Eagles vs Buccaneers Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 28)

Updated: 2025-09-21T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Philadelphia Eagles head down to Tampa Bay to take on the Buccaneers on September 28, 2025, in what has become a marquee NFC matchup between two 3–0 teams. The Eagles, defending champions, bring a high-octane offense led by Jalen Hurts and a roster built for depth, while the Bucs will try to test Philly’s balance and resilience at home.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 28, 2025

Start Time: 1:00 PM EST​

Venue: Raymond James Stadium​

Buccaneers Record: (3-0)

Eagles Record: (3-0)

OPENING ODDS

PHI Moneyline: -194

TB Moneyline: +161

PHI Spread: -3.5

TB Spread: +3.5

Over/Under: 44

PHI
Betting Trends

  • Philadelphia enters the game with a solid ATS history — they are listed with a 2–1 ATS record this season and have been reliable in “big game” spots. (From league-wide ATS trends showing Eagles at 2–1 in 2025)

TB
Betting Trends

  • Tampa Bay currently is 2–0 ATS in the 2025 season, having covered both games they’ve been favored in, giving bettors some confidence at home. (Team ATS trends show Buccaneers 2–0 ATS)

MATCHUP TRENDS

  • This matchup is the only one in Week 4 featuring two unbeaten teams, making it a favorite among bettors and media alike. The Bucs’ recent home games as favorites have seen strong public backing. Also, Tampa will be without star WR Mike Evans for several weeks due to a hamstring injury, a development that could shift value toward Philadelphia’s side. (Buccaneers’ Evans injury confirmed)

PHI vs. TB
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Hurts over 0.5 Passing Yards.

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Philadelphia vs Tampa Bay Prediction & Odds:
Free NFL Betting Insights for 9/28/25

The September 28, 2025 clash between the Philadelphia Eagles and Tampa Bay Buccaneers at Raymond James Stadium is one of the marquee matchups of Week 4, featuring two undefeated teams with playoff aspirations and a shared desire to prove they are the NFC’s most complete squad. The Eagles come in as defending champions, and they look every bit the part of a team built for sustained success, with Jalen Hurts orchestrating an offense that blends explosive downfield passing with a bruising ground attack led by Saquon Barkley. Philadelphia has won by dictating pace, winning the line of scrimmage, and keeping defenses on their heels with a wide variety of personnel looks, but against a Todd Bowles-led Tampa defense, they’ll need to be especially sharp with protections and reads to avoid negative plays. Tampa Bay, meanwhile, has embraced the underdog mentality and parlayed it into a 3–0 start, but the loss of Mike Evans for this game due to a hamstring injury removes a critical vertical element from Baker Mayfield’s passing arsenal, which shifts added responsibility to younger wideouts and tight ends who must prove capable of creating separation against a disciplined Eagles secondary.

The Buccaneers will need to lean on their running game and scheme up creative play designs to keep Philadelphia from pinning their ears back and unleashing their pass rush, while defensively they must collapse Hurts’ pocket and maintain strict gap integrity to prevent big gains on the ground. Turnovers and field position will loom large here, especially since both teams have shown the ability to flip momentum quickly and convert mistakes into points. Special teams, often overlooked, may be decisive in a game with narrow margins, particularly in the battle for hidden yardage and long-range field goals. Betting trends show Tampa is 2–0 ATS this season and has been reliable at home, but the absence of Evans combined with Philadelphia’s 2–1 ATS record and championship pedigree makes the Eagles a strong favorite despite traveling south. With the total sitting in the mid-40s, oddsmakers expect a balanced contest where both defenses may bend but not break, but if Philadelphia hits on a few explosive plays early, they could tilt the scoring pace and force the Bucs into an uphill climb. Ultimately, this matchup is about adaptability: how the Buccaneers reinvent their offense without their star receiver, and how the Eagles handle a road test against an aggressive defense. Whichever team maintains composure, capitalizes in the red zone, and minimizes self-inflicted wounds will likely emerge as one of the NFC’s defining powerhouses moving forward.

Philadelphia Eagles NFL Preview

The Philadelphia Eagles enter their September 28, 2025 road matchup against the Tampa Bay Buccaneers with the confidence of defending champions and a 3–0 record that has reaffirmed their place as one of the league’s premier teams. Jalen Hurts has been sharp in balancing his dual-threat ability, using his legs to extend plays and his arm to find A.J. Brown and DeVonta Smith for explosive gains, while Saquon Barkley’s arrival has added a powerful dimension to the run game that keeps defenses guessing. The offensive line remains one of the best in football, giving Hurts the time and space to operate efficiently, and against a Todd Bowles-coached defense that thrives on pressure and exotic looks, their ability to maintain composure in protection will be pivotal. Philadelphia’s defense has been equally impressive, anchored by a relentless pass rush and a deep rotation up front that can wear down opposing offensive lines; this week, they’ll face Baker Mayfield and a Tampa offense missing star wideout Mike Evans, which means their focus will be on shutting down the run early and forcing Mayfield to rely on less-proven receivers.

The Eagles’ secondary, led by veteran leadership and physicality, will need to maintain discipline against creative play designs and ensure no breakdowns occur in coverage that could hand Tampa momentum. On special teams, Philadelphia has been steady, with reliable kicking and coverage units that consistently help with field position. From a betting perspective, the Eagles’ 2–1 ATS record reflects a team that has generally matched expectations, and with Tampa adjusting to life without Evans, Philadelphia’s depth and balance make them attractive to back as road favorites. The key for the Eagles will be playing their brand of football—controlling the line of scrimmage, dictating pace, forcing turnovers on defense, and hitting on a few explosive plays to put the game out of reach. If Hurts remains poised under pressure and the defense continues to smother opponents, Philadelphia has every reason to believe they can leave Tampa with their perfect record intact and send a strong message to the rest of the NFC.

The Philadelphia Eagles head down to Tampa Bay to take on the Buccaneers on September 28, 2025, in what has become a marquee NFC matchup between two 3–0 teams. The Eagles, defending champions, bring a high-octane offense led by Jalen Hurts and a roster built for depth, while the Bucs will try to test Philly’s balance and resilience at home. Philadelphia vs Tampa Bay AI Prediction: Free NFL Betting Insights for Sep 28. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

Tampa Bay Buccaneers NFL Preview

The Tampa Bay Buccaneers enter their September 28, 2025 showdown with the Philadelphia Eagles riding a perfect 3–0 start, but the challenge ramps up significantly as they host the defending champions without star wide receiver Mike Evans, who is sidelined with a hamstring injury. Baker Mayfield has done well to manage games and deliver in clutch moments through the first three weeks, but against an Eagles defense loaded with depth and a relentless pass rush, he will need to be even sharper in spreading the ball to secondary options like Emeka Egbuka and Sterling Shepard, as well as leaning on tight ends and backs to keep the chains moving. The run game becomes crucial here, as sustaining drives and chewing clock will be vital to keep Jalen Hurts and Philadelphia’s offense off the field, while also giving Tampa’s defense time to rest. Todd Bowles’ defense, known for its aggressive schemes, will be tested against one of the league’s most balanced offenses, meaning the front seven must collapse the pocket and keep Hurts contained, while linebackers stay disciplined against play-action and Barkley’s rushing bursts.

The secondary, already under strain from Evans’ absence on the other side of the ball, must avoid breakdowns in coverage against Brown and Smith, both capable of flipping the game in a single play. Special teams may take on added weight, as field position and the ability to capitalize on every scoring chance will be critical in what is expected to be a hard-fought contest. Betting-wise, Tampa has been reliable early, going 2–0 ATS and showing resilience at home, but the loss of Evans has tilted market confidence toward Philadelphia, making this a true gut-check game for the Bucs. To pull off the upset, they’ll need to rally behind Mayfield, establish the run, lean on Bowles’ defense to generate turnovers or timely stops, and feed off the energy of their home crowd at Raymond James Stadium. If they can limit mistakes, control tempo, and make Philadelphia uncomfortable, the Buccaneers could not only prove they belong among the NFC elite but also deliver one of the season’s biggest statement wins.

Philadelphia vs. Tampa Bay Prop Picks (AI)

AI algorithm Remi is pouring through loads of datapoints on each line. In fact, anytime the Eagles and Buccaneers play there’s always several intriguing trends to key in on. Not to mention games played at Raymond James Stadium in Sep can often follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: J. Hurts over 0.5 Passing Yards.

Philadelphia vs. Tampa Bay Prediction (AI)

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Remi, our AI sports genius, has been pouring over mountains of data from every simulation between the Eagles and Buccaneers and using recursive machine learning and kick-ass AI to examine the data to a single cover probability.

Remi has been most fixated on the trending factor human bettors tend to put on coaching factors between a Eagles team going up against a possibly deflated Buccaneers team. We’ve found the true game analytics appear to reflect a strong lean against one Vegas line specifically.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI Philadelphia vs Tampa Bay picks, computer picks Eagles vs Buccaneers, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

Eagles Betting Trends

Philadelphia enters the game with a solid ATS history — they are listed with a 2–1 ATS record this season and have been reliable in “big game” spots. (From league-wide ATS trends showing Eagles at 2–1 in 2025)

Buccaneers Betting Trends

Tampa Bay currently is 2–0 ATS in the 2025 season, having covered both games they’ve been favored in, giving bettors some confidence at home. (Team ATS trends show Buccaneers 2–0 ATS)

Eagles vs. Buccaneers Matchup Trends

This matchup is the only one in Week 4 featuring two unbeaten teams, making it a favorite among bettors and media alike. The Bucs’ recent home games as favorites have seen strong public backing. Also, Tampa will be without star WR Mike Evans for several weeks due to a hamstring injury, a development that could shift value toward Philadelphia’s side. (Buccaneers’ Evans injury confirmed)

Philadelphia vs. Tampa Bay Game Info

Philadelphia vs Tampa Bay starts on September 28, 2025 at 1:00 PM EST.

Venue: Raymond James Stadium.

Spread: Tampa Bay +3.5
Moneyline: Philadelphia -194, Tampa Bay +161
Over/Under: 44

Philadelphia: (3-0)  |  Tampa Bay: (3-0)

Remi's searched hard and found the best prop for this matchup: J. Hurts over 0.5 Passing Yards.. Prices move—always shop for the best number.

This matchup is the only one in Week 4 featuring two unbeaten teams, making it a favorite among bettors and media alike. The Bucs’ recent home games as favorites have seen strong public backing. Also, Tampa will be without star WR Mike Evans for several weeks due to a hamstring injury, a development that could shift value toward Philadelphia’s side. (Buccaneers’ Evans injury confirmed)

PHI trend: Philadelphia enters the game with a solid ATS history — they are listed with a 2–1 ATS record this season and have been reliable in “big game” spots. (From league-wide ATS trends showing Eagles at 2–1 in 2025)

TB trend: Tampa Bay currently is 2–0 ATS in the 2025 season, having covered both games they’ve been favored in, giving bettors some confidence at home. (Team ATS trends show Buccaneers 2–0 ATS)

See our latest NFL picks and odds pages for 2025 to compare prices before you bet.

Philadelphia vs. Tampa Bay Odds

AI algorithm Remi is pouring through mountains of stats on each player. In fact, anytime the Philadelphia vs Tampa Bay trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps almost always follow normal, predictable betting trends.

Philadelphia vs Tampa Bay Opening Odds

PHI Moneyline: -194
TB Moneyline: +161
PHI Spread: -3.5
TB Spread: +3.5
Over/Under: 44

Philadelphia vs Tampa Bay Live Odds

Games PTS ML SPR O/U
Oct 30, 2025 8:15PM EDT
Baltimore Ravens
Miami Dolphins
10/30/25 8:15PM
Ravens
Dolphins
-440
+344
-7.5 (-110)
+7.5 (-110)
O 51 (-105)
U 51 (-115)
Nov 2, 2025 1:00PM EST
Chicago Bears
Cincinnati Bengals
11/2/25 1PM
Bears
Bengals
-160
+140
-2.5 (-125)
+2.5 (+105)
O 51.5 (-104)
U 51.5 (-116)
Nov 2, 2025 1:00PM EST
Indianapolis Colts
Pittsburgh Steelers
11/2/25 1PM
Colts
Steelers
-171
+150
-3 (-117)
+3 (-103)
O 50.5 (-110)
U 50.5 (-110)
Nov 2, 2025 1:00PM EST
Carolina Panthers
Green Bay Packers
11/2/25 1PM
Panthers
Packers
+613
-900
+13 (-105)
-13 (-115)
O 44 (-110)
U 44 (-110)
Nov 2, 2025 1:00PM EST
Atlanta Falcons
New England Patriots
11/2/25 1PM
Falcons
Patriots
+207
-250
+5 (-105)
-5 (-115)
O 45 (-110)
U 45 (-110)
Nov 2, 2025 1:00PM EST
Denver Broncos
Houston Texans
11/2/25 1PM
Broncos
Texans
+105
-125
+1 (+100)
-1 (-120)
O 40 (-110)
U 40 (-110)
Nov 2, 2025 1:00PM EST
San Francisco 49ers
New York Giants
11/2/25 1PM
49ers
Giants
-147
+127
-2.5 (-115)
+2.5 (-105)
O 49 (-103)
U 49 (-117)
Nov 2, 2025 1:00PM EST
Los Angeles Chargers
Tennessee Titans
11/2/25 1PM
Chargers
Titans
-500
+383
-9.5 (-105)
+9.5 (-115)
O 43.5 (-108)
U 43.5 (-112)
Nov 2, 2025 1:00PM EST
Minnesota Vikings
Detroit Lions
11/2/25 1PM
Vikings
Lions
+374
-485
+9 (-110)
-9 (-110)
O 47.5 (-117)
U 47.5 (-103)
Nov 2, 2025 4:05PM EST
New Orleans Saints
Los Angeles Rams
11/2/25 4:05PM
Saints
Rams
+754
-1200
+13.5 (+100)
-13.5 (-120)
O 44 (-107)
U 44 (-113)
Nov 2, 2025 4:05PM EST
Jacksonville Jaguars
Las Vegas Raiders
11/2/25 4:05PM
Jaguars
Raiders
-150
+130
-3 (+100)
+3 (-120)
O 44.5 (-110)
U 44.5 (-110)
Nov 2, 2025 4:25PM EST
Kansas City Chiefs
Buffalo Bills
11/2/25 4:25PM
Chiefs
Bills
-130
+110
-2 (-110)
+2 (-110)
O 52.5 (-110)
U 52.5 (-110)
Nov 2, 2025 8:20PM EST
Seattle Seahawks
Washington Commanders
11/2/25 8:20PM
Seahawks
Commanders
-163
+143
-3 (-113)
+3 (-107)
O 48 (-110)
U 48 (-110)
Nov 3, 2025 8:15PM EST
Arizona Cardinals
Dallas Cowboys
11/3/25 8:15PM
Cardinals
Cowboys
+130
-150
+2.5 (-105)
-2.5 (-115)
O 53.5 (-105)
U 53.5 (-115)
Nov 6, 2025 8:15PM EST
Las Vegas Raiders
Denver Broncos
11/6/25 8:15PM
Raiders
Broncos
+370
-480
+9.5 (-106)
-9.5 (-114)
O 42.5 (-110)
U 42.5 (-110)
Nov 9, 2025 9:30AM EST
Atlanta Falcons
Indianapolis Colts
11/9/25 9:30AM
Falcons
Colts
+290
-360
+7 (-106)
-7 (-114)
O 48.5 (-110)
U 48.5 (-110)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Philadelphia Eagles vs. Tampa Bay Buccaneers on September 28, 2025 at Raymond James Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TB@NO TB -3.5 52.3% 1 WIN
GB@PIT GB -2.5 52.3% 1 WIN
SF@HOU SF +2.5 56.0% 6 LOSS
NYG@PHI NYG +7.5 53.9% 3 LOSS
BUF@CAR CAR +7.5 54.2% 3 LOSS
DAL@DEN DAL +3.5 55.0% 4 LOSS
MIA@ATL MIA +7 54.3% 4 WIN
CLE@NE CLE +7 56.8% 6 LOSS
TB@NO BAKER MAYFIELD OVER 15.5 RUSH YDS 56.6% 6 LOSS
MIN@LAC JUSTIN HERBERT PASS ATT UNDER 35.5 55.5% 5 WIN
TB@DET TB +6.5 54.4% 4 LOSS
TB@DET RACHAAD WHITE UNDER 14.5 RUSH ATT 54.4% 4 WIN
NE@TEN NE -6.5 55.2% 5 WIN
CAR@NYJ CAR -110 57.4 4 WIN
PHI@MIN PHI -130 58.0% 6 WIN
GB@ARI ARI +7 54.8% 5 WIN
NO@CHI NO +4.5 57.4% 7 LOSS
WAS@DAL JAYDEN DANIELS 1H RUSH YDS OVER 22.5 56.1% 5 WIN
GB@ARI JORDAN LOVE 1Q PASS YDS OVER 54.5 56.6% 6 WIN
PIT@CIN JONNU SMITH RECEPTIONS OVER 3.5 55.3% 5 LOSS
BUF@ATL BUF -3.5 54.7% 4 LOSS
CHI@WAS JAYDEN DANIELS OVER 1.5 PASS TDS 56.6% 6 WIN
TEN@LV UNDER 42 54.8% 3 WIN
DET@KC DET +2.5 55.7% 7 LOSS
SEA@JAC SEA -112 55.7% 5 WIN
LAC@MIA LAC -3.5 54.0% 3 LOSS
ARI@IND IND -8.5 55.6% 5 LOSS
TEN@LV TEN +4.5 56.7% 6 LOSS
LAR@BAL LAR -7 56.2% 6 WIN
SF@TB SF +3.5 57.2% 7 LOSS
CLE@PIT JAYLEN WARREN UNDER 46.5 RUSH YDS 54.4% 4 LOSS
DEN@NYJ BREECE HALL OVER 26.5 RECV YDS 55.0% 4 LOSS
KC@JAC UNDER 45.5 54.9% 3 LOSS
KC@JAC PATRICK MAHOMES UNDER 23.5 PASS COMP 56.6% 6 LOSS
HOU@BAL HOU -125 58.5% 7 WIN
DET@CIN DET -10 55.6% 5 WIN
DAL@NYJ NYJ +1.5 53.7% 3 LOSS
TB@SEA TB +3.5 54.9% 4 WIN
TEN@ARI ARI -7 (BUY 0.5) 54.9% 4 LOSS
DEN@PHI DEN +4.5 57.5% 7 WIN
MIA@CAR TETAIROA MCMILLAN OVER 58.5 RECV YDS 54.5% 4 WIN
LV@IND ASHTON JEANTY UNDER 67.5 RUSH YDS 54.4% 4 WIN
SF@LAR DEMARCUS ROBINSON OVER 29.5 RECV YDS 55.7% 5 WIN
NYJ@MIA NYJ +3 53.8 3 LOSS
CIN@DEN DEN -7.5 54.8 4 WIN
NYJ@MIA OVER 44 52.9% 2 WIN
CIN@DEN UNDER 44.5 53.7% 3 WIN
NYJ@MIA GARRETT WILSON UNDER 9 TARGETS 53.7% 3 WIN
CIN@DEN TEE HIGGINS OVER 6.5 RECV TARGETS 55.5% 5 LOSS
WAS@ATL ATL -2.5 54.3 4 WIN
BAL@KC BAL -2.5 56.3% 6 LOSS