Patriots vs. Bills
FREE NFL AI Predictions
October 05, 2025
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

GAME INFO
Date: Oct 05, 2025
Start Time: 8:20 PM EST​
Venue: ​
Bills Record:
Patriots Record:
OPENING ODDS
NE Moneyline:
BUF Moneyline:
NE Spread: 0
BUF Spread:
Over/Under:
NE
Betting Trends
BUF
Betting Trends
MATCHUP TRENDS
NE vs. BUF
Best Prop Bet
LIVE NFL ODDS
NFL ODDS COMPARISON
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VS. SPREAD
295-209
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+417.7
NET PROFIT
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$100/UNIT
$41,768
VS. SPREAD
1519-1315
NET UNITS
(INCL VIG)
+312.6
NET PROFIT
(INCL VIG)
$100/UNIT
$31,258
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New England vs Buffalo AI Prediction:
Free NFL Betting Insights for 10/5/25
Patriots AI Preview

Credit: USA TODAY/IMAGN
Bills AI Preview
Patriots vs. Bills FREE Prop Pick
Remi is pouring through mountains of stats on each team. In fact, anytime the Patriots and Bills play there’s always several intriguing trends to key in on. Not to mention games played at in Oct rarely follow normal, predictable patterns.
New England vs. Buffalo NFL AI Pick

Remi, our AI sports wizard, has been pouring over mountains of data from every past game between the Patriots and Bills and using recursive machine learning and impressive AI to analyze the data to a single cover probability.
Interestingly enough, the data has been most focused on the linear correlation of factor human bettors often put on coaching factors between a Patriots team going up against a possibly healthy Bills team. Trends look to say the true game analytics might reflect a moderate lean against one Vegas line specifically.
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