Blues vs Sabres Prediction — AI Finds CAN'T MISS NHL Lines & Props (Nov 06)
Updated: 2025-11-04T03:31:50.923562ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Nov 06, 2025
Start Time: 7:00 PM EST
Venue:
Sabres Record:
Blues Record:
OPENING ODDS
STL Moneyline:
BUF Moneyline:
STL Spread: 0
BUF Spread:
Over/Under:
STL
Betting Trends
BUF
Betting Trends
MATCHUP TRENDS
STL vs. BUF
Best Prop Bet
LIVE NHL ODDS
NHL ODDS COMPARISON
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St. Louis vs Buffalo Prediction & Odds:
Free NHL Betting Insights for 11/6/25
St. Louis Blues NHL Preview
Credit: USA TODAY/IMAGN
Buffalo Sabres NHL Preview
St. Louis vs. Buffalo Prop Picks (AI)
St. Louis vs. Buffalo Prediction (AI)
Remi, our AI sports algorithm, has been pouring over tons of data from every angle between the Blues and Sabres and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most fixated on the trending factor knucklehead sportsbettors often put on Buffalo’s strength factors between a Blues team going up against a possibly tired Sabres team. It appears the true game analytics might reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NHL AI picks for FREE now.
Below is our current AI St. Louis vs Buffalo picks, computer picks Blues vs Sabres, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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| NHL | 10/21 | FLA@BOS | GET FREE PICK NOW | 7 | – | |
| NHL | 10/21 | CLB@DAL | UNLOCK THIS PICK | 1 |
INTEL
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| NHL | 10/21 | SEA@WAS | UNLOCK THIS PICK | 0 |
INTEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NHL schedule.
Blues Betting Trends
Sabres Betting Trends
Blues vs. Sabres Matchup Trends
St. Louis vs. Buffalo Game Info
What time does St. Louis vs Buffalo start on November 06, 2025?
St. Louis vs Buffalo starts on November 06, 2025 at 7:00 PM EST.
What are the opening odds for St. Louis vs Buffalo?
Spread: Buffalo
Moneyline: St. Louis , Buffalo
Over/Under:
What are the records for St. Louis vs Buffalo?
St. Louis: | Buffalo:
What is the AI best bet for St. Louis vs Buffalo?
. Prices move—always shop for the best number.
What are St. Louis trending bets?
STL trend:
What are Buffalo trending bets?
BUF trend:
Where can I find AI Picks for St. Louis vs Buffalo?
See our latest NHL picks and odds pages for 2025 to compare prices before you bet.
St. Louis vs. Buffalo Odds
AI algorithm Remi is pouring through mountains of stats on each player. In fact, anytime the St. Louis vs Buffalo trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude seemingly never follow normal, predictable betting trends.
St. Louis vs Buffalo Opening Odds
STL Moneyline:
BUF Moneyline:
STL Spread: 0
BUF Spread:
Over/Under:
St. Louis vs Buffalo Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Oct 21, 2025 7:10PM EDT
San Jose Sharks
New York Islanders
10/21/25 7:10PM
Sharks
Islanders
|
–
–
|
+180
-220
|
+1.5 (-130)
-1.5 (+110)
|
O 6.5 (-112)
U 6.5 (-108)
|
|
|
Oct 21, 2025 7:10PM EDT
Vancouver Canucks
Pittsburgh Penguins
10/21/25 7:10PM
Canucks
Penguins
|
–
–
|
-110
-110
|
-1.5 (+230)
+1.5 (-280)
|
O 6 (-117)
U 6 (-103)
|
|
|
Oct 21, 2025 7:10PM EDT
Edmonton Oilers
Ottawa Senators
10/21/25 7:10PM
Oilers
Senators
|
–
–
|
-130
+110
|
-1.5 (+180)
+1.5 (-220)
|
O 6 (-103)
U 6 (-117)
|
|
|
Oct 21, 2025 7:10PM EDT
New Jersey Devils
Toronto Maple Leafs
10/21/25 7:10PM
Devils
Maple Leafs
|
–
–
|
+105
-125
|
+1.5 (-250)
-1.5 (+210)
|
O 6 (-112)
U 6 (-108)
|
|
|
Oct 21, 2025 7:10PM EDT
Seattle Kraken
Washington Capitals
10/21/25 7:10PM
Kraken
Capitals
|
–
–
|
+225
-275
|
+1.5 (-105)
-1.5 (-115)
|
O 6 (-105)
U 6 (-115)
|
|
|
Oct 21, 2025 7:40PM EDT
Florida Panthers
Boston Bruins
10/21/25 7:40PM
Panthers
Bruins
|
–
–
|
-163
+137
|
-1.5 (+165)
+1.5 (-195)
|
O 5.5 (-105)
U 5.5 (-115)
|
|
|
Oct 21, 2025 8:10PM EDT
Columbus Blue Jackets
Dallas Stars
10/21/25 8:10PM
Blue Jackets
Stars
|
–
–
|
+160
-185
|
+1.5 (-155)
-1.5 (+133)
|
O 6.5 (-105)
U 6.5 (-115)
|
|
|
Oct 21, 2025 8:10PM EDT
Los Angeles Kings
St Louis Blues
10/21/25 8:10PM
Kings
Blues
|
–
–
|
+110
-130
|
+1.5 (-230)
-1.5 (+190)
|
O 6 (-110)
U 6 (-110)
|
|
|
Oct 21, 2025 8:10PM EDT
Anaheim Ducks
Nashville Predators
10/21/25 8:10PM
Ducks
Predators
|
–
–
|
+122
-142
|
+1.5 (-215)
-1.5 (+178)
|
O 6 (-112)
U 6 (-108)
|
|
|
Oct 22, 2025 7:00PM EDT
Minnesota Wild
New Jersey Devils
10/22/25 7PM
Wild
Devils
|
–
–
|
+110
-130
|
+1.5 (-250)
-1.5 (+210)
|
O 5.5 (-125)
U 5.5 (+105)
|
|
|
Oct 22, 2025 7:30PM EDT
Detroit Red Wings
Buffalo Sabres
10/22/25 7:30PM
Red Wings
Sabres
|
–
–
|
-108
-112
|
+1.5 (-260)
-1.5 (+215)
|
O 6 (-117)
U 6 (-103)
|
|
|
Oct 22, 2025 8:30PM EDT
Montreal Canadiens
Calgary Flames
10/22/25 8:30PM
Canadiens
Flames
|
–
–
|
+105
|
+1.5 (-245)
|
O 6 (-105)
U 6 (-115)
|
NHL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers St. Louis Blues vs. Buffalo Sabres on November 06, 2025 at .
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NHL odds pages, and compare prices before you place a bet.
| NHL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| MIN@WAS | WAS -120 | 56.2% | 3 | WIN |
| WPG@PHI | WPG -132 | 56.7% | 3 | WIN |
| NYR@TOR | TOR -133 | 58.6% | 4 | WIN |
| CGY@UTA | OVER 6 | 53.8% | 3 | LOSS |
| OTT@BUF | OTT -108 | 53.1% | 3 | LOSS |
| FLA@DET | AARON EKBLAD OVER 0.5 POINTS | 54.0% | 4 | LOSS |
| LA@MIN | LA -110 | 56.0% | 5 | LOSS |
| STL@VAN | VAN -121 | 54.6% | 4 | LOSS |
| BUF@BOS | BOS -114 | 54.9% | 3 | WIN |
| ANA@SEA | SEA -125 | 54.2% | 3 | WIN |
| ANA@SEA | TROY TERRY OVER 0.5 POINTS | 53.3% | 3 | LOSS |
| BOS@WAS | ALEX OVECHKIN TO SCORE A GOAL | 41.4% | 2 | LOSS |
| FLA@EDM | MATTHEW TKACHUK OVER 0.5 ASSTS | 53.70% | 3 | WIN |
| FLA@EDM | RYAN NUGENT-HOPKINS OVER 1.5 SHOTS ON GOAL | 54.50% | 4 | LOSS |
| EDM@FLA | ALEKSANDER BARKOV UNDER 11.5 FACEOFFS WON | 53.00% | 3 | LOSS |
| EDM@FLA | ALEKSANDER BARKOV UNDER 20.5 MINUTES ON THE ICE | 54.00% | 4 | LOSS |
| EDM@DAL | DAL -110 | 53.80% | 3 | LOSS |
| EDM@DAL | DAL -125 | 56.70% | 3 | WIN |
| TOR@FLA | MAX PACIORETTY UNDER 1.5 SHOTS ON GOAL | 55.60% | 5 | LOSS |
| TOR@FLA | WILLIAM NYLANDER UNDER 2.5 SHOTS ON GOAL | 54.90% | 4 | LOSS |
| CAR@WAS | WAS +140 | 47.70% | 3 | WIN |
| WPG@STL | STL -110 | 54.80% | 4 | WIN |
| WPG@STL | UNDER 5.5 | 55.70% | 4 | LOSS |
| CGY@LA | MACKENZIE WEEGAR OVER 2.5 BLOCKS | 53.10% | 3 | WIN |
| TB@NYR | TB +110 | 49.80% | 3 | LOSS |
| SJ@VAN | ALEXANDER GEORGIEV UNDER 24.5 SAVES | 54.50% | 4 | LOSS |
| BUF@TB | OVER 6.5 | 53.90% | 3 | WIN |
| NYI@PHI | PHI -110 | 54.00% | 3 | WIN |
| LV@EDM | RYAN NUGENT-HOPKINS OVER 1.5 SHOTS ON GOAL | 53.00% | 3 | WIN |
| EDM@ANA | OVER 6 | 54.20% | 3 | LOSS |
| CAR@BOS | OVER 5.5 | 54.00% | 3 | WIN |
| NYR@NJ | NJ -125 | 57.30% | 4 | WIN |
| COL@CLB | OVER 6.5 | 53.80% | 3 | WIN |
| LA@UTA | LA -125 | 54.70% | 3 | WIN |
| WPG@LV | LV -120 | 54.80% | 3 | LOSS |
| MIN@NJ | UNDER 5.5 | 53.80% | 3 | WIN |
| NSH@PHI | PHI -120 | 55.00% | 3 | WIN |
| OTT@BUF | OVER 6 | 54.00% | 3 | LOSS |
| CHI@SJ | CHI +105 | 51.60% | 3 | LOSS |
| WAS@LA | WAS +105 | 51.20% | 3 | LOSS |
| TB@CAR | CAR -130 | 56.40% | 3 | WIN |
| NSH@BOS | BOS -125 | 55.20% | 3 | LOSS |
| MIN@SEA | SEA -120 | 54.60% | 3 | LOSS |
| SJ@TOR | OVER 6 | 54.80% | 3 | LOSS |
| BUF@MON | MON -110 | 54.70% | 4 | WIN |
| BOS@PIT | PIT -120 | 54.90% | 3 | LOSS |
| LA@STL | STL -110 | 53.70% | 3 | WIN |
| LA@DAL | DAL -125 | 56.40% | 4 | WIN |
| PIT@PHI | PHI -116 | 54.20% | 3 | WIN |
| DET@MIN | MIN -115 | 54.20% | 3 | LOSS |
| MIN@DET | DET -130 | 58.00% | 3 | LOSS |