Red Sox vs. Orioles
Prediction, Odds & Props
Mar 31 | MLB AI Picks

Updated: 2025-03-29T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Baltimore Orioles will host the Boston Red Sox on March 31, 2025, at Oriole Park at Camden Yards in Baltimore, Maryland. Both teams aim to commence their seasons with a strong performance in this American League East division matchup.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Mar 31, 2025

Start Time: 2:35 PM EST​

Venue: Oriole Park at Camden Yards​

Orioles Record: (2-2)

Red Sox Record: (1-3)

OPENING ODDS

BOS Moneyline: +121

BAL Moneyline: -145

BOS Spread: +1.5

BAL Spread: -1.5

Over/Under: 9.5

BOS
Betting Trends

  • As this is the season opener, there are no recent Against The Spread (ATS) statistics available for the Red Sox.

BAL
Betting Trends

  • Similarly, with the season just beginning, no recent ATS data is available for the Orioles.

MATCHUP TRENDS

  • Historically, matchups between the Red Sox and Orioles have been competitive, often resulting in closely contested games, which may influence betting considerations.

BOS vs. BAL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: S. Newcomb under 3.5 Pitcher Strikeouts.

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Boston vs Baltimore Prediction & Odds:
Free MLB Betting Insights for 3/31/25

The Boston Red Sox and Baltimore Orioles are set to open their 2025 MLB seasons with a divisional clash on March 31 at Oriole Park at Camden Yards. This Opening Day game offers both teams an opportunity to set the tone for the year ahead in the highly competitive American League East. The Red Sox enter the season with renewed optimism, bolstered by strategic offseason acquisitions aimed at strengthening both their lineup and pitching staff. The addition of third baseman Alex Bregman is expected to provide a significant boost to the infield defense and add a potent bat to the heart of the order. On the mound, the signing of left-handed pitcher Garrett Crochet enhances the starting rotation, offering depth and versatility. Conversely, the Orioles approach the new season with a focus on building upon their young core of talented players. Despite a relatively quiet offseason in terms of major signings, Baltimore remains confident in the development of its prospects and the potential for internal improvements to drive success. Historically, games between these two teams have been closely contested, with each side securing victories in past encounters.

The familiarity between the division rivals adds an extra layer of intrigue to this Opening Day matchup. Key factors to watch in this game include the performance of the starting pitchers, the effectiveness of bullpen strategies, and the ability of hitters to capitalize on scoring opportunities. Defensive plays and base-running decisions will also play crucial roles in determining the game’s outcome. Fans can anticipate a competitive and engaging game as both teams strive to start the 2025 season on a high note. The outcome of this Opening Day matchup may provide early insights into the strengths and areas for improvement for both the Red Sox and the Orioles as they navigate the challenges of the new season.

Boston Red Sox MLB Preview

The Boston Red Sox enter the 2025 MLB season opener against the Baltimore Orioles on March 31 at Oriole Park at Camden Yards with renewed optimism and heightened expectations. Following a strategic offseason focused on bolstering their roster, the Red Sox are eager to set a strong tone in the highly competitive American League East. Under the leadership of veteran manager Alex Cora, the team combines seasoned experience with youthful promise, aiming to reclaim their status as perennial contenders and erase memories of recent struggles. A key offseason acquisition for Boston was third baseman Alex Bregman, whose arrival significantly upgrades the team’s offensive capabilities and infield defense. Bregman, a proven talent with consistent power, elite plate discipline, and postseason experience, immediately strengthens the middle of the Red Sox lineup. His veteran presence, along with existing stars like Rafael Devers and Masataka Yoshida, creates a formidable trio capable of challenging even the league’s top pitchers. Devers, in particular, remains a cornerstone of Boston’s offense, coming off consecutive seasons where he displayed impressive consistency, power, and clutch hitting. Yoshida adds versatility and reliable contact hitting, providing balance to the lineup and creating challenging matchups for opposing pitchers. Boston’s outfield, anchored by dynamic talents such as Jarren Duran and Alex Verdugo, emphasizes speed, athleticism, and defensive range. Duran continues to evolve as a key catalyst, showcasing elite speed on the base paths and growing confidence at the plate. Verdugo, a fan favorite known for his hustle and consistency, contributes valuable hitting depth and a strong arm in right field. Their defensive prowess will be particularly important in spacious ballparks such as Camden Yards, helping the pitching staff limit extra-base hits and run production.

On the pitching front, Boston made significant moves to bolster their rotation, highlighted by the acquisition of hard-throwing left-hander Garrett Crochet. Crochet, whose combination of high velocity and effective breaking pitches makes him a challenging matchup for hitters, immediately slots into the upper tier of Boston’s rotation. His arrival, alongside veterans like Brayan Bello and Tanner Houck, provides the Red Sox with a balanced and diverse pitching staff capable of competing consistently within a challenging division. Bello, in particular, showed great promise last season with his improved command and consistency, and his continued growth will be vital to Boston’s postseason aspirations. The bullpen, often a decisive factor in tightly contested divisional games, has also seen upgrades. Veteran closer Kenley Jansen anchors the relief corps, bringing experience and reliability in high-pressure situations. Supporting him, setup relievers John Schreiber and Chris Martin provide depth and versatility, offering Cora strategic flexibility to handle late-inning situations effectively. Maintaining leads late in games, especially on the road against division rivals like Baltimore, will be crucial for Boston’s success throughout the season. Defensively, the Red Sox emphasize strong fundamentals, especially within the infield. With Bregman at third, Devers handling first base more frequently, and Trevor Story providing veteran leadership up the middle, Boston boasts a sturdy defensive unit capable of limiting errors and supporting pitchers effectively. Defensive consistency will be especially important in a competitive environment like Camden Yards, where minimizing defensive miscues can greatly impact game outcomes. Overall, the Red Sox approach their season opener with optimism, having addressed several critical needs through strategic moves and player development. Their offensive depth, improved pitching rotation, and defensive reliability position them well to challenge the Orioles and set a positive trajectory for the season. A victory on Opening Day would not only provide valuable early-season momentum but also reinforce the team’s confidence as they pursue their ultimate goal of contending deep into October.

The Baltimore Orioles will host the Boston Red Sox on March 31, 2025, at Oriole Park at Camden Yards in Baltimore, Maryland. Both teams aim to commence their seasons with a strong performance in this American League East division matchup. Boston vs Baltimore AI Prediction: Free MLB Betting Insights for Mar 31. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Baltimore Orioles MLB Preview

The Baltimore Orioles enter the 2025 MLB season with a focus on nurturing their young talent and building upon the foundations laid in previous years. Under the guidance of manager Brandon Hyde, the Orioles aim to leverage their home-field advantage at Oriole Park at Camden Yards to kickstart their campaign positively against the Boston Red Sox on March 31. Offensively, the Orioles are anchored by emerging stars who have shown promise in their development. The lineup features a blend of speed and power, with players capable of impacting the game through various facets. The team’s approach at the plate emphasizes patience and discipline, aiming to increase on-base percentages and create scoring opportunities. The pitching staff, while youthful, has the potential to surprise opponents. The starting rotation comprises pitchers who have gained valuable experience and are expected to take on more significant roles this season. The bullpen, a critical component in close games, has been a focus during the offseason, with efforts made to enhance depth and reliability. Defensively, the Orioles prioritize fundamentals and cohesion. The infield and outfield units have worked extensively during spring training to improve communication and execution, aiming to reduce errors and support the pitching staff effectively.

As the Orioles prepare to face the Red Sox, several factors will be pivotal to their success. The performance of the starting pitcher in navigating Boston’s lineup, the ability of the offense to capitalize on scoring opportunities, and the effectiveness of bullpen management will all play crucial roles. Additionally, maintaining defensive solidity and executing strategic base running will contribute to the team’s competitiveness. The coaching staff has emphasized the importance of starting the season with intensity and focus. Preparations have included in-depth analysis of the Red Sox’s tendencies, allowing for the development of tailored game plans. The team’s readiness to adapt and respond to in-game developments will be a testament to their preparation and resilience. Hosting the Red Sox at Oriole Park offers the Orioles an opportunity to leverage home-field advantage. The support of the home crowd provides an energizing atmosphere that can inspire elevated performance. Engaging fans early in the season and building momentum at home are integral components of the Orioles’ strategy for success in 2025. In summary, the Baltimore Orioles approach the 2025 season opener with a blend of optimism and determination. The matchup against the Boston Red Sox serves as an early test of their progress and an opportunity to demonstrate their potential in the competitive landscape of the American League East.

Boston vs. Baltimore Prop Picks (AI)

Remi is pouring through mountains of data on each line. In fact, anytime the Red Sox and Orioles play there’s always several intriguing trends to key in on. Not to mention games played at Oriole Park at Camden Yards in Mar almost always follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: S. Newcomb under 3.5 Pitcher Strikeouts.

Boston vs. Baltimore Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over millions of data from every facet between the Red Sox and Orioles and using recursive machine learning and industry leading AI to crunch the data to a single cover probability.

Interestingly enough, the data has been most watching on the unproportionally assigned weight knucklehead sportsbettors regularly put on Boston’s strength factors between a Red Sox team going up against a possibly unhealthy Orioles team. We’ve found the true game analytics appear to reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Boston vs Baltimore picks, computer picks Red Sox vs Orioles, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Red Sox Betting Trends

As this is the season opener, there are no recent Against The Spread (ATS) statistics available for the Red Sox.

Orioles Betting Trends

Similarly, with the season just beginning, no recent ATS data is available for the Orioles.

Red Sox vs. Orioles Matchup Trends

Historically, matchups between the Red Sox and Orioles have been competitive, often resulting in closely contested games, which may influence betting considerations.

Boston vs. Baltimore Game Info

Boston vs Baltimore starts on March 31, 2025 at 2:35 PM EST.

Venue: Oriole Park at Camden Yards.

Spread: Baltimore -1.5
Moneyline: Boston +121, Baltimore -145
Over/Under: 9.5

Boston: (1-3)  |  Baltimore: (2-2)

Remi's searched hard and found the best prop for this matchup: S. Newcomb under 3.5 Pitcher Strikeouts.. Prices move—always shop for the best number.

Historically, matchups between the Red Sox and Orioles have been competitive, often resulting in closely contested games, which may influence betting considerations.

BOS trend: As this is the season opener, there are no recent Against The Spread (ATS) statistics available for the Red Sox.

BAL trend: Similarly, with the season just beginning, no recent ATS data is available for the Orioles.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Boston vs. Baltimore Odds

AI algorithm Remi is pouring through tons of data on each player. In fact, anytime the Boston vs Baltimore trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable patterns.

Boston vs Baltimore Opening Odds

BOS Moneyline: +121
BAL Moneyline: -145
BOS Spread: +1.5
BAL Spread: -1.5
Over/Under: 9.5

Boston vs Baltimore Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+190
-235
+1.5 (-110)
-1.5 (-110)
O 8.5 (-120)
U 8.5 (+100)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-175
 
-1.5 (+115)
O 9.5 (-105)
U 9.5 (-115)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+130
-155
+1.5 (-155)
-1.5 (+130)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
-1.5 (+165)
+1.5 (-200)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+185
-225
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+125)
+1.5 (-150)
O 8.5 (-105)
U 8.5 (-115)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+170
-205
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+125
-150
+1.5 (-180)
-1.5 (+150)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+140
-170
+1.5 (-155)
-1.5 (+130)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+135
-165
+1.5 (-180)
-1.5 (+150)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+115
-140
+1.5 (-190)
-1.5 (+155)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-165
+135
-1.5 (+105)
+1.5 (-125)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+100
-120
-1.5 (+170)
+1.5 (-205)
O 7.5 (-110)
U 7.5 (-110)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
-1.5 (+150)
+1.5 (-180)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Boston Red Sox vs. Baltimore Orioles on March 31, 2025 at Oriole Park at Camden Yards.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN