Chargers vs Giants Prediction — AI Finds CAN'T MISS NFL Lines & Props (Sep 28)

Updated: 2025-09-21T02:28:40.156150ZBy Remi at Leans.AI — AI picks for ATS, ML, OU & props

The Los Angeles Chargers travel to face the New York Giants on September 28, 2025, looking to stay perfect at 4–0, while the Giants aim to avoid starting 0–4 under a new quarterback regime. The Chargers opened as 6.5-point favorites in East Rutherford, with a total line in the neighborhood of 44.5.

Get key insights, betting trends, and AI-powered predictions to help incorporate into your betting strategies.

AI Sports Betting Algorithm Remi

GAME INFO

Date: Sep 28, 2025

Start Time: 1:00 PM EST​

Venue: MetLife Stadium​

Giants Record: (0-3)

Chargers Record: (3-0)

OPENING ODDS

LAC Moneyline: -295

NYG Moneyline: +236

LAC Spread: -6.5

NYG Spread: +6.5

Over/Under: 44

LAC
Betting Trends

  • Los Angeles is 6–1 ATS in its last 7 games overall, and 4–1 ATS in their last 5 on the road.

NYG
Betting Trends

  • The Giants are 2–6 SU in their last 8 home games and have struggled as underdogs, going 1–14 in SU in that span.

MATCHUP TRENDS

  • Los Angeles is 5–0 ATS in its last five meetings with New York. Also, the over has hit in 4 of the last 5 Chargers-Giants matchups.

LAC vs. NYG
Best Prop Bet

  • Remi's searched hard and found the best prop for this matchup: J. Dart under 36.5 Rushing Yards.

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Los Angeles vs New York Prediction & Odds:
Free NFL Betting Insights for 9/28/25

The September 28, 2025 matchup between the Los Angeles Chargers and New York Giants at MetLife Stadium looks like one of the more lopsided contests on the Week 4 slate, as the undefeated Chargers enter with momentum and a polished offense while the winless Giants turn to a rookie quarterback to salvage their season. Los Angeles, led by Justin Herbert, has been sharp on both sides of the ball, with an offense that ranks among the NFL’s best in yards per game and a defense that has thrived on creating pressure and forcing turnovers. Herbert’s ability to distribute the ball efficiently to a deep group of receivers, paired with a running game that keeps defenses honest, has allowed the Chargers to set tempo early in games and control the pace for four quarters. Against a Giants defense that has struggled to stop both the pass and the run, the Chargers will likely lean into play-action and vertical concepts to create explosive plays while relying on their offensive line to keep Herbert upright. The Giants, meanwhile, are desperate for a spark after an 0–3 start, benching Russell Wilson in favor of rookie Jaxson Dart, whose debut as the starter will come against one of the AFC’s hottest teams.

Protecting Dart will be paramount, as the Chargers’ front seven can collapse pockets quickly and force hurried decisions, and his best chance for success will come through quick throws, screens, and a run game that must stay productive enough to prevent Los Angeles from teeing off on obvious passing downs. New York’s defense faces an equally tall task, needing to generate pressure on Herbert without leaving their secondary exposed to one-on-one mismatches that have burned them throughout September. Historically, the Chargers have dominated this matchup, going 5–0 ATS in their last five meetings against the Giants, and the betting line of –6.5 reflects confidence in their ability to continue that trend. The total of 44.5 suggests modest scoring expectations, but with Herbert’s offense capable of pushing 30-plus points by itself, much of that number may depend on whether Dart and the Giants’ offense can keep pace. For the Giants to pull an upset, they’ll need turnovers, field position wins, and a disciplined defensive game that limits explosive plays—factors that have been elusive so far this season. For the Chargers, the formula is straightforward: protect Herbert, let their playmakers exploit mismatches, and pressure the rookie quarterback into mistakes. If executed, Los Angeles has the tools to remain undefeated and cover the spread, while New York will be left searching for answers in a season that is already threatening to spiral.

Los Angeles Chargers NFL Preview

The Los Angeles Chargers head into MetLife Stadium on September 28, 2025 with confidence and purpose, looking to extend their perfect 3–0 start against a New York Giants team still searching for its first win of the season. Justin Herbert has been the driving force behind their success, orchestrating one of the league’s most efficient offenses with precision passing, smart decision-making, and a strong supporting cast of receivers who consistently create mismatches. The offensive line has done its part as well, giving Herbert time to operate and paving the way for a balanced run game that forces defenses to respect multiple threats. Against a Giants defense that has struggled both against the run and in coverage, the Chargers’ offense is positioned to dictate tempo early, using play-action and vertical shots to open up scoring opportunities. Defensively, Los Angeles has tightened up significantly since last season, combining steady pass rush pressure with opportunistic play in the secondary that has helped generate turnovers and momentum swings.

Their mission against rookie quarterback Jaxson Dart will be to collapse pockets quickly, take away his comfort reads, and force him to play from behind the sticks where inexperience can lead to costly mistakes. Special teams has also been steady, with the kicking game reliable and coverage units giving the Chargers an edge in hidden yardage that often matters most on the road. From a betting standpoint, Los Angeles has been one of the most profitable teams, covering six of their last seven games overall and four of their last five on the road, while also owning this series historically with a 5–0 ATS record in their last five meetings against New York. The total sits at 44.5, and given the Chargers’ offensive firepower, the over has appeal, particularly since four of the last five meetings between these two teams have gone that way. Ultimately, the Chargers’ formula is straightforward: protect Herbert, attack aggressively with their versatile offense, and pressure Dart into mistakes. If they execute on those fronts, Los Angeles not only has the edge to stay unbeaten but also to cover the spread comfortably, sending a strong message that they are serious contenders in the AFC.

The Los Angeles Chargers travel to face the New York Giants on September 28, 2025, looking to stay perfect at 4–0, while the Giants aim to avoid starting 0–4 under a new quarterback regime. The Chargers opened as 6.5-point favorites in East Rutherford, with a total line in the neighborhood of 44.5. Los Angeles vs New York AI Prediction: Free NFL Betting Insights for Sep 28. Credit USA TODAY/IMAGN

Credit: USA TODAY/IMAGN

New York Giants NFL Preview

The New York Giants return to MetLife Stadium on September 28, 2025 desperate to avoid an 0–4 start, but they face a daunting challenge against the unbeaten Los Angeles Chargers. After three straight losses, the Giants made a bold move by turning to rookie quarterback Jaxson Dart, benching veteran Russell Wilson in hopes that fresh energy under center can revive an offense that has been among the league’s least productive. For Dart, success will hinge on protection from an offensive line that has struggled to keep pressure away, as the Chargers’ front seven is relentless and capable of collapsing the pocket quickly. Expect New York to lean on a run-heavy script and short, high-percentage throws to establish rhythm, slow down Los Angeles’ pass rush, and keep drives alive. The Giants’ receivers will need to step up with precise route running and yards after the catch, because asking Dart to push the ball downfield too often against a disciplined Chargers secondary could spell disaster.

Defensively, New York has to find ways to disrupt Justin Herbert’s timing, whether through blitz packages, disguised coverages, or forcing turnovers that can shift momentum in front of their home crowd. Discipline in the secondary is crucial, as Herbert has been surgical in exploiting breakdowns, and the Giants’ history of allowing big plays is exactly what Los Angeles thrives on. Special teams must also contribute, as field position battles will be key to keeping this game competitive and giving Dart manageable situations. From a betting perspective, the Giants have been a tough sell, going 2–6 straight up in their last eight home games and a dismal 1–14 straight up as underdogs in that span, while the Chargers have dominated this head-to-head series with a perfect 5–0 ATS run. For New York, the formula is clear but demanding: protect their rookie quarterback, establish the run, limit explosive plays defensively, and feed off the energy of their home fans. If the Giants can play mistake-free football and force the Chargers into uncharacteristic errors, they could turn what looks like a mismatch into a scrappy fight, but without significant improvement, this may be another long afternoon in East Rutherford.

Los Angeles vs. New York Prop Picks (AI)

AI algorithm Remi is pouring through tons of datapoints on each player. In fact, anytime the Chargers and Giants play there’s always several intriguing observations to key in on. Not to mention games played at MetLife Stadium in Sep almost always follow normal, predictable patterns.
Remi's searched hard and found the best prop for this matchup: J. Dart under 36.5 Rushing Yards.

Los Angeles vs. New York Prediction (AI)

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Remi, our AI sports algorithm, has been pouring over millions of data from every facet between the Chargers and Giants and using recursive machine learning and impressive AI to examine the data to a single cover probability.

Interestingly enough, the data has been most fixated on the linear correlation of weight emotional bettors regularly put on New York’s strength factors between a Chargers team going up against a possibly healthy Giants team. We’ve found the true game analytics appear to reflect a strong lean against one Vegas line in particular.

Unlock this in-depth AI prediction and all of our NFL AI picks for FREE now.

Below is our current AI Los Angeles vs New York picks, computer picks Chargers vs Giants, best bets, model edges, confidence ratings.

DATE GAME LEAN %WIN UNITS LEVEL
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These picks update as information changes—injury reports, weather, and market movement. Each line shows our model’s fair price, the edge versus the market, and a unit confidence rating (1–10). Odds and availability vary by sportsbook and time. Edges are computed against the listed price; value may change after line moves. Always shop for the best number. See the full NFL Schedule.

Chargers Betting Trends

Los Angeles is 6–1 ATS in its last 7 games overall, and 4–1 ATS in their last 5 on the road.

Giants Betting Trends

The Giants are 2–6 SU in their last 8 home games and have struggled as underdogs, going 1–14 in SU in that span.

Chargers vs. Giants Matchup Trends

Los Angeles is 5–0 ATS in its last five meetings with New York. Also, the over has hit in 4 of the last 5 Chargers-Giants matchups.

Los Angeles vs. New York Game Info

Los Angeles vs New York starts on September 28, 2025 at 1:00 PM EST.

Spread: New York +6.5
Moneyline: Los Angeles -295, New York +236
Over/Under: 44

Los Angeles: (3-0)  |  New York: (0-3)

Remi's searched hard and found the best prop for this matchup: J. Dart under 36.5 Rushing Yards.. Prices move—always shop for the best number.

Los Angeles is 5–0 ATS in its last five meetings with New York. Also, the over has hit in 4 of the last 5 Chargers-Giants matchups.

LAC trend: Los Angeles is 6–1 ATS in its last 7 games overall, and 4–1 ATS in their last 5 on the road.

NYG trend: The Giants are 2–6 SU in their last 8 home games and have struggled as underdogs, going 1–14 in SU in that span.

See our latest NFL picks and odds pages for 2025 to compare prices before you bet.

Los Angeles vs. New York Odds

AI algorithm Remi is pouring through mountains of data points on each player. In fact, anytime the Los Angeles vs New York trends are analyzed, there’s always several intriguing observations to key in on. Not to mention games played at extreme temps rarely follow normal, predictable patterns.

Los Angeles vs New York Opening Odds

LAC Moneyline: -295
NYG Moneyline: +236
LAC Spread: -6.5
NYG Spread: +6.5
Over/Under: 44

Los Angeles vs New York Live Odds

Games PTS ML SPR O/U
Oct 30, 2025 8:15PM EDT
Baltimore Ravens
Miami Dolphins
10/30/25 8:15PM
Ravens
Dolphins
-420
+330
-7.5 (-115)
+7.5 (-105)
O 51.5 (-105)
U 51.5 (-115)
Nov 2, 2025 1:00PM EST
Chicago Bears
Cincinnati Bengals
11/2/25 1PM
Bears
Bengals
-142
+120
-2.5 (-110)
+2.5 (-110)
O 50.5 (-120)
U 50.5 (-102)
Nov 2, 2025 1:00PM EST
Indianapolis Colts
Pittsburgh Steelers
11/2/25 1PM
Colts
Steelers
-158
+134
-3 (-115)
+3 (-105)
O 50.5 (-104)
U 50.5 (-118)
Nov 2, 2025 1:00PM EST
Carolina Panthers
Green Bay Packers
11/2/25 1PM
Panthers
Packers
+700
-1100
+13.5 (-108)
-13.5 (-112)
O 44.5 (-105)
U 44.5 (-115)
Nov 2, 2025 1:00PM EST
Atlanta Falcons
New England Patriots
11/2/25 1PM
Falcons
Patriots
+190
-230
+5.5 (-115)
-5.5 (-105)
O 44.5 (-110)
U 44.5 (-110)
Nov 2, 2025 1:00PM EST
Denver Broncos
Houston Texans
11/2/25 1PM
Broncos
Texans
+102
-120
+1.5 (-108)
-1.5 (-112)
O 39.5 (-110)
U 39.5 (-110)
Nov 2, 2025 1:00PM EST
San Francisco 49ers
New York Giants
11/2/25 1PM
49ers
Giants
-146
+126
-2.5 (-115)
+2.5 (-105)
O 48.5 (-115)
U 48.5 (-105)
Nov 2, 2025 1:00PM EST
Los Angeles Chargers
Tennessee Titans
11/2/25 1PM
Chargers
Titans
-480
+370
-9.5 (-110)
+9.5 (-110)
O 43.5 (-105)
U 43.5 (-115)
Nov 2, 2025 1:00PM EST
Minnesota Vikings
Detroit Lions
11/2/25 1PM
Vikings
Lions
+370
-480
+8.5 (-108)
-8.5 (-112)
O 48.5 (-110)
U 48.5 (-110)
Nov 2, 2025 4:05PM EST
New Orleans Saints
Los Angeles Rams
11/2/25 4:05PM
Saints
Rams
+730
-1150
+14.5 (-115)
-14.5 (-105)
O 43.5 (-110)
U 43.5 (-110)
Nov 2, 2025 4:05PM EST
Jacksonville Jaguars
Las Vegas Raiders
11/2/25 4:05PM
Jaguars
Raiders
-158
+134
-3 (-105)
+3 (-115)
O 44.5 (-115)
U 44.5 (-105)
Nov 2, 2025 4:25PM EST
Kansas City Chiefs
Buffalo Bills
11/2/25 4:25PM
Chiefs
Bills
-134
+114
-1.5 (-114)
+1.5 (-106)
O 52.5 (-105)
U 52.5 (-115)
Nov 2, 2025 8:20PM EST
Seattle Seahawks
Washington Commanders
11/2/25 8:20PM
Seahawks
Commanders
-166
+140
-3 (-110)
+3 (-110)
O 47.5 (-112)
U 47.5 (-108)
Nov 3, 2025 8:15PM EST
Arizona Cardinals
Dallas Cowboys
11/3/25 8:15PM
Cardinals
Cowboys
+128
-152
+2.5 (-104)
-2.5 (-118)
O 53.5 (-110)
U 53.5 (-110)
Nov 6, 2025 8:15PM EST
Las Vegas Raiders
Denver Broncos
11/6/25 8:15PM
Raiders
Broncos
+370
-480
+9.5 (-115)
-9.5 (-105)
O 42.5 (-120)
U 42.5 (-102)
Nov 9, 2025 9:30AM EST
Atlanta Falcons
Indianapolis Colts
11/9/25 9:30AM
Falcons
Colts
+290
-360
+7 (-105)
-7 (-115)
O 48.5 (-108)
U 48.5 (-112)

NFL Past Picks

Remi—our in-house AI—prices every game and prop using multi-season priors, tempo/efficiency, injury/usage signals, and market movement.
We publish fair prices, recommended “buy-to” numbers, and confidence so you can bet prices, not teams.

This preview covers Los Angeles Chargers vs. New York Giants on September 28, 2025 at MetLife Stadium.
Odds shown reflect widely available numbers and may update closer to kickoff.

Want more? Check live edges, player props, and line moves on our NFL odds pages, and compare prices before you place a bet.

    LEAN     %WIN     UNITS RESULT
TB@NO TB -3.5 52.3% 1 WIN
GB@PIT GB -2.5 52.3% 1 WIN
SF@HOU SF +2.5 56.0% 6 LOSS
NYG@PHI NYG +7.5 53.9% 3 LOSS
BUF@CAR CAR +7.5 54.2% 3 LOSS
DAL@DEN DAL +3.5 55.0% 4 LOSS
MIA@ATL MIA +7 54.3% 4 WIN
CLE@NE CLE +7 56.8% 6 LOSS
TB@NO BAKER MAYFIELD OVER 15.5 RUSH YDS 56.6% 6 LOSS
MIN@LAC JUSTIN HERBERT PASS ATT UNDER 35.5 55.5% 5 WIN
TB@DET TB +6.5 54.4% 4 LOSS
TB@DET RACHAAD WHITE UNDER 14.5 RUSH ATT 54.4% 4 WIN
NE@TEN NE -6.5 55.2% 5 WIN
CAR@NYJ CAR -110 57.4 4 WIN
PHI@MIN PHI -130 58.0% 6 WIN
GB@ARI ARI +7 54.8% 5 WIN
NO@CHI NO +4.5 57.4% 7 LOSS
WAS@DAL JAYDEN DANIELS 1H RUSH YDS OVER 22.5 56.1% 5 WIN
GB@ARI JORDAN LOVE 1Q PASS YDS OVER 54.5 56.6% 6 WIN
PIT@CIN JONNU SMITH RECEPTIONS OVER 3.5 55.3% 5 LOSS
BUF@ATL BUF -3.5 54.7% 4 LOSS
CHI@WAS JAYDEN DANIELS OVER 1.5 PASS TDS 56.6% 6 WIN
TEN@LV UNDER 42 54.8% 3 WIN
DET@KC DET +2.5 55.7% 7 LOSS
SEA@JAC SEA -112 55.7% 5 WIN
LAC@MIA LAC -3.5 54.0% 3 LOSS
ARI@IND IND -8.5 55.6% 5 LOSS
TEN@LV TEN +4.5 56.7% 6 LOSS
LAR@BAL LAR -7 56.2% 6 WIN
SF@TB SF +3.5 57.2% 7 LOSS
CLE@PIT JAYLEN WARREN UNDER 46.5 RUSH YDS 54.4% 4 LOSS
DEN@NYJ BREECE HALL OVER 26.5 RECV YDS 55.0% 4 LOSS
KC@JAC UNDER 45.5 54.9% 3 LOSS
KC@JAC PATRICK MAHOMES UNDER 23.5 PASS COMP 56.6% 6 LOSS
HOU@BAL HOU -125 58.5% 7 WIN
DET@CIN DET -10 55.6% 5 WIN
DAL@NYJ NYJ +1.5 53.7% 3 LOSS
TB@SEA TB +3.5 54.9% 4 WIN
TEN@ARI ARI -7 (BUY 0.5) 54.9% 4 LOSS
DEN@PHI DEN +4.5 57.5% 7 WIN
MIA@CAR TETAIROA MCMILLAN OVER 58.5 RECV YDS 54.5% 4 WIN
LV@IND ASHTON JEANTY UNDER 67.5 RUSH YDS 54.4% 4 WIN
SF@LAR DEMARCUS ROBINSON OVER 29.5 RECV YDS 55.7% 5 WIN
NYJ@MIA NYJ +3 53.8 3 LOSS
CIN@DEN DEN -7.5 54.8 4 WIN
NYJ@MIA OVER 44 52.9% 2 WIN
CIN@DEN UNDER 44.5 53.7% 3 WIN
NYJ@MIA GARRETT WILSON UNDER 9 TARGETS 53.7% 3 WIN
CIN@DEN TEE HIGGINS OVER 6.5 RECV TARGETS 55.5% 5 LOSS
WAS@ATL ATL -2.5 54.3 4 WIN
BAL@KC BAL -2.5 56.3% 6 LOSS