching.

On the mound, Miles Mikolas takes the ball for this matchup, aiming to continue the pitching staff’s strong start to the year. Mikolas is a veteran presence with excellent command and pitch efficiency, qualities that allow him to pitch deep into games and minimize damage. He’ll face a dangerous Angels lineup led by Mike Trout and Shohei Ohtani, but his ability to change speeds and stay around the strike zone makes him well-suited to handle tough assignments. Behind Mikolas, the Cardinals bullpen remains one of their greatest strengths, highlighted by closer Ryan Helsley, who led the league with 49 saves in 2024. Helsley’s velocity and ability to dominate hitters late in games make him a reliable weapon in preserving leads. Defensively, the Cardinals are once again among the most polished teams in the majors. Arenado and Edman provide elite infield defense, while Nootbaar and Walker cover considerable ground in the outfield. With excellent defensive positioning and execution being a point of emphasis in spring training, the Cardinals aim to limit extra-base hits and support their pitching staff with minimal mistakes. Manager Oliver Marmol has emphasized consistency, discipline, and smarter situational play—elements that appeared lacking at times in 2024. Through the first series of 2025, the team has already looked sharper in nearly every facet of the game. As they prepare to face an Angels team still searching for rhythm, the Cardinals will look to continue playing clean baseball, leaning on their depth, experience, and execution to extend their early winning streak. A strong series at home could further establish St. Louis as the team to beat in the NL Central this season.

Los Angeles Angels vs. St. Louis Prop Picks (AI)

Remi is pouring through tons of stats on each player. In fact, anytime the Angels and Cardinals play there’s always several intriguing angles to key in on. Not to mention games played at Busch Stadium in Mar almost always follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: N. Arenado over 0.5 Total Bases.

Los Angeles Angels vs. St. Louis Prediction (AI)

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Remi, our AI sports genius, has been pouring over tons of data from every past game between the Angels and Cardinals and using recursive machine learning and impressive AI to crunch the data to a single cover probability.

The Algorithm has been most watching on the trending weight emotional bettors tend to put on player performance factors between a Angels team going up against a possibly unhealthy Cardinals team. It appears the true game analytics might reflect a moderate lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Los Angeles Angels vs St. Louis picks, computer picks Angels vs Cardinals, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Angels Betting Trends

In the 2024 season, the Angels struggled on the road, impacting their performance against the spread (ATS).

Cardinals Betting Trends

The Cardinals had a mixed ATS record at home during the 2024 season, reflecting their overall performance fluctuations.

Angels vs. Cardinals Matchup Trends

Historically, interleague matchups between the Angels and Cardinals have seen varied outcomes, making ATS predictions challenging for this series.

Los Angeles Angels vs. St. Louis Game Info

Los Angeles Angels vs St. Louis starts on March 31, 2025 at 7:45 PM EST.

Spread: St. Louis -1.5
Moneyline: Los Angeles Angels +113, St. Louis -134
Over/Under: 8

Los Angeles Angels: (2-1)  |  St. Louis: (3-0)

Remi's searched hard and found the best prop for this matchup: N. Arenado over 0.5 Total Bases.. Prices move—always shop for the best number.

Historically, interleague matchups between the Angels and Cardinals have seen varied outcomes, making ATS predictions challenging for this series.

LAA trend: In the 2024 season, the Angels struggled on the road, impacting their performance against the spread (ATS).

STL trend: The Cardinals had a mixed ATS record at home during the 2024 season, reflecting their overall performance fluctuations.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Los Angeles Angels vs. St. Louis Odds

Remi is pouring through mountains of data points on each player. In fact, anytime the Los Angeles Angels vs St. Louis trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps almost always follow normal, predictable betting trends.

Los Angeles Angels vs St. Louis Opening Odds

LAA Moneyline: +113
STL Moneyline: -134
LAA Spread: +1.5
STL Spread: -1.5
Over/Under: 8

Los Angeles Angels vs St. Louis Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-180
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8 (-115)
U 8 (-105)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+125
-150
+1.5 (-180)
-1.5 (+150)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+145
-175
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-195)
-1.5 (+160)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+105
-125
+1.5 (-205)
-1.5 (+170)
O 7.5 (+105)
U 7.5 (-125)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Los Angeles Angels Angels vs. St. Louis Cardinals on March 31, 2025 at Busch Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN