Cardinals vs. Fighting Irish
Prediction, Odds & Props
Sep 28 | CFB AI Picks
Updated: 2024-09-21T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Louisville Cardinals (3-0) will face the Notre Dame Fighting Irish (3-1) on September 28, 2024, at Notre Dame Stadium. Notre Dame is a 6-point favorite, and both teams are eager to solidify their national rankings as they approach the midpoint of the season.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Sep 28, 2024
Start Time: 3:30 PM EST
Venue: Notre Dame Stadium
Fighting Irish Record: (3-1)
Cardinals Record: (3-0)
OPENING ODDS
LVILLE Moneyline: +183
ND Moneyline: -223
LVILLE Spread: +6
ND Spread: -6.0
Over/Under: 48.5
LVILLE
Betting Trends
- Louisville has a 2-1 record against the spread (ATS) this season. The Cardinals have won their last eight September games, showing strength early in the season. However, they have struggled in recent road games against ranked teams, going 1-4 ATS in their last five such matchups.
ND
Betting Trends
- Notre Dame holds a 2-2 ATS record this season and is particularly strong at home. They have covered the spread in 12 of their last 13 games when favored against AP-ranked teams. Additionally, Notre Dame has a long-standing undefeated record at home against ACC opponents.
MATCHUP TRENDS
- Notre Dame has won 18 consecutive home games against ACC teams. This historical dominance suggests they have a significant edge when playing at home against conference opponents.
LVILLE vs. ND
Best Prop Bet
- Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.
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Louisville vs Notre Dame Prediction & Odds:
Free CFB Betting Insights for 9/28/24
The Fighting Irish offense is complemented by their powerful rushing attack, spearheaded by Jeremiyah Love, who has racked up 339 rushing yards and four touchdowns this season. Louisville, undefeated at 3-0, enters this contest with plenty of confidence. Led by quarterback Tyler Shough, who has thrown for 850 yards and 8 touchdowns, the Cardinals have averaged an impressive 47.3 points per game. Louisville’s offense is dynamic, featuring a balanced attack with a solid rushing game led by Isaac Brown, who averages 10.8 yards per carry.
However, Louisville’s defensive unit will be tested against Notre Dame’s physical offensive line and balanced play calling. The key to this game will be whether Louisville’s explosive offense can penetrate Notre Dame’s stout defense, which is allowing just 14.5 points per game. The Cardinals will need to avoid costly turnovers and stay efficient in the red zone if they hope to keep this game close. On the other hand, Notre Dame will likely lean on their ground game and solid defense to control the tempo and grind out a victory.
Unreal catch 🤯🤯🤯#GoCards pic.twitter.com/NmPtzauLaM
— Louisville Football (@LouisvilleFB) September 24, 2024
Louisville Cardinals CFB Preview
Louisville enters this game undefeated, but this will be their toughest test so far. The Cardinals have relied on an efficient and explosive offense, with quarterback Tyler Shough leading the way. Shough has thrown for 850 yards and eight touchdowns with no interceptions, showcasing his ability to make smart decisions under pressure. The running game, led by Isaac Brown and Keyjuan Brown, has added balance to the offense, keeping defenses guessing. Louisville’s defense, while solid, has shown vulnerabilities against the pass. They’ll need a much-improved effort to slow down Notre Dame’s rushing attack and limit explosive plays. The Cardinals are allowing just 268.7 total yards per game, but they haven’t faced an offense as physical as Notre Dame’s. For Louisville to pull off the upset, they’ll need to win the turnover battle and capitalize on any mistakes Notre Dame makes. Containing Riley Leonard’s dual-threat ability and keeping Notre Dame’s rushing attack in check will be paramount. If Louisville’s offense can maintain its efficiency and keep the game close into the fourth quarter, they may be able to cover the spread or even steal a win on the road.
Credit: USA TODAY/IMAGN
Notre Dame Fighting Irish CFB Preview
The Notre Dame Fighting Irish come into this game with momentum following back-to-back wins. Quarterback Riley Leonard has been a dual threat, accounting for both passing and rushing touchdowns, though his passing game has struggled at times with only one passing touchdown and two interceptions. Notre Dame’s offense is highly reliant on their rushing attack, where Leonard and running back Jeremiyah Love have been the stars. The Irish average 7.5 yards per carry and will look to impose their will on Louisville’s defense, especially in short-yardage situations. Defensively, Notre Dame has been stellar, ranking among the top units in the nation in points allowed per game. They’ve been particularly effective against the pass, allowing only one passing touchdown all season. Notre Dame’s defensive line, led by Jack Kiser, has also been disruptive, with nine sacks through four games. The Irish will need to maintain their defensive intensity to stifle Louisville’s high-powered offense. Notre Dame’s keys to victory lie in dominating the line of scrimmage and forcing Louisville into third-and-long situations, where they can apply pressure on quarterback Tyler Shough. If the Irish control time of possession, they should cover the 6-point spread comfortably.
2️⃣4️⃣
— Notre Dame Football (@NDFootball) September 25, 2024
𝘛𝘩𝘦 𝘊𝘢𝘮𝘱𝘣𝘦𝘭𝘭 𝘛𝘳𝘰𝘱𝘩𝘺 𝘳𝘦𝘤𝘰𝘨𝘯𝘪𝘻𝘦𝘴 𝘢𝘯 𝘪𝘯𝘥𝘪𝘷𝘪𝘥𝘶𝘢𝘭 𝘢𝘴 𝘵𝘩𝘦 𝘢𝘣𝘴𝘰𝘭𝘶𝘵𝘦 𝘣𝘦𝘴𝘵 𝘧𝘰𝘰𝘵𝘣𝘢𝘭𝘭 𝘴𝘤𝘩𝘰𝘭𝘢𝘳-𝘢𝘵𝘩𝘭𝘦𝘵𝘦 𝘪𝘯 𝘵𝘩𝘦 𝘯𝘢𝘵𝘪𝘰𝘯 𝘧𝘰𝘳 𝘩𝘪𝘴 𝘤𝘰𝘮𝘣𝘪𝘯𝘦𝘥 𝘢𝘤𝘢𝘥𝘦𝘮𝘪𝘤 𝘴𝘶𝘤𝘤𝘦𝘴𝘴, 𝘧𝘰𝘰𝘵𝘣𝘢𝘭𝘭… pic.twitter.com/t1fITiOJUM
Louisville vs. Notre Dame Prop Picks (AI)
Louisville vs. Notre Dame Prediction (AI)
Remi, our AI sports algorithm, has been pouring over mountains of data from every past game between the Cardinals and Fighting Irish and using recursive machine learning and cutting-edge AI to boil down the data to a single cover probability.
Interestingly enough, the data has been most keyed in on the growing factor knucklehead sportsbettors tend to put on Notre Dame’s strength factors between a Cardinals team going up against a possibly strong Fighting Irish team. In reality, the true game analytics might reflect a strong lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our CFB AI picks for FREE now.
Below is our current AI Louisville vs Notre Dame picks, computer picks Cardinals vs Fighting Irish, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
|---|---|---|---|---|---|---|
| CFB | 9/26 | TCU@ARIZST | UNLOCK THIS PICK | 3 |
EXECUTIVE
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| CFB | 9/26 | FSU@UVA | UNLOCK THIS PICK | 0 |
INTEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full CFB schedule.
Cardinals Betting Trends
Louisville has a 2-1 record against the spread (ATS) this season. The Cardinals have won their last eight September games, showing strength early in the season. However, they have struggled in recent road games against ranked teams, going 1-4 ATS in their last five such matchups.
Fighting Irish Betting Trends
Notre Dame holds a 2-2 ATS record this season and is particularly strong at home. They have covered the spread in 12 of their last 13 games when favored against AP-ranked teams. Additionally, Notre Dame has a long-standing undefeated record at home against ACC opponents.
Cardinals vs. Fighting Irish Matchup Trends
Notre Dame has won 18 consecutive home games against ACC teams. This historical dominance suggests they have a significant edge when playing at home against conference opponents.
Louisville vs. Notre Dame Game Info
What time does Louisville vs Notre Dame start on September 28, 2024?
Louisville vs Notre Dame starts on September 28, 2024 at 3:30 PM EST.
Where is Louisville vs Notre Dame being played?
Venue: Notre Dame Stadium.
What are the opening odds for Louisville vs Notre Dame?
Spread: Notre Dame -6.0
Moneyline: Louisville +183, Notre Dame -223
Over/Under: 48.5
What are the records for Louisville vs Notre Dame?
Louisville: (3-0) | Notre Dame: (3-1)
What is the AI best bet for Louisville vs Notre Dame?
Remi's searched hard and is crunching tons of data, but hasn't found a good Prop Bet yet for this game.. Prices move—always shop for the best number.
What are Louisville vs Notre Dame trending bets?
Notre Dame has won 18 consecutive home games against ACC teams. This historical dominance suggests they have a significant edge when playing at home against conference opponents.
What are Louisville trending bets?
LVILLE trend: Louisville has a 2-1 record against the spread (ATS) this season. The Cardinals have won their last eight September games, showing strength early in the season. However, they have struggled in recent road games against ranked teams, going 1-4 ATS in their last five such matchups.
What are Notre Dame trending bets?
ND trend: Notre Dame holds a 2-2 ATS record this season and is particularly strong at home. They have covered the spread in 12 of their last 13 games when favored against AP-ranked teams. Additionally, Notre Dame has a long-standing undefeated record at home against ACC opponents.
Where can I find AI Picks for Louisville vs Notre Dame?
See our latest CFB picks and odds pages for 2024 to compare prices before you bet.
Louisville vs. Notre Dame Odds
Remi is pouring through mountains of stats on each player. In fact, anytime the Louisville vs Notre Dame trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme altitude seemingly never follow normal, predictable betting trends.
Louisville vs Notre Dame Opening Odds
LVILLE Moneyline:
+183 ND Moneyline: -223
LVILLE Spread: +6
ND Spread: -6.0
Over/Under: 48.5
Louisville vs Notre Dame Live Odds
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O 50 (-110)
U 50 (-110)
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–
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+6.5 (-107)
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O 60.5 (-115)
U 60.5 (-108)
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Notre Dame Fighting Irish
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-186
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-4.5 (-110)
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O 64 (-112)
U 64 (-110)
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Cincinnati Bearcats
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CINCY
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–
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+165
-200
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+4.5 (-110)
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O 56.5 (-110)
U 56.5 (-110)
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Sep 27, 2025 12:00PM EDT
Louisville Cardinals
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LVILLE
PITT
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–
–
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-175
+145
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-3.5 (-110)
+3.5 (-110)
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O 56 (-110)
U 56 (-110)
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Sep 27, 2025 12:00PM EDT
Rutgers Scarlet Knights
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RUT
MINN
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–
–
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+170
-205
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+5 (-110)
-5 (-110)
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O 51 (-110)
U 51 (-110)
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Sep 27, 2025 12:00PM EDT
Duke Blue Devils
Syracuse Orange
9/27/25 12PM
DUKE
CUSE
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–
–
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-190
+155
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-4.5 (-110)
+4.5 (-110)
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O 59.5 (-110)
U 59.5 (-110)
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Sep 27, 2025 12:45PM EDT
Utah State Aggies
Vanderbilt Commodores
9/27/25 12:45PM
UTAHST
VANDY
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–
–
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+1100
-2000
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+23.5 (-110)
-23.5 (-110)
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O 58 (-110)
U 58 (-110)
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Sep 27, 2025 1:00PM EDT
Eastern Michigan Eagles
Central Michigan Chippewas
9/27/25 1PM
EMICH
CMICH
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–
–
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+130
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+3.5 (-120)
-3.5 (+100)
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O 54.5 (-115)
U 54.5 (-105)
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Sep 27, 2025 1:30PM EDT
Georgia Southern Eagles
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–
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+490
-700
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+15.5 (-110)
-15.5 (-110)
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O 54.5 (-110)
U 54.5 (-110)
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Sep 27, 2025 3:00PM EDT
Arkansas State Red Wolves
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–
–
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+100
-120
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+1.5 (-115)
-1.5 (-105)
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O 55.5 (-105)
U 55.5 (-115)
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Sep 27, 2025 3:30PM EDT
San Diego State Aztecs
Northern Illinois Huskies
9/27/25 3:30PM
SDGST
NILL
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–
–
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-130
+110
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-2 (-110)
+2 (-110)
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O 43 (-110)
U 43 (-110)
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Sep 27, 2025 3:30PM EDT
UCLA Bruins
Northwestern Wildcats
9/27/25 3:30PM
UCLA
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–
–
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+180
-210
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+6 (-110)
-6 (-110)
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O 46 (-110)
U 46 (-110)
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Sep 27, 2025 3:30PM EDT
Akron Zips
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AKRON
TOLEDO
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+900
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+20.5 (-105)
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O 49 (-110)
U 49 (-110)
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Sep 27, 2025 3:30PM EDT
Ohio State Buckeyes
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WASH
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–
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-375
+265
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O 52.5 (-113)
U 52.5 (-110)
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Sep 27, 2025 3:30PM EDT
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+180
-240
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O 52.5 (-109)
U 52.5 (-114)
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Sep 27, 2025 3:30PM EDT
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-1400
+825
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-21 (-110)
+21 (-110)
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O 58.5 (-110)
U 58.5 (-110)
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Sep 27, 2025 3:30PM EDT
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9/27/25 3:30PM
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–
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+850
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+20.5 (-105)
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O 49.5 (-110)
U 49.5 (-110)
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Sep 27, 2025 3:30PM EDT
Indiana Hoosiers
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-345
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-9 (-112)
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O 47.5 (-110)
U 47.5 (-113)
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Sep 27, 2025 3:30PM EDT
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+420
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+14 (-115)
-14 (-105)
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O 45 (-110)
U 45 (-110)
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Sep 27, 2025 3:30PM EDT
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UTAH
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–
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-475
+355
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-12.5 (-110)
+12.5 (-110)
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O 47.5 (-110)
U 47.5 (-110)
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Sep 27, 2025 3:30PM EDT
UConn Huskies
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UCONN
BUFF
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–
–
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-170
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-3.5 (-110)
+3.5 (-110)
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O 50.5 (-110)
U 50.5 (-110)
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Sep 27, 2025 3:30PM EDT
California Golden Bears
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BC
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–
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+185
-225
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+6 (-110)
-6 (-110)
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O 53.5 (-110)
U 53.5 (-110)
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Sep 27, 2025 3:30PM EDT
LSU Tigers
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+102
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+1.5 (-109)
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O 57 (-112)
U 57 (-112)
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Sep 27, 2025 4:00PM EDT
New Mexico State Aggies
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–
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+475
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+16 (-110)
-16 (-110)
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O 53.5 (-110)
U 53.5 (-110)
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Sep 27, 2025 4:00PM EDT
Tulane Green Wave
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–
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-700
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-15.5 (-110)
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O 52 (-110)
U 52 (-110)
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Sep 27, 2025 4:10PM EDT
Hawaii Rainbow Warriors
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AF
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–
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+210
-250
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+6.5 (-105)
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O 52.5 (-110)
U 52.5 (-110)
|
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Sep 27, 2025 4:15PM EDT
Tennessee Volunteers
Mississippi State Bulldogs
9/27/25 4:15PM
TENN
MISSST
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–
–
|
-270
+225
|
-7 (-114)
+7 (-106)
|
O 62.5 (-110)
U 62.5 (-110)
|
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Sep 27, 2025 6:00PM EDT
MTSU Blue Raiders
Kennesaw State Owls
9/27/25 6PM
MTSU
KENSAW
|
–
–
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-260
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-7 (-110)
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O 53.5 (-110)
U 53.5 (-110)
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Sep 27, 2025 6:00PM EDT
Liberty Flames
Old Dominion Monarchs
9/27/25 6PM
LIB
OLDDOM
|
–
–
|
+465
-630
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+14.5 (-110)
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O 54 (-110)
U 54 (-110)
|
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Sep 27, 2025 6:30PM EDT
Rhode Island Rams
Western Michigan Broncos
9/27/25 6:30PM
RI
WMICH
|
–
–
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+235
-305
|
+7.5 (-113)
-7.5 (-110)
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O 43.5 (-113)
U 43.5 (-113)
|
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Sep 27, 2025 7:00PM EDT
Memphis Tigers
Florida Atlantic Owls
9/27/25 7PM
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FAU
|
–
–
|
-540
+417
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-14 (-110)
+14 (-110)
|
O 62 (-110)
U 62 (-110)
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Sep 27, 2025 7:00PM EDT
Virginia Tech Hokies
NC State Wolfpack
9/27/25 7PM
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NCST
|
–
–
|
+275
-340
|
+9.5 (-110)
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O 57.5 (-110)
U 57.5 (-110)
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Sep 27, 2025 7:00PM EDT
Western Kentucky Hilltoppers
Missouri State Bears
9/27/25 7PM
WKY
MIZZST
|
–
–
|
-180
+155
|
-3.5 (-110)
+3.5 (-110)
|
O 60 (-110)
U 60 (-110)
|
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|
Sep 27, 2025 7:00PM EDT
Arizona Wildcats
Iowa State Cyclones
9/27/25 7PM
ARIZ
IOWAST
|
–
–
|
+175
-205
|
+5 (-110)
-5 (-110)
|
O 48.5 (-110)
U 48.5 (-110)
|
|
|
Sep 27, 2025 7:00PM EDT
Jacksonville State Gamecocks
USM Golden Eagles
9/27/25 7PM
JAXST
USM
|
–
–
|
+150
|
+3.5 (-110)
|
O 56 (-110)
U 56 (-110)
|
|
|
Sep 27, 2025 7:30PM EDT
Oregon Ducks
Penn State Nittany Lions
9/27/25 7:30PM
OREG
PSU
|
–
–
|
+143
-180
|
+4 (-113)
-4 (-109)
|
O 53 (-113)
U 53 (-109)
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|
|
Sep 27, 2025 7:30PM EDT
App State Mountaineers
Boise State Broncos
9/27/25 7:30PM
APPST
BOISE
|
–
–
|
-750
|
-16.5 (-110)
|
O 59 (-110)
U 59 (-110)
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Sep 27, 2025 7:30PM EDT
Alabama Crimson Tide
Georgia Bulldogs
9/27/25 7:30PM
BAMA
UGA
|
–
–
|
+112
-141
|
+2.5 (-110)
-2.5 (-113)
|
O 53.5 (-114)
U 53.5 (-109)
|
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|
Sep 27, 2025 7:30PM EDT
Umass Minutemen
Missouri Tigers
9/27/25 7:30PM
UMASS
MIZZOU
|
–
–
|
|
-44.5 (-110)
|
O 56.5 (-110)
U 56.5 (-110)
|
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Sep 27, 2025 7:30PM EDT
San Jose State Spartans
Stanford Cardinal
9/27/25 7:30PM
SJST
STNFRD
|
–
–
|
+129
-150
|
+3 (-110)
-3 (-110)
|
O 49.5 (-110)
U 49.5 (-110)
|
|
|
Sep 27, 2025 7:30PM EDT
Washington State Cougars
Colorado State Rams
9/27/25 7:30PM
WASHST
COLOST
|
–
–
|
+175
-205
|
+5.5 (-110)
-5.5 (-110)
|
O 49.5 (-110)
U 49.5 (-110)
|
|
|
Sep 27, 2025 7:45PM EDT
Kentucky Wildcats
South Carolina Gamecocks
9/27/25 7:45PM
UK
SC
|
–
–
|
+180
-210
|
+5.5 (-110)
-5.5 (-110)
|
O 47.5 (-110)
U 47.5 (-110)
|
|
|
Sep 27, 2025 8:00PM EDT
Marshall Thundering Herd
Louisiana Ragin Cajuns
9/27/25 8PM
MARSH
UL
|
–
–
|
-125
+105
|
-2 (-110)
+2 (-110)
|
O 48 (-115)
U 48 (-105)
|
|
|
Sep 27, 2025 9:00PM EDT
Louisiana Tech Bulldogs
UTEP Miners
9/27/25 9PM
LATECH
UTEP
|
–
–
|
-175
+150
|
-3.5 (-110)
+3.5 (-110)
|
O 48 (-110)
U 48 (-110)
|
|
|
Sep 27, 2025 10:15PM EDT
BYU Cougars
Colorado Buffaloes
9/27/25 10:15PM
BYU
COLO
|
–
–
|
-235
+200
|
-6.5 (-110)
+6.5 (-110)
|
O 49.5 (-110)
U 49.5 (-110)
|
|
|
Oct 4, 2025 12:00PM EDT
Minnesota Golden Gophers
Ohio State Buckeyes
10/4/25 12PM
MINN
OHIOST
|
–
–
|
|
+21 (-110)
-21 (-110)
|
|
|
|
Oct 4, 2025 12:00PM EDT
Kentucky Wildcats
Georgia Bulldogs
10/4/25 12PM
UK
UGA
|
–
–
|
|
+20.5 (-110)
-20.5 (-110)
|
|
|
|
Oct 4, 2025 12:00PM EDT
Clemson Tigers
North Carolina Tar Heels
10/4/25 12PM
CLEM
UNC
|
–
–
|
-550
+400
|
-13.5 (-110)
+13.5 (-110)
|
O 48.5 (-110)
U 48.5 (-110)
|
|
|
Oct 4, 2025 12:00PM EDT
Wisconsin Badgers
Michigan Wolverines
10/4/25 12PM
WISC
MICH
|
–
–
|
+580
-880
|
+16.5 (-110)
-16.5 (-110)
|
O 41.5 (-105)
U 41.5 (-115)
|
|
|
Oct 4, 2025 1:00PM EDT
UTSA Roadrunners
Temple Owls
10/4/25 1PM
UTSA
TEMPLE
|
–
–
|
-210
+172
|
-5.5 (-115)
+5.5 (-105)
|
O 56.5 (-110)
U 56.5 (-110)
|
|
|
Oct 4, 2025 3:30PM EDT
Vanderbilt Commodores
Alabama Crimson Tide
10/4/25 3:30PM
VANDY
BAMA
|
–
–
|
+360
-480
|
+11.5 (-102)
-11.5 (-120)
|
O 51.5 (-110)
U 51.5 (-110)
|
|
|
Oct 4, 2025 3:30PM EDT
Washington Huskies
Maryland Terrapins
10/4/25 3:30PM
WASH
MD
|
–
–
|
|
-7 (-110)
+7 (-110)
|
|
|
|
Oct 4, 2025 3:30PM EDT
Boise State Broncos
Notre Dame Fighting Irish
10/4/25 3:30PM
BOISE
ND
|
–
–
|
+365
-490
|
+15.5 (-110)
-15.5 (-110)
|
O 61.5 (-110)
U 61.5 (-110)
|
|
|
Oct 4, 2025 3:30PM EDT
Texas Longhorns
Florida Gators
10/4/25 3:30PM
TEXAS
FLA
|
–
–
|
-300
+240
|
-7.5 (-110)
+7.5 (-110)
|
O 46.5 (-110)
U 46.5 (-110)
|
|
|
Oct 4, 2025 4:00PM EDT
Kent State Golden Flashes
Oklahoma Sooners
10/4/25 4PM
KENT
OKLA
|
–
–
|
|
+45.5 (-110)
-45.5 (-110)
|
O 52.5 (-115)
U 52.5 (-105)
|
|
|
Oct 4, 2025 4:00PM EDT
Michigan State Spartans
Nebraska Cornhuskers
10/4/25 4PM
MICHST
NEB
|
–
–
|
+360
-480
|
+12.5 (-105)
-12.5 (-115)
|
O 53.5 (-110)
U 53.5 (-110)
|
CFB Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Louisville Cardinals vs. Notre Dame Fighting Irish on September 28, 2024 at Notre Dame Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our CFB odds pages, and compare prices before you place a bet.
| CFB |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| TULANE@OLEMISS | MISS -11.5 | 54.3% | 4 | WIN |
| UNC@UCF | UCF -6.5 | 54.4% | 4 | WIN |
| ARKST@KENSAW | KENSAW +4.5 | 54.5% | 4 | WIN |
| ILL@IND | IND -6 | 53.2% | 3 | WIN |
| SELOU@LSU | LSU -47.5 | 55.3% | 5 | LOSS |
| TNMART@MIZZST | MIZZST -14.5 | 56.2% | 6 | WIN |
| FRESNO@HAWAII | HAWAII +3 | 56.6% | 6 | WIN |
| MRSHL@MTSU | MTSU +2.5 | 56.8% | 6 | LOSS |
| MICH@NEB | NEB +1.5 | 57.3% | 7 | LOSS |
| WASH@WASHST | DENZEL BOSTON UNDER 69.5 RECV YDS | 56.2% | 6 | LOSS |
| IOWA@RUT | ANTWAN RAYMOND OVER 0.5 TOUCHDOWNS | 54.4% | 4 | WIN |
| GEORGIA@TENN | UNDER 50.5 | 55.5% | 6 | LOSS |
| ARK@OLEMISS | MISS -225 | 72.0% | 9 | WIN |
| DUKE@TULANE | TULANE -120 | 56.5% | 4 | WIN |
| ARK@OLEMISS | MISS -6.5 | 53.9% | 3 | LOSS |
| AKRON@UAB | UAB -11 | 54.7% | 4 | LOSS |
| UCONN@DEL | DEL +9.5 | 55.0% | 5 | WIN |
| APLST@USM | USM +4 | 55.3% | 6 | WIN |
| MERIMK@KENSAW | KENSAW -13.5 | 56.2% | 7 | WIN |
| UMASS@IOWA | IOWA -34.5 | 56.4% | 7 | WIN |
| UMASS@IOWA | JAZIUN PATTERSON UNDER 0.5 RUSH TDS | 54.8% | 4 | WIN |
| NMEX@UCLA | NICO IAMALEAVA UNDER 31.5 PASS ATT | 53.4% | 3 | LOSS |
| KSTATE@ARIZ | ARIZ +1.5 | 56.1% | 6 | WIN |
| BC@MICHST | NICK MARSH OVER 47.5 RCV YDS | 53.6% | 3 | WIN |
| ARIZST@MISSST | MISSST +7 | 54.2% | 4 | WIN |
| TULSA@NMEXST | NMEXST +3.5 | 56.9% | 6 | WIN |
| UCLA@UNLV | OVER 54.5 | 56.2% | 6 | LOSS |
| FRESNO@OREGST | FRESNO +1.5 | 54.7% | 4 | WIN |
| VANDY@VATECH | VANDY +2.5 | 55.8% | 5 | WIN |
| JMAD@LVILLE | LVILLE -14.5 | 54.0% | 3 | LOSS |
| TCU@UNC | JOSEPH MANJACK OVER 37.5 RECV YDS | 53.8% | 3 | LOSS |
| ND@MIAMI | MIAMI +3 | 55.2% | 6 | WIN |
| MISSST@USM | USM +14.5 | 56.0% | 6 | LOSS |
| UTAH@UCLA | UCLA +5.5 | 56.2% | 6 | LOSS |
| CAL@OREGST | OREGST +1.5 | 55.1% | 5 | LOSS |
| FAU@MD | MD -13.5 | 55.2% | 5 | WIN |
| GAS@FRESNO | FRESNO +2 | 55.2% | 5 | WIN |
| TOLEDO@UK | UK -9.5 | 56.2% | 6 | LOSS |
| AUSTPEAY@MTSU | PEAY +12.5 | 56.2% | 6 | WIN |
| LSU@CLEM | GARRETT NUSSMEIER OVER 23.5 PASS COMP | 54.1% | 3 | WIN |
| WMICH@MICHST | WMICH +21.5 | 56.2% | 6 | WIN |
| ND@OHIOST | WILL HOWARD INTERCEPTIONS OVER 0.5 | 54.80% | 4 | LOSS |
| OHIOST@TEXAS | WILL HOWARD PASS + RUSH YDS UNDER 262.5 | 54.70% | 4 | LOSS |
| GEORGIA@TEXAS | TEXAS -144 | 54.40% | 4 | LOSS |
| AUBURN@BAMA | PAYTON THORNE PASS TDS - UNDER 1.5 | 53.20% | 3 | WIN |
| PURDUE@IND | IND -28.5 | 53.90% | 3 | WIN |
| FRESNO@UCLA | T.J. HARDEN LONGEST RUSH OVER 17.5 YDS | 54.50% | 4 | LOSS |
| TENN@VANDY | VANDY +10.5 | 54.90% | 4 | LOSS |
| WVU@TXTECH | TXTECH -2.5 | 54.60% | 4 | WIN |
| SC@CLEM | CLEM -130 | 58.70% | 4 | LOSS |
| TCU@CINCY | TCU -3 | 54.20% | 4 | WIN |