Away Team
Record 2-0
Last 5 2-3 last five
ATS 1-1 ATS
Road 1-0 road
Standings
CFB Game Preview
Schedule
Kickoff Countdown
5d 07:50:58
Start Time 7:30 PM EST
Date September 19, 2026
Venue Northwestern Medicine Field at Martin Stadium
Where To Watch FOX or FS1
Where To Stream FOX One
Season Series Series tied 1-1.

Colorado arrives 2-0 after Julian Lewis erupted for 366 passing yards, while Northwestern's early favorite price has been bet down roughly three points, creating a sharp test of whether the Buffaloes' explosive offense travels.

Home Team
Record 1-0
Last 5 3-2 last five
ATS 1-0 ATS
Home 1-0 home
Analysis Updated: 8:03 AM ET
Injuries Checked: 8:00 AM ET
Odds Updated: 11:34 AM ET

Betting Snapshot

Spread
NWEST -4.5
Open: NWEST -4.5
Market Steady

Spread Movement

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Odds Updated: 9/14 11:34 AM ET
Moneyline
NWEST -185
Open: NWEST -162
Favorite Taking Support

Moneyline Movement

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Odds Updated: 9/14 11:34 AM ET
Total
48.5
Open: 45.5
Total Rising

Total Movement

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Odds Updated: 9/14 11:34 AM ET

Best Free Prop Pick

FREE PROP
Remi's Still Searching
Aidan Chiles Over 225.5 passing yards: he opened with 273 on only 24 attempts. Aidan Chiles Over 225.5 passing yards: Colorado has allowed 241 passing yards per game. Aidan Chiles Over 225.5 passing yards: Northwestern's balanced run game should preserve efficient play-action volume.

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Odds Comparison Center

Shop for the best lines in one place.

Best Home Spread
BetRivers | NWEST -3.5
Best Home Moneyline
BetOnline.ag | NWEST -180
Best Over Line
BetRivers | 48
Best Away Spread
FanDuel | COLO +4.5
Best Away Moneyline
Bovada | COLO +165
Best Under Line
FanDuel | 49.5
Updated 11:34 AM ET
Sportsbook Spread Moneyline Total
FanDuelCOLO +4.5
NWEST -4.5
COLO +155
NWEST -188
O 49.5
U 49.5
DraftKingsCOLO +4.5
NWEST -4.5
COLO +154
NWEST -185
O 48.5
U 48.5
BetMGMCOLO +4
NWEST -4
COLO +150
NWEST -185
O 48.5
U 48.5
BetRiversCOLO +3.5
NWEST -3.5
COLO +150
NWEST -190
O 48
U 48
BovadaCOLO +4.5
NWEST -4.5
COLO +165
NWEST -195
O 48.5
U 48.5
BetOnline.agCOLO +4.5
NWEST -4.5
COLO +157
NWEST -180
O 49
U 49
LowVig.agCOLO +4.5
NWEST -4.5
COLO +157
NWEST -180
O 49
U 49
MyBookie.agCOLO +4.5
NWEST -4.5
COLO +163
NWEST -212
O 48.5
U 48.5
BetUSCOLO +4.5
NWEST -4.5
COLO +155
NWEST -180
O 49
U 49
CaesarsCOLO +4.5
NWEST -4.5
COLO +155
NWEST -190
O 49.5
U 49.5

Injury Report

Northwestern carries the bigger injury watch. Starting receiver Hayden Eligon II is questionable with a lower-body issue after leaving the opener, and starting center Jackson Carsello suffered a neck injury against South Dakota State but later returned to the team facility and was reported doing well. Colorado's Zach Atkins was listed out before Weber State, yet he appeared in the 52-21 win, reducing that concern.

Key Players

Colorado
Julian Lewis
Threw for 366 yards and four touchdowns against Weber State.
Northwestern
Aidan Chiles
Passed for 273 yards and added a rushing touchdown in Northwestern's opener.

Key Matchup Edge

Colorado's biggest betting edge is sudden downfield explosiveness. Lewis jumped from 124 passing yards in the opener to 366 and four touchdowns against Weber State, while Northwestern allowed 285 passing yards to South Dakota State. The Wildcats were excellent at limiting touchdowns, so Colorado's ability to turn chunk plays into red-zone finishes should decide whether the line move is justified.

3 Things to Watch

  • Colorado's explosive pass game
  • Northwestern's red-zone defensive resistance
  • Late market movement toward Buffaloes

Betting Breakdown

Colorado enters 2-0 after surviving Georgia Tech 14-13 and then unlocking its offense in a 52-21 rout of Weber State. Julian Lewis was the catalyst, throwing for 366 yards and four touchdowns as the Buffaloes generated repeated explosive plays. Northwestern has played only once, but its 34-18 win over South Dakota State showed a balanced Chip Kelly offense: Aidan Chiles threw for 273 yards, the Wildcats rushed for 224, and Griffin Wilde topped 100 receiving yards. The betting market has reacted strongly to Colorado's start. Northwestern was posted around -5.5 earlier in the week, while current prices have tightened toward -2.5 with a 45.5 total. That makes explosiveness versus finishing defense the core handicap. South Dakota State moved the ball for 432 yards but repeatedly settled for field goals, while Colorado now brings a quarterback who just punished single coverage deep. If Northwestern controls pace and forces long drives, the favorite has the cleaner path. If Lewis keeps producing chunk gains, Colorado can threaten another outright road win.

Colorado Betting Outlook

Colorado has already shown two different ways to win. The Buffaloes ground out a 14-13 road victory at Georgia Tech as a 6.5-point underdog, then exploded for 52 points and 578 yards against Weber State. Lewis now has 490 passing yards, five touchdowns, and no interceptions through two games, with Joseph Williams and DeAndre Moore Jr. providing big-play receiving juice. Colorado is 1-1 ATS because the 31-point Weber State win did not cover the massive closing spread. The market move toward the Buffaloes is understandable, but the next test is whether their new-found passing efficiency survives a more disciplined Northwestern defense away from Boulder.

Northwestern Betting Outlook

Northwestern is 1-0 and had a bye after beating South Dakota State 34-18, giving the Wildcats extra preparation for Colorado. Chiles looked comfortable in his debut, throwing for 273 yards without an interception, while the rushing committee produced 224 yards. Wilde delivered 104 receiving yards, and the defense repeatedly stiffened in scoring territory despite allowing 432 total yards. Northwestern also covered its opener, but the market has moved against the Wildcats from roughly -5.5 toward -2.5. The main concern is health along the offense, with Eligon questionable and Carsello's status worth monitoring. If the line holds, Northwestern needs its balanced offense and red-zone defense to validate the favorite role.

Latest Team Buzz

Colorado Buffaloes vs Northwestern Wildcats FAQ

What is the current spread for Colorado Buffaloes vs Northwestern Wildcats?

The current home spread is NWEST -4.5, while the away spread is COLO +4.5.

How far has the spread moved for Colorado Buffaloes vs Northwestern Wildcats?

The spread opened at NWEST -4.5 and is now NWEST -4.5.

What is the current moneyline for Colorado Buffaloes vs Northwestern Wildcats?

The current moneyline is COLO +154 / NWEST -185.

How far has the moneyline moved for Colorado Buffaloes vs Northwestern Wildcats?

The moneyline opened at COLO +136 / NWEST -162 and is now COLO +154 / NWEST -185.

What is the current total for Colorado Buffaloes vs Northwestern Wildcats?

The current total is 48.5.

How far has the total moved for Colorado Buffaloes vs Northwestern Wildcats?

The total opened at 45.5 and is now 48.5.

Is the market taking the underdog in Colorado Buffaloes vs Northwestern Wildcats?

Current market signal: Market Steady.

Is the market taking the favorite in Colorado Buffaloes vs Northwestern Wildcats?

Current market signal: Favorite Taking Support.

Is the total dropping for Colorado Buffaloes vs Northwestern Wildcats?

Current totals signal: Total Rising.

Is the total rising for Colorado Buffaloes vs Northwestern Wildcats?

Current totals signal: Total Rising.

Where to watch Colorado Buffaloes vs Northwestern Wildcats?

You can watch this game on FOX or FS1. For the latest broadcast details, see Where to Watch.

Where to stream Colorado Buffaloes vs Northwestern Wildcats?

You can stream this game on FOX One.

What is the best free prop bet for Colorado Buffaloes vs Northwestern Wildcats?

Remi's Still Searching

What is the biggest matchup edge for Colorado Buffaloes vs Northwestern Wildcats?

Colorado's biggest betting edge is sudden downfield explosiveness. Lewis jumped from 124 passing yards in the opener to 366 and four touchdowns against Weber State, while Northwestern allowed 285 passing yards to South Dakota State. The Wildcats were excellent at limiting touchdowns, so Colorado's ability to turn chunk plays into red-zone finishes should decide whether the line move is justified.

REMI AI PERFORMANCE

CFB Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement. We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

Matchup Colorado Buffaloes vs. Northwestern Wildcats
Game Date September 19, 2026
Venue Northwestern Medicine Field at Martin Stadium
RECENT COMPLETED PICKS

AI CFB PAST PICKS

30-21 58.8% WIN
GAME
LEAN
WIN %
UNITS
RESULT
ALBANY@BUFF
ALBANY +18.5
54.1%
4
WIN
ALBANY@BUFF
UNDER 47.5
57.1%
7
WIN
UAB@ILL
KATIN HOUSER OVER 18.5 PASS COMP
54.2%
4
LOSS
HAWAII@STNFRD
HAWAII +4.5
54.8%
4
LOSS
MEMP@UNLV
UNLV -4
53.2%
3
LOSS
SJST@USC
OVER 61.5
57.0%
6
WIN
JAXST@NDAKST
UNDER 46.5
56.8%
6
WIN
NCST@UVA
CJ BAILEY OVER 29.5 PASS ATT
54.2%
4
LOSS
MIAMI@IND
ROMAN HEMBY UNDER 15.5 RUSH ATT
55.2%
5
LOSS
OLEMISS@GEORGIA
KEWAN LACY ANYTIME TD
56.7%
6
WIN
BAMA@IND
FERNANDO MENDOZA UNDER 26.5 PASS ATT
55.2%
5
WIN
OREG@TXTECH
OREG -126
58.9%
6
WIN
NEB@UTAH
DEVON DAMPIER UNDER 185.5 PASS YDS
53.4%
3
LOSS
NOTEX@SDGST
NOTEX -7
54.2%
4
LOSS
BAMA@OKLA
ISAIAH SATEGNA III ANYTIME TD
54.2%
4
WIN
BYU@TTU
PARKER KINGSTON OVER 20.5 LONGEST RECEPTION
54.3%
4
WIN
UNLV@BOISE
BOISE -4.5
56.7%
6
WIN
ECU@FAU
FAU +7
57.8%
7
LOSS
OREG@WASH
WASH +7
54.9%
4
LOSS
WYO@HAWAII
WYO +7.5
55.1%
5
LOSS
COLO@KSTATE
COLO +17.5
54.0%
4
WIN
OHIOST@MICH
MICH +10.5
56.4%
6
LOSS
VATECH@UVA
VATECH +8
57.8%
7
LOSS
NWEST@ILL
LUKE ALTMYER UNDER 19.5 PASS COMP
54.3%
4
WIN
ORE@WAS
DEMOND WILLIAMS JR UNDER 43.5 RUSH YDS
55.2%
5
WIN
MIAMI@VATECH
VATECH +18.5
54.2%
4
WIN
GAST@TROY
TROY -9.5
55.7%
5
WIN
DEL@WAKE
DEL +18
56.7%
6
LOSS
NMEX@AF
NMEX -3.5
56.1%
5
WIN
WASHST@JMAD
WASHST +14.5
55.3%
5
WIN
ILL@WISC
WISC +9
55.1%
5
WIN
WKY@LSU
WKY +23.5
56.3%
6
WIN
WASH@UCLA
DEMOND WILLIAMS UNDER 27.5 PASS ATT
56.3%
6
WIN
TCU@HOU
AMARE THOMAS OVER 69.5 RECV YDS
55.2%
5
WIN
TEX@UGA
NATE FRAZIER UNDER 65.5 RUSH + REC YDS
55.5%
5
WIN
PUR@WASH
ANTONIO HARRIS UNDER 73.5 RUSH + REC YDS
54.1%
4
WIN
UVA@DUKE
DUKE -3.5
54.7%
3
LOSS
OKLA@BAMA
BAMA -6
54.5%
3
LOSS
OREGST@TULSA
OREGST -120
55.6%
5
LOSS
UTEP@MIZZST
MIZZST -5
54.3%
4
WIN
COLOST@NMEX
NMEX -14
57.1%
6
LOSS
PSU@MICHST
MICHST +7.5
56.5%
6
LOSS
MISSST@MIZZOU
MISSST +7.5
57.2%
7
LOSS
FAU@TULANE
FAU +17.5
56.0%
6
WIN
NCST@MIAMI
NCST +15.5
57.1%
7
LOSS
KENTST@AKRON
AKRON -6.5
55.4%
5
LOSS
JAXST@UTEP
JAXST -105
57.0%
7
WIN
FSU@CLEM
CLEM -118
57.1%
5
WIN
UNLV@COLOST
UNLV -4
55.2%
5
WIN
OREG@IOWA
IOWA +6.5
53.3%
2
WIN
NEB@UCLA
NEB +1.5
55.8%
5
WIN
Past performance is not a guarantee of future results. Picks are displayed for informational purposes only.