Panthers vs. Cardinals
Prediction, Odds & Props
Nov 23 | CFB AI Picks
Updated: 2024-11-16T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
On November 23, 2024, the Pittsburgh Panthers will face the Louisville Cardinals at L&N Federal Credit Union Stadium in Louisville, Kentucky. This ACC matchup is crucial for both teams as they vie for improved standings and potential bowl game invitations.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Nov 23, 2024
Start Time: 5:00 PM EST​
Venue: L&N Federal Credit Union Stadium​
Cardinals Record: (6-4)
Panthers Record: (7-3)
OPENING ODDS
PITT Moneyline: +225
LVILLE Moneyline: -280
PITT Spread: +7.5
LVILLE Spread: -7.5
Over/Under: 56.5
PITT
Betting Trends
- The Pittsburgh Panthers have struggled against the spread (ATS) recently, covering in only 2 of their last 5 games. Their inconsistent offensive performances have contributed to difficulties in meeting betting expectations.
LVILLE
Betting Trends
- The Louisville Cardinals have fared slightly better ATS, covering in 3 of their last 5 games. However, their performances have been erratic, particularly in close contests, affecting their reliability for bettors.
MATCHUP TRENDS
- In their last five head-to-head matchups, the underdog has covered the spread four times, indicating a trend of closely contested games regardless of team rankings.
PITT vs. LVILLE
Best Prop Bet
- Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.
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Pittsburgh vs Louisville Prediction & Odds:
Free CFB Betting Insights for 11/23/24
On the other hand, Louisville enters the game with a 6-4 record, reflecting a season of ups and downs. The Cardinals have shown flashes of brilliance but have struggled with consistency, particularly in conference play. Quarterback Jack Plummer has had a mixed season, with moments of promise tempered by turnovers and missed opportunities. The rushing attack, traditionally a strength for Louisville, has been led by running back Jawhar Jordan, who has been a bright spot in their offense. Defensively, the Cardinals have faced challenges, especially in containing high-powered offenses, which could be a concern against Pittsburgh’s dynamic playmakers. Key factors in this matchup include turnover margin, third-down efficiency, and red-zone performance. Pittsburgh’s ability to protect the football and capitalize on scoring opportunities will be crucial, while Louisville will need to find ways to sustain drives and finish in the end zone. Given Pittsburgh’s current form and aspirations, they appear to have the upper hand, but Louisville’s potential to disrupt top teams adds an element of unpredictability to this contest.
🔵 PITT vs Louisville 🟡
— Pitt Football (@Pitt_FB) November 18, 2024
🗓️ Saturday, Nov. 23rd
⏰ 4PM ET
📍 Louisville,KY
📺 ESPN 2#HailToPitt pic.twitter.com/z16KD1rpxe
Pittsburgh Panthers CFB Preview
The Pittsburgh Panthers have had a stellar season, entering this game with a 7-3 record. Head coach Pat Narduzzi has guided the team to a position where they are strong contenders for a favorable bowl game. Offensively, Pittsburgh has been prolific, averaging 20.2 points per game. Quarterback Christian Veilleux has been a revelation, throwing for over 1,179 yards and 7 touchdowns, demonstrating poise and precision in the pocket. His connection with wide receivers Bub Means and Konata Mumpfield has been particularly effective, stretching defenses and creating mismatches. The rushing attack has been equally formidable, with running back Rodney Hammond Jr. rushing for over 547 yards and 5 touchdowns. Hammond’s blend of speed and power has made him a constant threat, keeping defenses honest and opening up play-action opportunities. Defensively, the Panthers have been stout, allowing just 27.3 points per game. Their defense is anchored by a dominant front seven, with linebacker Shayne Simon leading the charge with 5 sacks and consistent pressure on opposing quarterbacks. Linebacker Donovan McMillon has been a tackling machine, recording over 104 tackles and showcasing his ability to disrupt both the run and pass games. The secondary, led by safety M.J. Devonshire, has been solid in limiting explosive plays and forcing turnovers with timely interceptions. This well-rounded defensive unit has been instrumental in keeping opponents’ scoring in check, particularly in high-stakes games. For Pittsburgh to secure a road win against Louisville, they must continue executing their balanced offensive strategy while maintaining discipline on both sides of the ball. Christian Veilleux needs to deliver an efficient passing performance, utilizing Bub Means and Konata Mumpfield to stretch the field and create mismatches. Rodney Hammond Jr. must establish the ground game early, controlling the tempo and opening up opportunities for play-action passes. Defensively, the Panthers need to contain Jawhar Jordan and pressure Jack Plummer, forcing the Cardinals into third-and-long situations where mistakes are more likely. Winning the turnover battle and converting red-zone opportunities will be critical for Pittsburgh as they aim to secure an important victory and solidify their standing in the ACC. With their combination of offensive firepower and defensive tenacity, the Panthers are well-positioned to overcome Louisville in a closely contested matchup.

Credit: USA TODAY/IMAGN
Louisville Cardinals CFB Preview
The Louisville Cardinals have experienced a roller-coaster season, entering this matchup with a 6-4 record. Under head coach Jeff Brohm, the team has showcased resilience but has been hampered by inconsistencies on both sides of the ball. Offensively, Louisville averages 30.7 points per game, with quarterback Jack Plummer leading the charge. Plummer has thrown for over 3,204 yards and 22 touchdowns but has also been prone to interceptions, which have stalled drives and shifted momentum in critical moments. The rushing attack, a cornerstone of Louisville’s offense, has been spearheaded by running back Jawhar Jordan, who has rushed for over 1,128 yards and 7 touchdowns. Jordan’s emergence has provided a spark, but the offensive line’s inconsistency has affected the ground game’s overall effectiveness. Defensively, the Cardinals have allowed an average of 21.3 points per game, struggling particularly against high-tempo offenses. The secondary has been a point of concern, giving up substantial yardage through the air, which could be problematic against Pittsburgh’s potent passing attack. Linebacker TJ Quinn has been a standout, leading the team in tackles and providing leadership on the field. However, the defense’s inability to generate consistent pressure on opposing quarterbacks has exposed vulnerabilities in coverage. For Louisville to compete effectively against Pittsburgh, they will need to play a disciplined game, minimizing turnovers and capitalizing on scoring opportunities. Establishing the run early with Jordan and utilizing play-action to open up passing lanes for Plummer will be essential strategies. Defensively, the Cardinals must find ways to disrupt Christian Veilleux’s rhythm and contain Rodney Hammond Jr. to prevent explosive plays. Special teams could also play a pivotal role, with field position and the kicking game potentially influencing the outcome. While Louisville faces an uphill battle against a top-ranked opponent, their capacity to rise to the occasion in high-stakes games cannot be underestimated.
Louisville personified 👏@RamonPuryear8 began his Louisville Football career as a walk-on & is now the program leader in games played#GoCards pic.twitter.com/Nm8VFnFkRo
— Louisville Football (@LouisvilleFB) November 18, 2024
Pittsburgh vs. Louisville Prop Picks (AI)
Pittsburgh vs. Louisville Prediction (AI)

Remi, our AI sports genius, has been pouring over tons of data from every facet between the Panthers and Cardinals and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.
The Algorithm has been most fixated on the linear correlation of weight knucklehead sportsbettors tend to put on Pittsburgh’s strength factors between a Panthers team going up against a possibly strong Cardinals team. Trends look to say the true game analytics might reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.
Below is our current AI Pittsburgh vs Louisville picks, computer picks Panthers vs Cardinals, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
---|---|---|---|---|---|---|
CFB | 9/26 | TCU@ARIZST | UNLOCK THIS PICK | 3 |
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CFB | 9/26 | FSU@UVA | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule.Â
Panthers Betting Trends
The Pittsburgh Panthers have struggled against the spread (ATS) recently, covering in only 2 of their last 5 games. Their inconsistent offensive performances have contributed to difficulties in meeting betting expectations.
Cardinals Betting Trends
The Louisville Cardinals have fared slightly better ATS, covering in 3 of their last 5 games. However, their performances have been erratic, particularly in close contests, affecting their reliability for bettors.
Panthers vs. Cardinals Matchup Trends
In their last five head-to-head matchups, the underdog has covered the spread four times, indicating a trend of closely contested games regardless of team rankings.
Pittsburgh vs. Louisville Game Info
What time does Pittsburgh vs Louisville start on November 23, 2024?
Pittsburgh vs Louisville starts on November 23, 2024 at 5:00 PM EST.
Where is Pittsburgh vs Louisville being played?
Venue: L&N Federal Credit Union Stadium.
What are the opening odds for Pittsburgh vs Louisville?
Spread: Louisville -7.5
Moneyline: Pittsburgh +225, Louisville -280
Over/Under: 56.5
What are the records for Pittsburgh vs Louisville?
Pittsburgh: (7-3) Â |Â Louisville: (6-4)
What is the AI best bet for Pittsburgh vs Louisville?
Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.. Prices move—always shop for the best number.
What are Pittsburgh vs Louisville trending bets?
In their last five head-to-head matchups, the underdog has covered the spread four times, indicating a trend of closely contested games regardless of team rankings.
What are Pittsburgh trending bets?
PITT trend: The Pittsburgh Panthers have struggled against the spread (ATS) recently, covering in only 2 of their last 5 games. Their inconsistent offensive performances have contributed to difficulties in meeting betting expectations.
What are Louisville trending bets?
LVILLE trend: The Louisville Cardinals have fared slightly better ATS, covering in 3 of their last 5 games. However, their performances have been erratic, particularly in close contests, affecting their reliability for bettors.
Where can I find AI Picks for Pittsburgh vs Louisville?
See our latest CFB picks and odds pages for 2024 to compare prices before you bet.
Pittsburgh vs. Louisville Odds
AI algorithm Remi is pouring through tons of data points on each player. In fact, anytime the Pittsburgh vs Louisville trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme hostile environments can often follow normal, predictable patterns.
Pittsburgh vs Louisville Opening Odds
PITT Moneyline:
+225 LVILLE Moneyline: -280
PITT Spread: +7.5
LVILLE Spread: -7.5
Over/Under: 56.5
Pittsburgh vs Louisville Live Odds
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-130
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O 49 (-110)
U 49 (-110)
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O 52 (-110)
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O 62.5 (-110)
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Sep 27, 2025 6:00PM EDT
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O 54 (-110)
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Sep 27, 2025 6:30PM EDT
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WMICH
|
–
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+235
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O 43.5 (-113)
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|
–
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-540
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O 62 (-110)
U 62 (-110)
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Sep 27, 2025 7:00PM EDT
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VATECH
NCST
|
–
–
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+275
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O 57.5 (-110)
U 57.5 (-110)
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Western Kentucky Hilltoppers
Missouri State Bears
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|
–
–
|
-180
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|
O 60 (-110)
U 60 (-110)
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|
–
–
|
+175
-205
|
+5 (-110)
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O 48.5 (-110)
U 48.5 (-110)
|
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Sep 27, 2025 7:00PM EDT
Jacksonville State Gamecocks
USM Golden Eagles
9/27/25 7PM
JAXST
USM
|
–
–
|
+150
|
+3.5 (-110)
|
O 56 (-110)
U 56 (-110)
|
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Sep 27, 2025 7:30PM EDT
Oregon Ducks
Penn State Nittany Lions
9/27/25 7:30PM
OREG
PSU
|
–
–
|
+143
-180
|
+4 (-113)
-4 (-109)
|
O 53 (-113)
U 53 (-109)
|
|
Sep 27, 2025 7:30PM EDT
App State Mountaineers
Boise State Broncos
9/27/25 7:30PM
APPST
BOISE
|
–
–
|
-750
|
-16.5 (-110)
|
O 59 (-110)
U 59 (-110)
|
|
Sep 27, 2025 7:30PM EDT
Alabama Crimson Tide
Georgia Bulldogs
9/27/25 7:30PM
BAMA
UGA
|
–
–
|
+112
-141
|
+2.5 (-110)
-2.5 (-113)
|
O 53.5 (-114)
U 53.5 (-109)
|
|
Sep 27, 2025 7:30PM EDT
Umass Minutemen
Missouri Tigers
9/27/25 7:30PM
UMASS
MIZZOU
|
–
–
|
|
-44.5 (-110)
|
O 56.5 (-110)
U 56.5 (-110)
|
|
Sep 27, 2025 7:30PM EDT
San Jose State Spartans
Stanford Cardinal
9/27/25 7:30PM
SJST
STNFRD
|
–
–
|
+129
-150
|
+3 (-110)
-3 (-110)
|
O 49.5 (-110)
U 49.5 (-110)
|
|
Sep 27, 2025 7:30PM EDT
Washington State Cougars
Colorado State Rams
9/27/25 7:30PM
WASHST
COLOST
|
–
–
|
+175
-205
|
+5.5 (-110)
-5.5 (-110)
|
O 49.5 (-110)
U 49.5 (-110)
|
|
Sep 27, 2025 7:45PM EDT
Kentucky Wildcats
South Carolina Gamecocks
9/27/25 7:45PM
UK
SC
|
–
–
|
+180
-210
|
+5.5 (-110)
-5.5 (-110)
|
O 47.5 (-110)
U 47.5 (-110)
|
|
Sep 27, 2025 8:00PM EDT
Marshall Thundering Herd
Louisiana Ragin Cajuns
9/27/25 8PM
MARSH
UL
|
–
–
|
-125
+105
|
-2 (-110)
+2 (-110)
|
O 48 (-115)
U 48 (-105)
|
|
Sep 27, 2025 9:00PM EDT
Louisiana Tech Bulldogs
UTEP Miners
9/27/25 9PM
LATECH
UTEP
|
–
–
|
-175
+150
|
-3.5 (-110)
+3.5 (-110)
|
O 48 (-110)
U 48 (-110)
|
|
Sep 27, 2025 10:15PM EDT
BYU Cougars
Colorado Buffaloes
9/27/25 10:15PM
BYU
COLO
|
–
–
|
-235
+200
|
-6.5 (-110)
+6.5 (-110)
|
O 49.5 (-110)
U 49.5 (-110)
|
|
Oct 4, 2025 12:00PM EDT
Minnesota Golden Gophers
Ohio State Buckeyes
10/4/25 12PM
MINN
OHIOST
|
–
–
|
|
+21 (-110)
-21 (-110)
|
|
|
Oct 4, 2025 12:00PM EDT
Kentucky Wildcats
Georgia Bulldogs
10/4/25 12PM
UK
UGA
|
–
–
|
|
+20.5 (-110)
-20.5 (-110)
|
|
|
Oct 4, 2025 12:00PM EDT
Clemson Tigers
North Carolina Tar Heels
10/4/25 12PM
CLEM
UNC
|
–
–
|
-550
+400
|
-13.5 (-110)
+13.5 (-110)
|
O 48.5 (-110)
U 48.5 (-110)
|
|
Oct 4, 2025 12:00PM EDT
Wisconsin Badgers
Michigan Wolverines
10/4/25 12PM
WISC
MICH
|
–
–
|
+580
-880
|
+16.5 (-110)
-16.5 (-110)
|
O 41.5 (-105)
U 41.5 (-115)
|
|
Oct 4, 2025 1:00PM EDT
UTSA Roadrunners
Temple Owls
10/4/25 1PM
UTSA
TEMPLE
|
–
–
|
-210
+172
|
-5.5 (-115)
+5.5 (-105)
|
O 56.5 (-110)
U 56.5 (-110)
|
|
Oct 4, 2025 3:30PM EDT
Vanderbilt Commodores
Alabama Crimson Tide
10/4/25 3:30PM
VANDY
BAMA
|
–
–
|
+360
-480
|
+11.5 (-102)
-11.5 (-120)
|
O 51.5 (-110)
U 51.5 (-110)
|
|
Oct 4, 2025 3:30PM EDT
Washington Huskies
Maryland Terrapins
10/4/25 3:30PM
WASH
MD
|
–
–
|
|
-7 (-110)
+7 (-110)
|
|
|
Oct 4, 2025 3:30PM EDT
Boise State Broncos
Notre Dame Fighting Irish
10/4/25 3:30PM
BOISE
ND
|
–
–
|
+365
-490
|
+15.5 (-110)
-15.5 (-110)
|
O 61.5 (-110)
U 61.5 (-110)
|
|
Oct 4, 2025 3:30PM EDT
Texas Longhorns
Florida Gators
10/4/25 3:30PM
TEXAS
FLA
|
–
–
|
-300
+240
|
-7.5 (-110)
+7.5 (-110)
|
O 46.5 (-110)
U 46.5 (-110)
|
|
Oct 4, 2025 4:00PM EDT
Kent State Golden Flashes
Oklahoma Sooners
10/4/25 4PM
KENT
OKLA
|
–
–
|
|
+45.5 (-110)
-45.5 (-110)
|
O 52.5 (-115)
U 52.5 (-105)
|
|
Oct 4, 2025 4:00PM EDT
Michigan State Spartans
Nebraska Cornhuskers
10/4/25 4PM
MICHST
NEB
|
–
–
|
+360
-480
|
+12.5 (-105)
-12.5 (-115)
|
O 53.5 (-110)
U 53.5 (-110)
|
CFB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Pittsburgh Panthers vs. Louisville Cardinals on November 23, 2024 at L&N Federal Credit Union Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.
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   LEAN |    %WIN |    UNITS | RESULT |
---|---|---|---|---|
TULANE@OLEMISS | MISS -11.5 | 54.3% | 4 | WIN |
UNC@UCF | UCF -6.5 | 54.4% | 4 | WIN |
ARKST@KENSAW | KENSAW +4.5 | 54.5% | 4 | WIN |
ILL@IND | IND -6 | 53.2% | 3 | WIN |
SELOU@LSU | LSU -47.5 | 55.3% | 5 | LOSS |
TNMART@MIZZST | MIZZST -14.5 | 56.2% | 6 | WIN |
FRESNO@HAWAII | HAWAII +3 | 56.6% | 6 | WIN |
MRSHL@MTSU | MTSU +2.5 | 56.8% | 6 | LOSS |
MICH@NEB | NEB +1.5 | 57.3% | 7 | LOSS |
WASH@WASHST | DENZEL BOSTON UNDER 69.5 RECV YDS | 56.2% | 6 | LOSS |
IOWA@RUT | ANTWAN RAYMOND OVER 0.5 TOUCHDOWNS | 54.4% | 4 | WIN |
GEORGIA@TENN | UNDER 50.5 | 55.5% | 6 | LOSS |
ARK@OLEMISS | MISS -225 | 72.0% | 9 | WIN |
DUKE@TULANE | TULANE -120 | 56.5% | 4 | WIN |
ARK@OLEMISS | MISS -6.5 | 53.9% | 3 | LOSS |
AKRON@UAB | UAB -11 | 54.7% | 4 | LOSS |
UCONN@DEL | DEL +9.5 | 55.0% | 5 | WIN |
APLST@USM | USM +4 | 55.3% | 6 | WIN |
MERIMK@KENSAW | KENSAW -13.5 | 56.2% | 7 | WIN |
UMASS@IOWA | IOWA -34.5 | 56.4% | 7 | WIN |
UMASS@IOWA | JAZIUN PATTERSON UNDER 0.5 RUSH TDS | 54.8% | 4 | WIN |
NMEX@UCLA | NICO IAMALEAVA UNDER 31.5 PASS ATT | 53.4% | 3 | LOSS |
KSTATE@ARIZ | ARIZ +1.5 | 56.1% | 6 | WIN |
BC@MICHST | NICK MARSH OVER 47.5 RCV YDS | 53.6% | 3 | WIN |
ARIZST@MISSST | MISSST +7 | 54.2% | 4 | WIN |
TULSA@NMEXST | NMEXST +3.5 | 56.9% | 6 | WIN |
UCLA@UNLV | OVER 54.5 | 56.2% | 6 | LOSS |
FRESNO@OREGST | FRESNO +1.5 | 54.7% | 4 | WIN |
VANDY@VATECH | VANDY +2.5 | 55.8% | 5 | WIN |
JMAD@LVILLE | LVILLE -14.5 | 54.0% | 3 | LOSS |
TCU@UNC | JOSEPH MANJACK OVER 37.5 RECV YDS | 53.8% | 3 | LOSS |
ND@MIAMI | MIAMI +3 | 55.2% | 6 | WIN |
MISSST@USM | USM +14.5 | 56.0% | 6 | LOSS |
UTAH@UCLA | UCLA +5.5 | 56.2% | 6 | LOSS |
CAL@OREGST | OREGST +1.5 | 55.1% | 5 | LOSS |
FAU@MD | MD -13.5 | 55.2% | 5 | WIN |
GAS@FRESNO | FRESNO +2 | 55.2% | 5 | WIN |
TOLEDO@UK | UK -9.5 | 56.2% | 6 | LOSS |
AUSTPEAY@MTSU | PEAY +12.5 | 56.2% | 6 | WIN |
LSU@CLEM | GARRETT NUSSMEIER OVER 23.5 PASS COMP | 54.1% | 3 | WIN |
WMICH@MICHST | WMICH +21.5 | 56.2% | 6 | WIN |
ND@OHIOST | WILL HOWARD INTERCEPTIONS OVER 0.5 | 54.80% | 4 | LOSS |
OHIOST@TEXAS | WILL HOWARD PASS + RUSH YDS UNDER 262.5 | 54.70% | 4 | LOSS |
GEORGIA@TEXAS | TEXAS -144 | 54.40% | 4 | LOSS |
AUBURN@BAMA | PAYTON THORNE PASS TDS - UNDER 1.5 | 53.20% | 3 | WIN |
PURDUE@IND | IND -28.5 | 53.90% | 3 | WIN |
FRESNO@UCLA | T.J. HARDEN LONGEST RUSH OVER 17.5 YDS | 54.50% | 4 | LOSS |
TENN@VANDY | VANDY +10.5 | 54.90% | 4 | LOSS |
WVU@TXTECH | TXTECH -2.5 | 54.60% | 4 | WIN |
SC@CLEM | CLEM -130 | 58.70% | 4 | LOSS |
TCU@CINCY | TCU -3 | 54.20% | 4 | WIN |