Blackhawks vs. Sabres
Prediction, Odds & Props
Nov 21 | NHL AI Picks
Updated: 2025-11-19T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Nov 21, 2025
Start Time: 7:00 PM EST​
Venue: ​
Sabres Record:
Blackhawks Record:
OPENING ODDS
CHI Moneyline:
BUF Moneyline:
CHI Spread:
BUF Spread:
Over/Under:
CHI
Betting Trends
BUF
Betting Trends
MATCHUP TRENDS
CHI vs. BUF
Best Prop Bet
LIVE NHL ODDS
NHL ODDS COMPARISON
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Chicago vs Buffalo Prediction & Odds:
Free NHL Betting Insights for 11/21/25
Chicago Blackhawks NHL Preview
Credit: USA TODAY/IMAGN
Buffalo Sabres NHL Preview
Chicago vs. Buffalo Prop Picks (AI)
Chicago vs. Buffalo Prediction (AI)
Remi, our AI sports wizard, has been pouring over mountains of data from every past game between the Blackhawks and Sabres and using recursive machine learning and impressive AI to boil down the data to a single cover probability.
Remi has been most keyed in on the unproportionally assigned factor knucklehead sportsbettors regularly put on Chicago’s strength factors between a Blackhawks team going up against a possibly tired Sabres team. It appears the true game analytics appear to reflect a slight lean against one Vegas line in particular.
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Below is our current AI Chicago vs Buffalo picks, computer picks Blackhawks vs Sabres, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
|---|---|---|---|---|---|---|
| ACTIVE PICKS LOCKED - SEE NOW | ||||||
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NHL schedule.Â
Blackhawks Betting Trends
Sabres Betting Trends
Blackhawks vs. Sabres Matchup Trends
Chicago vs. Buffalo Game Info
What time does Chicago vs Buffalo start on November 21, 2025?
Chicago vs Buffalo starts on November 21, 2025 at 7:00 PM EST.
What are the opening odds for Chicago vs Buffalo?
Spread: Buffalo
Moneyline: Chicago , Buffalo
Over/Under:
What are the records for Chicago vs Buffalo?
Chicago: Â |Â Buffalo:
What is the AI best bet for Chicago vs Buffalo?
. Prices move—always shop for the best number.
What are Chicago trending bets?
CHI trend:
What are Buffalo trending bets?
BUF trend:
Where can I find AI Picks for Chicago vs Buffalo?
See our latest NHL picks and odds pages for 2025 to compare prices before you bet.
Chicago vs. Buffalo Odds
AI algorithm Remi is pouring through tons of data points on each line. In fact, anytime the Chicago vs Buffalo trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme temps rarely follow normal, predictable betting trends.
Chicago vs Buffalo Opening Odds
CHI Moneyline:
BUF Moneyline:
CHI Spread:
BUF Spread:
Over/Under:
Chicago vs Buffalo Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Oct 7, 2025 5:00PM EDT
Chicago Blackhawks
Florida Panthers
10/7/25 5PM
Blackhawks
Panthers
|
–
–
|
+265
-350
|
+1.5 (+105)
-1.5 (-125)
|
O 5.5 (-125)
U 5.5 (+105)
|
|
|
Oct 7, 2025 8:10PM EDT
Pittsburgh Penguins
New York Rangers
10/7/25 8:10PM
Penguins
Rangers
|
–
–
|
+165
-210
|
+1.5 (-140)
-1.5 (+115)
|
O 5.5 (-130)
U 5.5 (+110)
|
|
|
Oct 7, 2025 10:40PM EDT
Colorado Avalanche
Los Angeles Kings
10/7/25 10:40PM
Avalanche
Kings
|
–
–
|
-115
-105
|
+1.5 (-285)
-1.5 (+220)
|
O 5.5 (-115)
U 5.5 (-105)
|
|
|
Oct 8, 2025 7:10PM EDT
Montreal Canadiens
Toronto Maple Leafs
10/8/25 7:10PM
Canadiens
Maple Leafs
|
–
–
|
-170
|
-1.5 (+140)
|
O 5.5 (-125)
U 5.5 (+105)
|
|
|
Oct 8, 2025 7:40PM EDT
Boston Bruins
Washington Capitals
10/8/25 7:40PM
Bruins
Capitals
|
–
–
|
+145
-185
|
+1.5 (-175)
-1.5 (+140)
|
O 5.5 (-110)
U 5.5 (-110)
|
|
|
Oct 8, 2025 10:10PM EDT
Calgary Flames
Edmonton Oilers
10/8/25 10:10PM
Flames
Oilers
|
–
–
|
+165
-210
|
+1.5 (-140)
-1.5 (+115)
|
O 6.5 (+105)
U 6.5 (-125)
|
|
|
Oct 8, 2025 10:10PM EDT
Los Angeles Kings
Las Vegas Golden Knights
10/8/25 10:10PM
Kings
Golden Knights
|
–
–
|
+155
|
+1.5 (-160)
|
O 5.5 (-120)
U 5.5 (+100)
|
|
|
Oct 9, 2025 7:10PM EDT
Ottawa Senators
Tampa Bay Lightning
10/9/25 7:10PM
Senators
Lightning
|
–
–
|
+136
-162
|
+1.5 (-185)
-1.5 (+154)
|
O 6.5 (+110)
U 6.5 (-130)
|
|
|
Oct 9, 2025 7:10PM EDT
Montreal Canadiens
Detroit Red Wings
10/9/25 7:10PM
Canadiens
Red Wings
|
–
–
|
-130
|
-1.5 (+180)
|
O 6.5 (+110)
U 6.5 (-130)
|
|
|
Oct 9, 2025 7:10PM EDT
Chicago Blackhawks
Boston Bruins
10/9/25 7:10PM
Blackhawks
Bruins
|
–
–
|
+124
-148
|
+1.5 (-205)
-1.5 (+170)
|
O 5.5 (-115)
U 5.5 (-105)
|
|
|
Oct 9, 2025 7:10PM EDT
New York Rangers
Buffalo Sabres
10/9/25 7:10PM
Rangers
Sabres
|
–
–
|
-120
+100
|
-1.5 (+210)
+1.5 (-258)
|
O 6.5 (+110)
U 6.5 (-130)
|
|
|
Oct 9, 2025 7:10PM EDT
New York Islanders
Pittsburgh Penguins
10/9/25 7:10PM
Islanders
Penguins
|
–
–
|
-120
+100
|
-1.5 (+205)
+1.5 (-250)
|
O 5.5 (-125)
U 5.5 (+105)
|
|
|
Oct 9, 2025 7:10PM EDT
Philadelphia Flyers
Florida Panthers
10/9/25 7:10PM
Flyers
Panthers
|
–
–
|
+164
-198
|
+1.5 (-135)
-1.5 (+114)
|
O 5.5 (-110)
U 5.5 (-110)
|
|
|
Oct 9, 2025 7:10PM EDT
New Jersey Devils
Carolina Hurricanes
10/9/25 7:10PM
Devils
Hurricanes
|
–
–
|
+136
-162
|
+1.5 (-198)
-1.5 (+164)
|
O 5.5 (-115)
U 5.5 (-105)
|
|
|
Oct 9, 2025 8:10PM EDT
Minnesota Wild
St Louis Blues
10/9/25 8:10PM
Wild
Blues
|
–
–
|
-110
-110
|
+1.5 (-265)
-1.5 (+215)
|
O 5.5 (-115)
U 5.5 (-105)
|
NHL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Chicago Blackhawks vs. Buffalo Sabres on November 21, 2025 at .
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NHL odds pages, and compare prices before you place a bet.
| NHL |
   LEAN |    %WIN |    UNITS | RESULT |
|---|---|---|---|---|
| CAR@WAS | WAS +140 | 47.70% | 3 | WIN |
| WPG@STL | STL -110 | 54.80% | 4 | WIN |
| WPG@STL | UNDER 5.5 | 55.70% | 4 | LOSS |
| CGY@LA | MACKENZIE WEEGAR OVER 2.5 BLOCKS | 53.10% | 3 | WIN |
| TB@NYR | TB +110 | 49.80% | 3 | LOSS |
| SJ@VAN | ALEXANDER GEORGIEV UNDER 24.5 SAVES | 54.50% | 4 | LOSS |
| BUF@TB | OVER 6.5 | 53.90% | 3 | WIN |
| NYI@PHI | PHI -110 | 54.00% | 3 | WIN |
| LV@EDM | RYAN NUGENT-HOPKINS OVER 1.5 SHOTS ON GOAL | 53.00% | 3 | WIN |
| EDM@ANA | OVER 6 | 54.20% | 3 | LOSS |
| CAR@BOS | OVER 5.5 | 54.00% | 3 | WIN |
| NYR@NJ | NJ -125 | 57.30% | 4 | WIN |
| COL@CLB | OVER 6.5 | 53.80% | 3 | WIN |
| LA@UTA | LA -125 | 54.70% | 3 | WIN |
| WPG@LV | LV -120 | 54.80% | 3 | LOSS |
| MIN@NJ | UNDER 5.5 | 53.80% | 3 | WIN |
| NSH@PHI | PHI -120 | 55.00% | 3 | WIN |
| OTT@BUF | OVER 6 | 54.00% | 3 | LOSS |
| CHI@SJ | CHI +105 | 51.60% | 3 | LOSS |
| WAS@LA | WAS +105 | 51.20% | 3 | LOSS |
| TB@CAR | CAR -130 | 56.40% | 3 | WIN |
| NSH@BOS | BOS -125 | 55.20% | 3 | LOSS |
| MIN@SEA | SEA -120 | 54.60% | 3 | LOSS |
| SJ@TOR | OVER 6 | 54.80% | 3 | LOSS |
| BUF@MON | MON -110 | 54.70% | 4 | WIN |
| BOS@PIT | PIT -120 | 54.90% | 3 | LOSS |
| LA@STL | STL -110 | 53.70% | 3 | WIN |
| LA@DAL | DAL -125 | 56.40% | 4 | WIN |
| PIT@PHI | PHI -116 | 54.20% | 3 | WIN |
| DET@MIN | MIN -115 | 54.20% | 3 | LOSS |
| MIN@DET | DET -130 | 58.00% | 3 | LOSS |
| DAL@LA | UNDER 5.5 | 53.80% | 3 | LOSS |
| LV@NJ | LV -115 | 53.80% | 3 | WIN |
| DET@SEA | LUCAS RAYMOND OVER 0.5 POINTS | 54.20% | 4 | WIN |
| STL@UTA | UTA -125 | 58.30% | 4 | LOSS |
| NSH@BUF | NSH -120 | 54.50% | 4 | LOSS |
| MIN@MON | MATT BOLDY OVER 0.5 POINTS | 55.60% | 5 | LOSS |
| ANA@SEA | SEA -125 | 56.10% | 3 | LOSS |
| DAL@LV | LV -120 | 55.00% | 3 | LOSS |
| VAN@STL | STL -130 | 57.40% | 4 | LOSS |
| COL@NYR | NYR -115 | 53.90% | 3 | LOSS |
| UTA@OTT | OTT -120 | 54.90% | 3 | WIN |
| FLA@LV | LV -123 | 56.00% | 4 | WIN |
| WAS@VAN | WAS -114 | 53.50% | 3 | LOSS |
| FLA@SJ | MATTHEW TKACHUK OVER 0.5 POINTS | 54.80% | 4 | WIN |
| PIT@SEA | SEA -114 | 54.80% | 4 | WIN |
| PHI@NYI | BO HORVAT OVER 0.5 POINTS | 54.70% | 4 | WIN |
| PHI@NYI | OVER 5.5 | 54.60% | 4 | LOSS |
| OTT@BOS | OVER 5.5 | 53.90% | 3 | LOSS |
| MON@DET | DET -122 | 56.40% | 4 | WIN |
| BUF@CGY | CGY -135 | 58.40% | 4 | WIN |