The September 28, 2025 matchup between the Los Angeles Chargers and New York Giants at MetLife Stadium looks like one of the more lopsided contests on the Week 4 slate, as the undefeated Chargers enter with momentum and a polished offense while the winless Giants turn to a rookie quarterback to salvage their season. Los Angeles, led by Justin Herbert, has been sharp on both sides of the ball, with an offense that ranks among the NFL’s best in yards per game and a defense that has thrived on creating pressure and forcing turnovers. Herbert’s ability to distribute the ball efficiently to a deep group of receivers, paired with a running game that keeps defenses honest, has allowed the Chargers to set tempo early in games and control the pace for four quarters. Against a Giants defense that has struggled to stop both the pass and the run, the Chargers will likely lean into play-action and vertical concepts to create explosive plays while relying on their offensive line to keep Herbert upright. The Giants, meanwhile, are desperate for a spark after an 0–3 start, benching Russell Wilson in favor of rookie Jaxson Dart, whose debut as the starter will come against one of the AFC’s hottest teams.

Protecting Dart will be paramount, as the Chargers’ front seven can collapse pockets quickly and force hurried decisions, and his best chance for success will come through quick throws, screens, and a run game that must stay productive enough to prevent Los Angeles from teeing off on obvious passing downs. New York’s defense faces an equally tall task, needing to generate pressure on Herbert without leaving their secondary exposed to one-on-one mismatches that have burned them throughout September. Historically, the Chargers have dominated this matchup, going 5–0 ATS in their last five meetings against the Giants, and the betting line of –6.5 reflects confidence in their ability to continue that trend. The total of 44.5 suggests modest scoring expectations, but with Herbert’s offense capable of pushing 30-plus points by itself, much of that number may depend on whether Dart and the Giants’ offense can keep pace. For the Giants to pull an upset, they’ll need turnovers, field position wins, and a disciplined defensive game that limits explosive plays—factors that have been elusive so far this season. For the Chargers, the formula is straightforward: protect Herbert, let their playmakers exploit mismatches, and pressure the rookie quarterback into mistakes. If executed, Los Angeles has the tools to remain undefeated and cover the spread, while New York will be left searching for answers in a season that is already threatening to spiral.