Twins vs. Cardinals
Prediction, Odds & Props
Mar 27 | MLB AI Picks

Updated: 2025-03-25T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Minnesota Twins and the St. Louis Cardinals are set to kick off their 2025 MLB seasons with an interleague matchup on March 27 at Busch Stadium in St. Louis. This game marks the earliest Opening Day in the history of both franchises.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Mar 27, 2025

Start Time: 4:15 PM EST​

Venue: Busch Stadium​

Cardinals Record: (0-0)

Twins Record: (0-0)

OPENING ODDS

MIN Moneyline: -118

STL Moneyline: -101

MIN Spread: -1.5

STL Spread: +1.5

Over/Under: 7.5

MIN
Betting Trends

  • The Twins concluded the 2024 season with an 82-80 record.

STL
Betting Trends

  • The Cardinals finished the 2024 season with a 65-97 record.

MATCHUP TRENDS

  • In their last meeting on August 24, 2024, the Twins defeated the Cardinals 6-0, showcasing a dominant performance.

MIN vs. STL
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: M. Winn over 0.5 Hits+Runs+RBI.

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Minnesota vs St. Louis Prediction & Odds:
Free MLB Betting Insights for 3/27/25

The 2025 MLB season opener between the Minnesota Twins and the St. Louis Cardinals at Busch Stadium brings together two teams with contrasting trajectories from the previous year. The Twins, coming off an 82-80 season, aim to build upon their performance and contend for the American League Central title. Conversely, the Cardinals, after a disappointing 65-97 record, seek a resurgence to reestablish themselves as contenders in the National League Central. Minnesota’s offseason was marked by strategic acquisitions aimed at bolstering both their lineup and pitching staff. Notably, they signed center fielder Harrison Bader to a one-year, $6.25 million contract. Bader, known for his defensive prowess, made 140 starts in center field for the New York Mets in 2024, and his addition is expected to strengthen the Twins’ outfield defense significantly. On the mound, the Twins will likely rely on their ace, Pablo López, to set the tone for the pitching staff. López’s consistent performance in 2024 provided stability, and the team hopes he can continue to anchor the rotation effectively. Offensively, Minnesota will look to key contributors such as Carlos Correa and Byron Buxton. Correa aims to rebound from a subpar 2024 season, while Buxton’s health remains a pivotal factor in the team’s offensive success. The Cardinals, under the leadership of manager Oliver Marmol, are determined to turn the page on a challenging 2024 season. They have named Sonny Gray as their Opening Day starter.

Gray, who had a notable tenure with the Twins before joining St. Louis, brings a wealth of experience and a competitive edge to the Cardinals’ rotation. His familiarity with the Twins’ lineup could provide an intriguing dynamic to the game. Offensively, the Cardinals will depend on stalwarts like Paul Goldschmidt and Nolan Arenado to drive in runs and provide leadership. Both players have been consistent performers and are crucial to the team’s success. The development of younger talents will also be closely watched, as the Cardinals aim to integrate fresh energy into their roster. Defensively, both teams have emphasized improvement. The Twins’ addition of Bader is expected to enhance their outfield coverage, while the Cardinals have focused on infield coordination and reducing errors. These defensive adjustments could play a significant role in the outcome of the game. As the teams take the field on March 27, fans can anticipate a competitive game that sets the tone for the season. The performance of the starting pitchers, López and Gray, will be pivotal, and the effectiveness of each team’s lineup in capitalizing on scoring opportunities will likely determine the outcome. Given the Cardinals’ home-field advantage and the Twins’ recent roster enhancements, this Opening Day matchup promises to be an engaging start to the 2025 MLB season.

Minnesota Twins MLB Preview

The Minnesota Twins arrive at the 2025 season with clear postseason expectations and a deep, talented roster ready to contend in the American League Central. After finishing the 2024 campaign with a modest 82-80 record and narrowly missing out on a playoff berth, the Twins made calculated offseason moves to address specific weaknesses, particularly in their outfield defense and lineup consistency. Leading the charge into St. Louis for Opening Day is their ace, Pablo López, who has solidified himself as one of the American League’s most reliable starters. López delivered another strong season in 2024, posting a 3.66 ERA across 194 innings with 208 strikeouts. His durability and command of a four-pitch mix anchored a rotation that kept the Twins afloat even during offensive dry spells. The team’s confidence in López is evidenced by his third straight Opening Day nod, and his matchup against former Twin Sonny Gray will provide an emotional and competitive edge to start the season. Offensively, the Twins have one of the most intriguing and balanced lineups in the league, blending power, speed, and contact. At the center of it is shortstop Carlos Correa, who looks to rebound after an underwhelming 2024 where he battled plantar fasciitis and hit just .231 with 12 home runs. Correa’s health and performance will be pivotal in determining the ceiling of this Twins squad, as he remains a leader in the clubhouse and a key two-way player. Byron Buxton, who also struggled to stay healthy last year, is reportedly entering 2025 with no restrictions and is expected to resume duties in center field—a huge boost to Minnesota’s defense and lineup versatility. When healthy, Buxton is one of the most dynamic players in baseball, capable of altering games with his power-speed combo and elite glove. To reinforce the outfield and give Buxton more flexibility, the Twins signed veteran outfielder Harrison Bader in the offseason to a one-year deal.

Known for his exceptional defensive range and instincts, Bader is expected to start most games in center field, allowing Buxton to rotate between DH and corner outfield to preserve his legs. Bader’s glove complements an outfield that also includes Max Kepler, who quietly posted a 24-homer season in 2024, and rising star Matt Wallner, whose left-handed bat offers significant slugging upside. In the infield, Edouard Julien emerged as a reliable presence at second base, showing improved defense and a patient eye at the plate, while Alex Kirilloff and Royce Lewis are expected to bring consistency to first and third base respectively. The bullpen, a source of strength in 2024, returns closer Jhoan Duran, one of the hardest-throwing relievers in the game. Duran saved 31 games with a 2.43 ERA and regularly touched 103 mph with his fastball. He’s supported by Griffin Jax, Brock Stewart, and Caleb Thielbar, all of whom provide matchup flexibility and late-inning reliability. Manager Rocco Baldelli has emphasized improved baserunning, situational hitting, and more aggressive use of platoon advantages heading into 2025. Facing Sonny Gray and the Cardinals on the road offers immediate narrative and competitive drama, particularly given Gray’s leadership role in Minnesota just one year ago. But with López leading the rotation, a healthier core, and defensive upgrades like Bader, the Twins are well-equipped to launch their season with a statement win and start their march toward October baseball.

The Minnesota Twins and the St. Louis Cardinals are set to kick off their 2025 MLB seasons with an interleague matchup on March 27 at Busch Stadium in St. Louis. This game marks the earliest Opening Day in the history of both franchises. Minnesota vs St. Louis AI Prediction: Free MLB Betting Insights for Mar 27. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

St. Louis Cardinals MLB Preview

The St. Louis Cardinals enter the 2025 MLB season with a renewed focus on reclaiming their status as contenders in the National League Central. After a disappointing 65-97 record in 2024, the organization has undertaken a series of strategic moves aimed at revitalizing the team’s performance. Central to these efforts is the acquisition of veteran pitcher Sonny Gray, who has been named the Opening Day starter. Gray’s experience and familiarity with the Twins, his former team, are expected to provide an immediate boost to the Cardinals’ rotation. Offensively, the Cardinals continue to rely on the proven talents of first baseman Paul Goldschmidt and third baseman Nolan Arenado. Both players have demonstrated consistent offensive production and leadership qualities that are invaluable to the team’s success. Goldschmidt’s ability to get on base and drive in runs, coupled with Arenado’s power and defensive prowess, form the cornerstone of the Cardinals’ lineup. The development and integration of younger players into the roster have also been a focal point during the offseason. The Cardinals have invested in their farm system, and several prospects are expected to make significant contributions during the 2025 season. This infusion of youth aims to complement the veteran core and provide the team with a balanced and dynamic roster. Defensively, the Cardinals have emphasized improving infield coordination and reducing errors. Spring training sessions have focused on fundamentals and communication, with the goal of enhancing overall team defense. The presence of Arenado at third base continues to be a significant asset, given his multiple Gold Glove awards and reputation as one of the best defensive players in the league. The bullpen has also been a point of emphasis, with the organization seeking to build a reliable group of relievers capable of maintaining leads and closing out games effectively. The Cardinals have explored various options, including potential acquisitions and promoting from within, to strengthen this aspect of the team. As the Cardinals head into Opening Day at Busch Stadium, there’s cautious optimism in the clubhouse and throughout the fanbase. After one of the franchise’s worst seasons in recent history, the front office and coaching staff made it clear during the offseason that improvement would not be optional—it would be expected. One of the team’s first priorities was to bring in veteran leadership on the mound, and signing Sonny Gray to a multi-year deal was the centerpiece of that effort. Gray, coming off a Cy Young-caliber year with the Twins in which he posted a 2.79 ERA and over 180 strikeouts, brings the kind of consistency and competitiveness that the rotation sorely lacked in 2024.

His Opening Day start against his former team adds an extra layer of intrigue, and his familiarity with Minnesota’s lineup could be a significant edge for St. Louis. Behind Gray, the Cardinals are expecting a more effective and consistent year from veterans like Miles Mikolas and Steven Matz, while also integrating young arms like Tink Hence and Gordon Graceffo into the mix over the course of the season. That infusion of youth won’t just apply to the pitching staff. Players like Jordan Walker, Masyn Winn, and Ivan Herrera are projected to take on larger roles in the everyday lineup. Walker, in particular, is viewed as a breakout candidate after showing flashes of power and athleticism last year. His development into a middle-of-the-order presence could take pressure off the aging but still dangerous bats of Goldschmidt and Arenado. Speaking of Goldschmidt and Arenado, both are coming off slightly down years by their lofty standards, but neither has shown signs of slowing down physically. Goldschmidt still maintains elite bat speed and zone control, while Arenado remains one of the most dangerous hitters with runners in scoring position. Their presence in the lineup, alongside Brendan Donovan and Tommy Edman—two switch-hitting, high-OBP utility players—gives the Cardinals lineup much-needed balance and versatility. In the offseason, the front office also prioritized getting more athletic and improving their run production from the bottom half of the order, aiming to avoid the scoring droughts that plagued them in 2024. Defensively, the Cardinals are expected to be much sharper this season. With Edman likely patrolling center field full-time and Winn bringing elite range and arm strength at shortstop, St. Louis should be able to cut down on mistakes that led to costly unearned runs last year. Add to that the perennial Gold Glove presence of Arenado at third and Goldschmidt at first, and the Cardinals once again have the potential to be one of the top defensive teams in the National League. Opening Day presents the Cardinals with an opportunity to begin rewriting the narrative after a rough 2024. Hosting a strong Twins team provides an immediate challenge, but it also serves as a litmus test for the offseason improvements and culture reset that have taken place. A dominant outing from Gray and early run support from the core lineup would not only energize the St. Louis faithful, but also send a message that one of baseball’s proudest franchises is ready to contend again in 2025.

Minnesota vs. St. Louis Prop Picks (AI)

AI algorithm Remi is pouring through tons of data on each team. In fact, anytime the Twins and Cardinals play there’s always several intriguing observations to key in on. Not to mention games played at Busch Stadium in Mar seemingly never follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: M. Winn over 0.5 Hits+Runs+RBI.

Minnesota vs. St. Louis Prediction (AI)

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Remi, our AI sports wizard, has been pouring over mountains of data from every facet between the Twins and Cardinals and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.

Interestingly enough, the data has been most focused on the trending weight knucklehead sportsbettors regularly put on coaching factors between a Twins team going up against a possibly unhealthy Cardinals team. In reality, the true game analytics might reflect a slight lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Minnesota vs St. Louis picks, computer picks Twins vs Cardinals, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
MLB 9/26 DET@BOS UNLOCK THIS PICK 5 EXECUTIVE Locked EXECUTIVE
MLB 9/26 BAL@NYY UNLOCK THIS PICK 4 INTEL Locked INTEL
MLB 9/26 ARI@SD UNLOCK THIS PICK 4 EXECUTIVE Locked EXECUTIVE
MLB 9/26 NYM@MIA UNLOCK THIS PICK 1 INTEL Locked INTEL
MLB 9/26 NYM@MIA GET FREE PICK NOW 1
MLB 9/26 COL@SF UNLOCK THIS PICK 0 INTEL Locked INTEL

These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Twins Betting Trends

The Twins concluded the 2024 season with an 82-80 record.

Cardinals Betting Trends

The Cardinals finished the 2024 season with a 65-97 record.

Twins vs. Cardinals Matchup Trends

In their last meeting on August 24, 2024, the Twins defeated the Cardinals 6-0, showcasing a dominant performance.

Minnesota vs. St. Louis Game Info

Minnesota vs St. Louis starts on March 27, 2025 at 4:15 PM EST.

Spread: St. Louis +1.5
Moneyline: Minnesota -118, St. Louis -101
Over/Under: 7.5

Minnesota: (0-0)  |  St. Louis: (0-0)

Remi's searched hard and found the best prop for this matchup: M. Winn over 0.5 Hits+Runs+RBI.. Prices move—always shop for the best number.

In their last meeting on August 24, 2024, the Twins defeated the Cardinals 6-0, showcasing a dominant performance.

MIN trend: The Twins concluded the 2024 season with an 82-80 record.

STL trend: The Cardinals finished the 2024 season with a 65-97 record.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Minnesota vs. St. Louis Odds

AI algorithm Remi is pouring through mountains of data on each team. In fact, anytime the Minnesota vs St. Louis trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme temps can often follow normal, predictable patterns.

Minnesota vs St. Louis Opening Odds

MIN Moneyline: -118
STL Moneyline: -101
MIN Spread: -1.5
STL Spread: +1.5
Over/Under: 7.5

Minnesota vs St. Louis Live Odds

Games PTS ML SPR O/U
Sep 27, 2025 1:06PM EDT
Baltimore Orioles
New York Yankees
9/27/25 1:06PM
Orioles
Yankees
+192
-235
+1.5 (-110)
-1.5 (-110)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 2:21PM EDT
St Louis Cardinals
Chicago Cubs
9/27/25 2:21PM
Cardinals
Cubs
 
-178
 
-1.5 (+115)
O 9.5 (+100)
U 9.5 (-120)
Sep 27, 2025 3:09PM EDT
Tampa Bay Rays
Toronto Blue Jays
9/27/25 3:09PM
Rays
Blue Jays
+135
-160
+1.5 (-160)
-1.5 (+135)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Chicago White Sox
Washington Nationals
9/27/25 4:06PM
White Sox
Nationals
+100
-120
+1.5 (-205)
-1.5 (+170)
O 8.5 (-110)
U 8.5 (-110)
Sep 27, 2025 4:06PM EDT
Colorado Rockies
San Francisco Giants
9/27/25 4:06PM
Rockies
Giants
+192
-235
+1.5 (-110)
-1.5 (-110)
O 8 (-105)
U 8 (-115)
Sep 27, 2025 4:11PM EDT
New York Mets
Miami Marlins
9/27/25 4:11PM
Mets
Marlins
-130
+110
-1.5 (+130)
+1.5 (-155)
O 8 (-120)
U 8 (+100)
Sep 27, 2025 4:11PM EDT
Detroit Tigers
Boston Red Sox
9/27/25 4:11PM
Tigers
Red Sox
+110
-130
+1.5 (-190)
-1.5 (+158)
O 9 (+100)
U 9 (-120)
Sep 27, 2025 6:05PM EDT
Minnesota Twins
Philadelphia Phillies
9/27/25 6:05PM
Twins
Phillies
+175
-210
+1.5 (-120)
-1.5 (+100)
O 8.5 (-115)
U 8.5 (-105)
Sep 27, 2025 7:11PM EDT
Cincinnati Reds
Milwaukee Brewers
9/27/25 7:11PM
Reds
Brewers
+115
-135
+1.5 (-190)
-1.5 (+158)
O 7.5 (-120)
U 7.5 (+100)
Sep 27, 2025 7:15PM EDT
Pittsburgh Pirates
Atlanta Braves
9/27/25 7:15PM
Pirates
Braves
+150
-178
+1.5 (-145)
-1.5 (+122)
O 8 (-110)
U 8 (-110)
Sep 27, 2025 7:16PM EDT
Texas Rangers
Cleveland Guardians
9/27/25 7:16PM
Rangers
Guardians
+122
-145
+1.5 (-190)
-1.5 (+158)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 8:40PM EDT
Arizona Diamondbacks
San Diego Padres
9/27/25 8:40PM
Diamondbacks
Padres
+118
-140
+1.5 (-190)
-1.5 (+158)
O 7.5 (-115)
U 7.5 (-105)
Sep 27, 2025 9:39PM EDT
Houston Astros
Los Angeles Angels
9/27/25 9:39PM
Astros
Angels
-145
+122
-1.5 (+115)
+1.5 (-135)
O 9 (-110)
U 9 (-110)
Sep 27, 2025 9:41PM EDT
Los Angeles Dodgers
Seattle Mariners
9/27/25 9:41PM
Dodgers
Mariners
+110
-130
+1.5 (-205)
-1.5 (+170)
O 7 (-120)
U 7 (+100)
Sep 27, 2025 10:05PM EDT
Kansas City Royals
Oakland Athletics
9/27/25 10:05PM
Royals
Athletics
+100
-120
+1.5 (-195)
-1.5 (+162)
O 10 (-110)
U 10 (-110)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Minnesota Twins vs. St. Louis Cardinals on March 27, 2025 at Busch Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN
PHI@NYM OVER 8.5 55.6% 4 LOSS
LAA@TEX LOGAN OHOPPE OVER 1.5 HITS+RUNS+RBIS 54.1% 4 LOSS
KC@CHW KC -109 54.2% 4 WIN
SD@SEA DYLAN CEASE OVER 16.5 OUTS 53.9% 3 LOSS
SD@SEA UNDER 8.5 54.4% 4 LOSS
MIN@TOR JOE RYAN UNDER 2.5 EARNED RUNS 54.1% 4 LOSS
SF@MIL MIL +100 54.0% 6 LOSS
TOR@MIA MIA +1.5 62.0% 6 WIN
CHC@LAA OVER 9.5 54.9% 4 LOSS
BOS@NYY CARLOS RODON UNDER 4.5 HITS ALLOWED 54.2% 4 WIN
KC@DET DET -115 56.1% 5 WIN
CHC@LAA LAA +1.5 57.6% 5 LOSS
CIN@ARI KEBRYAN HAYES STRIKEOUTS UNDER 0.5 56.2% 6 WIN
LAD@SD SD +110 50.9% 6 WIN