Lions vs Chiefs Prediction — AI Finds CAN'T MISS NFL Lines & Props (Oct 12)
Updated: 2025-10-05T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Detroit Lions (4–1) head into Arrowhead Stadium on October 12 to take on the Kansas City Chiefs (2–2) in a marquee AFC vs. NFC showdown. Betting lines currently favor Kansas City by around 4 points, with the total hovered near the low-50s.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Oct 12, 2025
Start Time: 8:20 PM EST
Venue: GEHA Field at Arrowhead Stadium
Chiefs Record: (2-3)
Lions Record: (4-1)
OPENING ODDS
DET Moneyline: +115
KC Moneyline: -137
DET Spread: +2.5
KC Spread: -2.5
Over/Under: 52.5
DET
Betting Trends
- Detroit has been one of the season’s stronger ATS teams, covering 75 % of their games so far.
KC
Betting Trends
- Kansas City has gone 2–2 ATS this season, about a 50 % cover rate.
MATCHUP TRENDS
- The Lions’ dominance in covering lines makes them one of the sharper underdog or road plays this year, while the Chiefs’ split ATS record at home suggests they’re not a sure bet despite Arrowhead advantages.
DET vs. KC
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: J. Gibbs over 65.5 Rushing Yards.
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Detroit vs Kansas City Prediction & Odds:
Free NFL Betting Insights for 10/12/25
The Week 6 matchup between the Detroit Lions and the Kansas City Chiefs on October 12, 2025, at Arrowhead Stadium promises to be one of the most fascinating cross-conference battles of the season, pitting Detroit’s ascending, balanced roster against a Kansas City team still fine-tuning its offensive rhythm in the post-dynasty adjustment phase. The Lions, led by quarterback Jared Goff and head coach Dan Campbell, have embraced a complete identity on both sides of the ball, leaning on power football and creative play design to out-execute opponents. Their offensive line, one of the league’s best, anchors everything — opening lanes for Jahmyr Gibbs and David Montgomery while keeping Goff upright long enough to find his weapons downfield, like Amon-Ra St. Brown and Sam LaPorta. Meanwhile, the defense, orchestrated by Aaron Glenn, has become a fierce, fast, and physical unit that thrives on pressure and tackling discipline, featuring breakout performances from Aidan Hutchinson and Brian Branch. Detroit enters this contest confident, with one of the best red-zone touchdown rates in the NFL and a top-five success rate on early downs, allowing them to control tempo and possession. On the other side, Kansas City, despite sitting around .500, remains one of the most dangerous teams in football simply because of Patrick Mahomes. Even in an uneven season, Mahomes’ improvisation, accuracy, and poise keep the Chiefs in every game.
Tight end Travis Kelce remains his most trusted option, and rookie Rashee Rice has stepped up as a legitimate secondary weapon. However, inconsistency from the offensive line and the running game has made the offense more predictable than in years past. Kansas City’s defense, led by coordinator Steve Spagnuolo, remains aggressive and opportunistic, but it will face a major test against Detroit’s balanced attack. Linebackers Nick Bolton and Willie Gay Jr. must contain the Lions’ screen and play-action game, while corner Trent McDuffie will likely draw coverage responsibilities against St. Brown in critical moments. Arrowhead’s crowd noise and home-field advantage could play a major role, as communication is vital for Detroit’s offensive timing. Still, if the Lions can limit Mahomes’ off-script magic and win the line of scrimmage on both sides, they have the formula to upset the Chiefs on their home turf. Expect a chess match between two elite coaching staffs, with Kansas City relying on Mahomes’ brilliance and Detroit leaning on execution, physicality, and discipline. This game could easily come down to a final drive, with both teams capable of manufacturing clutch plays. In a battle of experience versus momentum, the Lions’ steadiness and cohesion could be the difference if they can weather the Arrowhead storm and dictate the flow of the game early.
Get live NFL odds and precise AI NFL picks, predictions, and cover probabilities.
Anzo had a day 💪 pic.twitter.com/IKgTIgxI8o
— Detroit Lions (@Lions) October 8, 2025
Detroit Lions NFL Preview
The Detroit Lions enter their Week 6 clash against the Kansas City Chiefs at Arrowhead Stadium as one of the most complete and confident teams in the NFC, continuing their rise under Dan Campbell’s leadership and Jared Goff’s steady command at quarterback. Sitting near the top of the NFC standings, Detroit’s identity is clear — a tough, disciplined, and balanced football team built around physical dominance in the trenches and precision execution on both sides of the ball. Offensively, the Lions have become one of the league’s most efficient units thanks to Goff’s accuracy, play-action timing, and calm pocket presence. Behind one of the NFL’s elite offensive lines led by Penei Sewell and Frank Ragnow, Detroit’s run game has flourished with Jahmyr Gibbs’ speed and David Montgomery’s power forming a dynamic one-two punch. That balance allows offensive coordinator Ben Johnson to blend creative formations, pre-snap motion, and layered route concepts, keeping defenses constantly guessing. Amon-Ra St. Brown remains Goff’s most reliable target, excelling in the slot with his precise route running and ability to move the chains, while rookie tight end Sam LaPorta continues to prove himself as a red-zone weapon and mismatch nightmare. Against Kansas City’s aggressive front, Detroit’s success will depend on protection and composure — minimizing penalties and avoiding negative plays that stall drives in a hostile environment.
Defensively, the Lions have transformed from a liability into a legitimate strength. Aidan Hutchinson anchors a fierce pass rush that’s improved at collapsing pockets and forcing hurried decisions, while the linebacking corps led by Alex Anzalone and Jack Campbell has excelled in closing gaps and limiting yards after contact. Detroit’s secondary, featuring Brian Branch and Cam Sutton, will face one of its toughest assignments yet in trying to contain Patrick Mahomes and Travis Kelce. Expect defensive coordinator Aaron Glenn to mix zone disguises with selective pressure, aiming to keep Mahomes in the pocket and force him into methodical drives rather than explosive improvisations. The Lions have also been excellent on third downs, ranking among the league’s best at getting off the field, and that situational discipline will be crucial against a Chiefs team that thrives on extended possessions. Special teams, long a Campbell staple, continue to be a hidden weapon for Detroit, with kicker Michael Badgley steady and punter Jack Fox capable of flipping field position. The key for the Lions will be starting strong — establishing the run early, controlling time of possession, and neutralizing Arrowhead’s raucous atmosphere by dictating tempo. This Detroit team has proven it can win both shootouts and slugfests, and while facing Mahomes at home is one of football’s toughest tests, the Lions’ cohesion, depth, and physicality give them a legitimate chance to make a statement on one of the league’s biggest stages.
Credit: USA TODAY/IMAGN
Kansas City Chiefs NFL Preview
The Kansas City Chiefs return to Arrowhead Stadium in Week 6 with a renewed sense of urgency as they host the surging Detroit Lions in what feels like a midseason measuring stick for both franchises. At 2–2, Kansas City finds itself in unfamiliar territory — no longer the invincible juggernaut of recent years, but still a team with championship pedigree and the league’s most dangerous player in Patrick Mahomes. Despite some early inconsistencies, Mahomes remains the steadying force, capable of elevating his offense even when timing and execution falter. His connection with Travis Kelce continues to anchor the passing game, while wide receiver Rashee Rice has begun to emerge as a trusted secondary target who can stretch defenses vertically. However, the Chiefs’ offense has not looked as fluid as in previous seasons. The running game, led by Isiah Pacheco, has been serviceable but inconsistent, and the offensive line has struggled in both protection and penalties, leading to stalled drives. For Kansas City to find success against Detroit, balance will be critical — sustaining drives through Pacheco’s inside runs and screen plays, while allowing Mahomes to operate off rhythm throws rather than constant improvisation. Offensive coordinator Matt Nagy will likely emphasize quicker reads, jet motion, and misdirection to keep Detroit’s aggressive pass rush honest.
On defense, coordinator Steve Spagnuolo’s unit remains the team’s backbone. The Chiefs’ front seven, anchored by Chris Jones, will play a pivotal role in this matchup. Jones’ ability to collapse the pocket and disrupt timing is crucial against Jared Goff, who excels when protected and comfortable. Kansas City’s linebackers, led by Nick Bolton, must remain disciplined against Detroit’s dynamic backfield combination of Jahmyr Gibbs and David Montgomery, while corner Trent McDuffie will be tasked with limiting Amon-Ra St. Brown’s impact in the slot. The Chiefs’ secondary has shown flashes of brilliance, but lapses in zone communication have occasionally led to big plays — something they can’t afford against Detroit’s precision-based offense. Arrowhead’s home-field advantage will once again be a factor, with crowd noise creating communication challenges for Goff and Detroit’s offensive line. Special teams could also play a decisive role, with Harrison Butker remaining one of the league’s most reliable kickers and returner Mecole Hardman capable of flipping field position. For Kansas City, the formula to victory lies in execution and discipline: avoid turnovers, convert in the red zone, and keep Mahomes upright. This game presents an opportunity for the Chiefs to reestablish their dominance, silence critics, and remind the league that even with growing parity in the NFL, they remain the team to beat when it matters most. If Mahomes delivers another vintage performance and the defense holds its ground against Detroit’s balanced attack, Arrowhead could once again witness the Chiefs turning the corner from early-season uncertainty back toward their familiar contender form.
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Detroit vs Kansas City Prop Picks (AI)
Remi is pouring through loads of data on each player. In fact, anytime the Lions and Chiefs play there’s always several intriguing angles to key in on. Not to mention games played at GEHA Field at Arrowhead Stadium in Oct almost always follow normal, predictable patterns.
Detroit vs Kansas City Prediction (AI)
Remi, our AI sports wizard, has been pouring over millions of data from every angle between the Lions and Chiefs and using recursive machine learning and industry leading AI to analyze the data to a single cover probability.
Interestingly enough, the data has been most focused on the growing emphasis emotional bettors often put on Kansas City’s strength factors between a Lions team going up against a possibly healthy Chiefs team. We’ve found the true game analytics might reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Detroit vs Kansas City picks, computer picks Lions vs Chiefs, best bets, model edges, confidence ratings.
| DATE | GAME | LEAN | %WIN | UNITS | LEVEL | |
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| NFL | 12/4 | DAL@DET | UNLOCK THIS PICK | 7 |
VAULT v4
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| NFL | 12/4 | DAL@DET | UNLOCK THIS PICK | 4 |
EXECUTIVE
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| NFL | 12/4 | DAL@DET | UNLOCK THIS PICK | 1 |
INTEL
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These picks update as information changes—injury reports, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL schedule.
Detroit Betting Trends
Detroit has been one of the season’s stronger ATS teams, covering 75 % of their games so far.
Kansas City Betting Trends
Kansas City has gone 2–2 ATS this season, about a 50 % cover rate.
Lions vs. Chiefs Matchup Trends
The Lions’ dominance in covering lines makes them one of the sharper underdog or road plays this year, while the Chiefs’ split ATS record at home suggests they’re not a sure bet despite Arrowhead advantages.
Detroit vs. Kansas City Game Info
Detroit vs Kansas City starts on October 12, 2025 at 8:20 PM EST.
Venue: GEHA Field at Arrowhead Stadium.
Spread: Kansas City -2.5
Moneyline: Detroit +115, Kansas City -137
Over/Under: 52.5
Detroit: (4-1) | Kansas City: (2-3)
Remi's searched hard and found the best prop for this matchup: J. Gibbs over 65.5 Rushing Yards.. Prices move—always shop for the best number.
The Lions’ dominance in covering lines makes them one of the sharper underdog or road plays this year, while the Chiefs’ split ATS record at home suggests they’re not a sure bet despite Arrowhead advantages.
DET trend: Detroit has been one of the season’s stronger ATS teams, covering 75 % of their games so far.
KC trend: Kansas City has gone 2–2 ATS this season, about a 50 % cover rate.
See our latest NFL picks and odds pages for 2025 to compare prices before you bet.
Detroit vs. Kansas City Odds
AI algorithm Remi is pouring through tons of data on each line. In fact, anytime the Detroit vs Kansas City trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps almost always follow normal, predictable patterns.
| DET Moneyline | +115 |
|---|---|
| KC Moneyline | -137 |
| DET Spread | +2.5 |
| KC Spread | -2.5 |
| Over / Under | 52.5 |
Detroit vs Kansas City Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Dec 7, 2025 1:00PM EST
New Orleans Saints
Tampa Bay Buccaneers
12/7/25 1PM
Saints
Buccaneers
|
–
–
|
+330
-425
|
+8.5 (-112)
-8.5 (-108)
|
O 41.5 (-110)
U 41.5 (-110)
|
|
|
Dec 7, 2025 1:00PM EST
Indianapolis Colts
Jacksonville Jaguars
12/7/25 1PM
Colts
Jaguars
|
–
–
|
-130
+110
|
-1.5 (-112)
+1.5 (-108)
|
O 47.5 (-115)
U 47.5 (-105)
|
|
|
Dec 7, 2025 1:00PM EST
Pittsburgh Steelers
Baltimore Ravens
12/7/25 1PM
Steelers
Ravens
|
–
–
|
+210
-258
|
+5.5 (-105)
-5.5 (-115)
|
O 42.5 (-112)
U 42.5 (-108)
|
|
|
Dec 7, 2025 1:00PM EST
Washington Commanders
Minnesota Vikings
12/7/25 1PM
Commanders
Vikings
|
–
–
|
-105
-115
|
+1.5 (-118)
-1.5 (-102)
|
O 42.5 (-112)
U 42.5 (-108)
|
|
|
Dec 7, 2025 1:00PM EST
Cincinnati Bengals
Buffalo Bills
12/7/25 1PM
Bengals
Bills
|
–
–
|
+220
-270
|
+5.5 (+100)
-5.5 (-120)
|
O 53.5 (-112)
U 53.5 (-108)
|
|
|
Dec 7, 2025 1:00PM EST
Miami Dolphins
New York Jets
12/7/25 1PM
Dolphins
Jets
|
–
–
|
-155
+130
|
-2.5 (-120)
+2.5 (+100)
|
O 41.5 (-110)
U 41.5 (-110)
|
|
|
Dec 7, 2025 1:00PM EST
Seattle Seahawks
Atlanta Falcons
12/7/25 1PM
Seahawks
Falcons
|
–
–
|
-355
+280
|
-7 (-105)
+7 (-115)
|
O 44.5 (-112)
U 44.5 (-108)
|
|
|
Dec 7, 2025 1:00PM EST
Tennessee Titans
Cleveland Browns
12/7/25 1PM
Titans
Browns
|
–
–
|
+180
-218
|
+4.5 (-115)
-4.5 (-105)
|
O 33.5 (-115)
U 33.5 (-105)
|
|
|
Dec 7, 2025 4:05PM EST
Denver Broncos
Las Vegas Raiders
12/7/25 4:05PM
Broncos
Raiders
|
–
–
|
-410
+320
|
-7.5 (-108)
+7.5 (-112)
|
O 40.5 (+102)
U 40.5 (-122)
|
|
|
Dec 7, 2025 4:25PM EST
Los Angeles Rams
Arizona Cardinals
12/7/25 4:25PM
Rams
Cardinals
|
–
–
|
-455
+350
|
-8.5 (-105)
+8.5 (-115)
|
O 47.5 (-110)
U 47.5 (-110)
|
|
|
Dec 7, 2025 4:25PM EST
Chicago Bears
Green Bay Packers
12/7/25 4:25PM
Bears
Packers
|
–
–
|
+270
-340
|
+6.5 (-105)
-6.5 (-115)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
|
Dec 7, 2025 8:20PM EST
Houston Texans
Kansas City Chiefs
12/7/25 8:20PM
Texans
Chiefs
|
–
–
|
+150
-180
|
+3.5 (-115)
-3.5 (-105)
|
O 41.5 (-115)
U 41.5 (-105)
|
|
|
Dec 8, 2025 8:15PM EST
Philadelphia Eagles
Los Angeles Chargers
12/8/25 8:15PM
Eagles
Chargers
|
–
–
|
-148
+124
|
-2.5 (-115)
+2.5 (-105)
|
O 41.5 (-108)
U 41.5 (-112)
|
|
|
Dec 11, 2025 8:15PM EST
Atlanta Falcons
Tampa Bay Buccaneers
12/11/25 8:15PM
Falcons
Buccaneers
|
–
–
|
+205
-250
|
+6 (-112)
-6 (-108)
|
O 44.5 (-110)
U 44.5 (-110)
|
|
|
Dec 14, 2025 1:00PM EST
New York Jets
Jacksonville Jaguars
12/14/25 1PM
Jets
Jaguars
|
–
–
|
+340
-440
|
+9.5 (-112)
-9.5 (-108)
|
O 43.5 (-110)
U 43.5 (-110)
|
|
|
Dec 14, 2025 1:00PM EST
Baltimore Ravens
Cincinnati Bengals
12/14/25 1PM
Ravens
Bengals
|
–
–
|
-155
+130
|
-2.5 (-120)
+2.5 (+100)
|
O 51.5 (-110)
U 51.5 (-110)
|
|
|
Dec 14, 2025 1:00PM EST
Washington Commanders
New York Giants
12/14/25 1PM
Commanders
Giants
|
–
–
|
-130
+110
|
-1.5 (-115)
+1.5 (-105)
|
O 47.5 (-110)
U 47.5 (-110)
|
|
|
Dec 14, 2025 1:00PM EST
Las Vegas Raiders
Philadelphia Eagles
12/14/25 1PM
Raiders
Eagles
|
–
–
|
+625
-950
|
+12.5 (-110)
-12.5 (-110)
|
O 40.5 (-110)
U 40.5 (-110)
|
|
|
Dec 14, 2025 1:00PM EST
Cleveland Browns
Chicago Bears
12/14/25 1PM
Browns
Bears
|
–
–
|
+340
-440
|
+7.5 (-115)
-7.5 (-105)
|
O 39.5 (-112)
U 39.5 (-108)
|
|
|
Dec 14, 2025 1:00PM EST
Arizona Cardinals
Houston Texans
12/14/25 1PM
Cardinals
Texans
|
–
–
|
+280
-355
|
+7 (-105)
-7 (-115)
|
O 42.5 (-110)
U 42.5 (-110)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Detroit Lions vs. Kansas City Chiefs on October 12, 2025 at GEHA Field at Arrowhead Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| LEAN | %WIN | UNITS | RESULT | |
|---|---|---|---|---|
| ATL@NYJ | NYJ +3 | 56.9% | 6 | WIN |
| MIN@SEA | SEA -11.5 | 54.5% | 4 | WIN |
| BUF@PIT | PIT +3.5 | 56.9% | 6 | LOSS |
| HOU@IND | IND -3 | 57.9% | 7 | LOSS |
| LAR@CAR | OVER 44.5 | 54.4% | 4 | WIN |
| CHI@PHI | CALEB WILLIAMS OVER 18.5 PASS COMP | 55.7% | 5 | LOSS |
| KC@DAL | DAL +3.5 | 56.3% | 6 | WIN |
| GB@DET | JORDAN LOVE OVER 1.5 PASS TDS | 55.6% | 5 | WIN |
| CIN@BAL | LAMAR JACKSON OVER 24.5 RUSH YDS | 56.7% | 6 | WIN |
| CAR@SF | UNDER 49.5 | 53.0% | 1 | WIN |
| CAR@SF | SF -7 | 54.0% | 3 | WIN |
| CAR@SF | BRYCE YOUNG OVER 61.7 PASS COMP PCT | 55.7% | 5 | WIN |
| NYJ@BAL | DERRICK HENRY OVER 17.5 CARRIES | 53.7% | 3 | WIN |
| JAC@ARI | ARI +2.5 | 55.2% | 5 | LOSS |
| PHI@DAL | DAL +3 | 53.3% | 2 | WIN |
| SEA@TEN | SEA -12 | 57.1% | 7 | LOSS |
| MIN@GB | GB -6 | 54.1% | 3 | WIN |
| IND@KC | IND +3.5 | 54.6% | 4 | WIN |
| TB@LAR | UNDER 49.5 | 52.4% | 1 | WIN |
| IND@KC | UNDER 50.5 | 53.1% | 2 | WIN |
| NYJ@BAL | BREECE HALL OVER 18.5 RECV YDS | 56.7% | 6 | WIN |
| PHI@DAL | JAKE ELLIOT OVER 2.5 EXTRA POINTS MADE | 55.2% | 5 | WIN |
| BUF@HOU | JAMES COOK UNDER 17.5 RUSH ATT | 54.4% | 4 | WIN |
| BUF@HOU | JOSH ALLEN UNDER 63.3 PASS COMP PCT | 56.8% | 6 | LOSS |
| DAL@LV | UNDER 49.5 | 54.3% | 3 | WIN |
| DAL@LV | BROCK BOWERS OVER 6.5 RECEPTIONS | 57.6% | 7 | WIN |
| CAR@ATL | BRYCE YOUNG UNDER 0.5 INT | 56.1% | 6 | WIN |
| KC@DEN | PATRICK MAHOMES UNDER 266.5 PASS YDS | 55.3% | 5 | LOSS |
| SF@ARI | SF -3 | 56.4% | 6 | WIN |
| GB@NYG | GB -7 | 54.3% | 4 | PUSH |
| LAC@JAC | LAC -3 | 53.2% | 3 | LOSS |
| SEA@LAR | SEA +3.5 | 57.2% | 7 | WIN |
| CHI@MIN | MIN -2.5 | 53.4% | 2 | LOSS |
| DET@PHI | DET +3 | 55.8% | 5 | LOSS |
| KC@DEN | DEN +4.5 | 53.0% | 2 | WIN |
| DET@PHI | UNDER 47 | 53.4% | 2 | WIN |
| SEA@LAR | OVER 48.5 | 54.6% | 4 | LOSS |
| NYJ@NE | UNDER 43.5 | 53.4% | 3 | WIN |
| NYJ@NE | JAMIEN SHERWOOD OVER 4.5 TACKLES | 56.8% | 6 | LOSS |
| PHI@GB | PHI +1.5 | 54.8% | 4 | WIN |
| PHI@GB | UNDER 45.5 | 52.4% | 2 | WIN |
| PHI@GB | SAQUON BARKLEY OVER 17.5 RUSH ATT | 56.6% | 6 | WIN |
| PHI@GB | JOSH JACOBS UNDER 42.5 1ST HALF RUSH + REC YDS | 54.4% | 4 | LOSS |
| NO@CAR | CAR -5 | 55.4% | 5 | LOSS |
| BAL@MIN | BAL -3.5 | 57.6% | 7 | WIN |
| CLE@NYJ | CLE -130 | 65.4% | 7 | LOSS |
| NYG@CHI | CHI -4.5 | 55.2% | 5 | LOSS |
| NE@TB | TB -2 | 56.1% | 6 | LOSS |
| LAR@SF | LAR -5.5 | 53.3% | 2 | WIN |
| JAC@HOU | UNDER 38 | 54.8% | 5 | LOSS |
| ARI@SEA | TREY MCBRIDE OVER 9 RECV TARGETS | 55.8% | 5 | WIN |