Bears vs 49ers Prediction — AI Finds CAN'T MISS NFL Lines & Props (Dec 28)
Updated: 2025-12-21T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Dec 28, 2025
Start Time: 8:20 PM EST
Venue:
49ers Record:
Bears Record:
OPENING ODDS
CHI Moneyline:
SF Moneyline:
CHI Spread: 0
SF Spread:
Over/Under:
CHI
Betting Trends
SF
Betting Trends
MATCHUP TRENDS
CHI vs. SF
Best Prop Bet
LIVE NFL ODDS
NFL ODDS COMPARISON
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Chicago vs San Francisco Prediction & Odds:
Free NFL Betting Insights for 12/28/25
Get live NFL odds and precise AI NFL picks, predictions, and cover probabilities.
Chicago Bears NFL Preview
Credit: USA TODAY/IMAGN
San Francisco 49ers NFL Preview
Chicago vs San Francisco Prop Picks (AI)
AI algorithm Remi is pouring through tons of datapoints on each team. In fact, anytime the Bears and 49ers play there’s always several intriguing trends to key in on. Not to mention games played at in Dec rarely follow normal, predictable betting trends.
Chicago vs San Francisco Prediction (AI)
Remi, our AI sports algorithm, has been pouring over tons of data from every simulation between the Bears and 49ers and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.
Interestingly enough, the data has been most watching on the growing emphasis knucklehead sportsbettors often put on San Francisco’s strength factors between a Bears team going up against a possibly tired 49ers team. We’ve found the true game analytics might reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Chicago vs San Francisco picks, computer picks Bears vs 49ers, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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| NFL | 12/4 | DAL@DET | UNLOCK THIS PICK | 7 |
VAULT v4
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| NFL | 12/4 | DAL@DET | UNLOCK THIS PICK | 4 |
EXECUTIVE
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| NFL | 12/4 | DAL@DET | UNLOCK THIS PICK | 1 |
INTEL
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These picks update as information changes—injury reports, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL schedule.
Chicago Betting Trends
San Francisco Betting Trends
Bears vs. 49ers Matchup Trends
Chicago vs. San Francisco Game Info
Chicago vs San Francisco starts on December 28, 2025 at 8:20 PM EST.
Venue: .
Spread: San Francisco
Moneyline: Chicago , San Francisco
Over/Under:
Chicago: | San Francisco:
. Prices move—always shop for the best number.
CHI trend:
SF trend:
See our latest NFL picks and odds pages for 2025 to compare prices before you bet.
Chicago vs. San Francisco Odds
AI algorithm Remi is pouring through loads of data points on each line. In fact, anytime the Chicago vs San Francisco trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme temps almost always follow normal, predictable betting trends.
| CHI Moneyline | |
|---|---|
| SF Moneyline | |
| CHI Spread | 0 |
| SF Spread | |
| Over / Under |
Chicago vs San Francisco Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Dec 7, 2025 1:00PM EST
New Orleans Saints
Tampa Bay Buccaneers
12/7/25 1PM
Saints
Buccaneers
|
–
–
|
+340
-440
|
+8.5 (-109)
-8.5 (-112)
|
O 41.5 (-114)
U 41.5 (-106)
|
|
|
Dec 7, 2025 1:00PM EST
Indianapolis Colts
Jacksonville Jaguars
12/7/25 1PM
Colts
Jaguars
|
–
–
|
-129
+108
|
-1.5 (-113)
+1.5 (-107)
|
O 47 (-110)
U 47 (-109)
|
|
|
Dec 7, 2025 1:00PM EST
Pittsburgh Steelers
Baltimore Ravens
12/7/25 1PM
Steelers
Ravens
|
–
–
|
+215
-265
|
+5.5 (-108)
-5.5 (-112)
|
O 42.5 (-115)
U 42.5 (-105)
|
|
|
Dec 7, 2025 1:00PM EST
Washington Commanders
Minnesota Vikings
12/7/25 1PM
Commanders
Vikings
|
–
–
|
+102
-121
|
+1.5 (-112)
-1.5 (-108)
|
O 42.5 (-110)
U 42.5 (-110)
|
|
|
Dec 7, 2025 1:00PM EST
Cincinnati Bengals
Buffalo Bills
12/7/25 1PM
Bengals
Bills
|
–
–
|
+215
-265
|
+5.5 (-108)
-5.5 (-112)
|
O 53.5 (-107)
U 53.5 (-113)
|
|
|
Dec 7, 2025 1:00PM EST
Miami Dolphins
New York Jets
12/7/25 1PM
Dolphins
Jets
|
–
–
|
-155
+126
|
-3 (-106)
+3 (-114)
|
O 41.5 (-107)
U 41.5 (-113)
|
|
|
Dec 7, 2025 1:00PM EST
Seattle Seahawks
Atlanta Falcons
12/7/25 1PM
Seahawks
Falcons
|
–
–
|
-345
+275
|
-7 (-106)
+7 (-114)
|
O 44.5 (-109)
U 44.5 (-110)
|
|
|
Dec 7, 2025 1:00PM EST
Tennessee Titans
Cleveland Browns
12/7/25 1PM
Titans
Browns
|
–
–
|
+176
-213
|
+4 (-112)
-4 (-108)
|
O 34 (-110)
U 34 (-109)
|
|
|
Dec 7, 2025 4:05PM EST
Denver Broncos
Las Vegas Raiders
12/7/25 4:05PM
Broncos
Raiders
|
–
–
|
-420
+325
|
-7.5 (-107)
+7.5 (-113)
|
O 40 (-114)
U 40 (-107)
|
|
|
Dec 7, 2025 4:25PM EST
Los Angeles Rams
Arizona Cardinals
12/7/25 4:25PM
Rams
Cardinals
|
–
–
|
-440
+330
|
-8.5 (-105)
+8.5 (-115)
|
O 47.5 (-112)
U 47.5 (-108)
|
|
|
Dec 7, 2025 4:25PM EST
Chicago Bears
Green Bay Packers
12/7/25 4:25PM
Bears
Packers
|
–
–
|
+245
-310
|
+6.5 (-107)
-6.5 (-113)
|
O 44.5 (-113)
U 44.5 (-107)
|
|
|
Dec 7, 2025 8:20PM EST
Houston Texans
Kansas City Chiefs
12/7/25 8:20PM
Texans
Chiefs
|
–
–
|
+155
-195
|
+3.5 (-117)
-3.5 (-104)
|
O 41.5 (-114)
U 41.5 (-106)
|
|
|
Dec 8, 2025 8:15PM EST
Philadelphia Eagles
Los Angeles Chargers
12/8/25 8:15PM
Eagles
Chargers
|
–
–
|
-148
+124
|
-2.5 (-120)
+2.5 (-102)
|
O 41 (-114)
U 41 (-106)
|
|
|
Dec 11, 2025 8:15PM EST
Atlanta Falcons
Tampa Bay Buccaneers
12/11/25 8:15PM
Falcons
Buccaneers
|
–
–
|
+220
-275
|
+6 (-109)
-6 (-110)
|
O 44.5 (-107)
U 44.5 (-113)
|
|
|
Dec 14, 2025 1:00PM EST
New York Jets
Jacksonville Jaguars
12/14/25 1PM
Jets
Jaguars
|
–
–
|
+380
-500
|
+9.5 (-114)
-9.5 (-106)
|
O 43.5 (-104)
U 43.5 (-117)
|
|
|
Dec 14, 2025 1:00PM EST
Baltimore Ravens
Cincinnati Bengals
12/14/25 1PM
Ravens
Bengals
|
–
–
|
-152
+127
|
-2.5 (-118)
+2.5 (-102)
|
O 51.5 (-107)
U 51.5 (-113)
|
|
|
Dec 14, 2025 1:00PM EST
Washington Commanders
New York Giants
12/14/25 1PM
Commanders
Giants
|
–
–
|
-127
+106
|
-1.5 (-113)
+1.5 (-107)
|
O 47.5 (-113)
U 47.5 (-107)
|
|
|
Dec 14, 2025 1:00PM EST
Las Vegas Raiders
Philadelphia Eagles
12/14/25 1PM
Raiders
Eagles
|
–
–
|
+675
-1000
|
+12.5 (-110)
-12.5 (-110)
|
O 40 (-107)
U 40 (-113)
|
|
|
Dec 14, 2025 1:00PM EST
Cleveland Browns
Chicago Bears
12/14/25 1PM
Browns
Bears
|
–
–
|
+350
-480
|
+7.5 (-108)
-7.5 (-112)
|
O 39.5 (-117)
U 39.5 (-104)
|
|
|
Dec 14, 2025 1:00PM EST
Arizona Cardinals
Houston Texans
12/14/25 1PM
Cardinals
Texans
|
–
–
|
+265
-335
|
+7 (-109)
-7 (-110)
|
O 42.5 (-115)
U 42.5 (-105)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Chicago Bears vs. San Francisco 49ers on December 28, 2025 at .
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
|
NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| ATL@NYJ | NYJ +3 | 56.9% | 6 | WIN |
| MIN@SEA | SEA -11.5 | 54.5% | 4 | WIN |
| BUF@PIT | PIT +3.5 | 56.9% | 6 | LOSS |
| HOU@IND | IND -3 | 57.9% | 7 | LOSS |
| LAR@CAR | OVER 44.5 | 54.4% | 4 | WIN |
| CHI@PHI | CALEB WILLIAMS OVER 18.5 PASS COMP | 55.7% | 5 | LOSS |
| KC@DAL | DAL +3.5 | 56.3% | 6 | WIN |
| GB@DET | JORDAN LOVE OVER 1.5 PASS TDS | 55.6% | 5 | WIN |
| CIN@BAL | LAMAR JACKSON OVER 24.5 RUSH YDS | 56.7% | 6 | WIN |
| CAR@SF | UNDER 49.5 | 53.0% | 1 | WIN |
| CAR@SF | SF -7 | 54.0% | 3 | WIN |
| CAR@SF | BRYCE YOUNG OVER 61.7 PASS COMP PCT | 55.7% | 5 | WIN |
| NYJ@BAL | DERRICK HENRY OVER 17.5 CARRIES | 53.7% | 3 | WIN |
| JAC@ARI | ARI +2.5 | 55.2% | 5 | LOSS |
| PHI@DAL | DAL +3 | 53.3% | 2 | WIN |
| SEA@TEN | SEA -12 | 57.1% | 7 | LOSS |
| MIN@GB | GB -6 | 54.1% | 3 | WIN |
| IND@KC | IND +3.5 | 54.6% | 4 | WIN |
| TB@LAR | UNDER 49.5 | 52.4% | 1 | WIN |
| IND@KC | UNDER 50.5 | 53.1% | 2 | WIN |
| NYJ@BAL | BREECE HALL OVER 18.5 RECV YDS | 56.7% | 6 | WIN |
| PHI@DAL | JAKE ELLIOT OVER 2.5 EXTRA POINTS MADE | 55.2% | 5 | WIN |
| BUF@HOU | JAMES COOK UNDER 17.5 RUSH ATT | 54.4% | 4 | WIN |
| BUF@HOU | JOSH ALLEN UNDER 63.3 PASS COMP PCT | 56.8% | 6 | LOSS |
| DAL@LV | UNDER 49.5 | 54.3% | 3 | WIN |
| DAL@LV | BROCK BOWERS OVER 6.5 RECEPTIONS | 57.6% | 7 | WIN |
| CAR@ATL | BRYCE YOUNG UNDER 0.5 INT | 56.1% | 6 | WIN |
| KC@DEN | PATRICK MAHOMES UNDER 266.5 PASS YDS | 55.3% | 5 | LOSS |
| SF@ARI | SF -3 | 56.4% | 6 | WIN |
| GB@NYG | GB -7 | 54.3% | 4 | PUSH |
| LAC@JAC | LAC -3 | 53.2% | 3 | LOSS |
| SEA@LAR | SEA +3.5 | 57.2% | 7 | WIN |
| CHI@MIN | MIN -2.5 | 53.4% | 2 | LOSS |
| DET@PHI | DET +3 | 55.8% | 5 | LOSS |
| KC@DEN | DEN +4.5 | 53.0% | 2 | WIN |
| DET@PHI | UNDER 47 | 53.4% | 2 | WIN |
| SEA@LAR | OVER 48.5 | 54.6% | 4 | LOSS |
| NYJ@NE | UNDER 43.5 | 53.4% | 3 | WIN |
| NYJ@NE | JAMIEN SHERWOOD OVER 4.5 TACKLES | 56.8% | 6 | LOSS |
| PHI@GB | PHI +1.5 | 54.8% | 4 | WIN |
| PHI@GB | UNDER 45.5 | 52.4% | 2 | WIN |
| PHI@GB | SAQUON BARKLEY OVER 17.5 RUSH ATT | 56.6% | 6 | WIN |
| PHI@GB | JOSH JACOBS UNDER 42.5 1ST HALF RUSH + REC YDS | 54.4% | 4 | LOSS |
| NO@CAR | CAR -5 | 55.4% | 5 | LOSS |
| BAL@MIN | BAL -3.5 | 57.6% | 7 | WIN |
| CLE@NYJ | CLE -130 | 65.4% | 7 | LOSS |
| NYG@CHI | CHI -4.5 | 55.2% | 5 | LOSS |
| NE@TB | TB -2 | 56.1% | 6 | LOSS |
| LAR@SF | LAR -5.5 | 53.3% | 2 | WIN |
| JAC@HOU | UNDER 38 | 54.8% | 5 | LOSS |
| ARI@SEA | TREY MCBRIDE OVER 9 RECV TARGETS | 55.8% | 5 | WIN |