Cubs vs Diamondbacks Prediction — AI Finds CAN'T MISS MLB Lines & Props (Mar 27)

Updated: 2025-03-25T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Chicago Cubs are set to face the Arizona Diamondbacks on March 27, 2025, at Chase Field in Phoenix. This matchup marks the domestic season opener for both teams, with the Cubs looking to rebound after their Tokyo Series against the Dodgers and the Diamondbacks aiming to start strong at home.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Mar 27, 2025

Start Time: 10:10 PM EST​

Venue: Chase Field​

Diamondbacks Record: (0-0)

Cubs Record: (0-0)

OPENING ODDS

CHC Moneyline: +110

ARI Moneyline: -129

CHC Spread: +1.5

ARI Spread: -1.5

Over/Under: 8.5

CHC
Betting Trends

  • In the 2024 season, the Cubs concluded with an 83-79 record, reflecting a balanced performance throughout the year.

ARI
Betting Trends

  • The Diamondbacks finished the 2024 season with an 89-73 record, indicating a strong showing, particularly in home games.

MATCHUP TRENDS

  • In their 2024 matchups, the Cubs and Diamondbacks split the series 3-3, highlighting the competitive nature of their encounters.

CHC vs. ARI
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: S. Suzuki over 5 Fantasy Score.

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Chicago Cubs vs Arizona Prediction & Odds:
Free MLB Betting Insights for 3/27/25

The upcoming game between the Chicago Cubs and the Arizona Diamondbacks at Chase Field promises to be a compelling contest as both teams embark on their 2025 MLB campaigns. The Cubs, having faced early challenges in the Tokyo Series against the Dodgers, are eager to secure their first win on American soil. Conversely, the Diamondbacks, who narrowly missed the playoffs in 2024, are determined to leverage their home-field advantage to set a positive tone for the season. On the mound, the Cubs are expected to start left-hander Justin Steele, who has demonstrated reliability in the rotation. Steele’s ability to command the strike zone and manage high-pressure situations will be crucial against a Diamondbacks lineup known for its offensive depth. The Diamondbacks counter with their ace, Zac Gallen, whose impressive 2024 campaign solidified his reputation as a top-tier pitcher. Gallen’s arsenal and control present a significant challenge for the Cubs’ hitters.

Offensively, the Cubs are navigating uncertainties, particularly concerning the availability of second baseman Nico Hoerner, who is recovering from offseason surgery. His potential absence could impact the team’s infield dynamics and batting order. The Diamondbacks, meanwhile, have bolstered their roster with the acquisition of pitcher Corbin Burnes, aiming to enhance their competitiveness in the NL West. Historically, matchups between these two teams have been evenly contested, with a 3-3 split in their 2024 meetings. This parity suggests that fans can anticipate a closely fought game. Both teams have made strategic offseason moves, and their effectiveness will be tested in this early-season encounter.

Chicago Cubs Cubs MLB Preview

The Chicago Cubs arrive in Phoenix to face the Arizona Diamondbacks on Opening Day with renewed determination following a rollercoaster 2024 season that ended at 83-79 and just shy of the postseason. The early disappointment in Tokyo, where they dropped both games of the international series to the Los Angeles Dodgers, has only sharpened the focus of a team that believes it has the pieces to be a playoff contender in 2025. Despite facing questions about injuries, including the uncertain status of second baseman Nico Hoerner after offseason surgery, the Cubs bring a balanced, veteran-infused roster anchored by developing stars and newly added depth. Left-handed starter Justin Steele gets the nod for Opening Day and is coming off back-to-back seasons with sub-3.20 ERAs and exceptional control, emerging as the true ace of the staff with his ability to neutralize lefties and pitch deep into games. Steele will need to be at his best against a Diamondbacks lineup filled with speed and power, and he’ll rely on the defensive prowess of Gold Glove shortstop Dansby Swanson and slick-fielding third baseman Nick Madrigal.

Offensively, the Cubs are led by Ian Happ, Seiya Suzuki, and Cody Bellinger, the latter returning on a restructured deal after posting 26 home runs and 97 RBIs in 2024 while splitting time between center field and first base. The addition of veteran utilityman Garrett Cooper and former top prospect Michael Busch provides much-needed pop in the corners, while Christopher Morel remains a dynamic presence who can play multiple positions and serve as an X-factor at the plate with his aggressive approach and 25-homer upside. Behind the dish, Miguel Amaya and Yan Gomes form a capable catching tandem, bringing strong defensive skills and leadership to guide a rotation that also includes Jameson Taillon, Jordan Wicks, and a soon-to-return Marcus Stroman. The bullpen, while shaky in stretches last season, has been fortified with the return of Adbert Alzolay in the closer role and the additions of Yency Almonte and Julian Merryweather to handle high-leverage innings. Manager Craig Counsell, in his first full season with the Cubs after being lured away from Milwaukee, is widely regarded as one of the sharpest minds in the game and is expected to bring a new level of tactical awareness and player development focus that this team has often lacked in recent years. With a lineup that can manufacture runs, a defense capable of preventing them, and a pitching staff anchored by one of the best lefties in the league, the Cubs are positioned to contend—but must prove they can do it on the road and in tight games. Opening against the Diamondbacks will be no easy task, especially at Chase Field, where Arizona posted one of the best home records in 2024, but if the Cubs can strike early with Steele setting the tone and the bats finding holes against Zac Gallen, they have a real opportunity to notch a statement win and build early momentum in a tightly contested National League.

The Chicago Cubs are set to face the Arizona Diamondbacks on March 27, 2025, at Chase Field in Phoenix. This matchup marks the domestic season opener for both teams, with the Cubs looking to rebound after their Tokyo Series against the Dodgers and the Diamondbacks aiming to start strong at home. Chicago Cubs vs Arizona AI Prediction: Free MLB Betting Insights for Mar 27. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Arizona Diamondbacks MLB Preview

The Arizona Diamondbacks open the 2025 season at Chase Field with sky-high expectations after a strong 89-73 finish in 2024 that left them just short of a deep playoff run, but clearly trending upward. Their offseason made waves across the league with the marquee signing of former Cy Young winner Corbin Burnes to a six-year, $210 million deal, marking the largest free-agent contract in franchise history. Burnes joins a rotation that already features Zac Gallen, giving the D-backs one of the most formidable one-two punches in the National League. Gallen, who starts Opening Day, is coming off another stellar season where he logged over 190 innings with a sub-3.50 ERA and demonstrated elite command and poise in high-leverage situations. Backing him is an emerging lineup led by young superstar Corbin Carroll, who continues to establish himself as one of the best all-around players in the game after a 2024 campaign where he hit .298 with 27 home runs, 90 RBIs, and 42 stolen bases. The team also added key depth to their infield and outfield rotations, including veteran power bat Josh Naylor, acquired from the Guardians, to complement Christian Walker’s consistent production at first base.

Ketel Marte remains the heart of the infield at second base, providing switch-hitting versatility and Gold Glove-caliber defense, while Gabriel Moreno, a breakout catcher in 2024, returns to manage the staff and provide timely hitting in the lower half of the order. The bullpen, a source of vulnerability in recent years, has also been fortified with the signings of veteran relievers like Reynaldo López and the return of closer Paul Sewald, who saved 33 games last year and brings postseason experience. Defensively, Arizona is one of the fastest and most efficient teams in baseball, with Carroll, Alek Thomas, and Lourdes Gurriel Jr. providing elite coverage in the outfield. Manager Torey Lovullo, entering his ninth season at the helm, has emphasized defensive execution and team speed as cornerstones of the team’s strategy, with an aggressive approach on the bases that ranked among the league’s best in stolen base success rate last year. The front office has clearly signaled that the team is in win-now mode, and with young talent blossoming into stars, complemented by proven veterans and a strengthened pitching staff, the Diamondbacks are positioned not just to contend in the NL West, but to challenge for the pennant. Hosting the Cubs in their stateside season opener offers a chance to make an immediate statement against a well-known opponent with playoff aspirations of their own. With Gallen on the mound, a deeper, faster, and more powerful lineup, and the momentum of a successful 2024 campaign fueling their confidence, the Diamondbacks look to start 2025 by protecting their home turf and showing the league that their rebuild is complete—and their era of contention is in full swing.

Chicago Cubs vs. Arizona Prop Picks (AI)

AI algorithm Remi is pouring through loads of data on each team. In fact, anytime the Cubs and Diamondbacks play there’s always several intriguing observations to key in on. Not to mention games played at Chase Field in Mar can often follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: S. Suzuki over 5 Fantasy Score.

Chicago Cubs vs. Arizona Prediction (AI)

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Remi, our AI sports genius, has been pouring over tons of data from every simulation between the Cubs and Diamondbacks and using recursive machine learning and cutting-edge AI to boil down the data to a single cover probability.

Remi has been most keyed in on the unproportionally assigned emphasis knucklehead sportsbettors often put on player performance factors between a Cubs team going up against a possibly healthy Diamondbacks team. We’ve found the true game analytics might reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our MLB AI picks for FREE now.

Below is our current AI Chicago Cubs vs Arizona picks, computer picks Cubs vs Diamondbacks, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full MLB schedule.

Cubs Betting Trends

In the 2024 season, the Cubs concluded with an 83-79 record, reflecting a balanced performance throughout the year.

Diamondbacks Betting Trends

The Diamondbacks finished the 2024 season with an 89-73 record, indicating a strong showing, particularly in home games.

Cubs vs. Diamondbacks Matchup Trends

In their 2024 matchups, the Cubs and Diamondbacks split the series 3-3, highlighting the competitive nature of their encounters.

Chicago Cubs vs. Arizona Game Info

Chicago Cubs vs Arizona starts on March 27, 2025 at 10:10 PM EST.

Spread: Arizona -1.5
Moneyline: Chicago Cubs +110, Arizona -129
Over/Under: 8.5

Chicago Cubs: (0-0)  |  Arizona: (0-0)

Remi's searched hard and found the best prop for this matchup: S. Suzuki over 5 Fantasy Score.. Prices move—always shop for the best number.

In their 2024 matchups, the Cubs and Diamondbacks split the series 3-3, highlighting the competitive nature of their encounters.

CHC trend: In the 2024 season, the Cubs concluded with an 83-79 record, reflecting a balanced performance throughout the year.

ARI trend: The Diamondbacks finished the 2024 season with an 89-73 record, indicating a strong showing, particularly in home games.

See our latest MLB picks and odds pages for 2025 to compare prices before you bet.

Chicago Cubs vs. Arizona Odds

AI algorithm Remi is pouring through mountains of data on each team. In fact, anytime the Chicago Cubs vs Arizona trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable betting trends.

Chicago Cubs vs Arizona Opening Odds

CHC Moneyline: +110
ARI Moneyline: -129
CHC Spread: +1.5
ARI Spread: -1.5
Over/Under: 8.5

Chicago Cubs vs Arizona Live Odds

Games PTS ML SPR O/U
Oct 19, 2025 8:04PM EDT
Seattle Mariners
Toronto Blue Jays
10/19/25 8:04PM
Mariners
Blue Jays
+107
-128
+1.5 (-195)
-1.5 (+165)
O 7.5 (-115)
U 7.5 (-105)

MLB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Chicago Cubs Cubs vs. Arizona Diamondbacks on March 27, 2025 at Chase Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our MLB odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TOR@SEA OVER 7 54.9% 3 WIN
LAD@MIL UNDER 7.5 56.6% 6 WIN
TOR@NYY OVER 8 54.9% 4 WIN
TOR@NYY CARLOS RODON OVER 1.5 TOTAL WALKS ALLOWED 53.3% 3 WIN
NYY@TOR OVER 7.5 54.8% 2 WIN
LAD@PHI OVER 7 53.8% 3 WIN
SD@CHC CHC -109 53.8% 3 WIN
SD@CHC OVER 7.5 54.5% 4 LOSS
SD@CHC CHC -111 54.8% 4 LOSS
CIN@LAD SHOHEI OHTANI OVER 1.5 BASES 53.5% 3 WIN
BOS@NYY OVER 7 53.8% 3 LOSS
CIN@LAD ELLY DE LA CRUZ OVER 0.5 BASES 54.4% 4 LOSS
ARI@SD SD -131 57.3% 4 WIN
DET@BOS BOS -115 56.4% 5 WIN
NYM@CHC NYM -110 54.1% 3 WIN
HOU@ATH ATH +118 50.8% 4 WIN
NYM@CHC OVER 7 54.5% 3 WIN
STL@SF OVER 7.5 55.9% 5 LOSS
KC@LAA TYLER TOLBERT UNDER 1.5 BASES 54.4% 4 WIN
MIL@SD UNDER 9 54.7% 4 WIN
MIA@PHI KYLE SCHWARBER OVER 1.5 HITS+RUNS+RBIS 53.3% 3 WIN
WAS@NYM OVER 8.5 56.1% 6 LOSS
LAA@COL COL +108 50.5% 3 WIN
TOR@KC UNDER 9 54.7% 4 LOSS
SEA@KC KC +1.5 62.3% 5 LOSS
NYY@MIN OVER 9 55.1% 4 WIN
MIA@COL OVER 10.5 55.0% 4 WIN
MIA@COL AGUSTIN RAMIREZ OVER 1.5 HITS+RUNS+RBIS 54.3% 4 WIN
SEA@KC BOBBY WITT UNDER 0.5 SINGLES 54.4% 4 LOSS
PHI@LAD LAD -113 54.7% 4 LOSS
NYY@BOS OVER 7.5 54.3% 3 WIN
KC@PHI PHI -130 58.3% 4 WIN
LAD@SF OVER 7.5 54.7% 4 LOSS
NYM@PHI PHI -122 55.6% 4 WIN
KC@CLE KC -104 52.0% 3 WIN
CIN@SD JAKE CRONEWORTH OVER 0.5 HITS 53.1% 3 WIN
WAS@MIA MIA -123 55.2% 4 LOSS
LAA@KC UNDER 9.5 54.9% 3 WIN
TEX@ARI UNDER 9 54.2% 4 WIN
SF@COL UNDER 11.5 56.4% 6 LOSS
SF@COL RAFAEL DEVERS OVER 1.5 BASES 56.1% 6 WIN
MIA@WAS WAS -110 54.4% 4 WIN
NYM@DET OVER 8.5 54.5% 4 WIN
TEX@ARI UNDER 9.5 56.4% 6 WIN
TEX@ARI ALEJANDRO OSUNA UNDER 1.5 BASES 54.1% 4 LOSS
ATL@CHC CHC -116 55.1% 3 WIN
PHI@MIL OVER 8.5 55.0% 3 WIN
ARI@LAD SHOHEI OHTANI OVER 2.5 BASES 54.2% 4 WIN
SEA@CLE CLE +1.5 57.2% 3 WIN
CHC@SF CHC -105 54.1% 4 LOSS
NYY@CHW RYAN MCMAHON OVER 0.5 BASES 54.1% 4 WIN