Commanders vs Chargers Prediction — AI Finds CAN'T MISS NFL Lines & Props (Oct 05)
Updated: 2025-09-28T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Washington Commanders travel to SoFi Stadium on October 5, 2025 to take on the Los Angeles Chargers in a showdown between an ascending NFC contender and a powerhouse AFC club looking to reassert itself. With Washington coming off a 2–2 start and the Chargers aiming to bounce back, this matchup has playoff-implication undertones despite its relatively early calendar spot.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Oct 05, 2025
Start Time: 4:25 PM EST
Venue: SoFi Stadium
Chargers Record: (3-1)
Commanders Record: (2-2)
OPENING ODDS
WAS Moneyline: +134
LAC Moneyline: -159
WAS Spread: +2.5
LAC Spread: -2.5
Over/Under: 47.5
WAS
Betting Trends
- The Commanders are 2–1 against the spread so far in 2025, covering two of their first three games and showing a +7.7 ATS point differential.
LAC
Betting Trends
- The Chargers are unbeaten ATS in 2025 with a 2–0–1 mark, reflecting strong alignment with expectations and a +5.5 ATS margin.
MATCHUP TRENDS
- Given the Chargers’ strong ATS edge and Washington’s rising profile, oddsmakers are likely to set a modest spread in L.A., creating a spot where sharp bettors may look for angles in situational matchups. Washington’s 66.7% ATS rate and solid point differential suggest they may be undervalued on the road, especially if they can exploit matchup weaknesses or get offensive efficiencies on the road.
WAS vs. LAC
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup, but hasn't found a good Prop Bet yet for this game.
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Washington vs Los Angeles Prediction & Odds:
Free NFL Betting Insights for 10/5/25
Defensively, the Chargers will need to control Washington’s ground game to make their opponent one-dimensional, while also disguising coverages to bait mistakes from the quarterback, a tactic that has been effective for them in previous matchups. The spread projects to be narrow, somewhere in the field goal range, which underscores how tightly matched these squads may be and how much small details—third-down efficiency, special teams, penalties, and late-game play-calling—could dictate the final score. From a betting standpoint, the Chargers’ early-season perfection ATS indicates a team not only meeting but often exceeding expectations, while Washington’s positive ATS performance shows they are undervalued relative to their competitive play, creating intrigue for bettors looking for underdog potential. Ultimately, this contest is about whether the Commanders can slow down Los Angeles’ rhythm, exploit situational football, and keep themselves within striking distance late, or whether the Chargers’ firepower, home-field edge, and polished execution allow them to seize control and continue their unbeaten ATS streak. Expect a competitive and physical game where both defenses look to create turnovers, both offenses attempt to dictate tempo, and the outcome could hinge on a single possession in the fourth quarter.
Not our afternoon pic.twitter.com/hFh2t9Velo
— Washington Commanders (@Commanders) September 28, 2025
Washington Commanders NFL Preview
The Washington Commanders travel west to face the Los Angeles Chargers on October 5, 2025 with the goal of proving they can compete against one of the AFC’s more complete rosters in a difficult road environment, and while their 2-2 start has been uneven, their 2-1 ATS record suggests they have played above market expectations in spots where discipline and defensive intensity have carried them. For Washington, the offensive blueprint is clear: establish balance early with a committed ground game to keep the Chargers’ pass rush honest, use quick throws to neutralize pressure, and create mismatches with their receivers against a secondary that has at times been vulnerable to explosive plays. Sustaining drives will be critical, as long possessions not only give their quarterback confidence but also keep Los Angeles’ high-octane offense on the sidelines, reducing the total number of possessions and limiting shootout potential. Defensively, the Commanders must lean on their front to collapse the pocket quickly, as allowing the Chargers’ quarterback time to survey the field is a recipe for explosive plays, and pressure will also help protect their secondary from being exposed in one-on-one matchups.
Washington’s defense has been opportunistic early in the season, forcing turnovers and creating stops in red-zone situations, and they will need more of that bend-but-don’t-break mentality in order to frustrate Los Angeles and tilt the field position battle. Mental discipline on the road will be vital, as penalties, miscommunications, and lapses in execution are amplified in a hostile setting like SoFi Stadium, where crowd noise can disrupt timing and rhythm. From a betting perspective, Washington’s positive ATS differential early in the season indicates they bring value when overlooked, and this game sets up as another opportunity to surprise, particularly if their defense can generate momentum-changing plays and the offense avoids turnovers. The Commanders will also need special teams efficiency, as a flipped field or timely big return could swing momentum in what oddsmakers expect to be a close contest. While Los Angeles has the edge in offensive firepower and home-field advantage, Washington’s resilience, ability to adapt, and willingness to grind out possessions give them a fighting chance to keep this game close, cover the spread, and perhaps even shock the Chargers if they execute cleanly and force late-game pressure onto their opponent.

Credit: USA TODAY/IMAGN
Los Angeles Chargers NFL Preview
The Los Angeles Chargers welcome the Washington Commanders to SoFi Stadium on October 5, 2025 carrying the momentum of an unbeaten ATS start and the confidence that comes with playing in front of their home crowd, and they know this is a chance to further solidify themselves as one of the AFC’s early contenders. Offensively, the Chargers will look to dictate the game from the outset by leaning on their quarterback’s arm strength, their dynamic wide receiver corps, and a ground attack that has provided much-needed balance, giving them the ability to keep defenses off guard with tempo changes and varied play designs. Protecting the quarterback will remain critical, as Washington’s defense has thrived on generating pressure and disrupting timing, but if the Chargers’ offensive line can hold up, Los Angeles is capable of exploiting mismatches in the secondary with deep shots and quick-strike plays that energize the home crowd. On defense, Los Angeles must prioritize limiting Washington’s run game to force their opponent into obvious passing downs, where they can unleash pressure packages and disguise coverages to create turnovers or stalled drives.
The Chargers’ ability to win situational football—turning red-zone trips into touchdowns, avoiding penalties that extend drives, and dominating third-down efficiency—will be decisive in not only winning the game but also covering the spread, something they have excelled at with their 2-0-1 ATS mark through three games. Special teams execution will also be pivotal, as flipping field position could provide incremental advantages that tilt momentum in a contest where Washington has been scrappy and opportunistic. From a betting perspective, Los Angeles’ strong ATS performance reflects a team consistently matching or exceeding expectations, and at home, they will aim to use crowd noise and early execution to bury the Commanders before they can settle in. Ultimately, the Chargers’ formula for success will be built around leveraging their offensive firepower, maintaining discipline defensively, and riding the energy of SoFi Stadium, and if they play clean and opportunistic football, they have the personnel and momentum to hand Washington a difficult afternoon while keeping their ATS streak intact.
final. pic.twitter.com/6gWZ2ev93i
— Los Angeles Chargers (@chargers) September 28, 2025
Washington vs. Los Angeles Prop Picks (AI)
Washington vs. Los Angeles Prediction (AI)

Remi, our AI sports wizard, has been pouring over exorbitant amounts of data from every angle between the Commanders and Chargers and using recursive machine learning and kick-ass AI to crunch the data to a single cover probability.
Remi has been most watching on the growing weight human bettors often put on coaching factors between a Commanders team going up against a possibly healthy Chargers team. In reality, the true game analytics appear to reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Washington vs Los Angeles picks, computer picks Commanders vs Chargers, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
---|---|---|---|---|---|---|
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Commanders Betting Trends
The Commanders are 2–1 against the spread so far in 2025, covering two of their first three games and showing a +7.7 ATS point differential.
Chargers Betting Trends
The Chargers are unbeaten ATS in 2025 with a 2–0–1 mark, reflecting strong alignment with expectations and a +5.5 ATS margin.
Commanders vs. Chargers Matchup Trends
Given the Chargers’ strong ATS edge and Washington’s rising profile, oddsmakers are likely to set a modest spread in L.A., creating a spot where sharp bettors may look for angles in situational matchups. Washington’s 66.7% ATS rate and solid point differential suggest they may be undervalued on the road, especially if they can exploit matchup weaknesses or get offensive efficiencies on the road.
Washington vs. Los Angeles Game Info
What time does Washington vs Los Angeles start on October 05, 2025?
Washington vs Los Angeles starts on October 05, 2025 at 4:25 PM EST.
Where is Washington vs Los Angeles being played?
Venue: SoFi Stadium.
What are the opening odds for Washington vs Los Angeles?
Spread: Los Angeles -2.5
Moneyline: Washington +134, Los Angeles -159
Over/Under: 47.5
What are the records for Washington vs Los Angeles?
Washington: (2-2) | Los Angeles: (3-1)
What is the AI best bet for Washington vs Los Angeles?
Remi's searched hard and found the best prop for this matchup, but hasn't found a good Prop Bet yet for this game.. Prices move—always shop for the best number.
What are Washington vs Los Angeles trending bets?
Given the Chargers’ strong ATS edge and Washington’s rising profile, oddsmakers are likely to set a modest spread in L.A., creating a spot where sharp bettors may look for angles in situational matchups. Washington’s 66.7% ATS rate and solid point differential suggest they may be undervalued on the road, especially if they can exploit matchup weaknesses or get offensive efficiencies on the road.
What are Washington trending bets?
WAS trend: The Commanders are 2–1 against the spread so far in 2025, covering two of their first three games and showing a +7.7 ATS point differential.
What are Los Angeles trending bets?
LAC trend: The Chargers are unbeaten ATS in 2025 with a 2–0–1 mark, reflecting strong alignment with expectations and a +5.5 ATS margin.
Where can I find AI Picks for Washington vs Los Angeles?
See our latest NFL picks and odds pages for 2025 to compare prices before you bet.
Washington vs. Los Angeles Odds
Remi is pouring through mountains of data points on each player. In fact, anytime the Washington vs Los Angeles trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme altitude rarely follow normal, predictable patterns.
Washington vs Los Angeles Opening Odds
WAS Moneyline:
+134 LAC Moneyline: -159
WAS Spread: +2.5
LAC Spread: -2.5
Over/Under: 47.5
Washington vs Los Angeles Live Odds
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–
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+152
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U 44.5 (-108)
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+290
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O 40.5 (-105)
U 40.5 (-115)
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Oct 26, 2025 1:00PM EDT
Buffalo Bills
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–
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-390
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-7.5 (-102)
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O 46.5 (-105)
U 46.5 (-115)
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Oct 26, 2025 1:00PM EDT
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–
–
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+245
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+6.5 (-110)
-6.5 (-110)
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O 43.5 (-115)
U 43.5 (-105)
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Oct 26, 2025 1:00PM EDT
Chicago Bears
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10/26/25 1PM
Bears
Ravens
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–
–
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+265
-330
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+6.5 (-106)
-6.5 (-114)
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O 50.5 (-105)
U 50.5 (-115)
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Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
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Giants
Eagles
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–
–
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+285
-355
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+7 (-108)
-7 (-112)
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O 43.5 (-105)
U 43.5 (-115)
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Oct 26, 2025 1:00PM EDT
San Francisco 49ers
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10/26/25 1PM
49ers
Texans
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–
–
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-102
-118
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+1.5 (-115)
-1.5 (-105)
|
O 41.5 (-110)
U 41.5 (-110)
|
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Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
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–
–
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+300
-375
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+7.5 (-122)
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O 44.5 (-114)
U 44.5 (-106)
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Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
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–
–
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-225
+188
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-4.5 (-106)
+4.5 (-114)
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O 46.5 (-114)
U 46.5 (-106)
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Oct 26, 2025 4:25PM EDT
Dallas Cowboys
Denver Broncos
10/26/25 4:25PM
Cowboys
Broncos
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–
–
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+146
-174
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+3.5 (-118)
-3.5 (-104)
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O 50.5 (-110)
U 50.5 (-110)
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Oct 26, 2025 4:25PM EDT
Tennessee Titans
Indianapolis Colts
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Titans
Colts
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–
–
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+750
-1200
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+14.5 (-118)
-14.5 (-104)
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O 46.5 (-114)
U 46.5 (-106)
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Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
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–
–
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-176
+148
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-3.5 (-104)
+3.5 (-118)
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O 44.5 (-115)
U 44.5 (-105)
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Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
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–
–
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+430
-590
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+10.5 (-110)
-10.5 (-110)
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O 47.5 (-110)
U 47.5 (-110)
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Oct 30, 2025 8:15PM EDT
Baltimore Ravens
Miami Dolphins
10/30/25 8:15PM
Ravens
Dolphins
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–
–
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-430
+340
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-8.5 (-105)
+8.5 (-115)
|
O 47.5 (-105)
U 47.5 (-115)
|
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Nov 2, 2025 1:00PM EST
Chicago Bears
Cincinnati Bengals
11/2/25 1PM
Bears
Bengals
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–
–
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-120
+102
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-1.5 (-110)
+1.5 (-110)
|
O 47.5 (-105)
U 47.5 (-115)
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Nov 2, 2025 1:00PM EST
Indianapolis Colts
Pittsburgh Steelers
11/2/25 1PM
Colts
Steelers
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–
–
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-136
+116
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-2.5 (-110)
+2.5 (-110)
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O 47.5 (-110)
U 47.5 (-110)
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NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Washington Commanders vs. Los Angeles Chargers on October 05, 2025 at SoFi Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TB@DET | RACHAAD WHITE UNDER 14.5 RUSH ATT | 54.4% | 4 | WIN |
NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
GB@ARI | ARI +7 | 54.8% | 5 | WIN |
NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |
HOU@BAL | HOU -125 | 58.5% | 7 | WIN |
DET@CIN | DET -10 | 55.6% | 5 | WIN |
DAL@NYJ | NYJ +1.5 | 53.7% | 3 | LOSS |
TB@SEA | TB +3.5 | 54.9% | 4 | WIN |
TEN@ARI | ARI -7 (BUY 0.5) | 54.9% | 4 | LOSS |
DEN@PHI | DEN +4.5 | 57.5% | 7 | WIN |
MIA@CAR | TETAIROA MCMILLAN OVER 58.5 RECV YDS | 54.5% | 4 | WIN |
LV@IND | ASHTON JEANTY UNDER 67.5 RUSH YDS | 54.4% | 4 | WIN |
SF@LAR | DEMARCUS ROBINSON OVER 29.5 RECV YDS | 55.7% | 5 | WIN |
NYJ@MIA | NYJ +3 | 53.8 | 3 | LOSS |
CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
PIT@NE | PIT -116 | 60.1% | 6 | WIN |
ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |