Eagles vs Buccaneers Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 28)
Updated: 2025-09-21T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props
The Philadelphia Eagles head down to Tampa Bay to take on the Buccaneers on September 28, 2025, in what has become a marquee NFC matchup between two 3–0 teams. The Eagles, defending champions, bring a high-octane offense led by Jalen Hurts and a roster built for depth, while the Bucs will try to test Philly’s balance and resilience at home.
Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.
GAME INFO
Date: Sep 28, 2025
Start Time: 1:00 PM EST
Venue: Raymond James Stadium
Buccaneers Record: (3-0)
Eagles Record: (3-0)
OPENING ODDS
PHI Moneyline: -194
TB Moneyline: +161
PHI Spread: -3.5
TB Spread: +3.5
Over/Under: 44
PHI
Betting Trends
- Philadelphia enters the game with a solid ATS history — they are listed with a 2–1 ATS record this season and have been reliable in “big game” spots. (From league-wide ATS trends showing Eagles at 2–1 in 2025)
TB
Betting Trends
- Tampa Bay currently is 2–0 ATS in the 2025 season, having covered both games they’ve been favored in, giving bettors some confidence at home. (Team ATS trends show Buccaneers 2–0 ATS)
MATCHUP TRENDS
- This matchup is the only one in Week 4 featuring two unbeaten teams, making it a favorite among bettors and media alike. The Bucs’ recent home games as favorites have seen strong public backing. Also, Tampa will be without star WR Mike Evans for several weeks due to a hamstring injury, a development that could shift value toward Philadelphia’s side. (Buccaneers’ Evans injury confirmed)
PHI vs. TB
Best Prop Bet
- Remi's searched hard and found the best prop for this matchup: J. Hurts over 0.5 Passing Yards.
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Philadelphia vs Tampa Bay Prediction & Odds:
Free NFL Betting Insights for 9/28/25
The Buccaneers will need to lean on their running game and scheme up creative play designs to keep Philadelphia from pinning their ears back and unleashing their pass rush, while defensively they must collapse Hurts’ pocket and maintain strict gap integrity to prevent big gains on the ground. Turnovers and field position will loom large here, especially since both teams have shown the ability to flip momentum quickly and convert mistakes into points. Special teams, often overlooked, may be decisive in a game with narrow margins, particularly in the battle for hidden yardage and long-range field goals. Betting trends show Tampa is 2–0 ATS this season and has been reliable at home, but the absence of Evans combined with Philadelphia’s 2–1 ATS record and championship pedigree makes the Eagles a strong favorite despite traveling south. With the total sitting in the mid-40s, oddsmakers expect a balanced contest where both defenses may bend but not break, but if Philadelphia hits on a few explosive plays early, they could tilt the scoring pace and force the Bucs into an uphill climb. Ultimately, this matchup is about adaptability: how the Buccaneers reinvent their offense without their star receiver, and how the Eagles handle a road test against an aggressive defense. Whichever team maintains composure, capitalizes in the red zone, and minimizes self-inflicted wounds will likely emerge as one of the NFC’s defining powerhouses moving forward.
Who else but JD? pic.twitter.com/UU16Xd7OrV
— Philadelphia Eagles (@Eagles) September 24, 2025
Philadelphia Eagles NFL Preview
The Philadelphia Eagles enter their September 28, 2025 road matchup against the Tampa Bay Buccaneers with the confidence of defending champions and a 3–0 record that has reaffirmed their place as one of the league’s premier teams. Jalen Hurts has been sharp in balancing his dual-threat ability, using his legs to extend plays and his arm to find A.J. Brown and DeVonta Smith for explosive gains, while Saquon Barkley’s arrival has added a powerful dimension to the run game that keeps defenses guessing. The offensive line remains one of the best in football, giving Hurts the time and space to operate efficiently, and against a Todd Bowles-coached defense that thrives on pressure and exotic looks, their ability to maintain composure in protection will be pivotal. Philadelphia’s defense has been equally impressive, anchored by a relentless pass rush and a deep rotation up front that can wear down opposing offensive lines; this week, they’ll face Baker Mayfield and a Tampa offense missing star wideout Mike Evans, which means their focus will be on shutting down the run early and forcing Mayfield to rely on less-proven receivers.
The Eagles’ secondary, led by veteran leadership and physicality, will need to maintain discipline against creative play designs and ensure no breakdowns occur in coverage that could hand Tampa momentum. On special teams, Philadelphia has been steady, with reliable kicking and coverage units that consistently help with field position. From a betting perspective, the Eagles’ 2–1 ATS record reflects a team that has generally matched expectations, and with Tampa adjusting to life without Evans, Philadelphia’s depth and balance make them attractive to back as road favorites. The key for the Eagles will be playing their brand of football—controlling the line of scrimmage, dictating pace, forcing turnovers on defense, and hitting on a few explosive plays to put the game out of reach. If Hurts remains poised under pressure and the defense continues to smother opponents, Philadelphia has every reason to believe they can leave Tampa with their perfect record intact and send a strong message to the rest of the NFC.
Credit: USA TODAY/IMAGN
Tampa Bay Buccaneers NFL Preview
The Tampa Bay Buccaneers enter their September 28, 2025 showdown with the Philadelphia Eagles riding a perfect 3–0 start, but the challenge ramps up significantly as they host the defending champions without star wide receiver Mike Evans, who is sidelined with a hamstring injury. Baker Mayfield has done well to manage games and deliver in clutch moments through the first three weeks, but against an Eagles defense loaded with depth and a relentless pass rush, he will need to be even sharper in spreading the ball to secondary options like Emeka Egbuka and Sterling Shepard, as well as leaning on tight ends and backs to keep the chains moving. The run game becomes crucial here, as sustaining drives and chewing clock will be vital to keep Jalen Hurts and Philadelphia’s offense off the field, while also giving Tampa’s defense time to rest. Todd Bowles’ defense, known for its aggressive schemes, will be tested against one of the league’s most balanced offenses, meaning the front seven must collapse the pocket and keep Hurts contained, while linebackers stay disciplined against play-action and Barkley’s rushing bursts.
The secondary, already under strain from Evans’ absence on the other side of the ball, must avoid breakdowns in coverage against Brown and Smith, both capable of flipping the game in a single play. Special teams may take on added weight, as field position and the ability to capitalize on every scoring chance will be critical in what is expected to be a hard-fought contest. Betting-wise, Tampa has been reliable early, going 2–0 ATS and showing resilience at home, but the loss of Evans has tilted market confidence toward Philadelphia, making this a true gut-check game for the Bucs. To pull off the upset, they’ll need to rally behind Mayfield, establish the run, lean on Bowles’ defense to generate turnovers or timely stops, and feed off the energy of their home crowd at Raymond James Stadium. If they can limit mistakes, control tempo, and make Philadelphia uncomfortable, the Buccaneers could not only prove they belong among the NFC elite but also deliver one of the season’s biggest statement wins.
"You don't have to tell me... I know I look good." 😎
— Tampa Bay Buccaneers (@Buccaneers) September 24, 2025
Enjoy 7 minutes & 27 seconds of Baker Mayfield mic'd up. pic.twitter.com/HffIYGcDMc
Philadelphia vs. Tampa Bay Prop Picks (AI)
Philadelphia vs. Tampa Bay Prediction (AI)
Remi, our AI sports genius, has been pouring over mountains of data from every simulation between the Eagles and Buccaneers and using recursive machine learning and kick-ass AI to examine the data to a single cover probability.
Remi has been most fixated on the trending factor human bettors tend to put on coaching factors between a Eagles team going up against a possibly deflated Buccaneers team. We’ve found the true game analytics appear to reflect a strong lean against one Vegas line specifically.
Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.
Below is our current AI Philadelphia vs Tampa Bay picks, computer picks Eagles vs Buccaneers, best bets, model edges, confidence ratings.
| DATE | GAME | LEAN | %WIN | UNITS | LEVEL | |
|---|---|---|---|---|---|---|
| ACTIVE PICKS LOCKED - SEE NOW | ||||||
These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.
Eagles Betting Trends
Philadelphia enters the game with a solid ATS history — they are listed with a 2–1 ATS record this season and have been reliable in “big game” spots. (From league-wide ATS trends showing Eagles at 2–1 in 2025)
Buccaneers Betting Trends
Tampa Bay currently is 2–0 ATS in the 2025 season, having covered both games they’ve been favored in, giving bettors some confidence at home. (Team ATS trends show Buccaneers 2–0 ATS)
Eagles vs. Buccaneers Matchup Trends
This matchup is the only one in Week 4 featuring two unbeaten teams, making it a favorite among bettors and media alike. The Bucs’ recent home games as favorites have seen strong public backing. Also, Tampa will be without star WR Mike Evans for several weeks due to a hamstring injury, a development that could shift value toward Philadelphia’s side. (Buccaneers’ Evans injury confirmed)
Philadelphia vs. Tampa Bay Game Info
What time does Philadelphia vs Tampa Bay start on September 28, 2025?
Philadelphia vs Tampa Bay starts on September 28, 2025 at 1:00 PM EST.
Where is Philadelphia vs Tampa Bay being played?
Venue: Raymond James Stadium.
What are the opening odds for Philadelphia vs Tampa Bay?
Spread: Tampa Bay +3.5
Moneyline: Philadelphia -194, Tampa Bay +161
Over/Under: 44
What are the records for Philadelphia vs Tampa Bay?
Philadelphia: (3-0) | Tampa Bay: (3-0)
What is the AI best bet for Philadelphia vs Tampa Bay?
Remi's searched hard and found the best prop for this matchup: J. Hurts over 0.5 Passing Yards.. Prices move—always shop for the best number.
What are Philadelphia vs Tampa Bay trending bets?
This matchup is the only one in Week 4 featuring two unbeaten teams, making it a favorite among bettors and media alike. The Bucs’ recent home games as favorites have seen strong public backing. Also, Tampa will be without star WR Mike Evans for several weeks due to a hamstring injury, a development that could shift value toward Philadelphia’s side. (Buccaneers’ Evans injury confirmed)
What are Philadelphia trending bets?
PHI trend: Philadelphia enters the game with a solid ATS history — they are listed with a 2–1 ATS record this season and have been reliable in “big game” spots. (From league-wide ATS trends showing Eagles at 2–1 in 2025)
What are Tampa Bay trending bets?
TB trend: Tampa Bay currently is 2–0 ATS in the 2025 season, having covered both games they’ve been favored in, giving bettors some confidence at home. (Team ATS trends show Buccaneers 2–0 ATS)
Where can I find AI Picks for Philadelphia vs Tampa Bay?
See our latest NFL picks and odds pages for 2025 to compare prices before you bet.
Philadelphia vs. Tampa Bay Odds
AI algorithm Remi is pouring through mountains of stats on each player. In fact, anytime the Philadelphia vs Tampa Bay trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps almost always follow normal, predictable betting trends.
Philadelphia vs Tampa Bay Opening Odds
PHI Moneyline:
-194 TB Moneyline: +161
PHI Spread: -3.5
TB Spread: +3.5
Over/Under: 44
Philadelphia vs Tampa Bay Live Odds
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|---|---|---|---|---|---|
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–
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-440
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O 51 (-105)
U 51 (-115)
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O 50.5 (-110)
U 50.5 (-110)
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–
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+613
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+13 (-105)
-13 (-115)
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O 44 (-110)
U 44 (-110)
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Nov 2, 2025 1:00PM EST
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Patriots
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–
–
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+207
-250
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+5 (-105)
-5 (-115)
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O 45 (-110)
U 45 (-110)
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Nov 2, 2025 1:00PM EST
Denver Broncos
Houston Texans
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Broncos
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–
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+105
-125
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+1 (+100)
-1 (-120)
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O 40 (-110)
U 40 (-110)
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Nov 2, 2025 1:00PM EST
San Francisco 49ers
New York Giants
11/2/25 1PM
49ers
Giants
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–
–
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-147
+127
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-2.5 (-115)
+2.5 (-105)
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O 49 (-103)
U 49 (-117)
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Nov 2, 2025 1:00PM EST
Los Angeles Chargers
Tennessee Titans
11/2/25 1PM
Chargers
Titans
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–
–
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-500
+383
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-9.5 (-105)
+9.5 (-115)
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O 43.5 (-108)
U 43.5 (-112)
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Nov 2, 2025 1:00PM EST
Minnesota Vikings
Detroit Lions
11/2/25 1PM
Vikings
Lions
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–
–
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+374
-485
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+9 (-110)
-9 (-110)
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O 47.5 (-117)
U 47.5 (-103)
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Nov 2, 2025 4:05PM EST
New Orleans Saints
Los Angeles Rams
11/2/25 4:05PM
Saints
Rams
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–
–
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+754
-1200
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+13.5 (+100)
-13.5 (-120)
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O 44 (-107)
U 44 (-113)
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Nov 2, 2025 4:05PM EST
Jacksonville Jaguars
Las Vegas Raiders
11/2/25 4:05PM
Jaguars
Raiders
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–
–
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-150
+130
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-3 (+100)
+3 (-120)
|
O 44.5 (-110)
U 44.5 (-110)
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Nov 2, 2025 4:25PM EST
Kansas City Chiefs
Buffalo Bills
11/2/25 4:25PM
Chiefs
Bills
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–
–
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-130
+110
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-2 (-110)
+2 (-110)
|
O 52.5 (-110)
U 52.5 (-110)
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Nov 2, 2025 8:20PM EST
Seattle Seahawks
Washington Commanders
11/2/25 8:20PM
Seahawks
Commanders
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–
–
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-163
+143
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-3 (-113)
+3 (-107)
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O 48 (-110)
U 48 (-110)
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Nov 3, 2025 8:15PM EST
Arizona Cardinals
Dallas Cowboys
11/3/25 8:15PM
Cardinals
Cowboys
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–
–
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+130
-150
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+2.5 (-105)
-2.5 (-115)
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O 53.5 (-105)
U 53.5 (-115)
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Nov 6, 2025 8:15PM EST
Las Vegas Raiders
Denver Broncos
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Raiders
Broncos
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–
–
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+370
-480
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+9.5 (-106)
-9.5 (-114)
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O 42.5 (-110)
U 42.5 (-110)
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Nov 9, 2025 9:30AM EST
Atlanta Falcons
Indianapolis Colts
11/9/25 9:30AM
Falcons
Colts
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–
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+290
-360
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+7 (-106)
-7 (-114)
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O 48.5 (-110)
U 48.5 (-110)
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NFL Past Picks
Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.
This preview covers Philadelphia Eagles vs. Tampa Bay Buccaneers on September 28, 2025 at Raymond James Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.
Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.
| LEAN | %WIN | UNITS | RESULT | |
|---|---|---|---|---|
| TB@NO | TB -3.5 | 52.3% | 1 | WIN |
| GB@PIT | GB -2.5 | 52.3% | 1 | WIN |
| SF@HOU | SF +2.5 | 56.0% | 6 | LOSS |
| NYG@PHI | NYG +7.5 | 53.9% | 3 | LOSS |
| BUF@CAR | CAR +7.5 | 54.2% | 3 | LOSS |
| DAL@DEN | DAL +3.5 | 55.0% | 4 | LOSS |
| MIA@ATL | MIA +7 | 54.3% | 4 | WIN |
| CLE@NE | CLE +7 | 56.8% | 6 | LOSS |
| TB@NO | BAKER MAYFIELD OVER 15.5 RUSH YDS | 56.6% | 6 | LOSS |
| MIN@LAC | JUSTIN HERBERT PASS ATT UNDER 35.5 | 55.5% | 5 | WIN |
| TB@DET | TB +6.5 | 54.4% | 4 | LOSS |
| TB@DET | RACHAAD WHITE UNDER 14.5 RUSH ATT | 54.4% | 4 | WIN |
| NE@TEN | NE -6.5 | 55.2% | 5 | WIN |
| CAR@NYJ | CAR -110 | 57.4 | 4 | WIN |
| PHI@MIN | PHI -130 | 58.0% | 6 | WIN |
| GB@ARI | ARI +7 | 54.8% | 5 | WIN |
| NO@CHI | NO +4.5 | 57.4% | 7 | LOSS |
| WAS@DAL | JAYDEN DANIELS 1H RUSH YDS OVER 22.5 | 56.1% | 5 | WIN |
| GB@ARI | JORDAN LOVE 1Q PASS YDS OVER 54.5 | 56.6% | 6 | WIN |
| PIT@CIN | JONNU SMITH RECEPTIONS OVER 3.5 | 55.3% | 5 | LOSS |
| BUF@ATL | BUF -3.5 | 54.7% | 4 | LOSS |
| CHI@WAS | JAYDEN DANIELS OVER 1.5 PASS TDS | 56.6% | 6 | WIN |
| TEN@LV | UNDER 42 | 54.8% | 3 | WIN |
| DET@KC | DET +2.5 | 55.7% | 7 | LOSS |
| SEA@JAC | SEA -112 | 55.7% | 5 | WIN |
| LAC@MIA | LAC -3.5 | 54.0% | 3 | LOSS |
| ARI@IND | IND -8.5 | 55.6% | 5 | LOSS |
| TEN@LV | TEN +4.5 | 56.7% | 6 | LOSS |
| LAR@BAL | LAR -7 | 56.2% | 6 | WIN |
| SF@TB | SF +3.5 | 57.2% | 7 | LOSS |
| CLE@PIT | JAYLEN WARREN UNDER 46.5 RUSH YDS | 54.4% | 4 | LOSS |
| DEN@NYJ | BREECE HALL OVER 26.5 RECV YDS | 55.0% | 4 | LOSS |
| KC@JAC | UNDER 45.5 | 54.9% | 3 | LOSS |
| KC@JAC | PATRICK MAHOMES UNDER 23.5 PASS COMP | 56.6% | 6 | LOSS |
| HOU@BAL | HOU -125 | 58.5% | 7 | WIN |
| DET@CIN | DET -10 | 55.6% | 5 | WIN |
| DAL@NYJ | NYJ +1.5 | 53.7% | 3 | LOSS |
| TB@SEA | TB +3.5 | 54.9% | 4 | WIN |
| TEN@ARI | ARI -7 (BUY 0.5) | 54.9% | 4 | LOSS |
| DEN@PHI | DEN +4.5 | 57.5% | 7 | WIN |
| MIA@CAR | TETAIROA MCMILLAN OVER 58.5 RECV YDS | 54.5% | 4 | WIN |
| LV@IND | ASHTON JEANTY UNDER 67.5 RUSH YDS | 54.4% | 4 | WIN |
| SF@LAR | DEMARCUS ROBINSON OVER 29.5 RECV YDS | 55.7% | 5 | WIN |
| NYJ@MIA | NYJ +3 | 53.8 | 3 | LOSS |
| CIN@DEN | DEN -7.5 | 54.8 | 4 | WIN |
| NYJ@MIA | OVER 44 | 52.9% | 2 | WIN |
| CIN@DEN | UNDER 44.5 | 53.7% | 3 | WIN |
| NYJ@MIA | GARRETT WILSON UNDER 9 TARGETS | 53.7% | 3 | WIN |
| CIN@DEN | TEE HIGGINS OVER 6.5 RECV TARGETS | 55.5% | 5 | LOSS |
| WAS@ATL | ATL -2.5 | 54.3 | 4 | WIN |
| BAL@KC | BAL -2.5 | 56.3% | 6 | LOSS |