Colorado Buffaloes
Colorado (4-6) visits Cincinnati (5-5) on Saturday, November 21. The market has not posted a line yet, while Colorado is 3-6 ATS and Cincinnati is 5-5 ATS this season.
Cincinnati Bearcats
Betting Snapshot
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| Sportsbook | Spread | Moneyline | Total |
|---|---|---|---|
| FanDuel | COLO +2.5 CINCY -2.5 | COLO +118 CINCY -140 | O 57.5 U 57.5 |
Injury Report
Neither Colorado nor Cincinnati had released an official availability report for this game at time of writing, as those reports are issued later in game week. Quarterbacks Isaac Wilson and JC French IV are the most important statuses to monitor, along with lead rushers JaQuail Smith and Cole Tabb, since any limitation would affect the spread and player props.
Key Players
Key Matchup Edge
Cincinnati carries a +0.4 scoring margin per game against -6.7 for Colorado. JC French IV gives Cincinnati the steadier passing profile, and Colorado needs JaQuail Smith to control the ground game to keep this within the number.
3 Things to Watch
- Isaac Wilson efficiency on the road
- Cole Tabb and the home ground game
- Late-season weather and tempo
Betting Breakdown
Colorado visits Cincinnati on Saturday, November 21, for a 12:00 PM Eastern kickoff at Nippert Stadium, with ESPN+ carrying the game. Colorado is 4-6 after a 42-32 home win over Houston, while Cincinnati is 5-5 following a 41-13 road loss to Iowa State. No spread has been posted yet, so form and efficiency carry the early read. Against the spread, Colorado is 3-6-1 and Cincinnati is 5-5-0, while their lined games are 6-4 and 6-4 to the over. Colorado scores 22.0 and allows 28.7 points per game, compared with 31.0 scored and 30.6 allowed for Cincinnati. Isaac Wilson has completed 128 of 205 passes for 1,629 yards, nine touchdowns and nine interceptions this season. JC French IV has completed 176 of 266 passes for 2,087 yards, 16 touchdowns and three interceptions this season. The handicap centers on whether Cincinnati's margin profile holds against Colorado's best path, which runs through ball control and limiting explosive plays.
Colorado Betting Outlook
Colorado is 4-6 overall, 1-4 on the road and 2-3 last five. Its most recent result was a 42-32 home win over Houston. Colorado is 3-6-1 ATS this season, with its lined games going 6-4 to the over. Quarterback Isaac Wilson has completed 128 of 205 passes for 1,629 yards, nine touchdowns and nine interceptions. JaQuail Smith has 428 rushing yards and two touchdowns on 87 carries. Joseph Williams leads the receivers with 63 catches for 933 yards and seven touchdowns. With no line posted yet, its ability to win the turnover battle and finish drives will shape where the number opens.
Cincinnati Betting Outlook
Cincinnati is 5-5 overall, 5-1 at home and 1-4 last five. Its most recent result was a 41-13 road loss to Iowa State. Cincinnati is 5-5-0 ATS this season, with its lined games going 6-4 to the over. Quarterback JC French IV has completed 176 of 266 passes for 2,087 yards, 16 touchdowns and three interceptions. Cole Tabb has 977 rushing yards and ten touchdowns on 107 carries. JV Gibson leads the receivers with 39 catches for 515 yards and four touchdowns. With no line posted yet, its ability to win the turnover battle and finish drives will shape where the number opens.
Latest Team Buzz
VICTORY SATURDAY 🫡
— Colorado Buffaloes Football (@CUBuffsFootball) November 14, 2026
FINAL | UC 13 ISU 41
— Cincinnati Football (@GoBearcatsFB) November 14, 2026
Colorado Buffaloes vs Cincinnati Bearcats FAQ
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Where to watch Colorado Buffaloes vs Cincinnati Bearcats?
You can watch this game on ESPN+. For the latest broadcast details, see Where to Watch.
Where to stream Colorado Buffaloes vs Cincinnati Bearcats?
You can stream this game on ESPN+.
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What is the biggest matchup edge for Colorado Buffaloes vs Cincinnati Bearcats?
Cincinnati carries a +0.4 scoring margin per game against -6.7 for Colorado. JC French IV gives Cincinnati the steadier passing profile, and Colorado needs JaQuail Smith to control the ground game to keep this within the number.
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