Giants vs. Reds
Prediction, Odds & Props
Mar 29 | MLB AI Picks

Updated: 2025-03-27T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The San Francisco Giants will face the Cincinnati Reds on March 29, 2025, at Great American Ball Park in Cincinnati, Ohio. Both teams aim to secure an early-season victory in this National League matchup.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Mar 29, 2025

Start Time: 4:10 PM EST​

Venue: Great American Ball Park​

Reds Record: (0-1)

Giants Record: (1-0)

OPENING ODDS

SF Moneyline: +105

CIN Moneyline: -124

SF Spread: +1.5

CIN Spread: -1.5

Over/Under: 8.5

SF
Betting Trends

  • The Giants concluded the 2024 season with an 80-82 record, reflecting a competitive performance throughout the year.

CIN
Betting Trends

  • The Reds finished the 2024 season with a 77-85 record, indicating areas for improvement in the upcoming season.

MATCHUP TRENDS

  • In the 2024 season series, the Giants won 4 out of 6 games against the Reds, showcasing a slight edge in their head-to-head matchups.

SF vs. CIN
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Fraley over 0.5 Total Bases.

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San Francisco vs Cincinnati Prediction & Odds:
Free MLB Betting Insights for 3/29/25

The March 29, 2025, matchup between the San Francisco Giants and the Cincinnati Reds at Great American Ball Park promises to be an exciting early-season clash between two National League clubs in transition, each aiming to assert its identity following sub-.500 finishes in 2024. The Giants, who ended last season 80-82, have undergone a considerable transformation under new manager Buster Posey, headlined by a blend of veteran acquisitions and young talent meant to revitalize both the lineup and pitching staff. Key additions include shortstop Willy Adames, whose power and defensive range bring stability to the infield, and the return of South Korean star outfielder Jung Hoo Lee, who missed part of last season but has flashed elite bat-to-ball skills and speed at the top of the order. On the mound, the Giants will be led by 42-year-old ace Justin Verlander, who despite his age, delivered a strong spring training performance, posting a 3.43 ERA with 19 strikeouts over 21 innings and signaling his readiness to anchor a staff that also includes Robbie Ray, another former Cy Young winner expected to pitch later in the series. The bullpen has been a point of focus, with Camilo Doval returning as the closer after back-to-back seasons of dominance, and the middle relief corps looks sharper thanks to improved depth. On the other side, the Cincinnati Reds, who finished 77-85 last season, enter the new campaign with a fresh look and heightened expectations, led by newly appointed manager Terry Francona, whose championship pedigree and tactical acumen are expected to elevate the club’s competitive mindset.

The Reds made several notable additions in the offseason, including right-handed starter Nick Martinez and versatile infielder Gavin Lux, while Brady Singer is expected to play a significant role in bolstering a rotation that struggled with consistency in 2024. Offensively, the Reds are looking for breakout campaigns from second-year stars Elly De La Cruz and Spencer Steer, both of whom offer speed, power, and defensive versatility, and the return to health of TJ Friedl and Matt McLain could provide a jolt of production and energy to the top of the order. Joey Votto’s presence, whether in the lineup or as a clubhouse mentor, remains invaluable, and the outfield defense, one of the team’s weaknesses last year, is expected to be significantly improved with the emergence of Christian Encarnacion-Strand. This matchup marks the beginning of a three-game series and provides an early opportunity for each team to set the tone for 2025, with San Francisco holding a slight edge in last year’s head-to-head meetings, winning four of six games. Both clubs enter the game healthier, more balanced, and strategically retooled, and with potent offenses and intriguing starting pitching duels, fans should expect a highly competitive contest. The Giants will look to capitalize on their veteran leadership and rotation strength, while the Reds will aim to leverage their home-field advantage and youthful energy in front of an enthusiastic Cincinnati crowd eager to see signs of a playoff push. With both organizations signaling they’re ready to make a leap forward, this early-season battle may serve as a barometer for how far each team has come and how much further they need to go.

San Francisco Giants MLB Preview

The San Francisco Giants head into their March 29, 2025, road matchup against the Cincinnati Reds with a revitalized sense of purpose and direction following an 80-82 finish in the 2024 season that underscored the need for structural changes across the organization, which have since taken root in the form of a revamped front office, aggressive offseason acquisitions, and the appointment of franchise legend Buster Posey as the new manager. Posey’s transition from executive suite to dugout has brought a renewed focus on clubhouse culture, fundamentals, and accountability, while also infusing the team with a fresh energy that’s been evident throughout spring training. The Giants’ offseason was headlined by the high-profile acquisition of shortstop Willy Adames, whose combination of power, glove, and veteran leadership immediately upgrades both the infield defense and middle-of-the-order production; Adames brings a proven track record, including 24 home runs and a .766 OPS in 2024, and has historically tormented Reds pitching, making him a crucial figure in this series. Complementing Adames are established bats like Michael Conforto and Thairo Estrada, while outfield reinforcements have arrived in the form of the returning Jung Hoo Lee, the dynamic South Korean leadoff hitter who was limited by injuries last season but enters 2025 fully healthy and expected to set the tone atop the lineup with his elite contact skills, speed, and on-base presence.

LaMonte Wade Jr. provides additional left-handed power, and the Giants are optimistic about bounce-back seasons from J.D. Davis and Patrick Bailey, the latter of whom is gaining recognition for his defensive prowess behind the plate and growing rapport with the pitching staff. The Giants’ rotation, which underperformed in 2024, has received a massive boost with the signing of veteran ace Justin Verlander, who despite turning 42, impressed with a strong spring, logging a 3.43 ERA and 19 strikeouts across 21 innings; his presence gives San Francisco an immediate leader and mentor for younger starters like Kyle Harrison and Tristan Beck. Former Cy Young winner Robbie Ray is also expected to make a significant impact this season as he returns to full strength, likely making his first start in the finale of the Reds series. The bullpen remains anchored by flamethrowing closer Camilo Doval, whose 37 saves last year cemented his role as one of the top finishers in the game, while veterans like Taylor Rogers and Luke Jackson round out a deep, experienced relief corps. The Giants have placed emphasis on improving road performance, where they were a sub-.500 team last year, and much of that improvement hinges on generating early offense and avoiding prolonged scoreless stretches that plagued them in 2024. Posey has also prioritized better defensive execution and baserunning efficiency, areas where the Giants lagged behind playoff-caliber clubs. In what promises to be a competitive and wide-open National League West, San Francisco is banking on a combination of veteran stability and youthful upside to push them back into the playoff picture, and starting the season strong on the road in Cincinnati will be a vital early litmus test for this retooled club seeking to reestablish itself as a legitimate contender.

The San Francisco Giants will face the Cincinnati Reds on March 29, 2025, at Great American Ball Park in Cincinnati, Ohio. Both teams aim to secure an early-season victory in this National League matchup. San Francisco vs Cincinnati AI Prediction: Free MLB Betting Insights for Mar 29. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Cincinnati Reds MLB Preview

The Cincinnati Reds enter their March 29, 2025, home game against the San Francisco Giants with cautious optimism and a rejuvenated mindset following a 77-85 finish in 2024 that showed flashes of promise but ultimately fell short of postseason contention in the ultra-competitive National League. Now under the leadership of veteran manager Terry Francona, the Reds are entering a new era built on the foundations of elite athleticism, a deepening farm system, and key offseason additions aimed at stabilizing a roster that struggled with consistency last year. One of the biggest moves of the winter came with the signing of right-hander Brady Singer, who will play a pivotal role in reshaping a rotation that lacked reliability and often left the bullpen overexposed in 2024. Singer, along with versatile swingman Nick Martinez, gives the Reds much-needed innings and veteran presence to complement emerging arms like Andrew Abbott and Hunter Greene, who have shown electric stuff but continue to seek control and maturity on the mound. Offensively, the Reds are anchored by one of the most dynamic young players in baseball—Elly De La Cruz—whose electrifying speed, raw power, and highlight-reel defense at shortstop make him a legitimate superstar-in-the-making and a franchise cornerstone. De La Cruz’s development is the centerpiece of Cincinnati’s rebuild, and his continued improvement at the plate, particularly in pitch recognition and plate discipline, could unlock an MVP-caliber ceiling.

Around him, the Reds feature a collection of promising bats, including Spencer Steer, who quietly put together a breakout 2024 season with a .271 average, 23 home runs, and 86 RBIs, and Matt McLain, a polished contact hitter with defensive versatility who missed time last year due to injury but remains a major part of the club’s future. Outfielder TJ Friedl, fully healthy and ready to reclaim the leadoff role, adds a high-OBP, speed-focused threat at the top of the order, while slugger Christian Encarnacion-Strand brings legitimate right-handed power and the ability to lengthen the lineup with his raw hitting talent. The addition of infielder Gavin Lux from the Dodgers also provides depth and a steady glove up the middle, something the Reds lacked in 2024. Behind the plate, Tyler Stephenson continues to provide solid game-calling and some offensive pop, giving Cincinnati a reliable backstop to work with the young pitching staff. The bullpen, often a sore spot in past seasons, has been restructured with new arms and a more defined late-inning plan, with Alexis Díaz returning as the closer after converting 34 saves last year and boasting one of the best strikeout rates in the league. Great American Ball Park remains a hitter-friendly environment, which the Reds hope to leverage more effectively this season by improving their situational hitting and run manufacturing in tight games. While the NL Central remains wide open, the Reds believe they are well-positioned to contend if their young talent takes the next step, and an early home series against the Giants presents a prime opportunity to assert their readiness and ignite a playoff push in front of a passionate Cincinnati fanbase eager for a return to relevance.

San Francisco vs. Cincinnati Prop Picks (AI)

AI algorithm Remi is pouring through mountains of datapoints on each line. In fact, anytime the Giants and Reds play there’s always several intriguing observations to key in on. Not to mention games played at Great American Ball Park in Mar seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: J. Fraley over 0.5 Total Bases.

San Francisco vs. Cincinnati Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over millions of data from every angle between the Giants and Reds and using recursive machine learning and impressive AI to examine the data to a single cover probability.

Oddly enough, we’ve seen the AI has been most watching on the trending weight knucklehead sportsbettors tend to put on coaching factors between a Giants team going up against a possibly unhealthy Reds team. We’ve found the true game analytics might reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI San Francisco vs Cincinnati picks, computer picks Giants vs Reds, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Giants Betting Trends

The Giants concluded the 2024 season with an 80-82 record, reflecting a competitive performance throughout the year.

Reds Betting Trends

The Reds finished the 2024 season with a 77-85 record, indicating areas for improvement in the upcoming season.

Giants vs. Reds Matchup Trends

In the 2024 season series, the Giants won 4 out of 6 games against the Reds, showcasing a slight edge in their head-to-head matchups.

San Francisco vs. Cincinnati Game Info

San Francisco vs Cincinnati starts on March 29, 2025 at 4:10 PM EST.

Venue: Great American Ball Park.

Spread: Cincinnati -1.5
Moneyline: San Francisco +105, Cincinnati -124
Over/Under: 8.5

San Francisco: (1-0)  |  Cincinnati: (0-1)

Remi's searched hard and found the best prop for this matchup: J. Fraley over 0.5 Total Bases.. Prices move—always shop for the best number.

In the 2024 season series, the Giants won 4 out of 6 games against the Reds, showcasing a slight edge in their head-to-head matchups.

SF trend: The Giants concluded the 2024 season with an 80-82 record, reflecting a competitive performance throughout the year.

CIN trend: The Reds finished the 2024 season with a 77-85 record, indicating areas for improvement in the upcoming season.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

San Francisco vs. Cincinnati Odds

AI algorithm Remi is pouring through tons of data on each player. In fact, anytime the San Francisco vs Cincinnati trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme travel distance rarely follow normal, predictable betting trends.

San Francisco vs Cincinnati Opening Odds

SF Moneyline: +105
CIN Moneyline: -124
SF Spread: +1.5
CIN Spread: -1.5
Over/Under: 8.5

San Francisco vs Cincinnati Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+192
-235
+1.5 (-110)
-1.5 (-110)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-178
 
-1.5 (+115)
O 9.5 (+100)
U 9.5 (-120)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+135
-160
+1.5 (-160)
-1.5 (+135)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
+1.5 (-205)
-1.5 (+170)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+192
-235
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+130)
+1.5 (-155)
O 8 (-120)
U 8 (+100)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+110
-130
+1.5 (-190)
-1.5 (+158)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+175
-210
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+115
-135
+1.5 (-190)
-1.5 (+158)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+150
-178
+1.5 (-145)
-1.5 (+122)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+122
-145
+1.5 (-190)
-1.5 (+158)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+118
-140
+1.5 (-190)
-1.5 (+158)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-145
+122
-1.5 (+115)
+1.5 (-135)
O 9 (-110)
U 9 (-110)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+110
-130
+1.5 (-205)
-1.5 (+170)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
+1.5 (-195)
-1.5 (+162)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers San Francisco Giants vs. Cincinnati Reds on March 29, 2025 at Great American Ball Park.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN