The Week 7 clash between the Los Angeles Rams and the Jacksonville Jaguars on October 19, 2025, in London offers an intriguing blend of experience versus familiarity, with Sean McVay’s Rams adjusting to adversity while the Jaguars look to capitalize on their comfort playing overseas. The Rams enter this matchup facing questions surrounding their offensive identity with star wideout Puka Nacua sidelined by an ankle injury, forcing quarterback Matthew Stafford to rely on a mix of young receivers and a reshaped backfield to keep the offense balanced. Despite the setback, McVay’s creativity and offensive sequencing have kept Los Angeles competitive this season, particularly in close, possession-driven games. Stafford remains one of the league’s toughest and most cerebral quarterbacks, capable of commanding the pocket even under duress, but his success will hinge on how well the offensive line handles Jacksonville’s evolving front. Rookie running back Blake Corum has provided a much-needed jolt to the rushing attack, showcasing vision and burst that complement Kyren Williams’s steady production. The Rams will likely employ a rhythm-based attack with quick reads and play-action to keep the Jaguars’ aggressive pass rush off-balance. Defensively, Los Angeles has remained resilient despite roster turnover, anchored by a unit that thrives on discipline, gap integrity, and emerging young stars who’ve absorbed the leadership void left by veterans. Edge rusher Byron Young has developed into a consistent disruptor, while the secondary, featuring young corners like Cobie Durant, has improved communication and coverage awareness.

Their biggest test will be containing Trevor Lawrence, who has found renewed efficiency under Jacksonville’s new offensive system. The Jaguars’ offense is predicated on tempo, balance, and spreading the field to exploit mismatches. Running back Travis Etienne remains a cornerstone, blending patience with explosiveness to punish overpursuing defenders, and wide receiver Christian Kirk’s chemistry with Lawrence gives the Jaguars a reliable chain-mover in critical downs. Jacksonville’s offensive line has been inconsistent, and against a Rams defense that ranks among the best in third-down pressure rate, protection will be pivotal. On the flip side, Jacksonville’s defense has been quietly improving, with linebacker Devin Lloyd anchoring the middle and cornerback Tyson Campbell emerging as a premier coverage option. Defensive coordinator Ryan Nielsen has implemented a system built on disguised pressures and hybrid fronts that will challenge Stafford’s ability to identify blitzes pre-snap. Special teams may also play a deciding role, with both squads featuring reliable kickers and punters adept at controlling field position. The unique element here is Jacksonville’s London advantage—the Jaguars’ familiarity with the travel logistics and environment could provide a hidden edge. The Rams, accustomed to routine and precision, must avoid a sluggish start and handle the mental grind of an overseas trip. Ultimately, this matchup may come down to which team executes more efficiently in the red zone and wins the turnover battle. For the Rams, maintaining offensive rhythm without Nacua is critical; for the Jaguars, sustaining protection and consistency on third downs will determine whether they can secure another international statement win.