Giants vs Reds Prediction — AI Finds CAN'T MISS MLB Lines & Props (Mar 29)
Updated: 2025-03-27T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The San Francisco Giants will face the Cincinnati Reds on March 29, 2025, at Great American Ball Park in Cincinnati, Ohio. Both teams aim to secure an early-season victory in this National League matchup.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Mar 29, 2025
Start Time: 4:10 PM EST
Venue: Great American Ball Park
Reds Record: (0-1)
Giants Record: (1-0)
OPENING ODDS
SF Moneyline: +105
CIN Moneyline: -124
SF Spread: +1.5
CIN Spread: -1.5
Over/Under: 8.5
SF
Betting Trends
- The Giants concluded the 2024 season with an 80-82 record, reflecting a competitive performance throughout the year.
CIN
Betting Trends
- The Reds finished the 2024 season with a 77-85 record, indicating areas for improvement in the upcoming season.
MATCHUP TRENDS
- In the 2024 season series, the Giants won 4 out of 6 games against the Reds, showcasing a slight edge in their head-to-head matchups.
SF vs. CIN
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: J. Fraley over 0.5 Total Bases.
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San Francisco vs Cincinnati Prediction & Odds:
Free MLB Betting Insights for 3/29/25
The Reds made several notable additions in the offseason, including right-handed starter Nick Martinez and versatile infielder Gavin Lux, while Brady Singer is expected to play a significant role in bolstering a rotation that struggled with consistency in 2024. Offensively, the Reds are looking for breakout campaigns from second-year stars Elly De La Cruz and Spencer Steer, both of whom offer speed, power, and defensive versatility, and the return to health of TJ Friedl and Matt McLain could provide a jolt of production and energy to the top of the order. Joey Votto’s presence, whether in the lineup or as a clubhouse mentor, remains invaluable, and the outfield defense, one of the team’s weaknesses last year, is expected to be significantly improved with the emergence of Christian Encarnacion-Strand. This matchup marks the beginning of a three-game series and provides an early opportunity for each team to set the tone for 2025, with San Francisco holding a slight edge in last year’s head-to-head meetings, winning four of six games. Both clubs enter the game healthier, more balanced, and strategically retooled, and with potent offenses and intriguing starting pitching duels, fans should expect a highly competitive contest. The Giants will look to capitalize on their veteran leadership and rotation strength, while the Reds will aim to leverage their home-field advantage and youthful energy in front of an enthusiastic Cincinnati crowd eager to see signs of a playoff push. With both organizations signaling they’re ready to make a leap forward, this early-season battle may serve as a barometer for how far each team has come and how much further they need to go.
Which reaction was you yesterday? 🤔 pic.twitter.com/68s4jazh6u
— SFGiants (@SFGiants) March 28, 2025
San Francisco Giants MLB Preview
The San Francisco Giants head into their March 29, 2025, road matchup against the Cincinnati Reds with a revitalized sense of purpose and direction following an 80-82 finish in the 2024 season that underscored the need for structural changes across the organization, which have since taken root in the form of a revamped front office, aggressive offseason acquisitions, and the appointment of franchise legend Buster Posey as the new manager. Posey’s transition from executive suite to dugout has brought a renewed focus on clubhouse culture, fundamentals, and accountability, while also infusing the team with a fresh energy that’s been evident throughout spring training. The Giants’ offseason was headlined by the high-profile acquisition of shortstop Willy Adames, whose combination of power, glove, and veteran leadership immediately upgrades both the infield defense and middle-of-the-order production; Adames brings a proven track record, including 24 home runs and a .766 OPS in 2024, and has historically tormented Reds pitching, making him a crucial figure in this series. Complementing Adames are established bats like Michael Conforto and Thairo Estrada, while outfield reinforcements have arrived in the form of the returning Jung Hoo Lee, the dynamic South Korean leadoff hitter who was limited by injuries last season but enters 2025 fully healthy and expected to set the tone atop the lineup with his elite contact skills, speed, and on-base presence.
LaMonte Wade Jr. provides additional left-handed power, and the Giants are optimistic about bounce-back seasons from J.D. Davis and Patrick Bailey, the latter of whom is gaining recognition for his defensive prowess behind the plate and growing rapport with the pitching staff. The Giants’ rotation, which underperformed in 2024, has received a massive boost with the signing of veteran ace Justin Verlander, who despite turning 42, impressed with a strong spring, logging a 3.43 ERA and 19 strikeouts across 21 innings; his presence gives San Francisco an immediate leader and mentor for younger starters like Kyle Harrison and Tristan Beck. Former Cy Young winner Robbie Ray is also expected to make a significant impact this season as he returns to full strength, likely making his first start in the finale of the Reds series. The bullpen remains anchored by flamethrowing closer Camilo Doval, whose 37 saves last year cemented his role as one of the top finishers in the game, while veterans like Taylor Rogers and Luke Jackson round out a deep, experienced relief corps. The Giants have placed emphasis on improving road performance, where they were a sub-.500 team last year, and much of that improvement hinges on generating early offense and avoiding prolonged scoreless stretches that plagued them in 2024. Posey has also prioritized better defensive execution and baserunning efficiency, areas where the Giants lagged behind playoff-caliber clubs. In what promises to be a competitive and wide-open National League West, San Francisco is banking on a combination of veteran stability and youthful upside to push them back into the playoff picture, and starting the season strong on the road in Cincinnati will be a vital early litmus test for this retooled club seeking to reestablish itself as a legitimate contender.

Credit: USA TODAY/IMAGN
Cincinnati Reds MLB Preview
The Cincinnati Reds enter their March 29, 2025, home game against the San Francisco Giants with cautious optimism and a rejuvenated mindset following a 77-85 finish in 2024 that showed flashes of promise but ultimately fell short of postseason contention in the ultra-competitive National League. Now under the leadership of veteran manager Terry Francona, the Reds are entering a new era built on the foundations of elite athleticism, a deepening farm system, and key offseason additions aimed at stabilizing a roster that struggled with consistency last year. One of the biggest moves of the winter came with the signing of right-hander Brady Singer, who will play a pivotal role in reshaping a rotation that lacked reliability and often left the bullpen overexposed in 2024. Singer, along with versatile swingman Nick Martinez, gives the Reds much-needed innings and veteran presence to complement emerging arms like Andrew Abbott and Hunter Greene, who have shown electric stuff but continue to seek control and maturity on the mound. Offensively, the Reds are anchored by one of the most dynamic young players in baseball—Elly De La Cruz—whose electrifying speed, raw power, and highlight-reel defense at shortstop make him a legitimate superstar-in-the-making and a franchise cornerstone. De La Cruz’s development is the centerpiece of Cincinnati’s rebuild, and his continued improvement at the plate, particularly in pitch recognition and plate discipline, could unlock an MVP-caliber ceiling.
Around him, the Reds feature a collection of promising bats, including Spencer Steer, who quietly put together a breakout 2024 season with a .271 average, 23 home runs, and 86 RBIs, and Matt McLain, a polished contact hitter with defensive versatility who missed time last year due to injury but remains a major part of the club’s future. Outfielder TJ Friedl, fully healthy and ready to reclaim the leadoff role, adds a high-OBP, speed-focused threat at the top of the order, while slugger Christian Encarnacion-Strand brings legitimate right-handed power and the ability to lengthen the lineup with his raw hitting talent. The addition of infielder Gavin Lux from the Dodgers also provides depth and a steady glove up the middle, something the Reds lacked in 2024. Behind the plate, Tyler Stephenson continues to provide solid game-calling and some offensive pop, giving Cincinnati a reliable backstop to work with the young pitching staff. The bullpen, often a sore spot in past seasons, has been restructured with new arms and a more defined late-inning plan, with Alexis Díaz returning as the closer after converting 34 saves last year and boasting one of the best strikeout rates in the league. Great American Ball Park remains a hitter-friendly environment, which the Reds hope to leverage more effectively this season by improving their situational hitting and run manufacturing in tight games. While the NL Central remains wide open, the Reds believe they are well-positioned to contend if their young talent takes the next step, and an early home series against the Giants presents a prime opportunity to assert their readiness and ignite a playoff push in front of a passionate Cincinnati fanbase eager for a return to relevance.
Five strong innings for HG: pic.twitter.com/6TRMtRMZ8M
— Cincinnati Reds (@Reds) March 27, 2025
San Francisco vs. Cincinnati Prop Picks (AI)
San Francisco vs. Cincinnati Prediction (AI)

Remi, our AI sports genius, has been pouring over tons of data from every simulation between the Giants and Reds and using recursive machine learning and industry leading AI to examine the data to a single cover probability.
The Algorithm has been most focused on the linear correlation of weight knucklehead sportsbettors tend to put on Cincinnati’s strength factors between a Giants team going up against a possibly improved Reds team. It appears the true game analytics appear to reflect a strong lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI San Francisco vs Cincinnati picks, computer picks Giants vs Reds, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Giants Betting Trends
The Giants concluded the 2024 season with an 80-82 record, reflecting a competitive performance throughout the year.
Reds Betting Trends
The Reds finished the 2024 season with a 77-85 record, indicating areas for improvement in the upcoming season.
Giants vs. Reds Matchup Trends
In the 2024 season series, the Giants won 4 out of 6 games against the Reds, showcasing a slight edge in their head-to-head matchups.
San Francisco vs. Cincinnati Game Info
What time does San Francisco vs Cincinnati start on March 29, 2025?
San Francisco vs Cincinnati starts on March 29, 2025 at 4:10 PM EST.
Where is San Francisco vs Cincinnati being played?
Venue: Great American Ball Park.
What are the opening odds for San Francisco vs Cincinnati?
Spread: Cincinnati -1.5
Moneyline: San Francisco +105, Cincinnati -124
Over/Under: 8.5
What are the records for San Francisco vs Cincinnati?
San Francisco: (1-0) | Cincinnati: (0-1)
What is the AI best bet for San Francisco vs Cincinnati?
Remi's searched hard and found the best prop for this matchup: J. Fraley over 0.5 Total Bases.. Prices move—always shop for the best number.
What are San Francisco vs Cincinnati trending bets?
In the 2024 season series, the Giants won 4 out of 6 games against the Reds, showcasing a slight edge in their head-to-head matchups.
What are San Francisco trending bets?
SF trend: The Giants concluded the 2024 season with an 80-82 record, reflecting a competitive performance throughout the year.
What are Cincinnati trending bets?
CIN trend: The Reds finished the 2024 season with a 77-85 record, indicating areas for improvement in the upcoming season.
Where can I find AI Picks for San Francisco vs Cincinnati?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
San Francisco vs. Cincinnati Odds
AI algorithm Remi is pouring through loads of data on each team. In fact, anytime the San Francisco vs Cincinnati trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable patterns.
San Francisco vs Cincinnati Opening Odds
SF Moneyline:
+105 CIN Moneyline: -124
SF Spread: +1.5
CIN Spread: -1.5
Over/Under: 8.5
San Francisco vs Cincinnati Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 19, 2025 8:04PM EDT
Seattle Mariners
Toronto Blue Jays
10/19/25 8:04PM
Mariners
Blue Jays
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–
–
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+110
-121
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+1.5 (-195)
-1.5 (+168)
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O 7.5 (-120)
U 7.5 (+100)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers San Francisco Giants vs. Cincinnati Reds on March 29, 2025 at Great American Ball Park.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |