Nittany Lions vs. Trojans
Prediction, Odds & Props
Oct 12 | CFB AI Picks
Updated: 2024-10-05T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Penn State Nittany Lions (5-0) will face the USC Trojans (3-2) on October 12, 2024, at the Los Angeles Memorial Coliseum. Penn State is favored by 5.5 points, and the game is expected to be a high-stakes Big Ten clash between two strong programs looking to solidify their standing within the conference.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Oct 12, 2024
Start Time: 3:30 PM EST
Venue: United Airlines Field at the LA Memorial Coliseum
Trojans Record: (3-2)
Nittany Lions Record: (5-0)
OPENING ODDS
PSU Moneyline: -200
USC Moneyline: +164
PSU Spread: -5.5
USC Spread: +5.5
Over/Under: 47.5
PSU
Betting Trends
- Penn State is 3-2 against the spread (ATS) this season and has been consistent on the road, covering in four of their last five games as away favorites.
USC
Betting Trends
- USC is also 3-2 ATS this season but has struggled in conference matchups, going 1-3 ATS in their last four games against Big Ten opponents.
MATCHUP TRENDS
- Penn State has covered the spread in six of their last seven road games, while USC has gone under the total in six of their last nine games when playing as the underdog. This suggests that Penn State’s defensive strength may limit USC’s ability to generate explosive plays, favoring the under.
PSU vs. USC
Best Prop Bet
- Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.
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Penn State vs USC Prediction & Odds:
Free CFB Betting Insights for 10/12/24
The key for USC will be finding a way to protect Williams against a fierce Penn State pass rush led by defensive end Chop Robinson. The Trojans’ defense, allowing 28 points per game, will need to tighten up if they hope to slow down Penn State’s balanced attack. Penn State’s defense, which allows just 16 points per game, will look to limit Williams’ mobility and force him into making quick decisions. The Nittany Lions’ secondary, led by cornerback Kalen King, has been effective in shutting down opposing passing attacks. If Penn State can control the line of scrimmage and prevent USC from establishing a running game, they have a good chance to leave Los Angeles with a win.
The Recap: Stripe Out vs. UCLA 🎬 pic.twitter.com/iZddmI8ND5
— Penn State Football (@PennStateFball) October 7, 2024
Penn State Nittany Lions CFB Preview
The Penn State Nittany Lions are rolling into this matchup with a perfect 5-0 record. Quarterback Drew Allar has been exceptional, completing over 65% of his passes and throwing for 12 touchdowns. Running backs Nicholas Singleton and Kaytron Allen have provided balance, making Penn State difficult to defend. The offensive line has been solid, giving Allar time to dissect defenses and find his playmakers. Defensively, Penn State has been one of the best units in the Big Ten, allowing just 16 points per game. Their pass rush, led by Chop Robinson and Adisa Isaac, has been relentless, and the secondary has shut down opposing passing attacks. Against USC, the Nittany Lions will look to pressure Caleb Williams and force him into difficult situations. If Penn State’s defense can contain Williams and limit explosive plays, they should be able to control the game. Overall, this game will be a test for both teams, but Penn State’s balanced offense and stout defense give them the edge against a USC team that has struggled against top-tier competition this season.

Credit: USA TODAY/IMAGN
USC Trojans CFB Preview
The USC Trojans are looking to bounce back after a tough start to the season. At 3-2, the Trojans have been effective offensively but have struggled defensively against high-powered offenses. Caleb Williams, the reigning Heisman Trophy winner, has been the bright spot for USC, throwing for over 1,500 yards and 15 touchdowns. His ability to make plays with his legs and extend plays has made him difficult to defend, but the offensive line’s inconsistency has led to crucial sacks and turnovers. The Trojans’ running game, led by Austin Jones, has been underwhelming, averaging just 110 rushing yards per game. Against Penn State’s aggressive front seven, establishing the run will be critical to keep the defense honest and open up passing lanes for Williams. Defensively, USC has been vulnerable, allowing over 28 points per game. The secondary, which has struggled against top-tier quarterbacks, will need to step up against Drew Allar, who has been efficient and accurate this season.
Final. pic.twitter.com/5PYdccuVE9
— USC Football ✌️ (@uscfb) October 6, 2024
Penn State vs. USC Prop Picks (AI)
Penn State vs. USC Prediction (AI)

Remi, our AI sports algorithm, has been pouring over millions of data from every simulation between the Nittany Lions and Trojans and using recursive machine learning and cutting-edge AI to crunch the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most watching on the linear correlation of factor human bettors tend to put on Penn State’s strength factors between a Nittany Lions team going up against a possibly healthy Trojans team. Trends look to say the true game analytics might reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.
Below is our current AI Penn State vs USC picks, computer picks Nittany Lions vs Trojans, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
---|---|---|---|---|---|---|
CFB | 9/26 | TCU@ARIZST | UNLOCK THIS PICK | 3 |
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CFB | 9/26 | FSU@UVA | UNLOCK THIS PICK | 0 |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule.
Nittany Lions Betting Trends
Penn State is 3-2 against the spread (ATS) this season and has been consistent on the road, covering in four of their last five games as away favorites.
Trojans Betting Trends
USC is also 3-2 ATS this season but has struggled in conference matchups, going 1-3 ATS in their last four games against Big Ten opponents.
Nittany Lions vs. Trojans Matchup Trends
Penn State has covered the spread in six of their last seven road games, while USC has gone under the total in six of their last nine games when playing as the underdog. This suggests that Penn State’s defensive strength may limit USC’s ability to generate explosive plays, favoring the under.
Penn State vs. USC Game Info
What time does Penn State vs USC start on October 12, 2024?
Penn State vs USC starts on October 12, 2024 at 3:30 PM EST.
Where is Penn State vs USC being played?
Venue: United Airlines Field at the LA Memorial Coliseum.
What are the opening odds for Penn State vs USC?
Spread: USC +5.5
Moneyline: Penn State -200, USC +164
Over/Under: 47.5
What are the records for Penn State vs USC?
Penn State: (5-0) | USC: (3-2)
What is the AI best bet for Penn State vs USC?
Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.. Prices move—always shop for the best number.
What are Penn State vs USC trending bets?
Penn State has covered the spread in six of their last seven road games, while USC has gone under the total in six of their last nine games when playing as the underdog. This suggests that Penn State’s defensive strength may limit USC’s ability to generate explosive plays, favoring the under.
What are Penn State trending bets?
PSU trend: Penn State is 3-2 against the spread (ATS) this season and has been consistent on the road, covering in four of their last five games as away favorites.
What are USC trending bets?
USC trend: USC is also 3-2 ATS this season but has struggled in conference matchups, going 1-3 ATS in their last four games against Big Ten opponents.
Where can I find AI Picks for Penn State vs USC?
See our latest CFB picks and odds pages for 2024 to compare prices before you bet.
Penn State vs. USC Odds
Remi is pouring through mountains of stats on each line. In fact, anytime the Penn State vs USC trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme hostile environments rarely follow normal, predictable patterns.
Penn State vs USC Opening Odds
PSU Moneyline:
-200 USC Moneyline: +164
PSU Spread: -5.5
USC Spread: +5.5
Over/Under: 47.5
Penn State vs USC Live Odds
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+175
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+5 (-110)
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O 56.5 (-110)
U 56.5 (-110)
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-170
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-3.5 (-110)
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O 55 (-110)
U 55 (-110)
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+150
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O 51.5 (-110)
U 51.5 (-110)
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-185
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-4 (-110)
+4 (-110)
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O 60 (-110)
U 60 (-110)
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Sep 27, 2025 12:45PM EDT
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+1050
-2000
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+23.5 (-110)
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O 58 (-110)
U 58 (-110)
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Sep 27, 2025 1:00PM EDT
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+134
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-3 (-115)
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O 55 (-110)
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Sep 27, 2025 1:30PM EDT
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+15 (-110)
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+105
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+1.5 (-110)
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O 55 (-110)
U 55 (-110)
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Sep 27, 2025 3:30PM EDT
San Diego State Aztecs
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NILL
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–
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-125
+105
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-1.5 (-110)
+1.5 (-110)
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O 42.5 (-110)
U 42.5 (-110)
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Sep 27, 2025 3:30PM EDT
UCLA Bruins
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–
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+180
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O 46 (-110)
U 46 (-110)
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Sep 27, 2025 3:30PM EDT
Akron Zips
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+900
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+20.5 (-110)
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O 49.5 (-110)
U 49.5 (-110)
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Sep 27, 2025 3:30PM EDT
Ohio State Buckeyes
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O 53 (-110)
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Sep 27, 2025 3:30PM EDT
Auburn Tigers
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AUBURN
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+215
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+7 (-110)
-7 (-110)
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O 51 (-110)
U 51 (-110)
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Sep 27, 2025 3:30PM EDT
Baylor Bears
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9/27/25 3:30PM
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–
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-1500
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-21 (-110)
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O 58.5 (-110)
U 58.5 (-110)
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Sep 27, 2025 3:30PM EDT
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+980
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O 49.5 (-114)
U 49.5 (-110)
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Sep 27, 2025 3:30PM EDT
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9/27/25 3:30PM
IND
IOWA
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–
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-330
+270
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-9 (-110)
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O 47.5 (-110)
U 47.5 (-110)
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Sep 27, 2025 3:30PM EDT
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U 45.5 (-110)
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Sep 27, 2025 3:30PM EDT
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-460
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-12.5 (-110)
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O 47 (-110)
U 47 (-110)
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Sep 27, 2025 3:30PM EDT
UConn Huskies
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O 50.5 (-110)
U 50.5 (-110)
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Sep 27, 2025 3:30PM EDT
California Golden Bears
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-220
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+6 (-110)
-6 (-110)
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O 54 (-110)
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Sep 27, 2025 3:30PM EDT
LSU Tigers
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+110
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O 57.5 (-110)
U 57.5 (-110)
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Sep 27, 2025 4:00PM EDT
New Mexico State Aggies
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U 53.5 (-110)
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Sep 27, 2025 4:00PM EDT
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9/27/25 4PM
TULANE
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-700
+500
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-15 (-110)
+15 (-110)
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O 52 (-110)
U 52 (-110)
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Sep 27, 2025 4:10PM EDT
Hawaii Rainbow Warriors
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AF
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–
–
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+210
-250
|
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|
O 52.5 (-110)
U 52.5 (-110)
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Sep 27, 2025 4:15PM EDT
Tennessee Volunteers
Mississippi State Bulldogs
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|
–
–
|
-265
+223
|
-7 (-110)
+7 (-110)
|
O 63 (-110)
U 63 (-110)
|
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Sep 27, 2025 6:00PM EDT
MTSU Blue Raiders
Kennesaw State Owls
9/27/25 6PM
MTSU
KENSAW
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–
–
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-260
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-7 (-110)
|
O 53.5 (-110)
U 53.5 (-110)
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Sep 27, 2025 6:00PM EDT
Liberty Flames
Old Dominion Monarchs
9/27/25 6PM
LIB
OLDDOM
|
–
–
|
+465
-630
|
+14.5 (-110)
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|
O 54 (-110)
U 54 (-110)
|
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Sep 27, 2025 6:30PM EDT
Rhode Island Rams
Western Michigan Broncos
9/27/25 6:30PM
RI
WMICH
|
–
–
|
+205
-265
|
+7 (-113)
-7 (-109)
|
O 46.5 (-112)
U 46.5 (-114)
|
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Sep 27, 2025 7:00PM EDT
Memphis Tigers
Florida Atlantic Owls
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FAU
|
–
–
|
-600
+450
|
-14 (-110)
+14 (-110)
|
O 62 (-110)
U 62 (-110)
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Sep 27, 2025 7:00PM EDT
Virginia Tech Hokies
NC State Wolfpack
9/27/25 7PM
VATECH
NCST
|
–
–
|
+275
-340
|
+9.5 (-110)
-9.5 (-110)
|
O 57.5 (-110)
U 57.5 (-110)
|
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Sep 27, 2025 7:00PM EDT
Western Kentucky Hilltoppers
Missouri State Bears
9/27/25 7PM
WKY
MIZZST
|
–
–
|
-175
+150
|
-3.5 (-110)
+3.5 (-110)
|
O 60 (-110)
U 60 (-110)
|
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Sep 27, 2025 7:00PM EDT
Arizona Wildcats
Iowa State Cyclones
9/27/25 7PM
ARIZ
IOWAST
|
–
–
|
+175
-205
|
+5 (-110)
-5 (-110)
|
O 48.5 (-110)
U 48.5 (-110)
|
|
Sep 27, 2025 7:00PM EDT
Jacksonville State Gamecocks
USM Golden Eagles
9/27/25 7PM
JAXST
USM
|
–
–
|
+155
|
+3.5 (-110)
|
O 55.5 (-110)
U 55.5 (-110)
|
|
Sep 27, 2025 7:30PM EDT
Oregon Ducks
Penn State Nittany Lions
9/27/25 7:30PM
OREG
PSU
|
–
–
|
+150
-175
|
+3.5 (-105)
-3.5 (-115)
|
O 53 (-110)
U 53 (-110)
|
|
Sep 27, 2025 7:30PM EDT
App State Mountaineers
Boise State Broncos
9/27/25 7:30PM
APPST
BOISE
|
–
–
|
-800
|
-16.5 (-110)
|
O 59 (-110)
U 59 (-110)
|
|
Sep 27, 2025 7:30PM EDT
Alabama Crimson Tide
Georgia Bulldogs
9/27/25 7:30PM
BAMA
UGA
|
–
–
|
+110
-130
|
+2 (-110)
-2 (-110)
|
O 53.5 (-110)
U 53.5 (-110)
|
|
Sep 27, 2025 7:30PM EDT
Umass Minutemen
Missouri Tigers
9/27/25 7:30PM
UMASS
MIZZOU
|
–
–
|
|
-44.5 (-110)
|
O 57 (-110)
U 57 (-110)
|
|
Sep 27, 2025 7:30PM EDT
San Jose State Spartans
Stanford Cardinal
9/27/25 7:30PM
SJST
STNFRD
|
–
–
|
+134
-155
|
+3 (-110)
-3 (-110)
|
O 49.5 (-110)
U 49.5 (-110)
|
|
Sep 27, 2025 7:30PM EDT
Washington State Cougars
Colorado State Rams
9/27/25 7:30PM
WASHST
COLOST
|
–
–
|
+175
-205
|
+5.5 (-110)
-5.5 (-110)
|
O 48.5 (-110)
U 48.5 (-110)
|
|
Sep 27, 2025 7:45PM EDT
Kentucky Wildcats
South Carolina Gamecocks
9/27/25 7:45PM
UK
SC
|
–
–
|
+180
-210
|
+5.5 (-110)
-5.5 (-110)
|
O 47.5 (-110)
U 47.5 (-110)
|
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Sep 27, 2025 8:00PM EDT
Marshall Thundering Herd
Louisiana Ragin Cajuns
9/27/25 8PM
MARSH
UL
|
–
–
|
-130
+110
|
-2 (-110)
+2 (-110)
|
O 48 (-115)
U 48 (-105)
|
|
Sep 27, 2025 9:00PM EDT
Louisiana Tech Bulldogs
UTEP Miners
9/27/25 9PM
LATECH
UTEP
|
–
–
|
-175
+150
|
-3.5 (-110)
+3.5 (-110)
|
O 48 (-110)
U 48 (-110)
|
|
Sep 27, 2025 10:15PM EDT
BYU Cougars
Colorado Buffaloes
9/27/25 10:15PM
BYU
COLO
|
–
–
|
-240
+203
|
-6.5 (-110)
+6.5 (-110)
|
O 49.5 (-110)
U 49.5 (-110)
|
|
Oct 4, 2025 12:00PM EDT
Minnesota Golden Gophers
Ohio State Buckeyes
10/4/25 12PM
MINN
OHIOST
|
–
–
|
|
+21 (-110)
-21 (-110)
|
|
|
Oct 4, 2025 12:00PM EDT
Kentucky Wildcats
Georgia Bulldogs
10/4/25 12PM
UK
UGA
|
–
–
|
|
+20.5 (-110)
-20.5 (-110)
|
|
|
Oct 4, 2025 12:00PM EDT
Clemson Tigers
North Carolina Tar Heels
10/4/25 12PM
CLEM
UNC
|
–
–
|
-550
+400
|
-13.5 (-110)
+13.5 (-110)
|
O 48.5 (-110)
U 48.5 (-110)
|
|
Oct 4, 2025 12:00PM EDT
Wisconsin Badgers
Michigan Wolverines
10/4/25 12PM
WISC
MICH
|
–
–
|
+580
-880
|
+16.5 (-110)
-16.5 (-110)
|
O 41.5 (-105)
U 41.5 (-115)
|
|
Oct 4, 2025 1:00PM EDT
UTSA Roadrunners
Temple Owls
10/4/25 1PM
UTSA
TEMPLE
|
–
–
|
-210
+172
|
-5.5 (-115)
+5.5 (-105)
|
O 56.5 (-110)
U 56.5 (-110)
|
|
Oct 4, 2025 3:30PM EDT
Vanderbilt Commodores
Alabama Crimson Tide
10/4/25 3:30PM
VANDY
BAMA
|
–
–
|
+360
-480
|
+11.5 (-102)
-11.5 (-120)
|
O 51.5 (-110)
U 51.5 (-110)
|
|
Oct 4, 2025 3:30PM EDT
Washington Huskies
Maryland Terrapins
10/4/25 3:30PM
WASH
MD
|
–
–
|
|
-7 (-110)
+7 (-110)
|
|
|
Oct 4, 2025 3:30PM EDT
Boise State Broncos
Notre Dame Fighting Irish
10/4/25 3:30PM
BOISE
ND
|
–
–
|
+365
-490
|
+15.5 (-110)
-15.5 (-110)
|
O 61.5 (-110)
U 61.5 (-110)
|
|
Oct 4, 2025 3:30PM EDT
Texas Longhorns
Florida Gators
10/4/25 3:30PM
TEXAS
FLA
|
–
–
|
-300
+240
|
-7.5 (-110)
+7.5 (-110)
|
O 46.5 (-110)
U 46.5 (-110)
|
|
Oct 4, 2025 4:00PM EDT
Kent State Golden Flashes
Oklahoma Sooners
10/4/25 4PM
KENT
OKLA
|
–
–
|
|
+45.5 (-110)
-45.5 (-110)
|
O 52.5 (-115)
U 52.5 (-105)
|
|
Oct 4, 2025 4:00PM EDT
Michigan State Spartans
Nebraska Cornhuskers
10/4/25 4PM
MICHST
NEB
|
–
–
|
+360
-480
|
+12.5 (-105)
-12.5 (-115)
|
O 53.5 (-110)
U 53.5 (-110)
|
CFB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Penn State Nittany Lions vs. USC Trojans on October 12, 2024 at United Airlines Field at the LA Memorial Coliseum.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TULANE@OLEMISS | MISS -11.5 | 54.3% | 4 | WIN |
UNC@UCF | UCF -6.5 | 54.4% | 4 | WIN |
ARKST@KENSAW | KENSAW +4.5 | 54.5% | 4 | WIN |
ILL@IND | IND -6 | 53.2% | 3 | WIN |
SELOU@LSU | LSU -47.5 | 55.3% | 5 | LOSS |
TNMART@MIZZST | MIZZST -14.5 | 56.2% | 6 | WIN |
FRESNO@HAWAII | HAWAII +3 | 56.6% | 6 | WIN |
MRSHL@MTSU | MTSU +2.5 | 56.8% | 6 | LOSS |
MICH@NEB | NEB +1.5 | 57.3% | 7 | LOSS |
WASH@WASHST | DENZEL BOSTON UNDER 69.5 RECV YDS | 56.2% | 6 | LOSS |
IOWA@RUT | ANTWAN RAYMOND OVER 0.5 TOUCHDOWNS | 54.4% | 4 | WIN |
GEORGIA@TENN | UNDER 50.5 | 55.5% | 6 | LOSS |
ARK@OLEMISS | MISS -225 | 72.0% | 9 | WIN |
DUKE@TULANE | TULANE -120 | 56.5% | 4 | WIN |
ARK@OLEMISS | MISS -6.5 | 53.9% | 3 | LOSS |
AKRON@UAB | UAB -11 | 54.7% | 4 | LOSS |
UCONN@DEL | DEL +9.5 | 55.0% | 5 | WIN |
APLST@USM | USM +4 | 55.3% | 6 | WIN |
MERIMK@KENSAW | KENSAW -13.5 | 56.2% | 7 | WIN |
UMASS@IOWA | IOWA -34.5 | 56.4% | 7 | WIN |
UMASS@IOWA | JAZIUN PATTERSON UNDER 0.5 RUSH TDS | 54.8% | 4 | WIN |
NMEX@UCLA | NICO IAMALEAVA UNDER 31.5 PASS ATT | 53.4% | 3 | LOSS |
KSTATE@ARIZ | ARIZ +1.5 | 56.1% | 6 | WIN |
BC@MICHST | NICK MARSH OVER 47.5 RCV YDS | 53.6% | 3 | WIN |
ARIZST@MISSST | MISSST +7 | 54.2% | 4 | WIN |
TULSA@NMEXST | NMEXST +3.5 | 56.9% | 6 | WIN |
UCLA@UNLV | OVER 54.5 | 56.2% | 6 | LOSS |
FRESNO@OREGST | FRESNO +1.5 | 54.7% | 4 | WIN |
VANDY@VATECH | VANDY +2.5 | 55.8% | 5 | WIN |
JMAD@LVILLE | LVILLE -14.5 | 54.0% | 3 | LOSS |
TCU@UNC | JOSEPH MANJACK OVER 37.5 RECV YDS | 53.8% | 3 | LOSS |
ND@MIAMI | MIAMI +3 | 55.2% | 6 | WIN |
MISSST@USM | USM +14.5 | 56.0% | 6 | LOSS |
UTAH@UCLA | UCLA +5.5 | 56.2% | 6 | LOSS |
CAL@OREGST | OREGST +1.5 | 55.1% | 5 | LOSS |
FAU@MD | MD -13.5 | 55.2% | 5 | WIN |
GAS@FRESNO | FRESNO +2 | 55.2% | 5 | WIN |
TOLEDO@UK | UK -9.5 | 56.2% | 6 | LOSS |
AUSTPEAY@MTSU | PEAY +12.5 | 56.2% | 6 | WIN |
LSU@CLEM | GARRETT NUSSMEIER OVER 23.5 PASS COMP | 54.1% | 3 | WIN |
WMICH@MICHST | WMICH +21.5 | 56.2% | 6 | WIN |
ND@OHIOST | WILL HOWARD INTERCEPTIONS OVER 0.5 | 54.80% | 4 | LOSS |
OHIOST@TEXAS | WILL HOWARD PASS + RUSH YDS UNDER 262.5 | 54.70% | 4 | LOSS |
GEORGIA@TEXAS | TEXAS -144 | 54.40% | 4 | LOSS |
AUBURN@BAMA | PAYTON THORNE PASS TDS - UNDER 1.5 | 53.20% | 3 | WIN |
PURDUE@IND | IND -28.5 | 53.90% | 3 | WIN |
FRESNO@UCLA | T.J. HARDEN LONGEST RUSH OVER 17.5 YDS | 54.50% | 4 | LOSS |
TENN@VANDY | VANDY +10.5 | 54.90% | 4 | LOSS |
WVU@TXTECH | TXTECH -2.5 | 54.60% | 4 | WIN |
SC@CLEM | CLEM -130 | 58.70% | 4 | LOSS |
TCU@CINCY | TCU -3 | 54.20% | 4 | WIN |