Away Team
Record 2-2
Last 5 2-3 last five.
ATS 1-3-0 ATS.
Road 1-1 road.
Standings
CFB Game Preview
Schedule
Kickoff Countdown
4d 07:52:11
Start Time 3:30 PM EST
Date September 26, 2026
Venue Brooks Field at Wallace Wade Stadium
Where To Watch ACC Network Extra
Where To Stream ESPN App
Season Series William & Mary leads 6-1.

Duke enters 3-0 straight up and against the spread, but a massive 43.5-point number demands discipline as William & Mary tries to stabilize after allowing 96 points across consecutive losses.

Home Team
Record 3-0
Last 5 5-0 last five.
ATS 3-0-0 ATS.
Home 2-0 home.
Analysis Updated: 6:55 AM ET
Injuries Checked: 6:48 AM ET
Odds Updated: 7:34 AM ET

Betting Snapshot

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Best Free Prop Pick

FREE PROP
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Nate Sheppard over 124.5 rushing yards: he reached at least 147 rushing yards in all three games. Nate Sheppard over 124.5 rushing yards: William & Mary allows 281.3 rushing yards per game. Nate Sheppard over 124.5 rushing yards: Duke's massive favorite role supports sustained early rushing volume.

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Best Home Spread
FanDuel | DUKE -43.5
Best Home Moneyline
|
Best Over Line
FanDuel | 62.5
Best Away Spread
FanDuel | WMARY +43.5
Best Away Moneyline
|
Best Under Line
FanDuel | 62.5
Updated 7:34 AM ET
Sportsbook Spread Moneyline Total
FanDuelWMARY +43.5
DUKE -43.5
O 62.5
U 62.5

Injury Report

The latest public matchup report lists no injuries for William & Mary. Duke had wide receiver Qeanu Johnson and reserve quarterback Lawrence Gardner sidelined with undisclosed issues before the Stanford game, but neither has driven the current offense. No new absence has been publicly confirmed for core starters Walker Eget, Nate Sheppard, or Winston Watkins.

Key Players

William and Mary
Winston Watkins
Threw for 286 yards and two touchdowns against Fordham.
Duke
Nate Sheppard
Rushed for 154 yards and scored three total touchdowns versus Stanford.

Key Matchup Edge

Duke's rushing game is the clearest edge. The Blue Devils average 229.3 rushing yards per game, while William & Mary allows 281.3 and 7.0 yards per carry. With Nate Sheppard averaging 176 rushing yards through three games, Duke can attack the Tribe's weakest unit without leaning heavily on the pass.

3 Things to Watch

  • Sheppard versus a leaking run defense
  • Duke's pace after building a lead
  • William & Mary early-down efficiency

Betting Breakdown

Duke enters Saturday with the combination bettors want from a heavy favorite: a 3-0 record, a 3-0 ATS mark, and a repeatable strength that directly attacks William & Mary's biggest weakness. The Blue Devils are averaging 229.3 rushing yards per game, while the Tribe has allowed 281.3 per game and 7.0 per carry. Nate Sheppard has already produced 528 rushing yards in three games, including 154 against Stanford, and Duke's defense has surrendered only 79.3 rushing yards per game. William & Mary can still create resistance through Winston Watkins, who threw for 286 yards and two touchdowns last week, but the Tribe has lost consecutive games by 24 and 25 points while allowing 96 combined points. The 43.5-point spread is the main betting complication. Duke has covered every game, yet such a large number makes fourth-quarter substitutions, clock control, and William & Mary's ability to finish drives highly relevant. The matchup strongly favors Duke's physical run game, but the spread demands four-quarter margin.

William and Mary Betting Outlook

William & Mary arrives 2-2 after consecutive losses to Lehigh and Fordham, and the defensive trend is the central concern. The Tribe has allowed 281.3 rushing yards per game and 7.0 yards per carry, numbers that place enormous pressure on the front against Nate Sheppard. Offensively, Winston Watkins gives William & Mary a viable passing answer after throwing for 286 yards and two scores against Fordham. Andrew King also brings explosiveness after a 122-yard rushing game. For spread bettors, the Tribe's path is possession control, clean special teams, and enough third-down conversions to keep Duke from stacking short fields and repeated rushing possessions.

Duke Betting Outlook

Duke has opened 3-0 straight up and 3-0 ATS, with wins over Tulane, Illinois, and Stanford. The Blue Devils' formula is physical and stable: 229.3 rushing yards per game, only 79.3 rushing yards allowed, and a workhorse in Nate Sheppard who has reached at least 147 rushing yards in every outing. Walker Eget has been efficient enough to punish loaded boxes, throwing four touchdowns against one interception through three games. Against a William & Mary defense that has surrendered 96 points in its last two games, Duke should control the line of scrimmage. The betting question is whether that dominance remains aggressive enough after the margin becomes comfortable.

Latest Team Buzz

William and Mary Tribe vs Duke Blue Devils FAQ

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Where to watch William and Mary Tribe vs Duke Blue Devils?

You can watch this game on ACC Network Extra. For the latest broadcast details, see Where to Watch.

Where to stream William and Mary Tribe vs Duke Blue Devils?

You can stream this game on ESPN App.

What is the best free prop bet for William and Mary Tribe vs Duke Blue Devils?

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What is the biggest matchup edge for William and Mary Tribe vs Duke Blue Devils?

Duke's rushing game is the clearest edge. The Blue Devils average 229.3 rushing yards per game, while William & Mary allows 281.3 and 7.0 yards per carry. With Nate Sheppard averaging 176 rushing yards through three games, Duke can attack the Tribe's weakest unit without leaning heavily on the pass.

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CFB Past Picks

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Matchup William and Mary Tribe vs. Duke Blue Devils
Game Date September 26, 2026
Venue Brooks Field at Wallace Wade Stadium
RECENT COMPLETED PICKS

AI CFB PAST PICKS

29-22 56.9% WIN
GAME
LEAN
WIN %
UNITS
RESULT
JMAD@SDGST
UNDER 46.5
57.1%
7
WIN
MISSST@SC
OVER 58.5
58.1%
8
WIN
FRESNO@SJST
OVER 47.5
58.1%
8
LOSS
UL@USC
OVER 59.5
56.9%
6
WIN
MEMP@BOISE
UNDER 56.5
56.9%
6
LOSS
CAL@CUSE
UNDER 57.5
56.9%
6
WIN
RICE@ND
OVER 54.5
57.0%
6
LOSS
RUT@BC
UNDER 54.5
56.9%
6
WIN
WASHST@WASH
OVER 51.5
56.9%
6
LOSS
TOWSON@NAVY
OVER 51
57.4%
7
WIN
FURMAN@TENN
OVER 67.5
57.1%
7
LOSS
MIAOH@PITT
UNDER 47.5
57.2%
7
LOSS
UTEP@OKLA
OVER 51.5
56.9%
6
LOSS
ALBANY@BUFF
ALBANY +18.5
54.1%
4
WIN
ALBANY@BUFF
UNDER 47.5
57.1%
7
WIN
UAB@ILL
KATIN HOUSER OVER 18.5 PASS COMP
54.2%
4
LOSS
HAWAII@STNFRD
HAWAII +4.5
54.8%
4
LOSS
MEMP@UNLV
UNLV -4
53.2%
3
LOSS
SJST@USC
OVER 61.5
57.0%
6
WIN
JAXST@NDAKST
UNDER 46.5
56.8%
6
WIN
NCST@UVA
CJ BAILEY OVER 29.5 PASS ATT
54.2%
4
LOSS
MIAMI@IND
ROMAN HEMBY UNDER 15.5 RUSH ATT
55.2%
5
LOSS
OLEMISS@GEORGIA
KEWAN LACY ANYTIME TD
56.7%
6
WIN
BAMA@IND
FERNANDO MENDOZA UNDER 26.5 PASS ATT
55.2%
5
WIN
OREG@TXTECH
OREG -126
58.9%
6
WIN
NEB@UTAH
DEVON DAMPIER UNDER 185.5 PASS YDS
53.4%
3
LOSS
NOTEX@SDGST
NOTEX -7
54.2%
4
LOSS
BAMA@OKLA
ISAIAH SATEGNA III ANYTIME TD
54.2%
4
WIN
BYU@TTU
PARKER KINGSTON OVER 20.5 LONGEST RECEPTION
54.3%
4
WIN
UNLV@BOISE
BOISE -4.5
56.7%
6
WIN
ECU@FAU
FAU +7
57.8%
7
LOSS
OREG@WASH
WASH +7
54.9%
4
LOSS
WYO@HAWAII
WYO +7.5
55.1%
5
LOSS
COLO@KSTATE
COLO +17.5
54.0%
4
WIN
OHIOST@MICH
MICH +10.5
56.4%
6
LOSS
VATECH@UVA
VATECH +8
57.8%
7
LOSS
NWEST@ILL
LUKE ALTMYER UNDER 19.5 PASS COMP
54.3%
4
WIN
ORE@WAS
DEMOND WILLIAMS JR UNDER 43.5 RUSH YDS
55.2%
5
WIN
MIAMI@VATECH
VATECH +18.5
54.2%
4
WIN
GAST@TROY
TROY -9.5
55.7%
5
WIN
DEL@WAKE
DEL +18
56.7%
6
LOSS
NMEX@AF
NMEX -3.5
56.1%
5
WIN
WASHST@JMAD
WASHST +14.5
55.3%
5
WIN
ILL@WISC
WISC +9
55.1%
5
WIN
WKY@LSU
WKY +23.5
56.3%
6
WIN
WASH@UCLA
DEMOND WILLIAMS UNDER 27.5 PASS ATT
56.3%
6
WIN
TCU@HOU
AMARE THOMAS OVER 69.5 RECV YDS
55.2%
5
WIN
TEX@UGA
NATE FRAZIER UNDER 65.5 RUSH + REC YDS
55.5%
5
WIN
PUR@WASH
ANTONIO HARRIS UNDER 73.5 RUSH + REC YDS
54.1%
4
WIN
UVA@DUKE
DUKE -3.5
54.7%
3
LOSS
OKLA@BAMA
BAMA -6
54.5%
3
LOSS
Past performance is not a guarantee of future results. Picks are displayed for informational purposes only.