Guardians vs Royals Prediction — AI Finds CAN'T MISS MLB Lines & Props (Mar 29)
Updated: 2025-03-27T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Cleveland Guardians will face the Kansas City Royals on March 29, 2025, at Kauffman Stadium in Kansas City, Missouri. Both teams aim to build upon their 2024 performances and secure an early-season divisional victory.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Mar 29, 2025
Start Time: 4:10 PM EST
Venue: Kauffman Stadium
Royals Record: (0-1)
Guardians Record: (1-0)
OPENING ODDS
CLE Moneyline: +105
KC Moneyline: -125
CLE Spread: +1.5
KC Spread: -1.5
Over/Under: 8.5
CLE
Betting Trends
- The Guardians concluded the 2024 season with a 92-69 record, winning the American League Central division.
KC
Betting Trends
- The Royals finished the 2024 season with an 86-76 record, placing them in the AL Central.
MATCHUP TRENDS
- In the 2024 season series, the Royals won 8 of the 13 head-to-head matchups against the Guardians, demonstrating a competitive edge in their encounters.
CLE vs. KC
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: N. Jones over 0.5 Total Bases.
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Cleveland vs Kansas City Prediction & Odds:
Free MLB Betting Insights for 3/29/25
Second baseman Jonathan India adds versatility and a solid on-base presence to the lineup. Kansas City’s probable starter is Cole Ragans, who had an impressive 2024 season with an 11-9 record and a 3.14 ERA. Ragans’ ability to command the strike zone and limit opposing hitters will be vital in containing the Guardians’ offense. The bullpen, featuring reliable arms like Seth Lugo and Michael Wacha, offers stability in closing out games. Defensively, both teams exhibit strengths, with the Guardians showcasing a solid infield anchored by Ramírez and the Royals benefiting from Pérez’s experience behind the plate. The outfield matchups will also be pivotal, with both teams possessing players capable of making significant contributions both offensively and defensively. Given the Royals’ success in the 2024 season series against the Guardians, winning 8 out of 13 games, Kansas City may hold a psychological advantage. However, the Guardians’ overall stronger season record and divisional title indicate their capability to compete effectively. In summary, the March 29 game between the Cleveland Guardians and the Kansas City Royals is set to be an engaging matchup between two competitive AL Central teams. Both squads will look to leverage their strengths and address any weaknesses as they vie for an early-season victory that could set the tone for their divisional campaigns.
Manzo had himself an Opening Day to remember.#GuardsBall | #GuardiWins pic.twitter.com/PtCOiNokPf
— Cleveland Guardians (@CleGuardians) March 27, 2025
Cleveland Guardians MLB Preview
The Cleveland Guardians enter their March 29, 2025, matchup against the Kansas City Royals with high expectations and confidence following a successful 2024 campaign in which they captured the American League Central division crown with a 92-69 record, combining one of the league’s best pitching staffs with a fundamentally sound, contact-oriented offense. Under the steady leadership of manager Stephen Vogt, the Guardians have carved out a clear identity built around elite defense, disciplined at-bats, and dominant pitching, all of which contributed to their return to the postseason after falling short the year prior. At the heart of Cleveland’s offense remains superstar third baseman José Ramírez, who once again put together a complete season in 2024, slashing .287/.360/.505 with 31 home runs, 105 RBIs, and 27 stolen bases while continuing to play Gold Glove-caliber defense at the hot corner. Surrounding him in the lineup are contact hitters like Steven Kwan, who posted a .291 average with a league-low strikeout rate, and Andrés Giménez, whose ability to drive the ball into gaps and steal bases gives Cleveland a dangerous middle infield duo. Veteran Carlos Santana returns to Cleveland for a final run and adds a valuable switch-hitting presence and veteran leadership to a young clubhouse, while catcher Bo Naylor’s development into a consistent power threat from the left side provides offensive balance. Cleveland’s lineup doesn’t overwhelm with home run totals, but it excels at working deep counts, putting the ball in play, and forcing opposing pitchers to grind through innings.
On the mound, the Guardians feature one of the most exciting young rotations in baseball, led by right-hander Tanner Bibee, who is expected to get the start against Kansas City after a breakout 2024 campaign in which he posted a 12-8 record with a 3.47 ERA and 176 strikeouts in 172 innings. Bibee’s command of four pitches and poise under pressure make him a formidable Opening Series option, and he’s followed in the rotation by talented arms like Gavin Williams and Triston McKenzie, giving Cleveland the rare advantage of both youth and upside in their starting staff. The bullpen remains a major strength, anchored by flame-throwing closer Emmanuel Clase, who recorded 39 saves in 2024 and was a finalist for the AL Cy Young Award. Set-up men Trevor Stephan and Sam Hentges provide power from both sides of the mound, giving Vogt multiple late-inning options against any type of lineup. The Guardians’ defense, particularly on the infield, remains among the best in baseball, with Ramírez, Giménez, and first baseman Josh Naylor consistently converting difficult plays into outs. While Cleveland struggled against the Royals last season, winning just five of thirteen matchups, the Guardians view this as a chance to immediately reassert themselves within the division and make an early statement. With a combination of elite pitching, balanced offensive production, and one of the deepest farm systems in the league, Cleveland has built a sustainable contender that plans to remain atop the AL Central, and a strong performance on the road in Kansas City would reinforce that they are once again the team to beat.

Credit: USA TODAY/IMAGN
Kansas City Royals MLB Preview
The Kansas City Royals enter their March 29, 2025, matchup against the Cleveland Guardians with optimism and momentum following a much-improved 2024 campaign in which they finished 86-76 and took significant strides toward returning to playoff contention in the American League Central. After multiple seasons spent near the bottom of the standings, Kansas City has emerged as a balanced, well-coached team under manager Matt Quatraro, blending veteran leadership with rising young talent to build a foundation capable of sustaining success. The offense continues to revolve around longtime franchise icon Salvador Pérez, whose production and clubhouse presence remain vital as he transitions into a mentor role while still delivering with the bat, as evidenced by his 2024 slash line of .271/.317/.456 and 21 home runs. First baseman Vinnie Pasquantino has grown into a legitimate offensive force in the middle of the lineup, hitting .262 with 26 homers last season while also posting an impressive .345 OBP, giving the Royals both power and patience at the plate. Kansas City also benefited from the emergence of second baseman Jonathan India, a midseason acquisition who added depth and flexibility with his ability to work counts and get on base consistently, while MJ Melendez contributed as a power-hitting outfielder who can change games with one swing. Add to that the speed and defensive prowess of Bobby Witt Jr., and the Royals boast a lineup that can beat opponents with a combination of pop, situational hitting, and pressure on the bases.
On the mound, the Royals are anchored by breakout left-hander Cole Ragans, who earned the Opening Series start after posting an 11-9 record with a 3.14 ERA and 196 strikeouts over 186.1 innings in 2024, showcasing both durability and swing-and-miss stuff that made him one of the best stories in baseball last season. Ragans headlines a deeper and more stable rotation, joined by veterans like Michael Wacha and Seth Lugo, both of whom had ERAs below 3.40 last year, offering the Royals consistency every five days. The bullpen is also a strength, led by Lucas Erceg, who emerged as a reliable late-inning arm with a 3.36 ERA, and James McArthur, whose improved fastball command earned him high-leverage opportunities late in the 2024 season. The Royals have placed renewed emphasis on defense and fundamentals, with spring training drills focused on minimizing errors and executing in close games, areas that previously plagued the club during its rebuilding years. They also carry a psychological edge into this series, having won eight of their 13 meetings against the Guardians in 2024, showing they can compete against the reigning division champions. Playing at Kauffman Stadium, with a fanbase energized by last year’s improvement and eager for postseason baseball to return, the Royals will look to establish dominance early in the AL Central and send a message that their 2024 resurgence was no fluke. A strong showing against a division rival like Cleveland could go a long way in setting the tone for what Kansas City hopes will be their first winning season since 2015 and a legitimate run toward October baseball.
A special thank you to @Whiteman_AFB for our Opening Day flyover! #AFFlyover pic.twitter.com/a5f04SnWWM
— Kansas City Royals (@Royals) March 28, 2025
Cleveland vs. Kansas City Prop Picks (AI)
Cleveland vs. Kansas City Prediction (AI)

Remi, our AI sports genius, has been pouring over millions of data from every facet between the Guardians and Royals and using recursive machine learning and impressive AI to analyze the data to a single cover probability.
Interestingly enough, the data has been most watching on the growing factor knucklehead sportsbettors often put on player performance factors between a Guardians team going up against a possibly rested Royals team. In reality, the true game analytics might reflect a strong lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.
Below is our current AI Cleveland vs Kansas City picks, computer picks Guardians vs Royals, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.
Guardians Betting Trends
The Guardians concluded the 2024 season with a 92-69 record, winning the American League Central division.
Royals Betting Trends
The Royals finished the 2024 season with an 86-76 record, placing them in the AL Central.
Guardians vs. Royals Matchup Trends
In the 2024 season series, the Royals won 8 of the 13 head-to-head matchups against the Guardians, demonstrating a competitive edge in their encounters.
Cleveland vs. Kansas City Game Info
What time does Cleveland vs Kansas City start on March 29, 2025?
Cleveland vs Kansas City starts on March 29, 2025 at 4:10 PM EST.
Where is Cleveland vs Kansas City being played?
Venue: Kauffman Stadium.
What are the opening odds for Cleveland vs Kansas City?
Spread: Kansas City -1.5
Moneyline: Cleveland +105, Kansas City -125
Over/Under: 8.5
What are the records for Cleveland vs Kansas City?
Cleveland: (1-0) | Kansas City: (0-1)
What is the AI best bet for Cleveland vs Kansas City?
Remi's searched hard and found the best prop for this matchup: N. Jones over 0.5 Total Bases.. Prices move—always shop for the best number.
What are Cleveland vs Kansas City trending bets?
In the 2024 season series, the Royals won 8 of the 13 head-to-head matchups against the Guardians, demonstrating a competitive edge in their encounters.
What are Cleveland trending bets?
CLE trend: The Guardians concluded the 2024 season with a 92-69 record, winning the American League Central division.
What are Kansas City trending bets?
KC trend: The Royals finished the 2024 season with an 86-76 record, placing them in the AL Central.
Where can I find AI Picks for Cleveland vs Kansas City?
See our latest MLB picks and odds pages for 2025 to compare prices before you bet.
Cleveland vs. Kansas City Odds
AI algorithm Remi is pouring through loads of stats on each player. In fact, anytime the Cleveland vs Kansas City trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments seemingly never follow normal, predictable patterns.
Cleveland vs Kansas City Opening Odds
CLE Moneyline:
+105 KC Moneyline: -125
CLE Spread: +1.5
KC Spread: -1.5
Over/Under: 8.5
Cleveland vs Kansas City Live Odds
Games | PTS | ML | SPR | O/U | |
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Oct 19, 2025 8:04PM EDT
Seattle Mariners
Toronto Blue Jays
10/19/25 8:04PM
Mariners
Blue Jays
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–
–
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+110
-130
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+1.5 (-205)
-1.5 (+170)
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O 7.5 (-115)
U 7.5 (-105)
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MLB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Cleveland Guardians vs. Kansas City Royals on March 29, 2025 at Kauffman Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TOR@SEA | OVER 7 | 54.9% | 3 | WIN |
LAD@MIL | UNDER 7.5 | 56.6% | 6 | WIN |
TOR@NYY | OVER 8 | 54.9% | 4 | WIN |
TOR@NYY | CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED | 53.3% | 3 | WIN |
NYY@TOR | OVER 7.5 | 54.8% | 2 | WIN |
LAD@PHI | OVER 7 | 53.8% | 3 | WIN |
SD@CHC | CHC -109 | 53.8% | 3 | WIN |
SD@CHC | OVER 7.5 | 54.5% | 4 | LOSS |
SD@CHC | CHC -111 | 54.8% | 4 | LOSS |
CIN@LAD | SHOHEI OHTANI OVER 1.5 BASES | 53.5% | 3 | WIN |
BOS@NYY | OVER 7 | 53.8% | 3 | LOSS |
CIN@LAD | ELLY DE LA CRUZ OVER 0.5 BASES | 54.4% | 4 | LOSS |
ARI@SD | SD -131 | 57.3% | 4 | WIN |
DET@BOS | BOS -115 | 56.4% | 5 | WIN |
NYM@CHC | NYM -110 | 54.1% | 3 | WIN |
HOU@ATH | ATH +118 | 50.8% | 4 | WIN |
NYM@CHC | OVER 7 | 54.5% | 3 | WIN |
STL@SF | OVER 7.5 | 55.9% | 5 | LOSS |
KC@LAA | TYLER TOLBERT UNDER 1.5 BASES | 54.4% | 4 | WIN |
MIL@SD | UNDER 9 | 54.7% | 4 | WIN |
MIA@PHI | KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS | 53.3% | 3 | WIN |
WAS@NYM | OVER 8.5 | 56.1% | 6 | LOSS |
LAA@COL | COL +108 | 50.5% | 3 | WIN |
TOR@KC | UNDER 9 | 54.7% | 4 | LOSS |
SEA@KC | KC +1.5 | 62.3% | 5 | LOSS |
NYY@MIN | OVER 9 | 55.1% | 4 | WIN |
MIA@COL | OVER 10.5 | 55.0% | 4 | WIN |
MIA@COL | AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS | 54.3% | 4 | WIN |
SEA@KC | BOBBY WITT UNDER 0.5 SINGLES | 54.4% | 4 | LOSS |
PHI@LAD | LAD -113 | 54.7% | 4 | LOSS |
NYY@BOS | OVER 7.5 | 54.3% | 3 | WIN |
KC@PHI | PHI -130 | 58.3% | 4 | WIN |
LAD@SF | OVER 7.5 | 54.7% | 4 | LOSS |
NYM@PHI | PHI -122 | 55.6% | 4 | WIN |
KC@CLE | KC -104 | 52.0% | 3 | WIN |
CIN@SD | JAKE CRONEWORTH OVER 0.5 HITS | 53.1% | 3 | WIN |
WAS@MIA | MIA -123 | 55.2% | 4 | LOSS |
LAA@KC | UNDER 9.5 | 54.9% | 3 | WIN |
TEX@ARI | UNDER 9 | 54.2% | 4 | WIN |
SF@COL | UNDER 11.5 | 56.4% | 6 | LOSS |
SF@COL | RAFAEL DEVERS OVER 1.5 BASES | 56.1% | 6 | WIN |
MIA@WAS | WAS -110 | 54.4% | 4 | WIN |
NYM@DET | OVER 8.5 | 54.5% | 4 | WIN |
TEX@ARI | UNDER 9.5 | 56.4% | 6 | WIN |
TEX@ARI | ALEJANDRO OSUNA UNDER 1.5 BASES | 54.1% | 4 | LOSS |
ATL@CHC | CHC -116 | 55.1% | 3 | WIN |
PHI@MIL | OVER 8.5 | 55.0% | 3 | WIN |
ARI@LAD | SHOHEI OHTANI OVER 2.5 BASES | 54.2% | 4 | WIN |
SEA@CLE | CLE +1.5 | 57.2% | 3 | WIN |
CHC@SF | CHC -105 | 54.1% | 4 | LOSS |
NYY@CHW | RYAN MCMAHON OVER 0.5 BASES | 54.1% | 4 | WIN |