49ers vs. Cardinals
FREE NFL AI Predictions
November 16, 2025
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Nov 16, 2025
Start Time: 4:05 PM EST​
Venue: ​
Cardinals Record:
49ers Record:
OPENING ODDS
SF Moneyline:
ARI Moneyline:
SF Spread: 0
ARI Spread:
Over/Under:
SF
Betting Trends
ARI
Betting Trends
MATCHUP TRENDS
SF vs. ARI
Best Prop Bet
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NFL ODDS COMPARISON
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San Francisco vs Arizona AI Prediction:
Free NFL Betting Insights for 11/16/25
49ers AI Preview
Credit: USA TODAY/IMAGN
Cardinals AI Preview
49ers vs. Cardinals FREE Prop Pick
AI algorithm Remi is pouring through tons of data on each team. In fact, anytime the 49ers and Cardinals play there’s always several intriguing observations to key in on. Not to mention games played at in Nov seemingly never follow normal, predictable patterns.
San Francisco vs. Arizona NFL AI Pick
Remi, our AI sports wizard, has been pouring over tons of data from every angle between the 49ers and Cardinals and using recursive machine learning and kick-ass AI to boil down the data to a single cover probability.
Remi has been most fixated on the trending weight human bettors often put on Arizona’s strength factors between a 49ers team going up against a possibly tired Cardinals team. Trends look to say the true game analytics might reflect a moderate lean against one Vegas line specifically.
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