The September 28, 2025 clash between the Philadelphia Eagles and Tampa Bay Buccaneers at Raymond James Stadium is one of the marquee matchups of Week 4, featuring two undefeated teams with playoff aspirations and a shared desire to prove they are the NFC’s most complete squad. The Eagles come in as defending champions, and they look every bit the part of a team built for sustained success, with Jalen Hurts orchestrating an offense that blends explosive downfield passing with a bruising ground attack led by Saquon Barkley. Philadelphia has won by dictating pace, winning the line of scrimmage, and keeping defenses on their heels with a wide variety of personnel looks, but against a Todd Bowles-led Tampa defense, they’ll need to be especially sharp with protections and reads to avoid negative plays. Tampa Bay, meanwhile, has embraced the underdog mentality and parlayed it into a 3–0 start, but the loss of Mike Evans for this game due to a hamstring injury removes a critical vertical element from Baker Mayfield’s passing arsenal, which shifts added responsibility to younger wideouts and tight ends who must prove capable of creating separation against a disciplined Eagles secondary.

The Buccaneers will need to lean on their running game and scheme up creative play designs to keep Philadelphia from pinning their ears back and unleashing their pass rush, while defensively they must collapse Hurts’ pocket and maintain strict gap integrity to prevent big gains on the ground. Turnovers and field position will loom large here, especially since both teams have shown the ability to flip momentum quickly and convert mistakes into points. Special teams, often overlooked, may be decisive in a game with narrow margins, particularly in the battle for hidden yardage and long-range field goals. Betting trends show Tampa is 2–0 ATS this season and has been reliable at home, but the absence of Evans combined with Philadelphia’s 2–1 ATS record and championship pedigree makes the Eagles a strong favorite despite traveling south. With the total sitting in the mid-40s, oddsmakers expect a balanced contest where both defenses may bend but not break, but if Philadelphia hits on a few explosive plays early, they could tilt the scoring pace and force the Bucs into an uphill climb. Ultimately, this matchup is about adaptability: how the Buccaneers reinvent their offense without their star receiver, and how the Eagles handle a road test against an aggressive defense. Whichever team maintains composure, capitalizes in the red zone, and minimizes self-inflicted wounds will likely emerge as one of the NFC’s defining powerhouses moving forward.