Lions vs Eagles Prediction — AI Finds CAN'T MISS NFL Lines & Props (Nov 16)

Updated: 2025-11-09T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Detroit Lions visit the Philadelphia Eagles on November 16, 2025 in a marquee NFC showdown between two playoff‐contending clubs. With the Eagles entering 6-2 at home and the Lions at 6-3 on the road, this game carries major implications for NFC seeding and divisional supremacy.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Nov 16, 2025

Start Time: 9:20 PM EST​

Venue: Lincoln Financial Field​

Eagles Record: (7-2)

Lions Record: (6-3)

OPENING ODDS

DET Moneyline: +102

PHI Moneyline: -122

DET Spread: +1.5

PHI Spread: -1.5

Over/Under: 48.5

DET
Betting Trends

  • Detroit is 7-3 against the spread this season.

PHI
Betting Trends

  • Philadelphia is 5-3 against the spread this season.

MATCHUP TRENDS

  • Although the Eagles are slight favorites at home, the near‐parity in ATS records suggests the spread may be tighter than many expect. Given Detroit’s strong ATS performance and Philadelphia’s slight slip in consistency, value may exist in backing the Lions to cover or keep this within one possession.

DET vs. PHI
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: S. LaPorta over 49.5 Receiving Yards.

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Detroit vs Philadelphia Prediction & Odds:
Free NFL Betting Insights for 11/16/25

The Week 11 matchup between the Detroit Lions and the Philadelphia Eagles on November 16, 2025, at Lincoln Financial Field stands as one of the NFC’s most compelling showdowns, pairing two legitimate Super Bowl contenders in a game that could ultimately shape postseason seeding. Detroit, under head coach Dan Campbell, has evolved from a rebuilding project into one of the NFL’s most complete and fearless teams, while Nick Sirianni’s Eagles continue to operate as a model of consistency and balance at the top of the conference. The Lions enter this matchup at 7-3, boasting one of the league’s most dynamic offenses led by quarterback Jared Goff, whose mastery of offensive coordinator Ben Johnson’s system has elevated Detroit into a scoring juggernaut. Goff’s timing, anticipation, and precision passing have allowed Amon-Ra St. Brown to flourish as one of the league’s most reliable receivers, while rookie Jameson Williams continues to emerge as a deep-threat complement capable of stretching defenses. The backfield tandem of Jahmyr Gibbs and David Montgomery has given Detroit a perfect blend of speed and power, allowing the team to control tempo and wear down opposing defenses. Against Philadelphia’s defensive front, however, the Lions will face perhaps their toughest test yet. The Eagles’ interior line—anchored by Jalen Carter and Jordan Davis—has been dominant against the run, while edge rushers Josh Sweat and Haason Reddick have terrorized opposing quarterbacks all season. Expect Johnson to counter with creative formations, heavy motion, and play-action concepts designed to neutralize pressure and open quick-hitting passing windows. Defensively, Detroit has improved significantly under Aaron Glenn, boasting one of the league’s best run defenses and a front seven that consistently wins at the line of scrimmage. Aidan Hutchinson continues to emerge as one of the NFL’s premier edge rushers, combining relentless energy with elite hand technique, while Alim McNeill and Derrick Barnes provide interior toughness.

The Lions’ secondary, led by Cam Sutton and rookie Terrion Arnold, will face a major challenge against Philadelphia’s explosive receiving duo of A.J. Brown and DeVonta Smith, who remain among the most dangerous one-two combinations in football. For the Eagles, quarterback Jalen Hurts remains the centerpiece of an offense built on balance, physicality, and versatility. His chemistry with Brown has been electric, while Smith’s route precision and Dallas Goedert’s reliability underneath keep defenses guessing. Philadelphia’s offensive line, though occasionally tested by injuries, remains one of the best in the league, with center Jason Kelce and tackle Lane Johnson continuing to set the standard in protection and run blocking. Expect the Eagles to test Detroit’s defense early with designed quarterback runs and zone reads to slow down the Lions’ pass rush, forcing Hutchinson and company to respect Hurts’ dual-threat ability. The Eagles’ ground game, powered by D’Andre Swift and Kenneth Gainwell, will also be critical in maintaining balance and setting up play-action shots downfield. Defensively, coordinator Vic Fangio’s unit thrives on discipline and disguise, often baiting quarterbacks into checkdowns while collapsing the pocket with interior pressure. Detroit’s offensive efficiency will be tested by Fangio’s ability to adjust mid-game, a hallmark of Philadelphia’s coaching identity. Special teams could also play a decisive role—Detroit’s return game, led by Kalif Raymond, has been consistently productive, while Philadelphia’s kicking and coverage units remain among the most reliable in the league. From a betting perspective, this game is as close as it gets. Detroit’s 7-3 ATS record signals that they’ve been outperforming market expectations, particularly as road underdogs, while Philadelphia’s 5-3 ATS mark indicates they often win but don’t always dominate spreads against top-tier opponents. The contrast in styles—Detroit’s aggressive, fearless approach versus Philadelphia’s measured precision—should create a thrilling chess match that hinges on red-zone execution and turnover margin. The Eagles’ home-field advantage and experience give them a slight edge, but the Lions’ physicality and offensive creativity make them more than capable of pulling off an upset. Expect a high-intensity battle that goes down to the wire, with both teams trading momentum swings in a game that feels more like a playoff preview than a midseason meeting.

Detroit Lions NFL Preview

The Detroit Lions travel to Lincoln Financial Field on November 16, 2025, carrying the swagger of a team that has fully embraced its identity as a legitimate NFC powerhouse. At 7-3, the Lions have cemented themselves as one of the most balanced and disciplined squads in football under head coach Dan Campbell, combining physicality in the trenches with creative offensive design from coordinator Ben Johnson. Quarterback Jared Goff has been the steady hand guiding Detroit’s resurgence, ranking among the league leaders in completion percentage and turnover avoidance. His command of the offense and comfort within Johnson’s play-action-heavy scheme have allowed the Lions to dictate tempo and sustain drives against even the most formidable defenses. Goff’s chemistry with Amon-Ra St. Brown remains the backbone of Detroit’s passing game, as St. Brown’s elite route running and after-the-catch ability consistently move the chains. Meanwhile, Jameson Williams’ growth as a vertical threat has added an explosive dimension to an offense that was already one of the most efficient in football. Tight end Sam LaPorta continues to shine as one of the NFL’s most impactful young players at his position, serving as both a reliable outlet and a mismatch weapon over the middle. The Lions’ rushing attack, powered by the dynamic pairing of Jahmyr Gibbs and David Montgomery, remains the key to their offensive balance. Gibbs’ acceleration and versatility complement Montgomery’s bruising, downhill running style, giving Detroit a backfield capable of punishing defenses in multiple ways. Against a Philadelphia front seven that ranks among the league’s best in run defense, the Lions’ offensive line—anchored by Frank Ragnow, Penei Sewell, and Taylor Decker—will be tested but is more than capable of holding its own. Expect Detroit to use pre-snap motion, quick passes, and inside zone runs to slow down the Eagles’ pass rush and force their linebackers into coverage mismatches.

Defensively, Detroit continues to evolve under Aaron Glenn’s leadership. The Lions have developed a front that thrives on pressure and toughness, led by Aidan Hutchinson, who has blossomed into one of the NFL’s most disruptive edge defenders. Hutchinson’s relentless motor, paired with the interior presence of Alim McNeill, gives Detroit the ability to collapse pockets and limit explosive plays on the ground. Linebackers Derrick Barnes and Jack Campbell bring a blend of speed and physicality that’s been instrumental in shutting down opposing run games, and their performance will be vital in containing Jalen Hurts’ designed runs and scrambles. The secondary, a previous weakness, has stabilized with Cam Sutton providing leadership and rookie Terrion Arnold showcasing poise beyond his years. To succeed in Philadelphia, the Lions must maintain discipline in coverage, as Hurts thrives when extending plays and finding A.J. Brown or DeVonta Smith downfield. Detroit’s tackling efficiency will be critical—missed tackles against Philadelphia’s receivers often turn short gains into back-breaking plays. On special teams, Kalif Raymond has been a spark in the return game, while kicker Michael Badgley’s consistency gives Detroit confidence in close contests. From a betting standpoint, the Lions’ 7-3 ATS record underscores their reliability as road competitors; they’ve consistently outperformed market expectations by staying composed in hostile environments. Their physical style translates well on the road, and Campbell’s motivational edge ensures they rarely enter a game unprepared. To pull off the upset in Philadelphia, Detroit must control the clock, avoid turnovers, and convert red-zone opportunities into touchdowns rather than field goals. If Goff remains poised under pressure and the defense can limit Hurts’ explosive plays, the Lions have the tools to grind out a statement win that would not only strengthen their NFC North lead but also signal that Detroit is ready to challenge for the conference crown.

The Detroit Lions visit the Philadelphia Eagles on November 16, 2025 in a marquee NFC showdown between two playoff‐contending clubs. With the Eagles entering 6-2 at home and the Lions at 6-3 on the road, this game carries major implications for NFC seeding and divisional supremacy. Detroit vs Philadelphia AI Prediction: Free NFL Betting Insights for Nov 16. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Philadelphia Eagles NFL Preview

The Philadelphia Eagles enter their Week 11 showdown against the Detroit Lions on November 16, 2025, at Lincoln Financial Field with a clear mission—to reassert their dominance as the NFC’s most complete and battle-tested team. At 6-2, the Eagles remain firmly in control of their playoff destiny, and this matchup against the surging Lions offers both a statement opportunity and a potential postseason preview. Under head coach Nick Sirianni, Philadelphia has maintained its reputation for consistency and composure, blending elite physicality in the trenches with an offense that thrives on versatility and balance. Quarterback Jalen Hurts continues to serve as the emotional and tactical centerpiece of this team. His ability to blend power running with surgical passing has made him one of the league’s most dangerous dual-threat quarterbacks. Even when defenses load the box to contain him, Hurts finds ways to extend plays, attack open zones, and deliver timely strikes to his array of playmakers. His chemistry with wide receiver A.J. Brown has reached an elite level, as Brown’s combination of physicality, contested-catch prowess, and run-after-catch explosiveness has consistently tilted matchups in Philadelphia’s favor. DeVonta Smith, meanwhile, brings the finesse and route precision that perfectly complements Brown’s dominance, creating a receiving tandem that can stretch the field horizontally and vertically. Tight end Dallas Goedert remains a reliable safety valve, excelling on third downs and in the red zone where Hurts often leans on his trust and timing with the veteran pass-catcher. The Eagles’ ground game, featuring D’Andre Swift and Kenneth Gainwell, adds another dimension, giving the offense flexibility to adapt to defensive schemes while wearing down opponents over four quarters. Philadelphia’s offensive line, led by veterans Jason Kelce and Lane Johnson, remains among the league’s elite, setting the tone with toughness and discipline.

However, against a fierce Detroit front led by Aidan Hutchinson, protection will be critical—particularly in containing edge pressure and creating clean pockets for Hurts to operate. On defense, coordinator Vic Fangio’s scheme has continued to evolve into one of the NFL’s most intricate and adaptive units. The Eagles have emphasized generating pressure without sacrificing coverage integrity, with Jalen Carter and Jordan Davis anchoring a defensive line that overwhelms opponents at the point of attack. On the edges, Haason Reddick and Josh Sweat remain relentless disruptors capable of dictating protection schemes, and their ability to collapse the pocket could be the deciding factor against Jared Goff’s timing-based passing game. The secondary, featuring Darius Slay and James Bradberry, has regained rhythm after an uneven start to the season, providing the versatility needed to match up against Detroit’s mix of physical receivers and speed threats. The Eagles’ linebacking corps, though not the team’s strongest unit, has improved in communication and pursuit angles, reducing the explosive plays that plagued them early in the year. Special teams, long a quiet strength for Philadelphia, could also play a pivotal role in this contest, with kicker Jake Elliott continuing to deliver in high-pressure moments and Britain Covey’s return skills capable of flipping field position. From a betting perspective, Philadelphia’s 5-3 ATS record mirrors their on-field reality: a team that usually wins but doesn’t always dominate the spread due to their deliberate style and tendency to play close, physical games. Still, at home, the Eagles have been remarkably resilient, riding both crowd energy and situational awareness to control games in the second half. To secure victory against a dangerous Lions team, Philadelphia must play to its strengths—control the line of scrimmage, win early downs, and force Goff into uncomfortable situations where the pass rush can take over. Hurts’ composure, coupled with the team’s late-game execution, has often been the difference in tight contests, and that formula will once again be crucial. If the Eagles maintain their discipline, capitalize on Detroit’s mistakes, and leverage their veteran experience, they should have enough firepower and toughness to emerge from this heavyweight NFC clash with another statement win in front of their home crowd.

Detroit vs. Philadelphia Prop Picks (AI)

Remi is pouring through mountains of data on each line. In fact, anytime the Lions and Eagles play there’s always several intriguing observations to key in on. Not to mention games played at Lincoln Financial Field in Nov rarely follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: S. LaPorta over 49.5 Receiving Yards.

Detroit vs. Philadelphia Prediction (AI)

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Remi, our AI sports genius, has been pouring over millions of data from every past game between the Lions and Eagles and using recursive machine learning and cutting-edge AI to boil down the data to a single cover probability.

Remi has been most focused on the linear correlation of factor emotional bettors regularly put on coaching factors between a Lions team going up against a possibly deflated Eagles team. It appears the true game analytics appear to reflect a moderate lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI Detroit vs Philadelphia picks, computer picks Lions vs Eagles, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

Lions Betting Trends

Detroit is 7-3 against the spread this season.

Eagles Betting Trends

Philadelphia is 5-3 against the spread this season.

Lions vs. Eagles Matchup Trends

Although the Eagles are slight favorites at home, the near‐parity in ATS records suggests the spread may be tighter than many expect. Given Detroit’s strong ATS performance and Philadelphia’s slight slip in consistency, value may exist in backing the Lions to cover or keep this within one possession.

Detroit vs. Philadelphia Game Info

Detroit vs Philadelphia starts on November 16, 2025 at 9:20 PM EST.

Venue: Lincoln Financial Field.

Spread: Philadelphia -1.5
Moneyline: Detroit +102, Philadelphia -122
Over/Under: 48.5

Detroit: (6-3)  |  Philadelphia: (7-2)

Remi's searched hard and found the best prop for this matchup: S. LaPorta over 49.5 Receiving Yards.. Prices move—always shop for the best number.

Although the Eagles are slight favorites at home, the near‐parity in ATS records suggests the spread may be tighter than many expect. Given Detroit’s strong ATS performance and Philadelphia’s slight slip in consistency, value may exist in backing the Lions to cover or keep this within one possession.

DET trend: Detroit is 7-3 against the spread this season.

PHI trend: Philadelphia is 5-3 against the spread this season.

See our latest NFL picks and odds pages for 2025 to compare prices before you bet.

Detroit vs. Philadelphia Odds

AI algorithm Remi is pouring through tons of data on each team. In fact, anytime the Detroit vs Philadelphia trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude can often follow normal, predictable patterns.

Detroit vs Philadelphia Opening Odds

DET Moneyline: +102
PHI Moneyline: -122
DET Spread: +1.5
PHI Spread: -1.5
Over/Under: 48.5

Detroit vs Philadelphia Live Odds

Games PTS ML SPR O/U
Nov 13, 2025 8:15PM EST
New York Jets
New England Patriots
11/13/25 8:15PM
Jets
Patriots
+550
-800
+13 (-110)
-13 (-110)
O 43 (-110)
U 43 (-110)
Nov 16, 2025 9:30AM EST
Washington Commanders
Miami Dolphins
11/16/25 9:30AM
Commanders
Dolphins
+130
-155
+2.5 (-102)
-2.5 (-118)
O 47.5 (-110)
U 47.5 (-110)
Nov 16, 2025 1:00PM EST
Carolina Panthers
Atlanta Falcons
11/16/25 1PM
Panthers
Falcons
+165
-200
+3.5 (-110)
-3.5 (-110)
O 42.5 (-110)
U 42.5 (-110)
Nov 16, 2025 1:00PM EST
Chicago Bears
Minnesota Vikings
11/16/25 1PM
Bears
Vikings
+140
-165
+3 (-110)
-3 (-110)
O 48.5 (-110)
U 48.5 (-110)
Nov 16, 2025 1:00PM EST
Los Angeles Chargers
Jacksonville Jaguars
11/16/25 1PM
Chargers
Jaguars
-150
+125
-3 (-105)
+3 (-115)
O 43.5 (-110)
U 43.5 (-110)
Nov 16, 2025 1:00PM EST
Green Bay Packers
New York Giants
11/16/25 1PM
Packers
Giants
-350
+280
-7 (-110)
+7 (-110)
O 43.5 (-110)
U 43.5 (-110)
Nov 16, 2025 1:00PM EST
Cincinnati Bengals
Pittsburgh Steelers
11/16/25 1PM
Bengals
Steelers
+195
-235
+5.5 (-110)
-5.5 (-110)
O 49.5 (-110)
U 49.5 (-110)
Nov 16, 2025 1:00PM EST
Tampa Bay Buccaneers
Buffalo Bills
11/16/25 1PM
Buccaneers
Bills
+200
-250
+5.5 (-110)
-5.5 (-110)
O 48 (-110)
U 48 (-110)
Nov 16, 2025 1:00PM EST
Houston Texans
Tennessee Titans
11/16/25 1PM
Texans
Titans
-325
+260
-6.5 (-118)
+6.5 (-102)
O 37.5 (-110)
U 37.5 (-110)
Nov 16, 2025 4:05PM EST
San Francisco 49ers
Arizona Cardinals
11/16/25 4:05PM
49ers
Cardinals
-150
+125
-2.5 (-118)
+2.5 (-102)
O 48.5 (-110)
U 48.5 (-110)
Nov 16, 2025 4:05PM EST
Seattle Seahawks
Los Angeles Rams
11/16/25 4:05PM
Seahawks
Rams
+140
-165
+3 (-110)
-3 (-110)
O 48.5 (-110)
U 48.5 (-110)
Nov 16, 2025 4:25PM EST
Kansas City Chiefs
Denver Broncos
11/16/25 4:25PM
Chiefs
Broncos
-200
+165
-4 (-105)
+4 (-115)
O 44.5 (-110)
U 44.5 (-110)
Nov 16, 2025 4:25PM EST
Baltimore Ravens
Cleveland Browns
11/16/25 4:25PM
Ravens
Browns
-400
+300
-7.5 (-110)
+7.5 (-110)
O 39.5 (-110)
U 39.5 (-110)
Nov 16, 2025 8:20PM EST
Detroit Lions
Philadelphia Eagles
11/16/25 8:20PM
Lions
Eagles
+120
-145
+2.5 (-105)
-2.5 (-115)
O 46.5 (-110)
U 46.5 (-110)
Nov 17, 2025 8:15PM EST
Dallas Cowboys
Las Vegas Raiders
11/17/25 8:15PM
Cowboys
Raiders
-175
+145
-3.5 (-102)
+3.5 (-118)
O 50.5 (-110)
U 50.5 (-110)
Nov 20, 2025 8:15PM EST
Buffalo Bills
Houston Texans
11/20/25 8:15PM
Bills
Texans
-154
+130
-2.5 (-128)
+2.5 (+104)
O 45.5 (-104)
U 45.5 (-118)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Detroit Lions vs. Philadelphia Eagles on November 16, 2025 at Lincoln Financial Field.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
PHI@GB PHI +1.5 54.8% 4 WIN
PHI@GB UNDER 45.5 52.4% 2 WIN
PHI@GB SAQUON BARKLEY OVER 17.5 RUSH ATT 56.6% 6 WIN
PHI@GB JOSH JACOBS UNDER 42.5 1ST HALF RUSH + REC YDS 54.4% 4 LOSS
NO@CAR CAR -5 55.4% 5 LOSS
BAL@MIN BAL -3.5 57.6% 7 WIN
CLE@NYJ CLE -130 65.4% 7 LOSS
NYG@CHI CHI -4.5 55.2% 5 LOSS
NE@TB TB -2 56.1% 6 LOSS
LAR@SF LAR -5.5 53.3% 2 WIN
JAC@HOU UNDER 38 54.8% 5 LOSS
ARI@SEA TREY MCBRIDE OVER 9 RECV TARGETS 55.8% 5 WIN
DET@WAS TERRION ARNOLD OVER 4.5 TACKLES + ASSTS 56.8% 6 LOSS
JAC@HOU TRAVIS ETIENNE UNDER 74.5 RUSH + REC YDS 54.4 4 LOSS
LV@DEN DANIEL CARLSON OVER 1.5 FIELD GOALS 55.2% 5 LOSS
LV@DEN COURTLAND SUTTON OVER 53.5 RECV YDS 54.2% 4 LOSS
LV@DEN RILEY MOSS OVER 4.5 TACKLE + ASST 54.8% 4 WIN
LV@DEN UNDER 43 53.4% 2 WIN
ARI@DAL BUDDA BAKER OVER 7.5 TACKLES + ASSTS 54.4% 4 WIN
ARI@DAL GEORGE PICKENS OVER 4.5 RECEPTIONS 56.6% 6 WIN
DEN@HOU WIL LUTZ OVER 1.5 MADE FIELD GOALS 54.2% 3 LOSS
SEA@WAS SEA -3 56.7% 6 WIN
IND@PIT IND -3 56.8% 6 LOSS
LAC@TEN LAC -9.5 56.2% 6 LOSS
CHI@CIN CHI -2.5 52.6% 2 WIN
SEA@WAS OVER 48 52.9% 2 WIN
SEA@WAS JAYDEN DANIELS OVER 20.5 PASS COMP 56.7% 6 LOSS
JAC@LV JAC -140 64.2% 7 WIN
NO@LAR LAR -14 55.0% 4 WIN
DEN@HOU HOU -1.5 54.2% 3 LOSS
CAR@GB GB -12.5 55.4% 5 LOSS
SF@NYG NYG +2.5 56.1% 5 LOSS
BAL@MIA TUA TAGOVAILOA UNDER 0.5 INT 55.3% 5 LOSS
TB@NO TB -3.5 52.3% 1 WIN
GB@PIT GB -2.5 52.3% 1 WIN
SF@HOU SF +2.5 56.0% 6 LOSS
NYG@PHI NYG +7.5 53.9% 3 LOSS
BUF@CAR CAR +7.5 54.2% 3 LOSS
DAL@DEN DAL +3.5 55.0% 4 LOSS
MIA@ATL MIA +7 54.3% 4 WIN
CLE@NE CLE +7 56.8% 6 LOSS
TB@NO BAKER MAYFIELD OVER 15.5 RUSH YDS 56.6% 6 LOSS
MIN@LAC JUSTIN HERBERT PASS ATT UNDER 35.5 55.5% 5 WIN
TB@DET TB +6.5 54.4% 4 LOSS
TB@DET RACHAAD WHITE UNDER 14.5 RUSH ATT 54.4% 4 WIN
NE@TEN NE -6.5 55.2% 5 WIN
CAR@NYJ CAR -110 57.4 4 WIN
PHI@MIN PHI -130 58.0% 6 WIN
GB@ARI ARI +7 54.8% 5 WIN
NO@CHI NO +4.5 57.4% 7 LOSS
WAS@DAL JAYDEN DANIELS 1H RUSH YDS OVER 22.5 56.1% 5 WIN