Titans vs Cardinals Prediction — AI Finds CAN'T MISS NFL Lines & Props (Oct 05)
Updated: 2025-09-28T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Arizona Cardinals host the Tennessee Titans in Week 5 as the Cards look to build momentum in the NFC while Tennessee, currently winless, searches for its first spark under rookie quarterback Cam Ward. Expect a game where Arizona leans on ground control and pressure, and Tennessee tries to spark the scoreboard via tempo shifts and vertical shots.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Oct 05, 2025
Start Time: 4:05 PM EST
Venue: State Farm Stadium
Cardinals Record: (2-2)
Titans Record: (0-4)
OPENING ODDS
TEN Moneyline: +354
ARI Moneyline: -463
TEN Spread: +9
ARI Spread: -9.0
Over/Under: 41.5
TEN
Betting Trends
- Tennessee has struggled against the spread in 2025, sitting at 1–2 ATS through their first three games.
ARI
Betting Trends
- Arizona enters with a 2–2 ATS mark on the year, showing both capacity to cover and vulnerability.
MATCHUP TRENDS
- In games where a heavily run-oriented team faces a quarterback in development, the swing factors skew toward negative plays (sacks, turnovers) and third-down efficiency; when the underdog keeps those damage metrics low, cover chances increase. Also, Arizona’s games often produce swing spreads late due to turnovers or blowouts, meaning bettors will monitor line movement closely.
TEN vs. ARI
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: K. Murray over 31.5 Rushing Yards.
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Tennessee vs Arizona Prediction & Odds:
Free NFL Betting Insights for 10/5/25
Arizona, however, comes in with confidence, boasting a 2–2 ATS mark that reflects their ability to win when executing their formula, which starts with Murray’s mobility, a backfield committee filling in for the injured James Conner, and a playbook that mixes RPOs, read-option, and play-action to force defenses to hesitate at the second level; if Murray is protected and the ground game stays credible, the Cardinals can spread Tennessee thin and attack every blade of grass. Defensively, Arizona will likely aim to attack Ward early, disguising looks and bringing creative pressure to test the rookie’s decision-making and patience, while the secondary will seek to challenge receivers physically at the line and rally to the ball to limit yards after catch. The situational battle will be decisive, as Arizona has been efficient in the red zone and Tennessee has struggled to turn opportunities into touchdowns, meaning the Titans cannot afford to settle for field goals if they want to stay within reach. Special teams and hidden yardage could provide the Titans their best chance to flip momentum, but Arizona has generally been sound in that phase and will be determined not to give away cheap possessions. From a betting perspective, the gap in consistency, execution, and roster strength leans heavily toward the Cardinals, but desperation often fuels underdogs, and if Tennessee plays clean, avoids turnovers, and steals an extra possession through defense or special teams, they can hang around; otherwise, the Cardinals’ balance, home-field advantage, and quarterback experience should prove too much, making this matchup one where Arizona is well-positioned to cover and potentially win comfortably.
Hot Topics From Titans HC Brian Callahan's Monday Presser presented by @LeeCompany
— Tennessee Titans (@Titans) September 29, 2025
Tennessee Titans NFL Preview
The Tennessee Titans come into their October 5, 2025 road matchup against the Arizona Cardinals still searching for their first win of the season and facing the daunting task of relying on rookie quarterback Cam Ward to navigate an aggressive defense and a hostile environment, and their ability to adapt, protect, and seize opportunities will determine if they can remain competitive. Ward has shown glimpses of arm talent and athleticism, but his offensive line has struggled in pass protection, and against a Cardinals front that thrives on pressure and disguising blitz looks, the Titans must prioritize a quick-game approach with short throws, screens, and designed rollouts to minimize exposure to sacks and negative plays. The run game becomes critical not only as a stabilizer but as a way to create play-action opportunities that slow down Arizona’s pursuit, and while Tennessee does not boast an elite backfield, even grinding out modest yards can keep their offense balanced and prevent the Cardinals from keying solely on the pass. Ward will need to rely on receivers like Courtland Sutton and Treylon Burks to win contested catches and generate chunk gains when Arizona’s corners are isolated, and those plays may serve as lifelines if drives stall. Defensively, the Titans must aim to disrupt Kyler Murray by closing lanes and forcing him to stay in the pocket, which means discipline from the edge rushers and strong interior push to prevent improvisational plays that often extend drives.
Their linebackers and secondary will need to tackle crisply and stay disciplined against Arizona’s frequent use of motion, RPOs, and crossing routes, because one lapse could result in explosive gains that tilt the game. Tennessee’s chances hinge heavily on the turnover battle, as they cannot afford giveaways from their rookie quarterback, and they must generate at least one or two takeaways to swing momentum and set up short fields for an offense still trying to find rhythm. Special teams could provide a needed edge, whether through flipping field position with strong punts, generating hidden yards on returns, or converting long field goals that keep the scoreboard close, but mistakes in this phase would only magnify the gap between the teams. From a betting perspective, the Titans’ early ATS performance has been poor, with just one cover in their first three outings, and their youth and inconsistency suggest volatility that could either lead to a breakthrough effort or another lopsided loss. To cover or even push for a late upset, Tennessee must execute a near-perfect formula: protect Ward through scheme and discipline, avoid falling behind early, create defensive disruption that forces Arizona off schedule, and cash in on every scoring chance. If they manage those elements, they can transform desperation into competitiveness and silence a skeptical market, but if protection breaks down and turnovers mount, the Titans risk being overwhelmed by an Arizona team more prepared, balanced, and confident at home.

Credit: USA TODAY/IMAGN
Arizona Cardinals NFL Preview
The Arizona Cardinals enter their October 5, 2025 home matchup against the Tennessee Titans with a sense of control and confidence, facing a winless opponent while knowing that their formula of balanced offense, defensive pressure, and quarterback Kyler Murray’s improvisational brilliance gives them a distinct advantage if executed cleanly. With James Conner sidelined, the Cardinals have leaned on a committee approach to maintain a credible run game, mixing zone runs, draws, and misdirection to keep defenses honest while allowing Murray to use RPOs and play-action to manipulate linebackers and create openings downfield. Against a Titans defense that will try to generate chaos and shorten the game with pressure, Arizona must emphasize ball security, quick decision-making, and tempo shifts that prevent Tennessee from dictating with disguised blitzes or stacked boxes, and Murray’s ability to extend plays with his legs makes it difficult for even disciplined defenses to contain him for four quarters. Arizona’s receivers and tight ends will be tasked with winning one-on-one matchups and exploiting Tennessee’s secondary, especially if Murray can buy time and hit intermediate or vertical routes when safeties creep forward to defend the run. Defensively, the Cardinals will be aggressive in attacking rookie quarterback Cam Ward, who has struggled behind a vulnerable offensive line and is prone to hurried throws under pressure, and their pass rushers will look to collapse the pocket quickly while mixing stunts and disguised coverages to force him into mistakes.
The secondary’s focus will be on rallying to the football and limiting explosive plays to Courtland Sutton and Treylon Burks, while tackling in space will be key to preventing short throws from turning into drive-sustaining gains. In the red zone, Arizona will rely on heavy sets, condensed formations, and quick-hitting plays that maximize leverage, while defensively their priority will be forcing Tennessee to settle for field goals rather than touchdowns. Special teams are another critical phase, and Arizona must continue to execute with discipline on kick coverage, directional punting, and reliable field goal attempts, as avoiding errors in this area prevents underdogs from gaining momentum. From a betting perspective, the Cardinals have been steady at 2–2 ATS, proving capable of meeting expectations when they control tempo and finish drives, and against a Titans squad that has failed to cover in two of three games, the path is clear for Arizona to maintain its edge both straight up and against the spread. To ensure a comfortable win and a cover, the Cardinals must start fast, force Ward into early mistakes, and use the energy of the home crowd to sustain defensive intensity, all while leaning on Murray to orchestrate long, balanced drives that break Tennessee’s will. If Arizona avoids turnovers, executes situational football, and finishes possessions with touchdowns, they should be well-positioned to extend Tennessee’s misery, secure another home victory, and continue building credibility as a team capable of winning games they are expected to dominate.
A pure work of art 🖼️ pic.twitter.com/Em3fMCIn2A
— Arizona Cardinals (@AZCardinals) September 30, 2025
Tennessee vs. Arizona Prop Picks (AI)
Tennessee vs. Arizona Prediction (AI)

Remi, our AI sports algorithm, has been pouring over tons of data from every simulation between the Titans and Cardinals and using recursive machine learning and cutting-edge AI to analyze the data to a single cover probability.
Remi has been most watching on the trending factor human bettors often put on Tennessee’s strength factors between a Titans team going up against a possibly strong Cardinals team. In reality, the true game analytics appear to reflect a moderate lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Tennessee vs Arizona picks, computer picks Titans vs Cardinals, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Titans Betting Trends
Tennessee has struggled against the spread in 2025, sitting at 1–2 ATS through their first three games.
Cardinals Betting Trends
Arizona enters with a 2–2 ATS mark on the year, showing both capacity to cover and vulnerability.
Titans vs. Cardinals Matchup Trends
In games where a heavily run-oriented team faces a quarterback in development, the swing factors skew toward negative plays (sacks, turnovers) and third-down efficiency; when the underdog keeps those damage metrics low, cover chances increase. Also, Arizona’s games often produce swing spreads late due to turnovers or blowouts, meaning bettors will monitor line movement closely.
Tennessee vs. Arizona Game Info
What time does Tennessee vs Arizona start on October 05, 2025?
Tennessee vs Arizona starts on October 05, 2025 at 4:05 PM EST.
Where is Tennessee vs Arizona being played?
Venue: State Farm Stadium.
What are the opening odds for Tennessee vs Arizona?
Spread: Arizona -9.0
Moneyline: Tennessee +354, Arizona -463
Over/Under: 41.5
What are the records for Tennessee vs Arizona?
Tennessee: (0-4) | Arizona: (2-2)
What is the AI best bet for Tennessee vs Arizona?
Remi's searched hard and found the best prop for this matchup: K. Murray over 31.5 Rushing Yards.. Prices move—always shop for the best number.
What are Tennessee vs Arizona trending bets?
In games where a heavily run-oriented team faces a quarterback in development, the swing factors skew toward negative plays (sacks, turnovers) and third-down efficiency; when the underdog keeps those damage metrics low, cover chances increase. Also, Arizona’s games often produce swing spreads late due to turnovers or blowouts, meaning bettors will monitor line movement closely.
What are Tennessee trending bets?
TEN trend: Tennessee has struggled against the spread in 2025, sitting at 1–2 ATS through their first three games.
What are Arizona trending bets?
ARI trend: Arizona enters with a 2–2 ATS mark on the year, showing both capacity to cover and vulnerability.
Where can I find AI Picks for Tennessee vs Arizona?
See our latest NFL picks and odds pages for 2025 to compare prices before you bet.
Tennessee vs. Arizona Odds
AI algorithm Remi is pouring through loads of data points on each team. In fact, anytime the Tennessee vs Arizona trends are analyzed, there’s always several intriguing angles to key in on. Not to mention games played at extreme temps almost always follow normal, predictable betting trends.
Tennessee vs Arizona Opening Odds
TEN Moneyline:
+354 ARI Moneyline: -463
TEN Spread: +9
ARI Spread: -9.0
Over/Under: 41.5
Tennessee vs Arizona Live Odds
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+253
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U 50.5 (-110)
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Oct 26, 2025 1:00PM EDT
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Oct 26, 2025 1:00PM EDT
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49ers
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+105
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+1 (-105)
-1 (-115)
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O 41.5 (-110)
U 41.5 (-110)
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Oct 26, 2025 1:00PM EDT
Miami Dolphins
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+280
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U 44.5 (-110)
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Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
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U 46.5 (-110)
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O 50.5 (-110)
U 50.5 (-110)
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+750
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O 47 (-110)
U 47 (-110)
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-175
+150
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-3 (-120)
+3 (+100)
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O 45 (-110)
U 45 (-110)
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Oct 27, 2025 8:15PM EDT
Washington Commanders
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+465
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O 48 (-105)
U 48 (-115)
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O 49.5 (-110)
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NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Tennessee Titans vs. Arizona Cardinals on October 05, 2025 at State Farm Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
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LEAN | %WIN | UNITS | RESULT |
---|---|---|---|---|
TB@DET | RACHAAD WHITE UNDER 14.5 RUSH ATT | 54.4% | 4 | WIN |
NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
GB@ARI | ARI +7 | 54.8% | 5 | WIN |
NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |
HOU@BAL | HOU -125 | 58.5% | 7 | WIN |
DET@CIN | DET -10 | 55.6% | 5 | WIN |
DAL@NYJ | NYJ +1.5 | 53.7% | 3 | LOSS |
TB@SEA | TB +3.5 | 54.9% | 4 | WIN |
TEN@ARI | ARI -7 (BUY 0.5) | 54.9% | 4 | LOSS |
DEN@PHI | DEN +4.5 | 57.5% | 7 | WIN |
MIA@CAR | TETAIROA MCMILLAN OVER 58.5 RECV YDS | 54.5% | 4 | WIN |
LV@IND | ASHTON JEANTY UNDER 67.5 RUSH YDS | 54.4% | 4 | WIN |
SF@LAR | DEMARCUS ROBINSON OVER 29.5 RECV YDS | 55.7% | 5 | WIN |
NYJ@MIA | NYJ +3 | 53.8 | 3 | LOSS |
CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
PIT@NE | PIT -116 | 60.1% | 6 | WIN |
ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |