Bengals vs Broncos Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 29)
Updated: 2025-09-22T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Cincinnati Bengals take on the Denver Broncos on Monday night, September 29, 2025, in what is shaping up as one of the more unpredictable matchups of Week 4. With the Bengals reeling after a heavy loss and Denver eager to rebound at home in prime time, the betting line has centered around a 7-point spread in favor of the Broncos and an over/under in the low-40s.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Sep 29, 2025
Start Time: 8:15 PM EST
Venue: Empower Field at Mile High
Broncos Record: (1-2)
Bengals Record: (2-1)
OPENING ODDS
CIN Moneyline: +299
DEN Moneyline: -379
CIN Spread: +7.5
DEN Spread: -7.5
Over/Under: 44
CIN
Betting Trends
- Cincinnati is 1–1 ATS this season, showing a 50 % cover rate so far.
DEN
Betting Trends
- Denver is 0–2 ATS through the first three weeks, struggling to cover even in home settings.
MATCHUP TRENDS
- Oddsmakers have moved the line toward Denver following the Bengals’ latest blowout loss, and early sharp money is backing the Broncos, possibly in reaction to injuries or matchup concerns in Cincinnati’s offense. Also notable: the total was posted near 43.5, reflecting expectations for a lower-scoring affair with defensive leanings.
CIN vs. DEN
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: J.K. Dobbins over 59.5 Rushing Yards.
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Cincinnati vs Denver Prediction & Odds:
Free NFL Betting Insights for 9/29/25
Denver, meanwhile, knows its formula: control the clock with a ground game that has already proven effective, force Cincinnati into third-and-long situations, and capitalize on defensive pressure to create turnovers, all while finally learning how to close games after two losses by one score early in the year. The Broncos’ defense will look to pressure Cincinnati into mistakes, especially if the Bengals are forced into a one-dimensional passing attack, while their offense will rely on misdirection, play-action, and steady runs to wear down a Bengals front that has struggled with gap discipline. Special teams could loom large, as Denver’s altitude always adds volatility to kicking and coverage, and Cincinnati cannot afford to lose the hidden-yardage battle if they hope to stay close. Oddsmakers set the Broncos as touchdown favorites with a total in the low 40s, reflecting the expectation of a low-scoring contest dictated by defensive intensity and situational execution, with Denver seen as the safer side given their stronger run game and home-field edge. Still, with both teams plagued by inconsistency, the game could be decided by which side manages turnovers, executes better in the red zone, and avoids the costly mistakes that have haunted each of them through three weeks of the season.
Tee time. pic.twitter.com/dJqemsdvtf
— Cincinnati Bengals (@Bengals) September 23, 2025
Cincinnati Bengals NFL Preview
The Cincinnati Bengals head into Denver for their Week 4 Monday night showdown with a sense of urgency and the knowledge that their season could begin to unravel if they don’t find answers quickly, especially after a humiliating 48–10 loss to the Minnesota Vikings that exposed just how ineffective their offense has been through three games. Sitting near the bottom of the league in rushing offense and total yardage, the Bengals’ inability to establish balance has left their quarterback under siege and forced the passing game into predictable situations, leading to turnovers and stalled drives. For Cincinnati to have any chance of competing at Empower Field, they must commit to fixing their protection schemes and finding creative ways to generate big plays, whether through screen passes, quick outs to their receivers, or designed quarterback runs that keep the defense guessing. Their offensive line, in particular, will face a major test against a Denver defense that thrives on pressure, and if they can’t win in the trenches, it may be another long night.
Defensively, the Bengals must prioritize stopping the Broncos’ rushing attack, which has been one of Denver’s few bright spots this season, and focus on gap integrity so that the game doesn’t get away from them early with clock-controlling drives. Their secondary will need to remain disciplined against play-action, as the Broncos are likely to use the run to set up chunk gains through the air. Cincinnati’s special teams must also deliver, as in a low-scoring, grind-it-out contest, field position and hidden yardage will be critical. While the Bengals are 1–1 ATS this season and have shown occasional resilience on the road in years past, their current form raises doubts, and they’ll need to play their cleanest game yet to overcome Denver’s altitude, home crowd, and physical ground attack. For Cincinnati, the formula is clear but difficult: avoid turnovers, find ways to protect the quarterback, force Denver into mistakes, and seize any opportunities in the red zone. If they can execute in those areas, the Bengals could pull off a surprise, but given their recent struggles, they’ll enter Mile High as clear underdogs fighting uphill to prove they’re not slipping into an early-season spiral.
Credit: USA TODAY/IMAGN
Denver Broncos NFL Preview
The Denver Broncos return to the Mile High stage on Monday night against the Cincinnati Bengals with a perfect opportunity to reset their season in front of a national audience, knowing their strengths at home and on the ground give them a pathway to dictate the matchup. At 0–2 ATS and having lost multiple close games already this season, the Broncos are eager to prove they can finish contests rather than let opportunities slip away, and facing a Bengals squad that just surrendered 48 points in a blowout loss, Denver will look to apply pressure early and force Cincinnati into playing from behind. Offensively, Denver’s identity will continue to run through its rushing attack, which has been one of the more effective units in the AFC so far and a crucial stabilizer against defenses that try to force the game onto the quarterback’s arm. Expect heavy usage of zone runs, misdirection, and play-action to wear down a Bengals front that has been shaky in gap control, while Denver’s receivers will be tasked with winning one-on-one matchups off play-action shots when Cincinnati inevitably commits more defenders to the box.
Defensively, the Broncos know they can dictate tempo by collapsing the pocket, capitalizing on Cincinnati’s struggling offensive line, and forcing hurried decisions that can lead to turnovers, while the secondary must stay disciplined against the Bengals’ big-play threats even if the offense continues to sputter. Special teams execution, particularly in the altitude of Empower Field where long field goals and punt coverage can change momentum, will also be an advantage Denver hopes to lean on. Betting markets have swung in their favor, installing them as a touchdown favorite, a reflection of both home-field confidence and the perception that Denver’s defense and ground game are far superior to what Cincinnati currently offers. The Broncos’ formula is straightforward: pound the rock, protect the football, and keep Cincinnati uncomfortable with pressure and physicality, all while making sure this time they close the door in the fourth quarter instead of allowing late swings. If they execute that script, Denver not only has a strong chance to cover but also to reassert itself as a tough AFC opponent capable of defending its home field.
Congratulations to the 1️⃣2️⃣ former Broncos who have been named Modern-Era nominees for the @ProFootballHOF Class of 2026!
— Denver Broncos (@Broncos) September 24, 2025
📰 » https://t.co/R4F5XmCTVk pic.twitter.com/fOCqA5ndhF
Cincinnati vs. Denver Prop Picks (AI)
Cincinnati vs. Denver Prediction (AI)
Remi, our AI sports wizard, has been pouring over tons of data from every simulation between the Bengals and Broncos and using recursive machine learning and industry leading AI to examine the data to a single cover probability.
Oddly enough, we’ve seen the AI has been most fixated on the unproportionally assigned factor emotional bettors tend to put on Cincinnati’s strength factors between a Bengals team going up against a possibly tired Broncos team. It appears the true game analytics appear to reflect a slight lean against one Vegas line in particular.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Cincinnati vs Denver picks, computer picks Bengals vs Broncos, best bets, model edges, confidence ratings.
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DATE | GAME | LEAN | %WIN | UNITS | LEVEL |
|---|---|---|---|---|---|---|
| ACTIVE PICKS LOCKED - SEE NOW | ||||||
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Bengals Betting Trends
Cincinnati is 1–1 ATS this season, showing a 50 % cover rate so far.
Broncos Betting Trends
Denver is 0–2 ATS through the first three weeks, struggling to cover even in home settings.
Bengals vs. Broncos Matchup Trends
Oddsmakers have moved the line toward Denver following the Bengals’ latest blowout loss, and early sharp money is backing the Broncos, possibly in reaction to injuries or matchup concerns in Cincinnati’s offense. Also notable: the total was posted near 43.5, reflecting expectations for a lower-scoring affair with defensive leanings.
Cincinnati vs. Denver Game Info
What time does Cincinnati vs Denver start on September 29, 2025?
Cincinnati vs Denver starts on September 29, 2025 at 8:15 PM EST.
Where is Cincinnati vs Denver being played?
Venue: Empower Field at Mile High.
What are the opening odds for Cincinnati vs Denver?
Spread: Denver -7.5
Moneyline: Cincinnati +299, Denver -379
Over/Under: 44
What are the records for Cincinnati vs Denver?
Cincinnati: (2-1) | Denver: (1-2)
What is the AI best bet for Cincinnati vs Denver?
Remi's searched hard and found the best prop for this matchup: J.K. Dobbins over 59.5 Rushing Yards.. Prices move—always shop for the best number.
What are Cincinnati vs Denver trending bets?
Oddsmakers have moved the line toward Denver following the Bengals’ latest blowout loss, and early sharp money is backing the Broncos, possibly in reaction to injuries or matchup concerns in Cincinnati’s offense. Also notable: the total was posted near 43.5, reflecting expectations for a lower-scoring affair with defensive leanings.
What are Cincinnati trending bets?
CIN trend: Cincinnati is 1–1 ATS this season, showing a 50 % cover rate so far.
What are Denver trending bets?
DEN trend: Denver is 0–2 ATS through the first three weeks, struggling to cover even in home settings.
Where can I find AI Picks for Cincinnati vs Denver?
See our latest NFL picks and odds pages for 2025 to compare prices before you bet.
Cincinnati vs. Denver Odds
Remi is pouring through mountains of stats on each line. In fact, anytime the Cincinnati vs Denver trends are analyzed, there’s always several intriguing trends to key in on. Not to mention games played at extreme travel distance can often follow normal, predictable patterns.
Cincinnati vs Denver Opening Odds
CIN Moneyline:
+299 DEN Moneyline: -379
CIN Spread: +7.5
DEN Spread: -7.5
Over/Under: 44
Cincinnati vs Denver Live Odds
| Games | PTS | ML | SPR | O/U | |
|---|---|---|---|---|---|
|
Oct 23, 2025 8:15PM EDT
Minnesota Vikings
Los Angeles Chargers
10/23/25 8:15PM
Vikings
Chargers
|
–
–
|
+152
-180
|
+3 (-102)
-3 (-120)
|
O 44.5 (-112)
U 44.5 (-108)
|
|
|
Oct 26, 2025 1:00PM EDT
Cleveland Browns
New England Patriots
10/26/25 1PM
Browns
Patriots
|
–
–
|
+290
-360
|
+7 (-114)
-7 (-106)
|
O 40.5 (-105)
U 40.5 (-115)
|
|
|
Oct 26, 2025 1:00PM EDT
Buffalo Bills
Carolina Panthers
10/26/25 1PM
Bills
Panthers
|
–
–
|
-390
+310
|
-7.5 (-102)
+7.5 (-120)
|
O 46.5 (-105)
U 46.5 (-115)
|
|
|
Oct 26, 2025 1:00PM EDT
New York Jets
Cincinnati Bengals
10/26/25 1PM
Jets
Bengals
|
–
–
|
+245
-300
|
+6.5 (-110)
-6.5 (-110)
|
O 43.5 (-115)
U 43.5 (-105)
|
|
|
Oct 26, 2025 1:00PM EDT
Chicago Bears
Baltimore Ravens
10/26/25 1PM
Bears
Ravens
|
–
–
|
+265
-330
|
+6.5 (-106)
-6.5 (-114)
|
O 50.5 (-105)
U 50.5 (-115)
|
|
|
Oct 26, 2025 1:00PM EDT
New York Giants
Philadelphia Eagles
10/26/25 1PM
Giants
Eagles
|
–
–
|
+285
-355
|
+7 (-108)
-7 (-112)
|
O 43.5 (-105)
U 43.5 (-115)
|
|
|
Oct 26, 2025 1:00PM EDT
San Francisco 49ers
Houston Texans
10/26/25 1PM
49ers
Texans
|
–
–
|
-102
-118
|
+1.5 (-115)
-1.5 (-105)
|
O 41.5 (-110)
U 41.5 (-110)
|
|
|
Oct 26, 2025 1:00PM EDT
Miami Dolphins
Atlanta Falcons
10/26/25 1PM
Dolphins
Falcons
|
–
–
|
+300
-375
|
+7.5 (-122)
-7.5 (+100)
|
O 44.5 (-114)
U 44.5 (-106)
|
|
|
Oct 26, 2025 4:05PM EDT
Tampa Bay Buccaneers
New Orleans Saints
10/26/25 4:05PM
Buccaneers
Saints
|
–
–
|
-225
+188
|
-4.5 (-106)
+4.5 (-114)
|
O 46.5 (-114)
U 46.5 (-106)
|
|
|
Oct 26, 2025 4:25PM EDT
Dallas Cowboys
Denver Broncos
10/26/25 4:25PM
Cowboys
Broncos
|
–
–
|
+146
-174
|
+3.5 (-118)
-3.5 (-104)
|
O 50.5 (-110)
U 50.5 (-110)
|
|
|
Oct 26, 2025 4:25PM EDT
Tennessee Titans
Indianapolis Colts
10/26/25 4:25PM
Titans
Colts
|
–
–
|
+750
-1200
|
+14.5 (-118)
-14.5 (-104)
|
O 46.5 (-114)
U 46.5 (-106)
|
|
|
Oct 26, 2025 8:20PM EDT
Green Bay Packers
Pittsburgh Steelers
10/26/25 8:20PM
Packers
Steelers
|
–
–
|
-176
+148
|
-3.5 (-104)
+3.5 (-118)
|
O 44.5 (-115)
U 44.5 (-105)
|
|
|
Oct 27, 2025 8:15PM EDT
Washington Commanders
Kansas City Chiefs
10/27/25 8:15PM
Commanders
Chiefs
|
–
–
|
+430
-590
|
+10.5 (-110)
-10.5 (-110)
|
O 47.5 (-110)
U 47.5 (-110)
|
|
|
Oct 30, 2025 8:15PM EDT
Baltimore Ravens
Miami Dolphins
10/30/25 8:15PM
Ravens
Dolphins
|
–
–
|
-430
+340
|
-8.5 (-105)
+8.5 (-115)
|
O 47.5 (-105)
U 47.5 (-115)
|
|
|
Nov 2, 2025 1:00PM EST
Chicago Bears
Cincinnati Bengals
11/2/25 1PM
Bears
Bengals
|
–
–
|
-120
+102
|
-1.5 (-110)
+1.5 (-110)
|
O 47.5 (-105)
U 47.5 (-115)
|
|
|
Nov 2, 2025 1:00PM EST
Indianapolis Colts
Pittsburgh Steelers
11/2/25 1PM
Colts
Steelers
|
–
–
|
-136
+116
|
-2.5 (-110)
+2.5 (-110)
|
O 47.5 (-110)
U 47.5 (-110)
|
NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Cincinnati Bengals vs. Denver Broncos on September 29, 2025 at Empower Field at Mile High.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| NFL |
LEAN | %WIN | UNITS | RESULT |
|---|---|---|---|---|
| TB@DET | RACHAAD WHITE UNDER 14.5 RUSH ATT | 54.4% | 4 | WIN |
| NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
| CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
| PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
| GB@ARI | ARI +7 | 54.8% | 5 | WIN |
| NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
| WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
| GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
| PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
| BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
| CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
| TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
| DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
| SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
| LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
| ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
| TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
| LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
| SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
| CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
| DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
| KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
| KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |
| HOU@BAL | HOU -125 | 58.5% | 7 | WIN |
| DET@CIN | DET -10 | 55.6% | 5 | WIN |
| DAL@NYJ | NYJ +1.5 | 53.7% | 3 | LOSS |
| TB@SEA | TB +3.5 | 54.9% | 4 | WIN |
| TEN@ARI | ARI -7 (BUY 0.5) | 54.9% | 4 | LOSS |
| DEN@PHI | DEN +4.5 | 57.5% | 7 | WIN |
| MIA@CAR | TETAIROA MCMILLAN OVER 58.5 RECV YDS | 54.5% | 4 | WIN |
| LV@IND | ASHTON JEANTY UNDER 67.5 RUSH YDS | 54.4% | 4 | WIN |
| SF@LAR | DEMARCUS ROBINSON OVER 29.5 RECV YDS | 55.7% | 5 | WIN |
| NYJ@MIA | NYJ +3 | 53.8 | 3 | LOSS |
| CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
| NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
| CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
| NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
| CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
| WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
| BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |
| TEN@HOU | TEN +7.5 | 57.9% | 7 | LOSS |
| LAC@NYG | LAC -6 | 57.3% | 7 | LOSS |
| NO@BUF | UNDER 48.5 | 55.1% | 3 | LOSS |
| GB@DAL | JAVONTE WILLIAMS UNDER 72.5 RUSH + REC YDS | 55.5% | 5 | LOSS |
| CAR@NE | DRAKE MAYE TO THROW AN INT | 56.6% | 6 | LOSS |
| SEA@ARI | SEA -125 | 57.7% | 6 | WIN |
| SEA@ARI | KYLER MURRAY TO THROW AN INT | 56.6% | 6 | WIN |
| DET@BAL | JAHMYR GIBBS OVER 0.5 RUSH TDS | 55.8% | 5 | WIN |
| DAL@CHI | DAL -120 | 58.7% | 6 | LOSS |
| PIT@NE | PIT -116 | 60.1% | 6 | WIN |
| ATL@CAR | ATL -4.5 | 55.4% | 5 | LOSS |