Blues vs Sabres Prediction — AI Finds CAN'T MISS NHL Lines & Props (Nov 06)

Updated: 2025-11-04T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The St. Louis Blues head to Buffalo to take on the Buffalo Sabres on November 6, 2025 at KeyBank Center in what promises to be a crucial cross-conference test for both clubs. St. Louis arrives trying to stabilize a rough early stretch, while the Sabres aim to build momentum at home against a struggling but dangerous opponent.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Nov 06, 2025

Start Time: 7:00 PM EST​

Venue: KeyBank Center​

Sabres Record: (5-4)

Blues Record: (4-8)

OPENING ODDS

STL Moneyline: +113

BUF Moneyline: -134

STL Spread: +1.5

BUF Spread: -1.5

Over/Under: 6.5

STL
Betting Trends

  • The Blues have had difficulty covering on the road this season, entering this game with a sub-.500 record ATS away from home.

BUF
Betting Trends

  • The Sabres have frequently exceeded expectations at KeyBank Center, posting a stronger than average ATS mark at home compared to their overall record.

MATCHUP TRENDS

  • Head-to-head outings between these teams have tended toward high-scoring affairs and games where the underdog covers more often than expected.

STL vs. BUF
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: D. Holloway over 1.5 Shots on Goal.

LIVE NHL ODDS

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St. Louis vs Buffalo Prediction & Odds:
Free NHL Betting Insights for 11/6/25

The November 6, 2025 matchup between the St. Louis Blues and the Buffalo Sabres at KeyBank Center sets up as a cross-conference clash between two teams trending in opposite directions but both desperate to build momentum heading into the midseason grind. The Sabres have been one of the most entertaining and offensively explosive teams in the Eastern Conference, continuing to build on their young core led by Tage Thompson, Rasmus Dahlin, and Dylan Cozens. Buffalo’s offense has found rhythm at home, where its pace and creativity tend to overwhelm visiting defenses, particularly those that struggle with defensive coverage and puck retrieval under pressure. On the other side, the Blues remain a team caught between eras — a veteran-heavy roster still trying to compete but lacking the consistency to execute at the same level that once made them Stanley Cup contenders. Jordan Kyrou and Robert Thomas continue to drive the offense, while captain Brayden Schenn brings leadership and intensity, but St. Louis’s defensive zone coverage and goaltending inconsistency have been persistent issues. Jordan Binnington, once the team’s biggest strength, has been erratic on the road, forcing the Blues to rely more heavily on transition scoring rather than defensive stability. In contrast, the Sabres’ netminding tandem, bolstered by the emergence of Ukko-Pekka Luukkonen, has provided enough reliability to support their high-tempo attack.

This game could quickly turn into a special-teams battle — Buffalo’s power play, anchored by Dahlin’s puck movement and Thompson’s shooting threat, has been among the most dangerous in the league, while the Blues’ penalty kill remains a soft spot. St. Louis will need to play disciplined, stay out of the box, and control the tempo through puck management to avoid falling behind early. From a betting perspective, Buffalo’s strong ATS record at home and their offensive depth give them a statistical edge, while St. Louis’s struggles against the spread on the road make them a risky pick unless they can impose their physicality and grind the game into a slower rhythm. Expect the Sabres to test Binnington early with high-volume shooting from multiple angles, looking to open up passing lanes and capitalize on defensive lapses. For the Blues, the key will be countering with structured breakouts and limiting odd-man rushes, forcing Buffalo to work harder for zone entries. While St. Louis’s veteran experience gives them a chance to hang around, the Sabres’ youth, speed, and home-ice confidence make them the more complete team heading into this matchup. If Buffalo maintains discipline and controls possession, they should dictate play and extend their success at home, while the Blues will need a nearly flawless performance to pull off an upset in what’s shaping up to be a fast-paced, high-scoring contest.

St. Louis Blues NHL Preview

The St. Louis Blues travel to KeyBank Center on November 6, 2025, seeking to rediscover their defensive identity and consistency against a fast-rising Buffalo Sabres squad that thrives on tempo and creativity. The Blues enter this matchup as a team still searching for cohesion and balance, with flashes of offensive brilliance often undermined by defensive lapses and uneven goaltending. Robert Thomas and Jordan Kyrou remain the heartbeat of St. Louis’s attack, bringing elite speed and playmaking vision that can shift momentum in an instant. Thomas’s ability to distribute the puck and Kyrou’s explosiveness on the rush make the Blues dangerous in transition, but sustaining offensive pressure has been an issue, particularly on the road. Captain Brayden Schenn continues to provide leadership and physicality, yet the team’s depth scoring has been inconsistent, forcing too much reliance on the top line to generate offense. The defense, led by Justin Faulk and Torey Krug, has struggled to limit high-danger chances, and goaltender Jordan Binnington’s performance remains unpredictable — capable of stealing a game but equally prone to giving up momentum-shifting goals. Against Buffalo’s up-tempo style, the Blues will need to slow the pace, clog shooting lanes, and prioritize puck management through the neutral zone.

St. Louis cannot afford to get caught chasing the game, as the Sabres excel at capitalizing on turnovers and converting rush chances into goals. Special teams will play a pivotal role — the Blues’ penalty kill must be sharp against Buffalo’s lethal power play led by Tage Thompson and Rasmus Dahlin, while their own power play needs to find rhythm after struggling early in the season. For St. Louis to succeed, Binnington must deliver one of his sharper outings, with the defense providing better rebound control and clearing the crease effectively. Offensively, look for the Blues to focus on net-front presence and physical play along the boards to wear down Buffalo’s young defenders. From a betting standpoint, St. Louis has not been strong against the spread on the road this season, often falling short in high-paced matchups where defensive structure breaks down. However, as a veteran team, they still possess the ability to grind out results when they play disciplined, low-event hockey. The key for the Blues will be to dictate tempo early, avoid costly turnovers, and force Buffalo into a more physical, slower-paced contest rather than the wide-open offensive duels that typically favor the Sabres. If St. Louis can stay out of the penalty box, get timely goaltending, and generate balanced scoring beyond their top line, they could steal a hard-fought win and use it as a much-needed statement performance to steady their season on the road.

The St. Louis Blues head to Buffalo to take on the Buffalo Sabres on November 6, 2025 at KeyBank Center in what promises to be a crucial cross-conference test for both clubs. St. Louis arrives trying to stabilize a rough early stretch, while the Sabres aim to build momentum at home against a struggling but dangerous opponent. St. Louis vs Buffalo AI Prediction: Free NHL Betting Insights for Nov 06. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Buffalo Sabres NHL Preview

The Buffalo Sabres enter their November 6, 2025 matchup against the St. Louis Blues at KeyBank Center with confidence, momentum, and an identity that continues to solidify around their talented young core and offensive creativity. After years of rebuilding, the Sabres have emerged as one of the most entertaining and explosive teams in the Eastern Conference, blending speed, skill, and youth into a formula that has made them a dangerous opponent for any visiting team. Tage Thompson remains the driving force behind Buffalo’s attack, a towering forward with elite finishing ability and deceptive puck skills who consistently breaks open games when given space to operate. Alongside him, Dylan Cozens provides secondary scoring and two-way responsibility, while Rasmus Dahlin anchors the blue line as one of the league’s premier offensive defensemen, controlling possession and setting up scoring chances with his vision and precision. The addition of Owen Power has given the Sabres even more depth on defense, allowing them to transition fluidly and join the rush without sacrificing coverage. At home, Buffalo thrives on energy and tempo, often pushing opponents into mistakes through sustained forechecking pressure and quick zone exits.

Against the Blues, the Sabres will look to test goaltender Jordan Binnington early and often, peppering him with high-volume shots and screens while exploiting St. Louis’s defensive gaps and inconsistent clearing plays. Buffalo’s power play, which ranks among the best in the league, could prove decisive in this contest, particularly if the Blues’ penalty kill continues to struggle. Dahlin’s quarterbacking ability and Thompson’s one-timer from the circle make the Sabres lethal with the man advantage, while players like Jeff Skinner and Alex Tuch add secondary scoring depth and a physical edge around the net. Defensively, the Sabres must remain disciplined, as St. Louis still possesses enough veteran firepower to punish breakdowns, particularly through quick counterattacks led by Robert Thomas and Jordan Kyrou. Goaltending will again be key, with Ukko-Pekka Luukkonen expected to get the start following a strong stretch of home performances; his improved rebound control and positioning have brought much-needed stability to Buffalo’s back end. From a betting perspective, the Sabres have been one of the league’s more reliable teams at home, consistently covering the spread when they dictate the pace and convert on special teams. Their youth-fueled energy has translated into fast starts and strong second-period surges, areas where visiting teams often falter under pressure. For Buffalo to secure another win, they’ll need to sustain offensive-zone time, manage defensive assignments cleanly, and rely on their power play to exploit any St. Louis penalties. If the Sabres maintain their aggressive yet composed style, they have every opportunity to control the game’s flow and continue their rise as one of the NHL’s most promising and exciting home teams.

St. Louis vs. Buffalo Prop Picks (AI)

Remi is pouring through mountains of stats on each player. In fact, anytime the Blues and Sabres play there’s always several intriguing trends to key in on. Not to mention games played at KeyBank Center in Nov rarely follow normal, predictable betting trends.
Remi's searched hard and found the best prop for this matchup: D. Holloway over 1.5 Shots on Goal.

St. Louis vs. Buffalo Prediction (AI)

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Remi, our AI sports genius, has been pouring over exorbitant amounts of data from every simulation between the Blues and Sabres and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.

Interestingly enough, the data has been most watching on the trending emphasis human bettors tend to put on coaching factors between a Blues team going up against a possibly unhealthy Sabres team. We’ve found the true game analytics might reflect a slight lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our NHL AI picks for FREE now.

Below is our current AI St. Louis vs Buffalo picks, computer picks Blues vs Sabres, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NHL schedule

Blues Betting Trends

The Blues have had difficulty covering on the road this season, entering this game with a sub-.500 record ATS away from home.

Sabres Betting Trends

The Sabres have frequently exceeded expectations at KeyBank Center, posting a stronger than average ATS mark at home compared to their overall record.

Blues vs. Sabres Matchup Trends

Head-to-head outings between these teams have tended toward high-scoring affairs and games where the underdog covers more often than expected.

St. Louis vs. Buffalo Game Info

St. Louis vs Buffalo starts on November 06, 2025 at 7:00 PM EST.

Spread: Buffalo -1.5
Moneyline: St. Louis +113, Buffalo -134
Over/Under: 6.5

St. Louis: (4-8)  |  Buffalo: (5-4)

Remi's searched hard and found the best prop for this matchup: D. Holloway over 1.5 Shots on Goal.. Prices move—always shop for the best number.

Head-to-head outings between these teams have tended toward high-scoring affairs and games where the underdog covers more often than expected.

STL trend: The Blues have had difficulty covering on the road this season, entering this game with a sub-.500 record ATS away from home.

BUF trend: The Sabres have frequently exceeded expectations at KeyBank Center, posting a stronger than average ATS mark at home compared to their overall record.

See our latest NHL picks and odds pages for 2025 to compare prices before you bet.

St. Louis vs. Buffalo Odds

AI algorithm Remi is pouring through tons of data on each line. In fact, anytime the St. Louis vs Buffalo trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme temps rarely follow normal, predictable betting trends.

St. Louis vs Buffalo Opening Odds

STL Moneyline: +113
BUF Moneyline: -134
STL Spread: +1.5
BUF Spread: -1.5
Over/Under: 6.5

St. Louis vs Buffalo Live Odds

Games PTS ML SPR O/U
Nov 11, 2025 7:10PM EST
Toronto Maple Leafs
Boston Bruins
11/11/25 7:10PM
Maple Leafs
Bruins
-133
+117
-1.5 (+183)
+1.5 (-215)
O 6.5 (+104)
U 6.5 (-120)
Nov 11, 2025 7:10PM EST
Washington Capitals
Carolina Hurricanes
11/11/25 7:10PM
Capitals
Hurricanes
+140
-159
+1.5 (-185)
-1.5 (+161)
O 6 (-106)
U 6 (-110)
Nov 11, 2025 7:10PM EST
Los Angeles Kings
Montreal Canadiens
11/11/25 7:10PM
Kings
Canadiens
-102
 
+1.5 (-266)
 
O 6 (-101)
U 6 (-115)
Nov 11, 2025 7:10PM EST
Dallas Stars
Ottawa Senators
11/11/25 7:10PM
Stars
Senators
-118
+104
-1.5 (+215)
+1.5 (-260)
O 6 (+104)
U 6 (-120)
Nov 11, 2025 8:10PM EST
Calgary Flames
St Louis Blues
11/11/25 8:10PM
Flames
Blues
+130
-148
+1.5 (-200)
-1.5 (+174)
O 6 (+104)
U 6 (-120)
Nov 11, 2025 8:10PM EST
San Jose Sharks
Minnesota Wild
11/11/25 8:10PM
Sharks
Wild
+186
-213
+1.5 (-130)
-1.5 (+110)
O 6.5 (-112)
U 6.5 (-104)
Nov 11, 2025 9:40PM EST
Anaheim Ducks
Colorado Avalanche
11/11/25 9:40PM
Ducks
Avalanche
+191
-220
+1.5 (-132)
-1.5 (+112)
O 6.5 (-127)
U 6.5 (+111)
Nov 11, 2025 10:10PM EST
Winnipeg Jets
Vancouver Canucks
11/11/25 10:10PM
Jets
Canucks
-125
+110
-1.5 (+200)
+1.5 (-240)
O 6 (-101)
U 6 (-115)
Nov 11, 2025 10:10PM EST
Columbus Blue Jackets
Seattle Kraken
11/11/25 10:10PM
Blue Jackets
Kraken
+104
-118
+1.5 (-240)
-1.5 (+200)
O 6 (-130)
U 6 (+113)

NHL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers St. Louis Blues vs. Buffalo Sabres on November 06, 2025 at KeyBank Center.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NHL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
PIT@TOR OVER 6.5 53.5% 3 WIN
VAN@NSH OVER 5.5 53.9% 3 WIN
NJ@ANA ANA +110 44.8% 1 WIN
DET@ANA DET -100 51.5% 3 LOSS
NYI@CAR UNDER 6.5 54.1% 4 LOSS
WPG@MIN WPG -115 56.4% 4 WIN
NYI@BOS UNDER 6.5 55.0% 3 LOSS
MIN@NYR OVER 5.5 54.2% 3 LOSS
ANA@CHI ANA -125 56.9% 3 LOSS
MIN@WAS WAS -120 56.2% 3 WIN
WPG@PHI WPG -132 56.7% 3 WIN
NYR@TOR TOR -133 58.6% 4 WIN
CGY@UTA OVER 6 53.8% 3 LOSS
OTT@BUF OTT -108 53.1% 3 LOSS
FLA@DET AARON EKBLAD OVER 0.5 POINTS 54.0% 4 LOSS
LA@MIN LA -110 56.0% 5 LOSS
STL@VAN VAN -121 54.6% 4 LOSS
BUF@BOS BOS -114 54.9% 3 WIN
ANA@SEA SEA -125 54.2% 3 WIN
ANA@SEA TROY TERRY OVER 0.5 POINTS 53.3% 3 LOSS
BOS@WAS ALEX OVECHKIN TO SCORE A GOAL 41.4% 2 LOSS
FLA@EDM MATTHEW TKACHUK OVER 0.5 ASSTS 53.70% 3 WIN
FLA@EDM RYAN NUGENT-HOPKINS OVER 1.5 SHOTS ON GOAL 54.50% 4 LOSS
EDM@FLA ALEKSANDER BARKOV UNDER 11.5 FACEOFFS WON 53.00% 3 LOSS
EDM@FLA ALEKSANDER BARKOV UNDER 20.5 MINUTES ON THE ICE 54.00% 4 LOSS
EDM@DAL DAL -110 53.80% 3 LOSS
EDM@DAL DAL -125 56.70% 3 WIN
TOR@FLA MAX PACIORETTY UNDER 1.5 SHOTS ON GOAL 55.60% 5 LOSS
TOR@FLA WILLIAM NYLANDER UNDER 2.5 SHOTS ON GOAL 54.90% 4 LOSS
CAR@WAS WAS +140 47.70% 3 WIN
WPG@STL STL -110 54.80% 4 WIN
WPG@STL UNDER 5.5 55.70% 4 LOSS
CGY@LA MACKENZIE WEEGAR OVER 2.5 BLOCKS 53.10% 3 WIN
TB@NYR TB +110 49.80% 3 LOSS
SJ@VAN ALEXANDER GEORGIEV UNDER 24.5 SAVES 54.50% 4 LOSS
BUF@TB OVER 6.5 53.90% 3 WIN
NYI@PHI PHI -110 54.00% 3 WIN
LV@EDM RYAN NUGENT-HOPKINS OVER 1.5 SHOTS ON GOAL 53.00% 3 WIN
EDM@ANA OVER 6 54.20% 3 LOSS
CAR@BOS OVER 5.5 54.00% 3 WIN
NYR@NJ NJ -125 57.30% 4 WIN
COL@CLB OVER 6.5 53.80% 3 WIN
LA@UTA LA -125 54.70% 3 WIN
WPG@LV LV -120 54.80% 3 LOSS
MIN@NJ UNDER 5.5 53.80% 3 WIN
NSH@PHI PHI -120 55.00% 3 WIN
OTT@BUF OVER 6 54.00% 3 LOSS
CHI@SJ CHI +105 51.60% 3 LOSS
WAS@LA WAS +105 51.20% 3 LOSS
TB@CAR CAR -130 56.40% 3 WIN
NSH@BOS BOS -125 55.20% 3 LOSS