The Week 11 AFC South clash between the Houston Texans and Tennessee Titans on November 16, 2025, at Nissan Stadium sets the stage for a divisional battle between two teams trending in opposite directions. The Texans, rejuvenated under head coach DeMeco Ryans, are steadily climbing the AFC ladder behind a dynamic young core, while the Titans continue to search for stability amid a turbulent rebuilding season. Houston enters this matchup with confidence after a commanding defensive performance earlier in the year, including a 26-0 shutout of Tennessee that showcased their dominance in the trenches and the poise of quarterback C.J. Stroud. The Texans have found balance in their offensive approach, blending Stroud’s precision and leadership with a growing run game and a defense that has become one of the league’s most aggressive units. Stroud’s chemistry with wide receiver Nico Collins has flourished, while Tank Dell and Dalton Schultz provide reliable secondary targets, giving the Texans multiple ways to attack opposing defenses. Their offensive line has improved steadily, particularly in pass protection, though penalties and inconsistent run blocking have occasionally stalled drives. Running back Dameon Pierce remains the spark on the ground, using his physicality and burst to keep defenses honest. Against Tennessee, expect Houston to utilize tempo and spread formations to stress the Titans’ defense, which has struggled against quick passes and misdirection plays. On defense, the Texans’ front seven, anchored by Will Anderson Jr. and Jonathan Greenard, continues to set the tone. Houston ranks among the league’s best in pressure rate, and their ability to disrupt timing at the line of scrimmage has been critical to their success. Linebacker Blake Cashman has been a revelation in coverage, and the secondary, led by Derek Stingley Jr. and Jimmie Ward, has tightened up communication, allowing Ryans to mix coverages confidently. Their task will be to contain Titans running back Derrick Henry, whose combination of power and patience remains the centerpiece of Tennessee’s offense.

If Houston can limit Henry’s effectiveness early and force rookie quarterback Will Levis into predictable passing downs, the Texans will be well-positioned to control the tempo. Tennessee, meanwhile, enters at 2-7 and desperate to regain footing after a frustrating start marked by offensive stagnation and inconsistent execution. The Titans’ offensive line has been porous, surrendering constant pressure and limiting the effectiveness of both Levis and Henry. Tennessee’s inability to sustain drives has placed tremendous stress on their defense, which, while talented up front, has worn down late in games. Jeffery Simmons remains an elite disruptor, but the unit has struggled with communication in the secondary and missed tackles in space. Offensively, the Titans must find balance—Levis has a big arm and flashes of brilliance, particularly when connecting with DeAndre Hopkins, but his decision-making and accuracy under pressure remain concerns. Expect Tennessee to rely heavily on Henry early, using play-action to create rhythm and keep the Texans’ defense honest. However, Houston’s speed and physicality on defense pose serious problems for a Titans offensive line that has failed to handle interior pressure. From a betting standpoint, the Texans’ 8-2 ATS record in their last ten meetings with Tennessee highlights their historical dominance against the spread, while the Titans’ home struggles make them a risky play. Houston’s 3-4 ATS mark this season suggests they’ve been competitive but not always dominant, yet their improving defense and offensive efficiency give them a clear edge. The key to this matchup will be Houston’s ability to stay balanced and capitalize on short fields created by their defense. If the Texans continue to execute cleanly, limit turnovers, and sustain drives, they should have little trouble controlling this game. For Tennessee, it will take an almost flawless performance—winning at the line of scrimmage, protecting Levis, and getting a vintage effort from Henry—to keep things close. Given the trajectory of both teams, Houston enters as the more complete, confident, and better-coached squad, making them the safer pick to extend their division success and strengthen their playoff credentials with another convincing win.