Colts vs Chargers Prediction — AI Finds CAN'T MISS NFL Lines & Props (Oct 19)
Updated: 2025-10-12T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Indianapolis Colts travel to Los Angeles on October 19, 2025, to take on the Chargers in what could be a pivotal AFC battle between a rising Colts squad and a Chargers team fighting for stability. The Colts are slight road favorites given their momentum and consistency this season, while L.A. will look to leverage home support and recent clutch performances to stay in the mix.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Oct 19, 2025
Start Time: 4:05 PM EST
Venue: SoFi Stadium
Chargers Record: (4-2)
Colts Record: (5-1)
OPENING ODDS
IND Moneyline: -105
LAC Moneyline: -114
IND Spread: +1.5
LAC Spread: -1.5
Over/Under: 48.5
IND
Betting Trends
- The Colts are off to a strong start against the spread, posting a 4-1 ATS record, making them one of the more reliable “covering” teams early this year.
LAC
Betting Trends
- The Chargers are 2-2-1 ATS at home, sitting at the exact .500 mark when defending the line in their own stadium.
MATCHUP TRENDS
- This matchup figures to draw sharp betting action given both teams’ strong ATS trends — when elite ATS teams clash, the market often tightens late, and public moves can shift lines dramatically, especially in primetime settings.
IND vs. LAC
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: D. Jones over 17.5 Rushing Yards.
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Indianapolis vs Los Angeles Prediction & Odds:
Free NFL Betting Insights for 10/19/25
The absence of a dominant run game has placed extra pressure on Herbert, forcing him into predictable passing situations where defenses can tee off. Against an Indianapolis defense that thrives on creating turnovers and collapsing pockets, the Chargers will need to establish balance early or risk falling behind against a Colts squad that excels at controlling possession. Defensively, Los Angeles remains a mixed bag — their pass rush is capable of game-breaking moments, particularly with Joey Bosa and Khalil Mack leading the charge, but lapses in coverage and tackling have cost them in key moments. The Colts will likely look to attack the Chargers’ linebackers with screens, draws, and intermediate crossing routes to open up deeper shots later in the game. For Los Angeles, the key will be to disrupt Richardson’s timing, force third-and-longs, and capitalize on any rookie mistakes. If the Chargers’ defensive front can apply consistent pressure and Herbert can find early chemistry with his receivers, they have the firepower to keep pace. However, the Colts’ structured, run-first approach and defensive discipline give them a slight edge in what figures to be a tactical and tightly contested matchup. Both teams are likely to keep the score close, but the Colts’ edge in ball control and defensive efficiency could make the difference in what should be one of Week 7’s most intriguing interconference battles.
JT’s just that guy. pic.twitter.com/4gW0imyKlU
— Indianapolis Colts (@Colts) October 12, 2025
Indianapolis Colts NFL Preview
The Indianapolis Colts enter Week 7 against the Los Angeles Chargers riding a wave of confidence built on balanced offensive execution and defensive discipline, two hallmarks of Shane Steichen’s coaching philosophy. The Colts have developed an identity centered around quarterback Anthony Richardson’s dynamic dual-threat ability, complemented by Jonathan Taylor’s punishing running style that allows Indianapolis to dictate tempo and wear down defenses over four quarters. Richardson’s growth in 2025 has been one of the biggest storylines in the AFC — his decision-making has improved, turnovers are down, and his confidence in navigating blitzes and extending plays has made the Colts’ offense far less predictable. Indianapolis uses play-action effectively to open up space for wideouts like Michael Pittman Jr. and Josh Downs, both of whom thrive in intermediate routes that move the chains. The offensive line has also been a major strength, creating running lanes and protecting Richardson against pressure-heavy defenses. In this matchup, the Colts’ offensive front will need to handle the Chargers’ pass rush tandem of Joey Bosa and Khalil Mack, whose ability to collapse pockets and force hurried throws can swing games. Defensively, Indianapolis has become a model of consistency — DeForest Buckner anchors the front line, while linebackers Zaire Franklin and E.J. Speed have been relentless in run support and short-zone coverage.
The Colts’ secondary, led by JuJu Brents and Julian Blackmon, has limited explosive plays, forcing opposing quarterbacks to sustain long drives. That bend-but-don’t-break approach has paid dividends, with Indianapolis ranking among the league’s better teams in red-zone defense. Against Justin Herbert and the Chargers’ aerial attack, the Colts’ focus will be on containing deep routes and forcing Los Angeles to settle for checkdowns. The Colts’ defense thrives when it can pressure without blitzing, allowing more coverage bodies in space, and Buckner’s interior disruption could be crucial in preventing Herbert from stepping into throws. On the road, Indianapolis’s composure will be tested by the crowd and SoFi Stadium’s fast track, but their ability to control the pace of the game through time of possession gives them a strong foundation. If the Colts can establish the run early, limit turnovers, and keep Herbert uncomfortable, they’re well-positioned to extend their impressive road form. This team has embraced a resilient mentality, finding ways to grind out wins even in hostile environments, and their recent success against the spread reflects their balance and situational awareness. For Indianapolis, this game is another chance to reinforce that they’re not just an up-and-coming squad — they’re a legitimate AFC contender capable of winning tough games against top-tier opponents.

Credit: USA TODAY/IMAGN
Los Angeles Chargers NFL Preview
The Los Angeles Chargers return home in Week 7 to face the Indianapolis Colts in a matchup that will test their resilience and their ability to win close, high-pressure games — something that has eluded them at times this season. Justin Herbert remains the centerpiece of the Chargers’ offensive identity, and despite flashes of brilliance, his unit has struggled with consistency, particularly in protecting the pocket and sustaining drives in key moments. The Chargers’ offensive line, while improved, faces a significant challenge in this contest against an Indianapolis front anchored by DeForest Buckner and a physical, fast-flowing linebacker corps. For Los Angeles to control the tempo, they must establish some semblance of balance, leaning on their running game with backs like Gus Edwards and rookie depth options to keep Indianapolis’s defense honest. Herbert will need to stay composed and take advantage of mismatches against the Colts’ secondary — Keenan Allen’s reliability, Quentin Johnston’s size-speed combination, and the emergence of tight end Gerald Everett as a third-down target all factor into that strategy. Expect offensive coordinator Greg Roman to utilize motion and quick-hitting concepts to slow down the Colts’ pass rush and keep Herbert in rhythm. Defensively, the Chargers’ success hinges on their ability to pressure rookie quarterback Anthony Richardson and limit the Colts’ explosive ground game led by Jonathan Taylor.
Joey Bosa and Khalil Mack will be tasked with containing the edges, forcing Richardson to stay in the pocket rather than using his legs to extend plays. However, the real test lies in how well the Chargers’ linebackers and safeties handle Indianapolis’s run-pass options and play-action sequences — areas where Los Angeles has been vulnerable. The secondary, led by Asante Samuel Jr. and Derwin James, must remain disciplined, as one mistimed assignment could result in a big gain. Special teams could also play a critical role; field position battles and missed opportunities have haunted Los Angeles in previous tight games, and the Chargers will need a mistake-free performance to outlast a disciplined Colts squad. Playing in front of their home crowd, the Chargers will look to reassert their defensive intensity early and feed off crowd energy to generate momentum. If Herbert can find rhythm, Bosa and Mack can influence the line of scrimmage, and the offense capitalizes on red-zone chances, Los Angeles has the tools to pull off a much-needed statement win. But if the same lapses in protection, tackling, or situational awareness creep in, the Chargers risk letting another winnable home game slip away — a scenario that has too often defined this team in recent years. This game represents more than just another AFC matchup; it’s a measuring stick for whether the Chargers can execute consistently enough to be taken seriously as postseason contenders.
justin herbert how ???? pic.twitter.com/j7pD9kV2EO
— Los Angeles Chargers (@chargers) October 12, 2025
Indianapolis vs. Los Angeles Prop Picks (AI)
Indianapolis vs. Los Angeles Prediction (AI)

Remi, our AI sports algorithm, has been pouring over tons of data from every past game between the Colts and Chargers and using recursive machine learning and industry leading AI to boil down the data to a single cover probability.
Remi has been most keyed in on the unproportionally assigned factor emotional bettors often put on Indianapolis’s strength factors between a Colts team going up against a possibly improved Chargers team. It appears the true game analytics appear to reflect a slight lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Indianapolis vs Los Angeles picks, computer picks Colts vs Chargers, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
---|---|---|---|---|---|---|
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Colts Betting Trends
The Colts are off to a strong start against the spread, posting a 4-1 ATS record, making them one of the more reliable “covering” teams early this year.
Chargers Betting Trends
The Chargers are 2-2-1 ATS at home, sitting at the exact .500 mark when defending the line in their own stadium.
Colts vs. Chargers Matchup Trends
This matchup figures to draw sharp betting action given both teams’ strong ATS trends — when elite ATS teams clash, the market often tightens late, and public moves can shift lines dramatically, especially in primetime settings.
Indianapolis vs. Los Angeles Game Info
What time does Indianapolis vs Los Angeles start on October 19, 2025?
Indianapolis vs Los Angeles starts on October 19, 2025 at 4:05 PM EST.
Where is Indianapolis vs Los Angeles being played?
Venue: SoFi Stadium.
What are the opening odds for Indianapolis vs Los Angeles?
Spread: Los Angeles -1.5
Moneyline: Indianapolis -105, Los Angeles -114
Over/Under: 48.5
What are the records for Indianapolis vs Los Angeles?
Indianapolis: (5-1) | Los Angeles: (4-2)
What is the AI best bet for Indianapolis vs Los Angeles?
Remi's searched hard and found the best prop for this matchup: D. Jones over 17.5 Rushing Yards.. Prices move—always shop for the best number.
What are Indianapolis vs Los Angeles trending bets?
This matchup figures to draw sharp betting action given both teams’ strong ATS trends — when elite ATS teams clash, the market often tightens late, and public moves can shift lines dramatically, especially in primetime settings.
What are Indianapolis trending bets?
IND trend: The Colts are off to a strong start against the spread, posting a 4-1 ATS record, making them one of the more reliable “covering” teams early this year.
What are Los Angeles trending bets?
LAC trend: The Chargers are 2-2-1 ATS at home, sitting at the exact .500 mark when defending the line in their own stadium.
Where can I find AI Picks for Indianapolis vs Los Angeles?
See our latest NFL picks and odds pages for 2025 to compare prices before you bet.
Indianapolis vs. Los Angeles Odds
Remi is pouring through loads of stats on each player. In fact, anytime the Indianapolis vs Los Angeles trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme travel distance rarely follow normal, predictable betting trends.
Indianapolis vs Los Angeles Opening Odds
IND Moneyline:
-105 LAC Moneyline: -114
IND Spread: +1.5
LAC Spread: -1.5
Over/Under: 48.5
Indianapolis vs Los Angeles Live Odds
Games | PTS | ML | SPR | O/U | |
---|---|---|---|---|---|
Oct 23, 2025 8:15PM EDT
Minnesota Vikings
Los Angeles Chargers
10/23/25 8:15PM
Vikings
Chargers
|
–
–
|
+152
-180
|
+3 (-102)
-3 (-120)
|
O 44.5 (-112)
U 44.5 (-108)
|
|
Oct 26, 2025 1:00PM EDT
Cleveland Browns
New England Patriots
10/26/25 1PM
Browns
Patriots
|
–
–
|
+290
-360
|
+7 (-114)
-7 (-106)
|
O 40.5 (-105)
U 40.5 (-115)
|
|
Oct 26, 2025 1:00PM EDT
Buffalo Bills
Carolina Panthers
10/26/25 1PM
Bills
Panthers
|
–
–
|
-390
+310
|
-7.5 (-102)
+7.5 (-120)
|
O 46.5 (-105)
U 46.5 (-115)
|
|
Oct 26, 2025 1:00PM EDT
New York Jets
Cincinnati Bengals
10/26/25 1PM
Jets
Bengals
|
–
–
|
+245
-300
|
+6.5 (-110)
-6.5 (-110)
|
O 43.5 (-115)
U 43.5 (-105)
|
|
Oct 26, 2025 1:00PM EDT
Chicago Bears
Baltimore Ravens
10/26/25 1PM
Bears
Ravens
|
–
–
|
+265
-330
|
+6.5 (-106)
-6.5 (-114)
|
O 50.5 (-105)
U 50.5 (-115)
|
|
Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
10/26/25 1PM
Giants
Eagles
|
–
–
|
+285
-355
|
+7 (-108)
-7 (-112)
|
O 43.5 (-105)
U 43.5 (-115)
|
|
Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
10/26/25 1PM
49ers
Texans
|
–
–
|
-102
-118
|
+1.5 (-115)
-1.5 (-105)
|
O 41.5 (-110)
U 41.5 (-110)
|
|
Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
|
–
–
|
+300
-375
|
+7.5 (-122)
-7.5 (+100)
|
O 44.5 (-114)
U 44.5 (-106)
|
|
Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
|
–
–
|
-225
+188
|
-4.5 (-106)
+4.5 (-114)
|
O 46.5 (-114)
U 46.5 (-106)
|
|
Oct 26, 2025 4:25PM EDT
Dallas Cowboys
Denver Broncos
10/26/25 4:25PM
Cowboys
Broncos
|
–
–
|
+146
-174
|
+3.5 (-118)
-3.5 (-104)
|
O 50.5 (-110)
U 50.5 (-110)
|
|
Oct 26, 2025 4:25PM EDT
Tennessee Titans
Indianapolis Colts
10/26/25 4:25PM
Titans
Colts
|
–
–
|
+750
-1200
|
+14.5 (-118)
-14.5 (-104)
|
O 46.5 (-114)
U 46.5 (-106)
|
|
Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
|
–
–
|
-176
+148
|
-3.5 (-104)
+3.5 (-118)
|
O 44.5 (-115)
U 44.5 (-105)
|
|
Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
|
–
–
|
+430
-590
|
+10.5 (-110)
-10.5 (-110)
|
O 47.5 (-110)
U 47.5 (-110)
|
|
Oct 30, 2025 8:15PM EDT
Baltimore Ravens
Miami Dolphins
10/30/25 8:15PM
Ravens
Dolphins
|
–
–
|
-430
+340
|
-8.5 (-105)
+8.5 (-115)
|
O 47.5 (-105)
U 47.5 (-115)
|
|
Nov 2, 2025 1:00PM EST
Chicago Bears
Cincinnati Bengals
11/2/25 1PM
Bears
Bengals
|
–
–
|
-120
+102
|
-1.5 (-110)
+1.5 (-110)
|
O 47.5 (-105)
U 47.5 (-115)
|
|
Nov 2, 2025 1:00PM EST
Indianapolis Colts
Pittsburgh Steelers
11/2/25 1PM
Colts
Steelers
|
–
–
|
-136
+116
|
-2.5 (-110)
+2.5 (-110)
|
O 47.5 (-110)
U 47.5 (-110)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Indianapolis Colts vs. Los Angeles Chargers on October 19, 2025 at SoFi Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TB@DET | RACHAAD WHITE UNDER 14.5 RUSH ATT | 54.4% | 4 | WIN |
NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
GB@ARI | ARI +7 | 54.8% | 5 | WIN |
NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |
HOU@BAL | HOU -125 | 58.5% | 7 | WIN |
DET@CIN | DET -10 | 55.6% | 5 | WIN |
DAL@NYJ | NYJ +1.5 | 53.7% | 3 | LOSS |
TB@SEA | TB +3.5 | 54.9% | 4 | WIN |
TEN@ARI | ARI -7 (BUY 0.5) | 54.9% | 4 | LOSS |
DEN@PHI | DEN +4.5 | 57.5% | 7 | WIN |
MIA@CAR | TETAIROA MCMILLAN OVER 58.5 RECV YDS | 54.5% | 4 | WIN |
LV@IND | ASHTON JEANTY UNDER 67.5 RUSH YDS | 54.4% | 4 | WIN |
SF@LAR | DEMARCUS ROBINSON OVER 29.5 RECV YDS | 55.7% | 5 | WIN |
NYJ@MIA | NYJ +3 | 53.8 | 3 | LOSS |
CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
PIT@NE | PIT -116 | 60.1% | 6 | WIN |
ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |