Titans vs. 49ers
Prediction, Odds & Props
Dec 14 | NFL AI Picks
Updated: 2025-12-07T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Dec 14, 2025
Start Time: 4:25 PM EST​
Venue: ​
49ers Record:
Titans Record:
OPENING ODDS
TEN Moneyline:
SF Moneyline:
TEN Spread: 0
SF Spread:
Over/Under:
TEN
Betting Trends
SF
Betting Trends
MATCHUP TRENDS
TEN vs. SF
Best Prop Bet
LIVE NFL ODDS
NFL ODDS COMPARISON
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Tennessee vs San Francisco Prediction & Odds:
Free NFL Betting Insights for 12/14/25
Tennessee Titans NFL Preview
Credit: USA TODAY/IMAGN
San Francisco 49ers NFL Preview
Tennessee vs. San Francisco Prop Picks (AI)
Tennessee vs. San Francisco Prediction (AI)
Remi, our AI sports genius, has been pouring over mountains of data from every facet between the Titans and 49ers and using recursive machine learning and industry leading AI to examine the data to a single cover probability.
The Algorithm has been most keyed in on the trending emphasis emotional bettors regularly put on San Francisco’s strength factors between a Titans team going up against a possibly tired 49ers team. Trends look to say the true game analytics might reflect a strong lean against one Vegas line specifically.
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Below is our current AI Tennessee vs San Francisco picks, computer picks Titans vs 49ers, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
|---|---|---|---|---|---|---|
| ACTIVE PICKS LOCKED - SEE NOW | ||||||
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Titans Betting Trends
49ers Betting Trends
Titans vs. 49ers Matchup Trends
Tennessee vs. San Francisco Game Info
What time does Tennessee vs San Francisco start on December 14, 2025?
Tennessee vs San Francisco starts on December 14, 2025 at 4:25 PM EST.
What are the opening odds for Tennessee vs San Francisco?
Spread: San Francisco
Moneyline: Tennessee , San Francisco
Over/Under:
What are the records for Tennessee vs San Francisco?
Tennessee: Â |Â San Francisco:
What is the AI best bet for Tennessee vs San Francisco?
. Prices move—always shop for the best number.
What are Tennessee trending bets?
TEN trend:
What are San Francisco trending bets?
SF trend:
Where can I find AI Picks for Tennessee vs San Francisco?
See our latest NFL picks and odds pages for 2025 to compare prices before you bet.
Tennessee vs. San Francisco Odds
AI algorithm Remi is pouring through loads of stats on each player. In fact, anytime the Tennessee vs San Francisco trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme travel distance can often follow normal, predictable patterns.
Tennessee vs San Francisco Opening Odds
TEN Moneyline:
SF Moneyline:
TEN Spread: 0
SF Spread:
Over/Under:
Tennessee vs San Francisco Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Oct 2, 2025 8:16PM EDT
San Francisco 49ers
Los Angeles Rams
10/2/25 8:16PM
49ers
Rams
|
–
–
|
+270
-330
|
+7 (-115)
-7 (-105)
|
O 46.5 (-110)
U 46.5 (-110)
|
|
|
Oct 5, 2025 9:31AM EDT
Minnesota Vikings
Cleveland Browns
10/5/25 9:31AM
Vikings
Browns
|
–
–
|
-200
+170
|
-3.5 (-110)
+3.5 (-110)
|
O 36 (-110)
U 36 (-110)
|
|
|
Oct 5, 2025 1:01PM EDT
Las Vegas Raiders
Indianapolis Colts
10/5/25 1:01PM
Raiders
Colts
|
–
–
|
+265
-325
|
+7 (-115)
-7 (-105)
|
O 48 (-110)
U 48 (-110)
|
|
|
Oct 5, 2025 1:01PM EDT
New York Giants
New Orleans Saints
10/5/25 1:01PM
Giants
Saints
|
–
–
|
+112
-132
|
+1 (+100)
-1 (-120)
|
O 42 (-110)
U 42 (-110)
|
|
|
Oct 5, 2025 1:01PM EDT
Houston Texans
Baltimore Ravens
10/5/25 1:01PM
Texans
Ravens
|
–
–
|
-120
+100
|
-1 (-110)
+1 (-110)
|
O 40.5 (-110)
U 40.5 (-110)
|
|
|
Oct 5, 2025 1:01PM EDT
Denver Broncos
Philadelphia Eagles
10/5/25 1:01PM
Broncos
Eagles
|
–
–
|
+175
-205
|
+3.5 (-105)
-3.5 (-115)
|
O 43.5 (-110)
U 43.5 (-110)
|
|
|
Oct 5, 2025 1:01PM EDT
Dallas Cowboys
New York Jets
10/5/25 1:01PM
Cowboys
Jets
|
–
–
|
-140
+120
|
-2 (-120)
+2 (+100)
|
O 47.5 (-110)
U 47.5 (-110)
|
|
|
Oct 5, 2025 1:01PM EDT
Miami Dolphins
Carolina Panthers
10/5/25 1:01PM
Dolphins
Panthers
|
–
–
|
+105
-125
|
-1 (-110)
+1 (-110)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
|
Oct 5, 2025 4:06PM EDT
Tampa Bay Buccaneers
Seattle Seahawks
10/5/25 4:06PM
Buccaneers
Seahawks
|
–
–
|
+155
-180
|
+3.5 (-115)
-3.5 (-105)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
|
Oct 5, 2025 4:06PM EDT
Tennessee Titans
Arizona Cardinals
10/5/25 4:06PM
Titans
Cardinals
|
–
–
|
+330
-415
|
+7.5 (-115)
-7.5 (-105)
|
O 41.5 (-110)
U 41.5 (-110)
|
|
|
Oct 5, 2025 4:26PM EDT
Washington Commanders
Los Angeles Chargers
10/5/25 4:26PM
Commanders
Chargers
|
–
–
|
+130
-150
|
+3 (-110)
-3 (+100)
|
O 48 (-107)
U 48 (-107)
|
|
|
Oct 5, 2025 4:26PM EDT
Detroit Lions
Cincinnati Bengals
10/5/25 4:26PM
Lions
Bengals
|
–
–
|
-500
+390
|
-10.5 (+100)
+10.5 (-120)
|
O 50 (-110)
U 50 (-110)
|
|
|
Oct 5, 2025 8:21PM EDT
New England Patriots
Buffalo Bills
10/5/25 8:21PM
Patriots
Bills
|
–
–
|
+345
-440
|
+9 (-120)
-9 (+100)
|
O 49.5 (-110)
U 49.5 (-110)
|
|
|
Oct 6, 2025 8:16PM EDT
Kansas City Chiefs
Jacksonville Jaguars
10/6/25 8:16PM
Chiefs
Jaguars
|
–
–
|
-185
+159
|
-3.5 (-105)
+3.5 (-115)
|
O 46.5 (-110)
U 46.5 (-110)
|
|
|
Oct 9, 2025 8:16PM EDT
Philadelphia Eagles
New York Giants
10/9/25 8:16PM
Eagles
Giants
|
–
–
|
-430
+340
|
-7.5 (-110)
+7.5 (-110)
|
O 42.5 (-110)
U 42.5 (-110)
|
|
|
Oct 12, 2025 8:31AM EDT
Denver Broncos
New York Jets
10/12/25 8:31AM
Broncos
Jets
|
–
–
|
-245
+200
|
-6.5 (-110)
+6.5 (-110)
|
O 43 (-110)
U 43 (-110)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Tennessee Titans vs. San Francisco 49ers on December 14, 2025 at .
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
   LEAN |    %WIN |    UNITS | RESULT |
|---|---|---|---|---|
| CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
| NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
| CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
| NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
| CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
| WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
| BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
| TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
| LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
| NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
| GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
| CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |
| LV@WAS | LV +3 | 54.3% | 4 | LOSS |
| GB@CLE | GB -7 | 54.3% | 4 | LOSS |
| ARI@SF | ARI +3 | 57.7% | 6 | WIN |
| KC@NYG | PATRICK MAHOMES OVER 230.5 PASS YDS | 54.7% | 4 | WIN |
| GB@CLE | JOE FLACCO OVER 37.5 PASS ATT | 56.6% | 6 | LOSS |
| MIA@BUF | TYREEK HILL OVER 5.5 TOTAL RECEPTIONS | 56.8% | 6 | LOSS |
| LAC@LV | LAC -3 | 54.9% | 4 | WIN |
| TB@HOU | BAKER MAYFIELD OVER 1.5 PASS TDS | 54.4% | 4 | WIN |
| CHI@DET | DET -6.5 | 54.3% | 4 | WIN |
| DEN@IND | DEN -118 | 60.1% | 10 | LOSS |
| PHI@KC | PHI -115 | 56.7% | 6 | WIN |
| SF@NO | SF -3 | 58.8% | 8 | WIN |
| SEA@PIT | OVER 40 | 54.9% | 4 | WIN |
| CAR@ARI | BRYCE YOUNG INTERCEPTIONS UNDER 0.5 | 56.4% | 6 | LOSS |
| DEN@IND | JOSH DOWNS RECEPTIONS OVER 3.5 | 54.7% | 4 | WIN |
| ATL@MIN | BIJAN ROBINSON RUSH + REC YDS OVER 94.5 | 53.4% | 3 | WIN |
| WAS@GB | WAS +3.5 | 56.5% | 6 | LOSS |
| WAS@GB | JORDAN LOVE OVER 5.5 RUSH YDS | 54.7% | 4 | WIN |
| MIN@CHI | CALEB WILLIAMS OVER 219.5 PASS YDS | 53.4% | 3 | LOSS |
| TEN@DEN | DEN -8.5 | 55.3% | 5 | LOSS |
| SF@SEA | SF -115 | 54.6% | 4 | WIN |
| SF@SEA | KENNETH WALKER III UNDER 79.5 RUSH+REC YDS | 54.6% | 4 | WIN |
| CAR@JAC | TANK BIGSBY OVER 10.5 RUSH ATT | 56.1% | 6 | LOSS |
| KC@LAC | JUSTIN HERBERT UNDER 0.5 INT | 54.1% | 3 | WIN |
| DAL@PHI | GEORGE PICKENS LONGEST RECEPTION OVER 22.5 YDS | 54.1% | 4 | LOSS |
| KC@PHI | JUJU SMITH-SCHUSTER UNDER 16.5 RECV YDS | 53.90% | 5 | WIN |
| KC@PHI | DEVONTA SMITH LONGEST RECEPTION OVER 20.5 YDS | 54.40% | 6 | WIN |
| KC@PHI | PATRICK MAHOMES UNDER 68.3% PASS COMP | 55.00% | 8 | WIN |
| KC@PHI | JALEN HURTS LONGEST RUSH OVER 12.5 YDS | 55.60% | 8 | WIN |
| BUF@KC | DALTON KINCAID OVER 29.5 RECV YDS | 55.10% | 8 | LOSS |
| WAS@PHI | DEVONTA SMITH OVER 3.5 RECEPTIONS | 55.80% | 8 | WIN |
| BUF@KC | JAMES COOK ANYTIME TD | 53.00% | 5 | WIN |
| LAR@PHI | SAQUON BARKLEY UNDER 128 RUSH + REC YDS | 53.20% | 5 | LOSS |